Entry Name Glycine, serine and threonine metabolism
Description Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:
M00020 ], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:
M00018 ].
Class Metabolism; Amino acid metabolismBRITE hierarchy
Pathway map map00260 Glycine, serine and threonine metabolism
Ortholog table Module M00018 Threonine biosynthesis, aspartate => homoserine => threonine [PATH:map00260 ]
M00338 Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:map00260 ]
M00974 Betaine metabolism, animals, betaine => glycine [PATH:map00260 ]
M00975 Betaine degradation, bacteria, betaine => pyruvate [PATH:map00260 ]
Other DBs Reference Authors Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
Title [Cellular Functions and Metabolic Maps] (In Japanese)
Journal Tokyo Kagaku Dojin (1997)
Reference Authors Kuhlmann AU, Bremer E.
Title Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
Journal Reference Authors Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
Title Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
Journal Reference Authors Bursy J, Pierik AJ, Pica N, Bremer E.
Title Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
Journal Reference Authors Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
Title The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
Journal Reference Authors Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
Title FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
Journal Reference Authors Rees WD, Hay SM
Title The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
Journal Reference Authors Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
Title Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
Journal Reference Authors Chen X, Jhee KH, Kruger WD
Title Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
Journal Related map00250 Alanine, aspartate and glutamate metabolism
map00270 Cysteine and methionine metabolism
map00290 Valine, leucine and isoleucine biosynthesis
map00330 Arginine and proline metabolism
map00630 Glyoxylate and dicarboxylate metabolism
KO pathway LinkDB All DBs
