URL: https://web.expasy.org/cellosaurus/CVCL_0007
Proper Citation: (RRID:CVCL_0007)
Description: Cell line U-937 is a Cancer cell line with a species of origin Homo sapiens (Human)
Sex: Male
Disease: Adult acute monocytic leukemia
Defining Citation: PMID:178611, PMID:1083890, PMID:1571549, PMID:1913629, PMID:2140233, PMID:2985879, PMID:3159941, PMID:3874327, PMID:6091813, PMID:6582512, PMID:7759961, PMID:8300570, PMID:8547074, PMID:8558913, PMID:8558920, PMID:8643484, PMID:9371509, PMID:9510473, PMID:9685479, PMID:9738977, PMID:10352142, PMID:10676951, PMID:10739008, PMID:10966170, PMID:11226526, PMID:11416159, PMID:11701946, PMID:12393283, PMID:15637111, PMID:15843827, PMID:16311011, PMID:16337770, PMID:16408098, PMID:20801507, PMID:21269460, PMID:22460905, PMID:25485619, PMID:25877200, PMID:26589293, PMID:29787063, PMID:30285677, PMID:30629668, PMID:30894373, PMID:31068700, PMID:31160637, PMID:31978347, PMID:33317567, PMID:34707142
Comments: Anecdotal: Have been flown in space on shuttle flight STS-76 and on Shenzhou-8 to study growth and cytoskeletal changes in microgravity (PubMed=10352142; DOI=10.1016/j.actaastro.2013.06.007)., Omics: Transcriptome analysis by RNAseq., Omics: Transcriptome analysis by microarray., Omics: SNP array analysis., Omics: Proteome analysis by 2D-DE/MS., Omics: DNA methylation analysis., Omics: Deep quantitative proteome analysis., Omics: Deep proteome analysis., Omics: Deep exome analysis., Omics: Deep antibody staining analysis., Karyotypic information: Has lost chromosome Y., Characteristics: Can be induced to differentiate into macrophages by several factors such as phorbol ester (PMA) and 12-O-tetradecanoyl-13-phorbol acetate (TPA)., Population: Caucasian., Part of: LL-100 blood cancer cell line panel., Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE)., Problematic cell line: Partially contaminated. Some ATCC stocks were cross-contaminated by K-562 initially (PubMed=7759961). The problem was corrected and subsequent stocks have been confirmed to carry only U-937.., Group: Space-flown cell line (cellonaut).
Category: Cancer cell line
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No rating or validation information has been found for U-937.
Partially Contaminated
Problematic cell line: Partially contaminated. Some ATCC stocks were cross-contaminated by K-562 initially (PubMed=7759961). The problem was corrected and subsequent stocks have been confirmed to carry only U-937.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00168.
Discontinued
Discontinued: RCB; RCB1978
Discontinued
Discontinued: ATCC; CRL-1593
Possibly Discontinued
Discontinued: TKG; TKG 0279
Source: Cellosaurus
