URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=34830
Proper Citation: RRID:MMRRC_034830-JAX
Description: Mus musculus with name B6;129-Tg(APPSwe,tauP301L)1Lfa Psen1tm1Mpm/Mmjax from MMRRC.
Species: Mus musculus
Notes: Research areas: ; Mutation Type: Targeted Mutation ; Collection:
Phenotype: abnormal microglial cell morphology [MP:0000136]| short tail [MP:0000592]| increased anxiety-related response [MP:0001363]| hypoactivity [MP:0001402]| abnormal contextual conditioning behavior [MP:0001469]| increased circulating corticosterone level [MP:0001745]| hemorrhage [MP:0001914]| abnormal learning/memory/conditioning [MP:0002063]| abnormal brain morphology [MP:0002152]| neurodegeneration [MP:0002229]| neurofibrillary tangles [MP:0003214]| neuron degeneration [MP:0003224]| amyloid beta deposits [MP:0003329]| increased fear-related response [MP:0003459]| abnormal microglial cell physiology [MP:0003691]| decreased fetal size [MP:0004200]| tau protein deposits [MP:0004250]| abnormal behavior [MP:0004924]| abnormal limb development [MP:0006279]| increased susceptibility to neuronal excitotoxicity [MP:0008235]| abnormal spatial working memory [MP:0008428]| enhanced contextual conditioning behavior [MP:0009453]| abnormal neuron differentiation [MP:0009937]| lethality throughout fetal growth and development [MP:0011099]
Affected Gene: |Psen1||MAPT|APP|Thy1
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Source: Integrated Animals
Source Database: Mutant Mouse Resource and Research Center (MMRRC)