Escherichia coli K-12 MG1655
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Working With: Genome: Escherichia coli K-12 MG1655 Version: v3

ABE-0001072 (betB) - Escherichia coli K-12 MG1655 - Feature Annotation

ASAP ID
ABE-0001072 showshow history
Names
betB JW0304 ECK0310 b0312
Product
betaine aldehyde dehydrogenase
Type
CDS
Location
# Contig Strand Left Right Length (b.p.) Length (a.a.)
1 Chromosome complement 327261 328733 1473 491
Sequence

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Context

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Protein Families to toptop
Author Approval Family Annotated
Automated Process Approved IPR011264 (IPR011264 Betaine aldehyde dehydrogenase) Apr 2008
Automated Process Approved IPR012303 (IPR012303 (DEPRECATED) NAD-dependent aldehyde dehydrogenase) Apr 2008
Automated Process Approved IPR015590 (IPR015590 Aldehyde dehydrogenase domain) Apr 2008
Automated Process Approved IPR016161 (IPR016161 Aldehyde/histidinol dehydrogenase) Jul 2018
Automated Process Approved PF00171 (PF00171 Aldehyde dehydrogenase family) Jul 2018
Gene Ontology to toptop
Author Approval Type Annotation Evidence Annotated
Person Uncurated GO biological process GO:0006578 amino-acid betaine biosynthetic process Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Uncurated GO biological process GO:0019285 glycine betaine biosynthetic process from choline GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR011264
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Uncurated GO biological process GO:0008152 metabolic process GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR015590, IPR016161
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Uncurated GO biological process GO:0055114 (OBSOLETE) oxidation-reduction process GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR015590, IPR016161
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Person Uncurated GO biological process GO:0006970 response to osmotic stress Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Approved GO biological process GO:0006578 amino-acid betaine biosynthetic process GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR011264
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO cellular component GO:0005737 cytoplasm GO Inferred from Electronic Annotation - PubMed ID: 15501914
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Automated Process Uncurated GO molecular function GO:0046872 metal ion binding GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR011264
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Uncurated GO molecular function GO:0016491 oxidoreductase activity GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR015590, IPR016161
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved GO molecular function GO:0008802 betaine-aldehyde dehydrogenase activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR011264
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Annotations to toptop
Author Approval Type Annotation Evidence Annotated
Nomenclature
Person Approved name betB Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Oct 1998
Person Approved synonym ECK0310 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved synonym JW0304 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved locus tag b0312 Unique Identifier - Origin: Guy Plunkett III, guy@genome.wisc.edu May 2004
Product
Person Uncurated product betaine aldehyde dehydrogenase Published Annotation - PubMed ID: 16397293
Reference: Escherichia coli K-12 		Oct 2021
Person Approved alternate product name NAD+-dependent betaine aldehyde dehydrogenase Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Jan 2006
Protein Family
Automated Process Approved protein family IPR015590 Aldehyde dehydrogenase domain Protein Sequence Similarity - InterPro Domain: IPR015590
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family IPR011264 Betaine aldehyde dehydrogenase Protein Sequence Similarity - InterPro Domain: IPR011264
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family PF00171 Aldehyde dehydrogenase family Protein Sequence Similarity - PFAM Model Name: PF00171
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved protein family IPR012303 (DEPRECATED) NAD-dependent aldehyde dehydrogenase Protein Sequence Similarity - InterPro Domain: IPR012303
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family IPR016161 Aldehyde/histidinol dehydrogenase Protein Sequence Similarity - InterPro Domain: IPR016161
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Other
Automated Process Uncurated EC number 1.-.-.- Published Annotation - Database Name: EC2GO: GO:0016491
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Person Approved EC number 1.2.1.8 Published Annotation - Swiss-Prot Accession Number: P17445 Feb 2006
Person Uncurated MultiFun 5.5.1 (cell processes; adaptation to stress; osmotic pressure) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Person Uncurated MultiFun 1.7.18 (metabolism; central intermediary metabolism; betaine biosynthesis) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Automated Process Approved codon start 1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref EcoGene:EG10110 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref UniProtKB/Swiss-Prot:P17445 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref ASAP:ABE-0001072 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref GeneID:947376 Published Annotation - Entrez Gene Database ID: 947376
Reference: Escherichia coli K-12 MG1655 		Jun 2009
Automated Process Approved db xref GI:1786504 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Person Approved db xref UniProtKB:P17445 Published Annotation - Swiss-Prot Accession Number: P17445 Jan 2005
Person Approved function enzyme; Osmotic adaptation Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Oct 1998
Automated Process Approved note NAD+-dependent betaine aldehyde dehydrogenase; GO_process: GO:0006578 - betaine biosynthetic process; GO_process: GO:0006970 - response to osmotic stress Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved protein id AAC73415.1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Uncurated subcellular localization Cytoplasmic Predicted by PSORTb - PSORTb Final_Score: 9.26
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Person Uncurated subsystem component of in silico model iJR904 Experimental - PubMed ID: 12952533
Reference: Escherichia coli K-12 MG1655 		Feb 2009
Person Uncurated subsystem component of in silico model iMC1010 Experimental - PubMed ID: 15129285
Reference: Escherichia coli K-12 MG1655 		Mar 2009
Person Uncurated subsystem component of in silico model iAF1260 Experimental - PubMed ID: 17593909
Reference: Escherichia coli K-12 MG1655 		Jan 2009
Automated Process Approved transl table 11 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Gene Ontology
Person Uncurated GO biological process GO:0006578 amino-acid betaine biosynthetic process Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Uncurated GO biological process GO:0019285 glycine betaine biosynthetic process from choline GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR011264
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Uncurated GO biological process GO:0008152 metabolic process GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR015590, IPR016161
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Uncurated GO biological process GO:0055114 (OBSOLETE) oxidation-reduction process GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR015590, IPR016161
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved GO biological process GO:0006578 amino-acid betaine biosynthetic process GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR011264
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Person Uncurated GO biological process GO:0006970 response to osmotic stress Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Uncurated GO cellular component GO:0005737 cytoplasm GO Inferred from Electronic Annotation - PubMed ID: 15501914
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Automated Process Uncurated GO molecular function GO:0016491 oxidoreductase activity GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR015590, IPR016161
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Uncurated GO molecular function GO:0046872 metal ion binding GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR011264
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved GO molecular function GO:0008802 betaine-aldehyde dehydrogenase activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR011264
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Comparative to toptop
Author Approval Details Genome Feature Name Type
Member
Automated Process Uncurated Go view OrthoMCL (14 enterobacteria) AMM-0003293 CDS
Automated Process Uncurated Go view OrthoMCL (205 gammaproteobacteria) APP-0002953 betB CDS
Automated Process Uncurated Go view OrthoMCL (307 Enterobacteriaceae) ATM-0002700 betB CDS
Automated Process Uncurated Go view OrthoMCL (42 Serratia) BEZ-0002308 betB CDS
Automated Process Uncurated Go view OrthoMCL (UW draft) CQJ-0002880 betB CDS
Ortholog
Automated Process Uncurated Go view Brenneria salicis ATCC 15712 [T] AMK-0000968 CDS
Automated Process Uncurated Go view Cedecea davisae ATCC 33431 [T] ALZ-0001967 betB CDS
Automated Process Approved Go view Citrobacter amalonaticus ATCC 25405 [T] AUW-0001390 betB CDS
Person Approved Go view Dickeya dadantii 3937 ABF-0019709 betB CDS
Automated Process Uncurated Go view Enterobacter cloacae subsp. cloacae ATCC 13047 [T] (AToL DRAFT) AMB-0001623 betB CDS
Automated Process Uncurated Go view Erwinia amylovora ATCC 49946 ACW-0301371 betB CDS
Automated Process Uncurated Go view Erwinia amylovora ATCC BAA-2158 APN-0001878 betB CDS
Automated Process Uncurated Go view Erwinia tasmaniensis Et1/99 [T] AFI-0001842 betB CDS
Automated Process Uncurated Go view Escherichia coli 101-1 (EAEC) BAB-0007458 betB CDS
Automated Process Approved Go view Escherichia coli 536 (UPEC) AEF-0000391 CDS
Automated Process Approved Go view Escherichia coli APEC O1 (APEC) AEG-0000307 betB CDS
Automated Process Approved Go view Escherichia coli ATCC 11775 [T] AMC-0003997 betB CDS
Person Approved Go view Escherichia coli ATCC 8739 AEM-0009322 CDS
Automated Process Uncurated Go view Escherichia coli B171 (EPEC) ADN-0007082 betB CDS
Automated Process Uncurated Go view Escherichia coli B7A (ETEC) ADK-0005799 CDS
Person Approved Go view Escherichia coli CFT073 (UPEC) ABR-0076508 betB CDS
Automated Process Uncurated Go view Escherichia coli DEC7E (UM-IGS draft) CFX-0000368 betB CDS
Automated Process Uncurated Go view Escherichia coli DEC9A (UM-IGS draft) CFY-0000455 betB CDS
Automated Process Uncurated Go view Escherichia coli E110019 (EPEC) ADM-0007068 betB CDS
Automated Process Uncurated Go view Escherichia coli E22 (EPEC) ADL-0008091 betB CDS
Person Approved Go view Escherichia coli E2348/69 (EPEC) BCI-0000293 betB CDS
Automated Process Approved Go view Escherichia coli E24377A (ETEC) ADO-0004777 betB CDS
Automated Process Uncurated Go view Escherichia coli EC4024 (EHEC) BBI-0003869 CDS
Automated Process Uncurated Go view Escherichia coli EC4042 (EHEC) BBA-0010546 betB CDS
Automated Process Uncurated Go view Escherichia coli EC4045 (EHEC) BBB-0008129 betB CDS
Automated Process Uncurated Go view Escherichia coli EC4076 (EHEC) BAZ-0009206 betB CDS
Automated Process Uncurated Go view Escherichia coli EC4113 (EHEC) BAY-0007301 betB CDS
Person Approved Go view Escherichia coli EC4115 (EHEC) BAS-0005213 betB CDS
Automated Process Uncurated Go view Escherichia coli EC4196 (EHEC) BAX-0007988 betB CDS
Automated Process Uncurated Go view Escherichia coli EC4206 (EHEC) BAW-0008945 betB CDS
Automated Process Uncurated Go view Escherichia coli EC4401 (EHEC) BAV-0007836 betB CDS
Automated Process Uncurated Go view Escherichia coli EC4486 (EHEC) BAU-0009108 betB CDS
Automated Process Uncurated Go view Escherichia coli EC4501 (EHEC) BAT-0007550 betB CDS
Automated Process Uncurated Go view Escherichia coli EC508 (EHEC) BBJ-0007470 betB CDS
Automated Process Uncurated Go view Escherichia coli EC869 (EHEC) BBC-0008909 betB CDS
Person Approved Go view Escherichia coli EDL933 (EHEC) ABH-0024287 betB CDS
Automated Process Approved Go view Escherichia coli F11 (UPEC) ADQ-0008748 betB CDS
Automated Process Approved Go view Escherichia coli HS ADR-0005053 betB CDS
Automated Process Uncurated Go view Escherichia coli J96 (UPEC) CQK-0000641 CDS
Person Approved Go view Escherichia coli K-12 DH10B AEC-0000336 betB CDS
Person Approved Go view Escherichia coli K-12 W3110 ADY-0000316 betB CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR68 CGA-0000514 CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR71 CGB-0000594 CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR8 CFZ-0000445 CDS
Automated Process Uncurated Go view Escherichia coli Nissle 1917 AML-0000430 CDS
Automated Process Uncurated Go view Escherichia coli RS218 (NMEC) ACK-0174519 CDS
Person Approved Go view Escherichia coli SE11 AFS-0000342 CDS
Person Approved Go view Escherichia coli SMS-3-5 AFT-0000342 betB CDS
Person Approved Go view Escherichia coli Sakai (EHEC) ACA-0130249 betB CDS
Automated Process Uncurated Go view Escherichia coli TW14588 (EHEC) BBK-0004920 CDS
Automated Process Approved Go view Escherichia coli UTI89 (UPEC) AEA-0000342 betB CDS
Automated Process Uncurated Go view Ewingella americana ATCC 33852 [T] AMA-0000948 betB CDS
Person Approved Go view Klebsiella pneumoniae subsp. pneumoniae MGH 78578 AEP-0000587 CDS
Automated Process Uncurated Go view Pantoea agglomerans IG1 APM-0001548 CDS
Automated Process Uncurated Go view Pantoea agglomerans SL1-M5 ALY-0003465 CDS
Automated Process Uncurated Go view Pantoea ananatis AJ13355 AOV-0001511 betB CDS
Automated Process Uncurated Go view Pantoea ananatis B1-9 APL-0002559 CDS
Automated Process Uncurated Go view Pantoea ananatis LMG 20103 AKB-0002233 betB CDS
Automated Process Uncurated Go view Pantoea ananatis PA13 APK-0001979 CDS
Automated Process Uncurated Go view Pantoea sp. At-9b AGM-0009484 CDS
Automated Process Uncurated Go view Pantoea sp. aB AJV-0001628 CDS
Automated Process Uncurated Go view Pantoea stewartii DC283 ACV-0285613 betB CDS
Automated Process Uncurated Go view Pantoea vagans C9-1 ALK-0005377 betB CDS
Person Approved Go view Pectobacterium atrosepticum SCRI1043 ABL-0062003 betB CDS
Person Uncurated Go view Pectobacterium carotovorum WPP14 ADT-0002786 betB CDS
Automated Process Uncurated Go view Pectobacterium sp. PC1 AFL-0007556 CDS
Person Uncurated Go view Pseudomonas syringae pv. tomato DC3000 ADG-0000443 betB CDS
Automated Process Uncurated Go view Serratia marcescens subsp. marcescens ATCC 13880 [T] AMF-0004292 betB CDS
Person Uncurated Go view Serratia proteamaculans 568 AEN-0007844 CDS
Automated Process Approved Go view Shigella flexneri 8401 BAG-0000337 betB CDS
Person Uncurated Go view Xenorhabdus nematophila ATCC 19061 [T] ADW-0002177 betB CDS
Person Approved Go view Yersinia pestis 91001 (biovar Microtus) ACQ-0236572 betB CDS
Automated Process Approved Go view Yersinia pestis Antiqua (biovar Antiqua) BAE-0001304 betB CDS
Automated Process Uncurated Go view Yersinia pestis B42003004 (biovar Antiqua) BAL-0005231 betB CDS
Automated Process Uncurated Go view Yersinia pestis CA88-4125 (biovar Orientalis) BAF-0002201 betB CDS
Person Approved Go view Yersinia pestis CO92 (biovar Orientalis) ABY-0119074 betB CDS
Automated Process Uncurated Go view Yersinia pestis E1979001 (biovar Antiqua) BAM-0008071 betB CDS
Automated Process Uncurated Go view Yersinia pestis F1991016 (biovar Orientalis) BAQ-0004776 betB CDS
Automated Process Uncurated Go view Yersinia pestis FV-1 (biovar Orientalis) BAK-0001641 CDS
Automated Process Uncurated Go view Yersinia pestis K1973002 (biovar Mediaevalis) BAO-0005354 betB CDS
Automated Process Approved Go view Yersinia pestis Nepal516 (biovar Antiqua) BAD-0003410 betB CDS
Automated Process Approved Go view Yersinia pestis Pestoides F (biovar Pestoides) BAI-0003043 CDS
Automated Process Uncurated Go view Yersinia pestis UG05-0454 (biovar Antiqua) BAN-0006318 betB CDS
Automated Process Approved Go view Yersinia pseudotuberculosis IP31758 ADS-0006820 betB CDS
Person Approved Go view Yersinia pseudotuberculosis IP32953 ACZ-0001264 betB CDS
Person Uncurated Go view Yersinia pseudotuberculosis PB1/+ AFV-0001506 CDS
Person Uncurated Go view Yersinia pseudotuberculosis YPIII AFW-0003466 CDS
Molecular Interactions to toptop
Author Approval Feature Name Technique Evidence Comment Annotated
Person Approved ABE-0001072 betB lambda repressor assay Doodle - bnumber: b0312 Oct 2003
Experimental to toptop
SelectSetNameSetDetailsNotes
stringent responsetranscriptional profile of the stringent responseNone
Recombinant heat-shock dataexpression data for recombinant strain under heat shockThese data are from the Harcum laboratory. (Jeremy Glasner)
Suppressor tRNA expressionexperiment comparing transcript levels in cells with and without suppressor tRNA expressionThese data were reported in the paper: Herring and Blattner. 2004. Global transcriptional effects of a suppressor tRNA and the inactivation of the regulator frmR. J. Bacteriol. 186(20):6714-20. Link to Abstract (Jeremy Glasner)
Recombinant E. coli expressionexperiment comparing expression of wild-type E. coli with the same strain harboring a plasmid that expresses protein when induced with IPTG These data were reported in the paper: F. T. Haddadin, S. W. Harcum (2005) Transcriptome profiles for high-cell-density recombinant and wild-type Escherichia coli, Biotechnology and Bioengineering, 90:127-153. Link to Abstract (Jeremy Glasner)
Aerobic shiftAerobic shiftThese data were reported in the paper: Covert MW, Knight EM, Reed JL, Herrgard MJ, Palsson BO. 2004. Integrating high-throughput and computational data elucidates bacterial networks. Nature. 2004 May 6;429(6987):92-6. Link to Abstract (Jeremy Glasner)
CalibratorCalibrated microarray experiments (50 hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
AffyData1Affymetrix Experiments (data from 41 chip hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
Context Table to toptop

Listed below are features that lie nearby this feature. Features encoded in multiple intervals may appear more than once in the table. Features that span the origin will have a left endpoint greater than the right endpoint.

Features overlapping the region 322261 to 333733
FeatureIDNameFeature TypeStrandLeft EndRight EndRelationship
ABE-0000001sourceforward14641652Contains
ABE-0001058ykgECDSforward321608322327Downstream
ABE-0001060ykgFCDSforward322338323765Downstream
ABE-0001062ykgGCDSforward323758324453Downstream
ABE-0001066ykgHCDScomplement324696325364Downstream
ABE-0001070betACDScomplement325577327247Downstream
ABE-0001072betBCDScomplement327261328733Matches
ABE-0001076betICDScomplement328747329334Upstream
ABE-0001080betTCDSforward329463331496Upstream
ABE-0285783yahVCDSforward331802331876Upstream
ABE-0001086pdeLCDSforward332371333459Upstream
ABE-0001088yahBCDScomplement333501334433Upstream
Release Notes to toptop
All MG1655 annotations and sequence data are publicly available, and investigators can use these data in publications without contacting the genome curators. This version of the sequence was the source of GenBank record U00096.3. Ongoing annotation updates to that GenBank record are being generated from a collaboration that includes ASAP, EcoGene, the Coli Genetic Stock Center, EcoliHub, EcoCyc, RegulonDB and UniProtKB/Swiss-Prot.