Escherichia coli K-12 MG1655
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Working With: Genome: Escherichia coli K-12 MG1655 Version: v3

ABE-0001181 (lacY) - Escherichia coli K-12 MG1655 - Feature Annotation

ASAP ID
ABE-0001181 showshow history
Names
lacY JW0334 ECK0340 b0343
Product
lactose/galactose transporter
Type
CDS
Location
# Contig Strand Left Right Length (b.p.) Length (a.a.)
1 Chromosome complement 361926 363179 1254 418
Sequence

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View sequence with flanking regions: bases upstream and bases downstream

Context

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Protein Families to toptop
Author Approval Family Annotated
Automated Process Approved IPR000576 (IPR000576 LacY/RafB permease family) Apr 2008
Automated Process Approved IPR007114 (IPR007114 (DEPRECATED) Major facilitator superfamily) Apr 2008
Automated Process Approved IPR036259 (IPR036259 MFS transporter superfamily) Jul 2018
Automated Process Approved PF01306 (PF01306 LacY proton/sugar symporter) Jul 2018
Gene Ontology to toptop
Author Approval Type Annotation Evidence Annotated
Person Approved GO biological process GO:0016052 carbohydrate catabolic process Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Uncurated GO biological process GO:0008643 carbohydrate transport GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR000576
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved GO biological process GO:0006810 transport GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR000576
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO cellular component GO:0016021 integral component of membrane GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR007114
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO cellular component GO:0016020 membrane GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR000576
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO cellular component GO:0005886 plasma membrane GO Inferred from Electronic Annotation - PubMed ID: 15501914
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Person Approved GO cellular component GO:0019866 organelle inner membrane Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Uncurated GO molecular function GO:0005351 carbohydrate:proton symporter activity GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR000576
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved GO molecular function GO:0005403 (DEPRECATED) hydrogen:sugar symporter activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR000576
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO molecular function GO:0005215 transporter activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR007114
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Annotations to toptop
Author Approval Type Annotation Evidence Annotated
Nomenclature
Person Approved name lacY Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Oct 1998
Person Approved synonym ECK0340 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved synonym JW0334 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved locus tag b0343 Unique Identifier - Origin: Guy Plunkett III, guy@genome.wisc.edu May 2004
Product
Person Approved product lactose/galactose transporter Published Annotation - PubMed ID: 16397293 Jan 2006
Automated Process Approved alternate product name lactose permease Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Person Approved alternate product name galactoside permease (lactose permease, M protein) (MFS family) Published Annotation - Database Name: GenProtEC Jan 2006
Protein Family
Automated Process Approved protein family IPR000576 LacY/RafB permease family Protein Sequence Similarity - InterPro Domain: IPR000576
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family IPR036259 MFS transporter superfamily Protein Sequence Similarity - InterPro Domain: IPR036259
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved protein family IPR007114 (DEPRECATED) Major facilitator superfamily Protein Sequence Similarity - InterPro Domain: IPR007114
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family PF01306 LacY proton/sugar symporter Protein Sequence Similarity - PFAM Model Name: PF01306
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Other
Person Approved MultiFun 4.2.A.1 (transport; Electrochemical potential driven transporters; Porters (Uni-, Sym- and Antiporters); The Major Facilitator Superfamily (MFS)) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Person Approved MultiFun 7.3 (location of gene products; inner membrane) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Person Approved MultiFun 4.S.99 (transport; substrate; lactose) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Person Approved MultiFun 6.1 (cell structure; membrane) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Person Approved MultiFun 1.1.1 (metabolism; carbon utilization; carbon compounds) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Automated Process Approved codon start 1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref GeneID:949083 Published Annotation - Entrez Gene Database ID: 949083
Reference: Escherichia coli K-12 MG1655 		Jun 2009
Person Approved db xref UniProtKB:P02920 Published Annotation - Swiss-Prot Accession Number: P02920 Jan 2005
Automated Process Approved db xref UniProtKB/Swiss-Prot:P02920 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref EcoGene:EG10526 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref GI:1786538 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref ASAP:ABE-0001181 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved function 6.1 cell structure; membrane Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved function 1.1.1 metabolism; carbon utilization; carbon compounds Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved function 4.S.99 transport; substrate; lactose Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved function 4.2.A.1 transport; Electrochemical potential driven transporters; Porters (Uni-, Sym- and Antiporters); The Major Facilitator Superfamily (MFS) Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Person Approved function transport; Transport of small molecules: Carbohydrates, organic acids, alcohols Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Oct 1998
Automated Process Approved function 7.3 location of gene products; inner membrane Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved note galactoside permease (lactose permease, M protein) (MFS family); GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane; GO_process: GO:0016052 - carbohydrate catabolic process Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved protein id AAC73446.1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Uncurated subcellular localization Cytoplasmic Membrane Predicted by PSORTb - PSORTb Final_Score: 10.00
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Person Uncurated subsystem component of in silico model iJR904 Experimental - PubMed ID: 12952533
Reference: Escherichia coli K-12 MG1655 		Feb 2009
Person Uncurated subsystem component of in silico model iMC1010 Experimental - PubMed ID: 15129285
Reference: Escherichia coli K-12 MG1655 		Mar 2009
Person Uncurated subsystem component of in silico model iAF1260 Experimental - PubMed ID: 17593909
Reference: Escherichia coli K-12 MG1655 		Jan 2009
Automated Process Approved transl table 11 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Gene Ontology
Automated Process Uncurated GO biological process GO:0008643 carbohydrate transport GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR000576
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Person Approved GO biological process GO:0016052 carbohydrate catabolic process Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Approved GO biological process GO:0006810 transport GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR000576
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Person Approved GO cellular component GO:0019866 organelle inner membrane Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Uncurated GO cellular component GO:0005886 plasma membrane GO Inferred from Electronic Annotation - PubMed ID: 15501914
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Automated Process Approved GO cellular component GO:0016021 integral component of membrane GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR007114
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO cellular component GO:0016020 membrane GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR000576
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO molecular function GO:0005351 carbohydrate:proton symporter activity GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR000576
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved GO molecular function GO:0005215 transporter activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR007114
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO molecular function GO:0005403 (DEPRECATED) hydrogen:sugar symporter activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR000576
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Comparative to toptop
Author Approval Details Genome Feature Name Type
Member
Automated Process Uncurated Go view OrthoMCL (14 enterobacteria) AMM-0000065 CDS
Automated Process Uncurated Go view OrthoMCL (205 gammaproteobacteria) APP-0002493 lacY CDS
Automated Process Uncurated Go view OrthoMCL (307 Enterobacteriaceae) ATM-0002291 lacY CDS
Automated Process Uncurated Go view OrthoMCL (42 Serratia) BEZ-0003238 lacY CDS
Automated Process Uncurated Go view OrthoMCL (UW draft) CQJ-0002531 lacY CDS
Ortholog
Automated Process Uncurated Go view Brenneria salicis ATCC 15712 [T] AMK-0002611 CDS
Automated Process Uncurated Go view Brenneria sp. EniD312 AKG-0003320 CDS
Automated Process Uncurated Go view Citrobacter freundii ATCC 8090 [T] AVI-0001620 lacY_1 CDS
Automated Process Uncurated Go view Dickeya chrysanthemi Ech1591 AFK-0007561 CDS
Person Uncurated Go view Dickeya dadantii 3937 ABF-0019138 rafB CDS
Automated Process Uncurated Go view Dickeya parazeae Ech586 AGC-0001517 CDS
Automated Process Uncurated Go view Enterobacter cloacae subsp. cloacae ATCC 13047 [T] (AToL DRAFT) AMB-0003827 CDS
Automated Process Uncurated Go view Erwinia tasmaniensis Et1/99 [T] AFI-0001953 rafB CDS
Automated Process Uncurated Go view Escherichia coli 101-1 (EAEC) BAB-0007491 lacY CDS
Automated Process Approved Go view Escherichia coli 536 (UPEC) AEF-0000420 CDS
Automated Process Approved Go view Escherichia coli APEC O1 (APEC) AEG-0000335 lacY CDS
Automated Process Approved Go view Escherichia coli ATCC 11775 [T] AMC-0003967 CDS
Automated Process Approved Go view Escherichia coli ATCC 8739 AEM-0009288 CDS
Automated Process Uncurated Go view Escherichia coli B171 (EPEC) ADN-0007041 lacY CDS
Automated Process Uncurated Go view Escherichia coli B7A (ETEC) ADK-0005761 CDS
Person Approved Go view Escherichia coli CFT073 (UPEC) ABR-0076533 lacY CDS
Automated Process Uncurated Go view Escherichia coli DEC7E (UM-IGS draft) CFX-0000403 lacY CDS
Automated Process Uncurated Go view Escherichia coli DEC9A (UM-IGS draft) CFY-0000492 lacY CDS
Automated Process Uncurated Go view Escherichia coli E22 (EPEC) ADL-0008052 lacY CDS
Automated Process Approved Go view Escherichia coli E2348/69 (EPEC) BCI-0000317 lacY CDS
Automated Process Approved Go view Escherichia coli E24377A (ETEC) ADO-0004817 lacY CDS
Automated Process Uncurated Go view Escherichia coli EC4024 (EHEC) BBI-0003912 CDS
Automated Process Uncurated Go view Escherichia coli EC4042 (EHEC) BBA-0010588 lacY CDS
Automated Process Uncurated Go view Escherichia coli EC4045 (EHEC) BBB-0008170 lacY CDS
Automated Process Uncurated Go view Escherichia coli EC4076 (EHEC) BAZ-0009248 lacY CDS
Automated Process Uncurated Go view Escherichia coli EC4113 (EHEC) BAY-0007340 lacY CDS
Automated Process Approved Go view Escherichia coli EC4115 (EHEC) BAS-0005255 lacY CDS
Automated Process Uncurated Go view Escherichia coli EC4196 (EHEC) BAX-0007948 lacY CDS
Automated Process Uncurated Go view Escherichia coli EC4206 (EHEC) BAW-0008986 lacY CDS
Automated Process Uncurated Go view Escherichia coli EC4401 (EHEC) BAV-0007877 lacY CDS
Automated Process Uncurated Go view Escherichia coli EC4486 (EHEC) BAU-0009150 lacY CDS
Automated Process Uncurated Go view Escherichia coli EC4501 (EHEC) BAT-0007592 lacY CDS
Automated Process Uncurated Go view Escherichia coli EC508 (EHEC) BBJ-0007430 lacY CDS
Automated Process Uncurated Go view Escherichia coli EC869 (EHEC) BBC-0008950 lacY CDS
Person Approved Go view Escherichia coli EDL933 (EHEC) ABH-0024330 lacY CDS
Automated Process Approved Go view Escherichia coli F11 (UPEC) ADQ-0008720 lacY_2 CDS
Automated Process Approved Go view Escherichia coli HS ADR-0005089 lacY CDS
Automated Process Uncurated Go view Escherichia coli J96 (UPEC) CQK-0000811 CDS
Person Uncurated Go view Escherichia coli K-12 DH10B AEC-0000348 lacY CDS
Person Approved Go view Escherichia coli K-12 W3110 ADY-0000346 lacY CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR68 CGA-0000610 CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR71 CGB-0000561 CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR8 CFZ-0000472 CDS
Automated Process Uncurated Go view Escherichia coli Nissle 1917 AML-0000456 lacY CDS
Automated Process Uncurated Go view Escherichia coli RS218 (NMEC) ACK-0174552 lacY CDS
Automated Process Approved Go view Escherichia coli SE11 AFS-0000377 CDS
Automated Process Approved Go view Escherichia coli SMS-3-5 AFT-0000373 lacY CDS
Person Approved Go view Escherichia coli Sakai (EHEC) ACA-0130287 lacY CDS
Automated Process Uncurated Go view Escherichia coli TW14588 (EHEC) BBK-0004962 CDS
Automated Process Approved Go view Escherichia coli UTI89 (UPEC) AEA-0000371 lacY CDS
Automated Process Uncurated Go view Ewingella americana ATCC 33852 [T] AMA-0003069 CDS
Person Uncurated Go view Klebsiella pneumoniae subsp. pneumoniae MGH 78578 AEP-0004921 lacY CDS
Automated Process Uncurated Go view Musicola paradisiaca Ech703 AGA-0005930 CDS
Automated Process Uncurated Go view Pantoea ananatis AJ13355 AOV-0003584 lacY CDS
Automated Process Uncurated Go view Pantoea ananatis B1-9 APL-0000394 CDS
Automated Process Uncurated Go view Pantoea ananatis LMG 20103 AKB-0000354 lacY CDS
Automated Process Uncurated Go view Pantoea ananatis PA13 APK-0004031 CDS
Automated Process Uncurated Go view Pantoea stewartii DC283 ACV-0288999 lacY CDS
Person Uncurated Go view Pectobacterium atrosepticum SCRI1043 ABL-0061745 lacY CDS
Automated Process Uncurated Go view Pectobacterium brasiliensis 1692 AED-0000849 lacY CDS
Person Uncurated Go view Pectobacterium carotovorum WPP14 ADT-0003733 lacY CDS
Automated Process Uncurated Go view Pectobacterium parmentieri WPP163 AFJ-0001765 lacY CDS
Automated Process Uncurated Go view Pectobacterium sp. PC1 AFL-0006097 CDS
Automated Process Uncurated Go view Salmonella Arizonae CDC 346-86 BCD-0002975 CDS
Automated Process Uncurated Go view Yersinia frederiksenii ATCC 33641 [T] AEI-0003309 lacY CDS
Person Uncurated Go view Yersinia pestis 91001 (biovar Microtus) ACQ-0237795 CDS
Automated Process Uncurated Go view Yersinia pestis Angola (biovar Pestoides) ADI-0005794 lacY CDS
Automated Process Uncurated Go view Yersinia pestis Antiqua (biovar Antiqua) BAE-0001070 CDS
Automated Process Uncurated Go view Yersinia pestis B42003004 (biovar Antiqua) BAL-0005719 CDS
Person Uncurated Go view Yersinia pestis CO92 (biovar Orientalis) ABY-0120573 pseudogene
Automated Process Uncurated Go view Yersinia pestis E1979001 (biovar Antiqua) BAM-0008273 CDS
Automated Process Uncurated Go view Yersinia pestis F1991016 (biovar Orientalis) BAQ-0004343 CDS
Automated Process Uncurated Go view Yersinia pestis IP275 (biovar Orientalis) BAC-0009631 CDS
Automated Process Uncurated Go view Yersinia pestis K1973002 (biovar Mediaevalis) BAO-0008520 CDS
Person Uncurated Go view Yersinia pestis KIM (biovar Mediaevalis) ABI-0032311 pseudogene
Automated Process Uncurated Go view Yersinia pestis MG05-1020 (biovar Orientalis) BAP-0007712 CDS
Automated Process Uncurated Go view Yersinia pestis Nepal516 (biovar Antiqua) BAD-0002881 CDS
Automated Process Uncurated Go view Yersinia pestis Pestoides F (biovar Pestoides) BAI-0001666 CDS
Automated Process Uncurated Go view Yersinia pestis UG05-0454 (biovar Antiqua) BAN-0006525 CDS
Automated Process Uncurated Go view Yersinia pseudotuberculosis IP31758 ADS-0006375 CDS
Person Uncurated Go view Yersinia pseudotuberculosis IP32953 ACZ-0001682 CDS
Automated Process Uncurated Go view Yersinia pseudotuberculosis PB1/+ AFV-0002049 CDS
Automated Process Uncurated Go view Yersinia pseudotuberculosis YPIII AFW-0002954 CDS
Experimental to toptop
SelectSetNameSetDetailsNotes
stringent responsetranscriptional profile of the stringent responseNone
Recombinant heat-shock dataexpression data for recombinant strain under heat shockThese data are from the Harcum laboratory. (Jeremy Glasner)
Suppressor tRNA expressionexperiment comparing transcript levels in cells with and without suppressor tRNA expressionThese data were reported in the paper: Herring and Blattner. 2004. Global transcriptional effects of a suppressor tRNA and the inactivation of the regulator frmR. J. Bacteriol. 186(20):6714-20. Link to Abstract (Jeremy Glasner)
Recombinant E. coli expressionexperiment comparing expression of wild-type E. coli with the same strain harboring a plasmid that expresses protein when induced with IPTG These data were reported in the paper: F. T. Haddadin, S. W. Harcum (2005) Transcriptome profiles for high-cell-density recombinant and wild-type Escherichia coli, Biotechnology and Bioengineering, 90:127-153. Link to Abstract (Jeremy Glasner)
Aerobic shiftAerobic shiftThese data were reported in the paper: Covert MW, Knight EM, Reed JL, Herrgard MJ, Palsson BO. 2004. Integrating high-throughput and computational data elucidates bacterial networks. Nature. 2004 May 6;429(6987):92-6. Link to Abstract (Jeremy Glasner)
AffyData1Affymetrix Experiments (data from 41 chip hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
Context Table to toptop

Listed below are features that lie nearby this feature. Features encoded in multiple intervals may appear more than once in the table. Features that span the origin will have a left endpoint greater than the right endpoint.

Features overlapping the region 356926 to 368179
FeatureIDNameFeature TypeStrandLeft EndRight EndRelationship
ABE-0000001sourceforward14641652Contains
ABE-0001161codACDSforward356171357454Downstream
ABE-0285350repeat_regionforward357484357562Downstream
ABE-0285351repeat_regionforward357684357762Downstream
ABE-0001165cynRCDScomplement357791358690Downstream
ABE-0001171cynTCDSforward358799359458Downstream
ABE-0001173cynSCDSforward359489359959Downstream
ABE-0001175cynXCDSforward359992361146Downstream
ABE-0285352repeat_regionforward361208361236Downstream
ABE-0001177lacACDScomplement361249361860Downstream
ABE-0285353repeat_regionforward361883361916Downstream
ABE-0001181lacYCDScomplement361926363179Matches
ABE-0001183lacZCDScomplement363231366305Upstream
ABE-0001189lacICDScomplement366428367510Upstream
ABE-0001191mhpRCDScomplement367587368420Upstream
Release Notes to toptop
All MG1655 annotations and sequence data are publicly available, and investigators can use these data in publications without contacting the genome curators. This version of the sequence was the source of GenBank record U00096.3. Ongoing annotation updates to that GenBank record are being generated from a collaboration that includes ASAP, EcoGene, the Coli Genetic Stock Center, EcoliHub, EcoCyc, RegulonDB and UniProtKB/Swiss-Prot.