Escherichia coli K-12 MG1655
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Working With: Genome: Escherichia coli K-12 MG1655 Version: v3

ABE-0001209 (mhpE) - Escherichia coli K-12 MG1655 - Feature Annotation

ASAP ID
ABE-0001209 showshow history
Names
mhpE JW0343 ECK0349 b0352
Product
4-hydroxy-2-oxovalerate aldolase
Type
CDS
Location
# Contig Strand Left Right Length (b.p.) Length (a.a.)
1 Chromosome forward 373868 374881 1014 338
Sequence

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Context

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Protein Families to toptop
Author Approval Family Annotated
Automated Process Approved IPR013785 (IPR013785 Aldolase-type TIM barrel) Apr 2008
Automated Process Approved IPR000891 (IPR000891 Pyruvate carboxyltransferase) Apr 2008
Automated Process Approved IPR012425 (IPR012425 DmpG-like communication) Apr 2008
Automated Process Approved IPR017629 (IPR017629 4-hydroxy-2-oxovalerate aldolase) Jul 2018
Automated Process Approved PF07836 (PF07836 DmpG-like communication domain) Jul 2018
Automated Process Approved PF00682 (PF00682 HMGL-like) Jul 2018
Gene Ontology to toptop
Author Approval Type Annotation Evidence Annotated
Automated Process Approved GO biological process GO:0019439 aromatic compound catabolic process GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR012425
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO biological process GO:0008152 metabolic process GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR013785
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Person Uncurated GO biological process GO:0019395 fatty acid oxidation Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Uncurated GO cellular component GO:0005737 cytoplasm GO Inferred from Electronic Annotation - PubMed ID: 15501914
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Automated Process Uncurated GO molecular function GO:0008701 4-hydroxy-2-oxovalerate aldolase activity GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR017629
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved GO molecular function GO:0016833 oxo-acid-lyase activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR012425
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO molecular function GO:0003824 catalytic activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR013785
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Annotations to toptop
Author Approval Type Annotation Evidence Annotated
Nomenclature
Person Approved name mhpE Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Oct 1998
Person Approved synonym ECK0349 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved synonym JW0343 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved locus tag b0352 Unique Identifier - Origin: Guy Plunkett III, guy@genome.wisc.edu May 2004
Product
Person Uncurated product 4-hydroxy-2-oxovalerate aldolase Protein Sequence Similarity - InterPro Domain: IPR017629
Reference: Escherichia coli K-12 MG1655 		Sep 2021
Person Uncurated alternate product name 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase, class I Published Annotation - PubMed ID: 16397293
Reference: Escherichia coli K-12 		Sep 2021
Person Approved alternate product name 4-hydroxy-2-ketovalerate aldolase Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Jan 2006
Person Uncurated alternate product name 4-hydroxy-2-oxovalerate/4-hydroxy-2-keto-pentanoic acid aldolase, class I aldolase Published Annotation - Database Name: GenProtEC Aug 2016
Protein Family
Automated Process Approved protein family PF00682 HMGL-like Protein Sequence Similarity - PFAM Model Name: PF00682
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved protein family PF07836 DmpG-like communication domain Protein Sequence Similarity - PFAM Model Name: PF07836
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved protein family IPR017629 4-hydroxy-2-oxovalerate aldolase Protein Sequence Similarity - InterPro Domain: IPR017629
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved protein family IPR012425 DmpG-like communication Protein Sequence Similarity - InterPro Domain: IPR012425
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family IPR000891 Pyruvate carboxyltransferase Protein Sequence Similarity - InterPro Domain: IPR000891
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family IPR013785 Aldolase-type TIM barrel Protein Sequence Similarity - InterPro Domain: IPR013785
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Other
Person Approved EC number 4.1.3.- Published Annotation - Swiss-Prot Accession Number: P51020 Feb 2006
Automated Process Uncurated EC number 4.1.3.39 Published Annotation - Database Name: EC2GO: GO:0008701
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Person Uncurated MultiFun 1.1.2 (metabolism; carbon utilization; fatty acids) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Automated Process Approved codon start 1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref EcoGene:EG13292 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref ASAP:ABE-0001209 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref GI:1786548 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Person Approved db xref UniProtKB:P51020 Published Annotation - Swiss-Prot Accession Number: P51020 Jan 2005
Automated Process Approved db xref UniProtKB/Swiss-Prot:P51020 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref GeneID:945012 Published Annotation - Entrez Gene Database ID: 945012
Reference: Escherichia coli K-12 MG1655 		Jun 2009
Person Approved function enzyme; Degradation of small molecules: Carbon compounds Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Oct 1998
Automated Process Approved note 4-hydroxy-2-ketovalerate aldolase; GO_process: GO:0019395 - fatty acid oxidation Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved protein id AAC73455.1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Uncurated subcellular localization Cytoplasmic Predicted by PSORTb - PSORTb Final_Score: 10.00
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Person Uncurated subsystem component of in silico model iMC1010 Experimental - PubMed ID: 15129285
Reference: Escherichia coli K-12 MG1655 		Mar 2009
Person Uncurated subsystem component of in silico model iJR904 Experimental - PubMed ID: 12952533
Reference: Escherichia coli K-12 MG1655 		Feb 2009
Person Uncurated subsystem component of in silico model iAF1260 Experimental - PubMed ID: 17593909
Reference: Escherichia coli K-12 MG1655 		Jan 2009
Automated Process Approved transl table 11 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Gene Ontology
Automated Process Approved GO biological process GO:0019439 aromatic compound catabolic process GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR012425
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO biological process GO:0008152 metabolic process GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR013785
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Person Uncurated GO biological process GO:0019395 fatty acid oxidation Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Uncurated GO cellular component GO:0005737 cytoplasm GO Inferred from Electronic Annotation - PubMed ID: 15501914
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Automated Process Uncurated GO molecular function GO:0008701 4-hydroxy-2-oxovalerate aldolase activity GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR017629
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved GO molecular function GO:0016833 oxo-acid-lyase activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR012425
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO molecular function GO:0003824 catalytic activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR013785
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Comparative to toptop
Author Approval Details Genome Feature Name Type
Member
Automated Process Uncurated Go view OrthoMCL (14 enterobacteria) AMM-0005199 CDS
Automated Process Uncurated Go view OrthoMCL (205 gammaproteobacteria) APP-0004512 mhpE CDS
Automated Process Uncurated Go view OrthoMCL (307 Enterobacteriaceae) ATM-0004830 mhpE CDS
Automated Process Uncurated Go view OrthoMCL (42 Serratia) BEZ-0004874 mhpE CDS
Automated Process Uncurated Go view OrthoMCL (UW draft) CQJ-0003813 mhpE CDS
Ortholog
Automated Process Approved Go view Citrobacter freundii ATCC 8090 [T] AVI-0001637 mhpE CDS
Automated Process Uncurated Go view Escherichia coli 101-1 (EAEC) BAB-0008201 mhpE CDS
Automated Process Uncurated Go view Escherichia coli 53638 (EIEC) ADP-0006163 mhpE CDS
Automated Process Approved Go view Escherichia coli ATCC 8739 AEM-0009279 CDS
Automated Process Uncurated Go view Escherichia coli B171 (EPEC) ADN-0010219 mhpE CDS
Automated Process Uncurated Go view Escherichia coli B7A (ETEC) ADK-0009973 CDS
Automated Process Uncurated Go view Escherichia coli DEC7E (UM-IGS draft) CFX-0000412 dmpG CDS
Automated Process Uncurated Go view Escherichia coli DEC9A (UM-IGS draft) CFY-0000501 dmpG CDS
Automated Process Uncurated Go view Escherichia coli E22 (EPEC) ADL-0008983 mhpE CDS
Automated Process Approved Go view Escherichia coli E24377A (ETEC) ADO-0004826 mhpE CDS
Automated Process Uncurated Go view Escherichia coli EC4024 (EHEC) BBI-0000380 CDS
Automated Process Uncurated Go view Escherichia coli EC4042 (EHEC) BBA-0010599 mhpE CDS
Automated Process Uncurated Go view Escherichia coli EC4045 (EHEC) BBB-0008181 mhpE CDS
Automated Process Uncurated Go view Escherichia coli EC4076 (EHEC) BAZ-0010785 mhpE CDS
Automated Process Uncurated Go view Escherichia coli EC4113 (EHEC) BAY-0007913 mhpE CDS
Automated Process Approved Go view Escherichia coli EC4115 (EHEC) BAS-0005266 mhpE CDS
Automated Process Uncurated Go view Escherichia coli EC4196 (EHEC) BAX-0010470 mhpE CDS
Automated Process Uncurated Go view Escherichia coli EC4206 (EHEC) BAW-0008997 mhpE CDS
Automated Process Uncurated Go view Escherichia coli EC4401 (EHEC) BAV-0007888 mhpE CDS
Automated Process Uncurated Go view Escherichia coli EC4486 (EHEC) BAU-0007716 mhpE CDS
Automated Process Uncurated Go view Escherichia coli EC4501 (EHEC) BAT-0007082 mhpE CDS
Automated Process Uncurated Go view Escherichia coli EC508 (EHEC) BBJ-0010318 mhpE CDS
Automated Process Uncurated Go view Escherichia coli EC869 (EHEC) BBC-0010754 mhpE CDS
Person Approved Go view Escherichia coli EDL933 (EHEC) ABH-0024342 mhpE CDS
Automated Process Approved Go view Escherichia coli HS ADR-0005098 mhpE CDS
Person Approved Go view Escherichia coli K-12 W3110 ADY-0000355 mhpE CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR68 CGA-0000600 dmpG CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR71 CGB-0000551 dmpG CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR8 CFZ-0000462 dmpG CDS
Automated Process Approved Go view Escherichia coli SE11 AFS-0000386 CDS
Automated Process Approved Go view Escherichia coli SMS-3-5 AFT-0000382 mhpE CDS
Person Approved Go view Escherichia coli Sakai (EHEC) ACA-0130298 mhpE CDS
Automated Process Uncurated Go view Escherichia coli TW14588 (EHEC) BBK-0004973 CDS
Person Uncurated Go view Klebsiella pneumoniae subsp. pneumoniae MGH 78578 AEP-0002123 mhpE CDS
Person Uncurated Go view Pectobacterium atrosepticum SCRI1043 ABL-0061685 nahM CDS
Person Approved Go view Shigella sonnei 046 ADD-0000359 mhpE CDS
Experimental to toptop
SelectSetNameSetDetailsNotes
stringent responsetranscriptional profile of the stringent responseNone
Recombinant heat-shock dataexpression data for recombinant strain under heat shockThese data are from the Harcum laboratory. (Jeremy Glasner)
Suppressor tRNA expressionexperiment comparing transcript levels in cells with and without suppressor tRNA expressionThese data were reported in the paper: Herring and Blattner. 2004. Global transcriptional effects of a suppressor tRNA and the inactivation of the regulator frmR. J. Bacteriol. 186(20):6714-20. Link to Abstract (Jeremy Glasner)
Recombinant E. coli expressionexperiment comparing expression of wild-type E. coli with the same strain harboring a plasmid that expresses protein when induced with IPTG These data were reported in the paper: F. T. Haddadin, S. W. Harcum (2005) Transcriptome profiles for high-cell-density recombinant and wild-type Escherichia coli, Biotechnology and Bioengineering, 90:127-153. Link to Abstract (Jeremy Glasner)
Aerobic shiftAerobic shiftThese data were reported in the paper: Covert MW, Knight EM, Reed JL, Herrgard MJ, Palsson BO. 2004. Integrating high-throughput and computational data elucidates bacterial networks. Nature. 2004 May 6;429(6987):92-6. Link to Abstract (Jeremy Glasner)
CalibratorCalibrated microarray experiments (50 hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
AffyData1Affymetrix Experiments (data from 41 chip hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
Context Table to toptop

Listed below are features that lie nearby this feature. Features encoded in multiple intervals may appear more than once in the table. Features that span the origin will have a left endpoint greater than the right endpoint.

Features overlapping the region 368868 to 379881
FeatureIDNameFeature TypeStrandLeft EndRight EndRelationship
ABE-0000001sourceforward14641652Contains
ABE-0001196mhpACDSforward368611370275Upstream
ABE-0001198mhpBCDSforward370277371221Upstream
ABE-0001201mhpCCDSforward371239372105Upstream
ABE-0001205mhpDCDSforward372115372924Upstream
ABE-0001207mhpFCDSforward372921373871Overlaps Upstream
ABE-0001209mhpECDSforward373868374881Matches
ABE-0285354repeat_regionforward374930375365Downstream
ABE-0001213mhpTCDSforward375459376670Downstream
ABE-0001216yaiLCDSforward376772377311Downstream
ABE-0285355repeat_regionforward377335377521Downstream
ABE-0001219frmBCDScomplement377535378368Downstream
ABE-0001221frmACDScomplement378462379571Downstream
ABE-0001226frmRCDScomplement379606379881Downstream
Release Notes to toptop
All MG1655 annotations and sequence data are publicly available, and investigators can use these data in publications without contacting the genome curators. This version of the sequence was the source of GenBank record U00096.3. Ongoing annotation updates to that GenBank record are being generated from a collaboration that includes ASAP, EcoGene, the Coli Genetic Stock Center, EcoliHub, EcoCyc, RegulonDB and UniProtKB/Swiss-Prot.