Escherichia coli K-12 MG1655
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Working With: Genome: Escherichia coli K-12 MG1655 Version: v3

ABE-0001548 (cof) - Escherichia coli K-12 MG1655 - Feature Annotation

ASAP ID
ABE-0001548 showshow history
Names
cof JW0436 ECK0440 b0446
Product
thiamin pyrimidine pyrophosphate hydrolase
Type
CDS
Location
# Contig Strand Left Right Length (b.p.) Length (a.a.)
1 Chromosome forward 467412 468230 819 273
Sequence

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Context

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Protein Families to toptop
Author Approval Family Annotated
Automated Process Approved IPR006379 (IPR006379 HAD-superfamily hydrolase, subfamily IIB) Apr 2008
Automated Process Approved IPR000150 (IPR000150 Cof family) Apr 2008
Automated Process Approved IPR005834 (IPR005834 (DEPRECATED) Haloacid dehalogenase-like hydrolase) Apr 2008
Automated Process Approved IPR023938 (IPR023938 HMP-PP phosphatase) Jul 2018
Automated Process Approved IPR036412 (IPR036412 HAD-like superfamily) Jul 2018
Automated Process Approved PF08282 (PF08282 haloacid dehalogenase-like hydrolase) Jul 2018
Gene Ontology to toptop
Author Approval Type Annotation Evidence Annotated
Automated Process Approved GO biological process GO:0008152 metabolic process GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR006379
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO cellular component GO:0005737 cytoplasm GO Inferred from Electronic Annotation - PubMed ID: 15501914
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Automated Process Uncurated GO molecular function GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR023938
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved GO molecular function GO:0003824 catalytic activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR006379
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO molecular function GO:0016787 hydrolase activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR000150
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Annotations to toptop
Author Approval Type Annotation Evidence Annotated
Nomenclature
Person Approved name cof Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Oct 1998
Person Approved synonym ECK0440 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved synonym JW0436 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved locus tag b0446 Unique Identifier - Origin: Guy Plunkett III, guy@genome.wisc.edu May 2004
Product
Person Approved product thiamin pyrimidine pyrophosphate hydrolase Published Annotation - PubMed ID: 16397293 Jan 2006
Automated Process Approved alternate product name thiamin pyrimidine pyrophosphate hydrolase; HMP-PP phosphatase Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Person Uncurated alternate product name putative hydrolase, contains phophatase-like domain Published Annotation - Database Name: GenProtEC Jan 2006
Protein Family
Automated Process Approved protein family IPR006379 HAD-superfamily hydrolase, subfamily IIB Protein Sequence Similarity - InterPro Domain: IPR006379
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family IPR000150 Cof family Protein Sequence Similarity - InterPro Domain: IPR000150
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family IPR023938 HMP-PP phosphatase Protein Sequence Similarity - InterPro Domain: IPR023938
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved protein family IPR005834 (DEPRECATED) Haloacid dehalogenase-like hydrolase Protein Sequence Similarity - InterPro Domain: IPR005834
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family IPR036412 HAD-like superfamily Protein Sequence Similarity - InterPro Domain: IPR036412
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved protein family PF08282 haloacid dehalogenase-like hydrolase Protein Sequence Similarity - PFAM Model Name: PF08282
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Other
Person Approved EC number 3.-.-.- Protein Sequence Similarity - InterPro Domain: IPR005834
Reference: Escherichia coli K-12 MG1655 		Dec 2008
Automated Process Uncurated EC number 3.6.1.- Published Annotation - Database Name: EC2GO: GO:0016818
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved codon start 1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref EcoGene:EG13216 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref ASAP:ABE-0001548 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref GeneID:945089 Published Annotation - Entrez Gene Database ID: 945089
Reference: Escherichia coli K-12 MG1655 		Jun 2009
Person Approved db xref UniProtKB:P46891 Published Annotation - Swiss-Prot Accession Number: P46891 Jan 2005
Automated Process Approved db xref GI:87081741 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref UniProtKB/Swiss-Prot:P46891 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved protein id AAC73549.2 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Uncurated subcellular localization Cytoplasmic Predicted by PSORTb - PSORTb Final_Score: 8.96
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Person Uncurated subsystem component of in silico model iAF1260 Experimental - PubMed ID: 17593909
Reference: Escherichia coli K-12 MG1655 		Jan 2009
Automated Process Approved transl table 11 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Gene Ontology
Automated Process Approved GO biological process GO:0008152 metabolic process GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR006379
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO cellular component GO:0005737 cytoplasm GO Inferred from Electronic Annotation - PubMed ID: 15501914
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Automated Process Approved GO molecular function GO:0003824 catalytic activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR006379
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO molecular function GO:0016787 hydrolase activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR000150
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO molecular function GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR023938
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Comparative to toptop
Author Approval Details Genome Feature Name Type
Member
Automated Process Uncurated Go view OrthoMCL (14 enterobacteria) AMM-0005371 CDS
Automated Process Uncurated Go view OrthoMCL (205 gammaproteobacteria) APP-0002206 cof CDS
Automated Process Uncurated Go view OrthoMCL (307 Enterobacteriaceae) ATM-0002311 cof CDS
Automated Process Uncurated Go view OrthoMCL (42 Serratia) BEZ-0001831 cof CDS
Automated Process Uncurated Go view OrthoMCL (UW draft) CQJ-0002406 cof CDS
Ortholog
Automated Process Uncurated Go view Buttiauxella agrestis ATCC 33320 [T] APC-0001002 cof CDS
Automated Process Uncurated Go view Cedecea davisae ATCC 33431 [T] ALZ-0003163 CDS
Automated Process Uncurated Go view Citrobacter amalonaticus ATCC 25405 [T] AUW-0001216 cof_1 CDS
Automated Process Uncurated Go view Enterobacter cloacae subsp. cloacae ATCC 13047 [T] (AToL DRAFT) AMB-0001433 CDS
Automated Process Uncurated Go view Escherichia albertii TW07627 AFX-0000462 cof CDS
Automated Process Uncurated Go view Escherichia coli 101-1 (EAEC) BAB-0006649 cof CDS
Automated Process Approved Go view Escherichia coli 536 (UPEC) AEF-0000511 CDS
Automated Process Uncurated Go view Escherichia coli 53638 (EIEC) ADP-0006064 cof CDS
Automated Process Approved Go view Escherichia coli APEC O1 (APEC) AEG-0000420 cof CDS
Automated Process Approved Go view Escherichia coli ATCC 11775 [T] AMC-0003873 CDS
Person Uncurated Go view Escherichia coli ATCC 8739 AEM-0009171 cof pseudogene
Automated Process Uncurated Go view Escherichia coli B171 (EPEC) ADN-0008706 cof CDS
Automated Process Uncurated Go view Escherichia coli B7A (ETEC) ADK-0008613 CDS
Person Approved Go view Escherichia coli CFT073 (UPEC) ABR-0076636 cof CDS
Automated Process Uncurated Go view Escherichia coli DEC7E (UM-IGS draft) CFX-0000510 cof CDS
Automated Process Uncurated Go view Escherichia coli DEC9A (UM-IGS draft) CFY-0000608 cof CDS
Automated Process Uncurated Go view Escherichia coli E110019 (EPEC) ADM-0006045 cof CDS
Automated Process Uncurated Go view Escherichia coli E22 (EPEC) ADL-0007939 cof CDS
Automated Process Approved Go view Escherichia coli E2348/69 (EPEC) BCI-0000400 cof CDS
Automated Process Approved Go view Escherichia coli E24377A (ETEC) ADO-0004932 cof CDS
Automated Process Uncurated Go view Escherichia coli EC4024 (EHEC) BBI-0001535 CDS
Automated Process Uncurated Go view Escherichia coli EC4042 (EHEC) BBA-0010703 cof CDS
Automated Process Uncurated Go view Escherichia coli EC4045 (EHEC) BBB-0008285 cof CDS
Automated Process Uncurated Go view Escherichia coli EC4076 (EHEC) BAZ-0005549 cof CDS
Automated Process Uncurated Go view Escherichia coli EC4113 (EHEC) BAY-0006062 cof CDS
Automated Process Approved Go view Escherichia coli EC4115 (EHEC) BAS-0005372 cof CDS
Automated Process Uncurated Go view Escherichia coli EC4196 (EHEC) BAX-0009714 cof CDS
Automated Process Uncurated Go view Escherichia coli EC4206 (EHEC) BAW-0009105 cof CDS
Automated Process Uncurated Go view Escherichia coli EC4401 (EHEC) BAV-0006497 cof CDS
Automated Process Uncurated Go view Escherichia coli EC4486 (EHEC) BAU-0007821 cof CDS
Automated Process Uncurated Go view Escherichia coli EC4501 (EHEC) BAT-0006004 cof CDS
Automated Process Uncurated Go view Escherichia coli EC508 (EHEC) BBJ-0005759 cof CDS
Automated Process Uncurated Go view Escherichia coli EC869 (EHEC) BBC-0006593 cof CDS
Person Approved Go view Escherichia coli EDL933 (EHEC) ABH-0024442 cof CDS
Automated Process Approved Go view Escherichia coli F11 (UPEC) ADQ-0008854 cof CDS
Automated Process Approved Go view Escherichia coli HS ADR-0005204 cof CDS
Automated Process Uncurated Go view Escherichia coli J96 (UPEC) CQK-0000722 CDS
Person Uncurated Go view Escherichia coli K-12 DH10B AEC-0000446 cof CDS
Person Approved Go view Escherichia coli K-12 W3110 ADY-0000448 cof CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR68 CGA-0000673 cof CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR71 CGB-0000641 cof CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR8 CFZ-0000587 cof CDS
Automated Process Uncurated Go view Escherichia coli Nissle 1917 AML-0000556 CDS
Automated Process Uncurated Go view Escherichia coli RS218 (NMEC) ACK-0174647 CDS
Automated Process Approved Go view Escherichia coli SE11 AFS-0000481 CDS
Automated Process Approved Go view Escherichia coli SMS-3-5 AFT-0000488 cof CDS
Person Approved Go view Escherichia coli Sakai (EHEC) ACA-0130391 cof CDS
Automated Process Uncurated Go view Escherichia coli TW14588 (EHEC) BBK-0005133 CDS
Automated Process Approved Go view Escherichia coli UTI89 (UPEC) AEA-0000475 cof CDS
Automated Process Uncurated Go view Ewingella americana ATCC 33852 [T] AMA-0002740 CDS
Person Uncurated Go view Klebsiella pneumoniae subsp. pneumoniae MGH 78578 AEP-0000410 cof CDS
Automated Process Uncurated Go view Leclercia adecarboxylata ATCC 23216 [T] AME-0003409 CDS
Automated Process Uncurated Go view Pantoea agglomerans IG1 APM-0000309 CDS
Automated Process Uncurated Go view Pantoea agglomerans SL1-M5 ALY-0001622 CDS
Automated Process Uncurated Go view Pantoea sp. At-9b AGM-0008716 CDS
Automated Process Uncurated Go view Pantoea sp. aB AJV-0002698 CDS
Automated Process Uncurated Go view Pantoea vagans C9-1 ALK-0004152 cof CDS
Automated Process Uncurated Go view Salmonella Agona SL483 BBX-0004675 CDS
Automated Process Uncurated Go view Salmonella Arizonae CDC 346-86 BCD-0002601 CDS
Person Uncurated Go view Salmonella Choleraesuis SC-B67 ADB-0000575 cof CDS
Automated Process Uncurated Go view Salmonella Dublin CT_02021853 BCB-0004776 CDS
Automated Process Uncurated Go view Salmonella Enteritidis P125109 BCF-0001481 cof CDS
Automated Process Uncurated Go view Salmonella Gallinarum 287/91 BCG-0001454 cof CDS
Automated Process Uncurated Go view Salmonella Hadar RI_05P066 BBT-0005677 CDS
Automated Process Uncurated Go view Salmonella Heidelberg SL476 BBV-0004926 CDS
Automated Process Uncurated Go view Salmonella Heidelberg SL486 BBW-0004282 CDS
Automated Process Uncurated Go view Salmonella Javiana GA_MM04042433 BCA-0007745 CDS
Automated Process Uncurated Go view Salmonella Kentucky CDC 191 BBZ-0005903 CDS
Automated Process Uncurated Go view Salmonella Kentucky CVM29188 BBP-0008946 CDS
Automated Process Uncurated Go view Salmonella Newport SL254 BBQ-0004876 CDS
Automated Process Uncurated Go view Salmonella Newport SL317 BBR-0007015 CDS
Automated Process Uncurated Go view Salmonella Paratyphi A AKU_12601 BCH-0002282 CDS
Person Uncurated Go view Salmonella Paratyphi A ATCC 9150 ADA-0002265 cof CDS
Automated Process Uncurated Go view Salmonella Paratyphi B SPB7 BCC-0003132 CDS
Automated Process Uncurated Go view Salmonella Saintpaul SARA23 BBN-0005165 CDS
Automated Process Uncurated Go view Salmonella Saintpaul SARA29 BBM-0006947 CDS
Automated Process Uncurated Go view Salmonella Schwarzengrund CVM19633 BBO-0004606 CDS
Automated Process Uncurated Go view Salmonella Schwarzengrund SL480 BBY-0006825 CDS
Person Approved Go view Salmonella Typhi CT18 ABX-0106253 CDS
Person Uncurated Go view Salmonella Typhi Ty2 ABS-0084118 CDS
Automated Process Uncurated Go view Salmonella Typhimurium 14028S AJR-0000542 cof CDS
Person Uncurated Go view Salmonella Typhimurium LT2 [T] ABU-0091974 cof CDS
Automated Process Uncurated Go view Salmonella Virchow SL491 BBS-0009031 CDS
Automated Process Uncurated Go view Salmonella Weltevreden SL484 BBU-0005375 CDS
Automated Process Uncurated Go view Salmonella enterica CVM23701 BBL-0004840 CDS
Automated Process Uncurated Go view Serratia marcescens subsp. marcescens ATCC 13880 [T] AMF-0004765 CDS
Person Uncurated Go view Shigella boydii 227 ADV-0000367 cof CDS
Automated Process Approved Go view Shigella boydii BS512 ADJ-0005765 cof CDS
Person Approved Go view Shigella flexneri 2457T ABQ-0071366 cof CDS
Person Approved Go view Shigella flexneri 301 ABT-0086749 cof CDS
Automated Process Approved Go view Shigella flexneri 8401 BAG-0000439 cof CDS
Person Approved Go view Shigella sonnei 046 ADD-0000470 cof CDS
Automated Process Uncurated Go view Yersinia bercovieri ATCC 43970 [T] AEK-0002829 CDS
Automated Process Uncurated Go view Yersinia enterocolitica 8081 BAH-0009055 CDS
Automated Process Uncurated Go view Yersinia frederiksenii ATCC 33641 [T] AEI-0001848 cof_1 CDS
Automated Process Uncurated Go view Yersinia intermedia ATCC 29909 [T] AEH-0000857 cof_1 CDS
Automated Process Uncurated Go view Yersinia mollaretii ATCC 43969 [T] AEJ-0001354 CDS
Person Uncurated Go view Yersinia pestis 91001 (biovar Microtus) ACQ-0236020 cof1 CDS
Automated Process Uncurated Go view Yersinia pestis Angola (biovar Pestoides) ADI-0007161 CDS
Automated Process Uncurated Go view Yersinia pestis Antiqua (biovar Antiqua) BAE-0003175 CDS
Automated Process Uncurated Go view Yersinia pestis B42003004 (biovar Antiqua) BAL-0006923 CDS
Automated Process Uncurated Go view Yersinia pestis CA88-4125 (biovar Orientalis) BAF-0000382 CDS
Person Uncurated Go view Yersinia pestis CO92 (biovar Orientalis) ABY-0125888 CDS
Automated Process Uncurated Go view Yersinia pestis E1979001 (biovar Antiqua) BAM-0007503 CDS
Automated Process Uncurated Go view Yersinia pestis F1991016 (biovar Orientalis) BAQ-0006888 CDS
Automated Process Uncurated Go view Yersinia pestis FV-1 (biovar Orientalis) BAK-0002404 CDS
Automated Process Uncurated Go view Yersinia pestis IP275 (biovar Orientalis) BAC-0005108 CDS
Automated Process Uncurated Go view Yersinia pestis K1973002 (biovar Mediaevalis) BAO-0004508 CDS
Person Uncurated Go view Yersinia pestis KIM (biovar Mediaevalis) ABI-0030692 cof CDS
Automated Process Uncurated Go view Yersinia pestis MG05-1020 (biovar Orientalis) BAP-0007611 CDS
Automated Process Uncurated Go view Yersinia pestis Nepal516 (biovar Antiqua) BAD-0001146 CDS
Automated Process Uncurated Go view Yersinia pestis Pestoides F (biovar Pestoides) BAI-0003340 CDS
Automated Process Uncurated Go view Yersinia pestis UG05-0454 (biovar Antiqua) BAN-0005159 CDS
Automated Process Uncurated Go view Yersinia pseudotuberculosis IP31758 ADS-0007090 CDS
Person Uncurated Go view Yersinia pseudotuberculosis IP32953 ACZ-0001020 cof CDS
Automated Process Uncurated Go view Yersinia pseudotuberculosis PB1/+ AFV-0001192 CDS
Automated Process Uncurated Go view Yersinia pseudotuberculosis YPIII AFW-0003826 CDS
Automated Process Uncurated Go view Yokenella regensburgei ATCC 43003 APO-0009117 CDS
Automated Process Uncurated Go view Yokenella regensburgei ATCC 49455 [T] AMG-0001512 CDS
Experimental to toptop
SelectSetNameSetDetailsNotes
stringent responsetranscriptional profile of the stringent responseNone
Recombinant heat-shock dataexpression data for recombinant strain under heat shockThese data are from the Harcum laboratory. (Jeremy Glasner)
Suppressor tRNA expressionexperiment comparing transcript levels in cells with and without suppressor tRNA expressionThese data were reported in the paper: Herring and Blattner. 2004. Global transcriptional effects of a suppressor tRNA and the inactivation of the regulator frmR. J. Bacteriol. 186(20):6714-20. Link to Abstract (Jeremy Glasner)
Recombinant E. coli expressionexperiment comparing expression of wild-type E. coli with the same strain harboring a plasmid that expresses protein when induced with IPTG These data were reported in the paper: F. T. Haddadin, S. W. Harcum (2005) Transcriptome profiles for high-cell-density recombinant and wild-type Escherichia coli, Biotechnology and Bioengineering, 90:127-153. Link to Abstract (Jeremy Glasner)
Aerobic shiftAerobic shiftThese data were reported in the paper: Covert MW, Knight EM, Reed JL, Herrgard MJ, Palsson BO. 2004. Integrating high-throughput and computational data elucidates bacterial networks. Nature. 2004 May 6;429(6987):92-6. Link to Abstract (Jeremy Glasner)
CalibratorCalibrated microarray experiments (50 hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
AffyData1Affymetrix Experiments (data from 41 chip hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
Strains to toptop

Strains with mutations in this feature.

Strain NameStrain TypeStrain InformationStrain RequestFeatureIDNameMutation DetailsExperiments Using StrainSubmitter
FB20179mutantTn5 InsertionRequest the StrainABE-0001548cofcof::Tn5KAN-2 at position 603 in Minus orientation ,- pKD460Blattner Laboratory
Context Table to toptop

Listed below are features that lie nearby this feature. Features encoded in multiple intervals may appear more than once in the table. Features that span the origin will have a left endpoint greater than the right endpoint.

Features overlapping the region 462412 to 473230
FeatureIDNameFeature TypeStrandLeft EndRight EndRelationship
ABE-0000001sourceforward14641652Contains
ABE-0001531ppiDCDSforward461915463786Upstream
ABE-0001534ybaVCDSforward463937464308Upstream
ABE-0001537fadMCDSforward464402464800Upstream
ABE-0285365repeat_regionforward464813464837Upstream
ABE-0001539queCCDScomplement464852465547Upstream
ABE-0001542ybaECDScomplement465612467312Upstream
ABE-0001548cofCDSforward467412468230Matches
ABE-0001553decRCDSforward468383468841Downstream
ABE-0001555mdlACDSforward468871470643Downstream
ABE-0001557mdlBCDSforward470636472417Downstream
ABE-0001562glnKCDSforward472598472936Downstream
ABE-0001564amtBCDSforward472966474252Downstream
Release Notes to toptop
All MG1655 annotations and sequence data are publicly available, and investigators can use these data in publications without contacting the genome curators. This version of the sequence was the source of GenBank record U00096.3. Ongoing annotation updates to that GenBank record are being generated from a collaboration that includes ASAP, EcoGene, the Coli Genetic Stock Center, EcoliHub, EcoCyc, RegulonDB and UniProtKB/Swiss-Prot.