Escherichia coli K-12 MG1655
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Working With: Genome: Escherichia coli K-12 MG1655 Version: v3

ABE-0001759 (glxR) - Escherichia coli K-12 MG1655 - Feature Annotation

ASAP ID
ABE-0001759 showshow history
Names
glxR glxB1 JW0497 ECK0502 ybbQ b0509
Product
tartronate semialdehyde reductase
Type
CDS
Location
# Contig Strand Left Right Length (b.p.) Length (a.a.)
1 Chromosome forward 536586 537464 879 293
Sequence

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Context

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Protein Families to toptop
Author Approval Family Annotated
Automated Process Approved IPR006398 (IPR006398 2-hydroxy-3-oxopropionate reductase) Apr 2008
Automated Process Approved IPR002204 (IPR002204 3-hydroxyisobutyrate dehydrogenase-related, conserved site) Apr 2008
Automated Process Approved IPR006115 (IPR006115 6-phosphogluconate dehydrogenase, NADP-binding) Apr 2008
Automated Process Approved IPR006183 (IPR006183 6-phosphogluconate dehydrogenase) Apr 2008
Automated Process Approved IPR008927 (IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily) Apr 2008
Automated Process Approved IPR013328 (IPR013328 6-phosphogluconate dehydrogenase, domain 2) Apr 2008
Automated Process Approved IPR029154 (IPR029154 3-hydroxyisobutyrate dehydrogenase, NAD-binding domain) Jul 2018
Automated Process Approved IPR036291 (IPR036291 NAD(P)-binding domain superfamily) Jul 2018
Automated Process Approved PF03446 (PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase) Jul 2018
Automated Process Approved PF14833 (PF14833 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase) Jul 2018
Gene Ontology to toptop
Author Approval Type Annotation Evidence Annotated
Automated Process Approved GO biological process GO:0006573 valine metabolic process GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR002204
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Person Uncurated GO biological process GO:0016052 carbohydrate catabolic process Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Approved GO biological process GO:0046487 glyoxylate metabolic process GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR006398
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO biological process GO:0055114 (OBSOLETE) oxidation-reduction process GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR006398, IPR008927
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Person Uncurated GO biological process GO:0009442 allantoin assimilation pathway Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Person Uncurated GO biological process GO:0009441 glycolate metabolic process Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Uncurated GO molecular function GO:0050661 NADP binding GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR006115
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Uncurated GO molecular function GO:0051287 NAD binding GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR029154
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved GO molecular function GO:0050662 (OBSOLETE) coenzyme binding GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR013328
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO molecular function GO:0008442 3-hydroxyisobutyrate dehydrogenase activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR002204
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO molecular function GO:0008679 2-hydroxy-3-oxopropionate reductase activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR006398
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO molecular function GO:0016491 oxidoreductase activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR013328
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Annotations to toptop
Author Approval Type Annotation Evidence Annotated
Nomenclature
Person Approved name glxR Experimental - PubMed ID: 10601204
Reference: Escherichia coli 		Aug 2002
Person Approved synonym ECK0502 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved synonym ybbQ Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Oct 1998
Person Approved synonym JW0497 Published Annotation - PubMed ID: 16397293 Jan 2006
Automated Process Approved synonym glxB1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Person Approved locus tag b0509 Unique Identifier - Origin: Guy Plunkett III, guy@genome.wisc.edu May 2004
Product
Person Uncurated product tartronate semialdehyde reductase Published Annotation - PubMed ID: 16397293
Reference: Escherichia coli K-12 		Oct 2021
Person Uncurated alternate product name tartronic semialdehyde reductase Experimental - PubMed ID: 10601204
Reference: Escherichia coli 		Jan 2006
Protein Family
Automated Process Approved protein family IPR006115 6-phosphogluconate dehydrogenase, NADP-binding Protein Sequence Similarity - InterPro Domain: IPR006115
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family IPR036291 NAD(P)-binding domain superfamily Protein Sequence Similarity - InterPro Domain: IPR036291
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved protein family PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase Protein Sequence Similarity - PFAM Model Name: PF03446
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved protein family PF14833 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Protein Sequence Similarity - PFAM Model Name: PF14833
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved protein family IPR013328 6-phosphogluconate dehydrogenase, domain 2 Protein Sequence Similarity - InterPro Domain: IPR013328
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family IPR029154 3-hydroxyisobutyrate dehydrogenase, NAD-binding domain Protein Sequence Similarity - InterPro Domain: IPR029154
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved protein family IPR002204 3-hydroxyisobutyrate dehydrogenase-related, conserved site Protein Sequence Similarity - InterPro Domain: IPR002204
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily Protein Sequence Similarity - InterPro Domain: IPR008927
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family IPR006398 2-hydroxy-3-oxopropionate reductase Protein Sequence Similarity - InterPro Domain: IPR006398
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family IPR006183 6-phosphogluconate dehydrogenase Protein Sequence Similarity - InterPro Domain: IPR006183
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Other
Person Approved EC number 1.1.1.60 Published Annotation - Swiss-Prot Accession Number: P77161 Feb 2006
Person Uncurated MultiFun 1.7.25 (metabolism; central intermediary metabolism; glycolate metabolism) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Person Uncurated MultiFun 1.1.1 (metabolism; carbon utilization; carbon compounds) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Person Uncurated MultiFun 1.7.26 (metabolism; central intermediary metabolism; allantoin assimilation) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Automated Process Approved codon start 1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref EcoGene:EG13265 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref UniProtKB/Swiss-Prot:P77161 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Person Approved db xref UniProtKB:P77161 Published Annotation - Swiss-Prot Accession Number: P77161 Jan 2005
Automated Process Approved db xref ASAP:ABE-0001759 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref GeneID:945146 Published Annotation - Entrez Gene Database ID: 945146
Reference: Escherichia coli K-12 MG1655 		Jun 2009
Automated Process Approved db xref GI:1786719 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Person Approved function putative enzyme; Not classified Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Oct 1998
Automated Process Approved note GO_process: GO:0016052 - carbohydrate catabolic process; GO_process: GO:0009441 - glycolate metabolic process; GO_process: GO:0009442 - allantoin assimilation pathway Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved protein id AAC73611.1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Uncurated subcellular localization Unknown Predicted by PSORTb - PSORTb Final_Score: 2.00
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Person Uncurated subsystem component of in silico model iMC1010 Experimental - PubMed ID: 15129285
Reference: Escherichia coli K-12 MG1655 		Mar 2009
Person Uncurated subsystem component of in silico model iAF1260 Experimental - PubMed ID: 17593909
Reference: Escherichia coli K-12 MG1655 		Jan 2009
Person Uncurated subsystem component of in silico model iJR904 Experimental - PubMed ID: 12952533
Reference: Escherichia coli K-12 MG1655 		Feb 2009
Automated Process Approved transl table 11 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Gene Ontology
Automated Process Approved GO biological process GO:0006573 valine metabolic process GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR002204
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Person Uncurated GO biological process GO:0016052 carbohydrate catabolic process Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Approved GO biological process GO:0046487 glyoxylate metabolic process GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR006398
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Person Uncurated GO biological process GO:0009442 allantoin assimilation pathway Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Person Uncurated GO biological process GO:0009441 glycolate metabolic process Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Uncurated GO biological process GO:0055114 (OBSOLETE) oxidation-reduction process GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR006398, IPR008927
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved GO molecular function GO:0008442 3-hydroxyisobutyrate dehydrogenase activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR002204
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO molecular function GO:0051287 NAD binding GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR029154
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Uncurated GO molecular function GO:0050661 NADP binding GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR006115
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved GO molecular function GO:0050662 (OBSOLETE) coenzyme binding GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR013328
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO molecular function GO:0016491 oxidoreductase activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR013328
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO molecular function GO:0008679 2-hydroxy-3-oxopropionate reductase activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR006398
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Comparative to toptop
Author Approval Details Genome Feature Name Type
Member
Automated Process Uncurated Go view OrthoMCL (14 enterobacteria) AMM-0006638 CDS
Automated Process Uncurated Go view OrthoMCL (205 gammaproteobacteria) APP-0003320 glxR CDS
Automated Process Uncurated Go view OrthoMCL (307 Enterobacteriaceae) ATM-0003694 glxR CDS
Automated Process Uncurated Go view OrthoMCL (42 Serratia) BEZ-0003490 glxR CDS
Automated Process Uncurated Go view OrthoMCL (UW draft) CQJ-0003186 glxR CDS
Ortholog
Automated Process Uncurated Go view Buttiauxella agrestis ATCC 33320 [T] APC-0001077 CDS
Automated Process Approved Go view Citrobacter freundii ATCC 8090 [T] AVI-0001852 garR_2 CDS
Automated Process Uncurated Go view Escherichia coli 101-1 (EAEC) BAB-0006584 CDS
Automated Process Approved Go view Escherichia coli 536 (UPEC) AEF-0000574 CDS
Automated Process Uncurated Go view Escherichia coli 53638 (EIEC) ADP-0005998 CDS
Automated Process Approved Go view Escherichia coli APEC O1 (APEC) AEG-0000480 ybbQ CDS
Automated Process Approved Go view Escherichia coli ATCC 11775 [T] AMC-0003808 CDS
Automated Process Approved Go view Escherichia coli ATCC 8739 AEM-0009084 CDS
Automated Process Uncurated Go view Escherichia coli B171 (EPEC) ADN-0009342 CDS
Automated Process Uncurated Go view Escherichia coli B7A (ETEC) ADK-0008489 pseudogene
Person Approved Go view Escherichia coli CFT073 (UPEC) ABR-0076699 glxR CDS
Automated Process Uncurated Go view Escherichia coli DEC7E (UM-IGS draft) CFX-0000571 CDS
Automated Process Uncurated Go view Escherichia coli DEC9A (UM-IGS draft) CFY-0000675 CDS
Automated Process Uncurated Go view Escherichia coli E110019 (EPEC) ADM-0005981 CDS
Automated Process Uncurated Go view Escherichia coli E22 (EPEC) ADL-0007875 CDS
Automated Process Approved Go view Escherichia coli E2348/69 (EPEC) BCI-0000465 glxR CDS
Automated Process Approved Go view Escherichia coli E24377A (ETEC) ADO-0004995 CDS
Automated Process Uncurated Go view Escherichia coli EC4042 (EHEC) BBA-0010782 CDS
Automated Process Uncurated Go view Escherichia coli EC4045 (EHEC) BBB-0008364 CDS
Automated Process Uncurated Go view Escherichia coli EC4076 (EHEC) BAZ-0005627 CDS
Automated Process Uncurated Go view Escherichia coli EC4113 (EHEC) BAY-0005983 CDS
Automated Process Approved Go view Escherichia coli EC4115 (EHEC) BAS-0005450 CDS
Automated Process Uncurated Go view Escherichia coli EC4196 (EHEC) BAX-0007227 CDS
Automated Process Uncurated Go view Escherichia coli EC4206 (EHEC) BAW-0009183 CDS
Automated Process Uncurated Go view Escherichia coli EC4401 (EHEC) BAV-0006574 CDS
Automated Process Uncurated Go view Escherichia coli EC4486 (EHEC) BAU-0007902 CDS
Automated Process Uncurated Go view Escherichia coli EC4501 (EHEC) BAT-0005926 CDS
Automated Process Uncurated Go view Escherichia coli EC508 (EHEC) BBJ-0005835 CDS
Automated Process Uncurated Go view Escherichia coli EC869 (EHEC) BBC-0006672 CDS
Person Approved Go view Escherichia coli EDL933 (EHEC) ABH-0024515 glxR CDS
Automated Process Approved Go view Escherichia coli F11 (UPEC) ADQ-0007342 glxR CDS
Automated Process Approved Go view Escherichia coli HS ADR-0005265 CDS
Automated Process Uncurated Go view Escherichia coli J96 (UPEC) CQK-0000834 CDS
Person Uncurated Go view Escherichia coli K-12 DH10B AEC-0000506 glxR CDS
Person Approved Go view Escherichia coli K-12 W3110 ADY-0000510 glxR CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR68 CGA-0000742 CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR71 CGB-0000703 CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR8 CFZ-0000688 CDS
Automated Process Uncurated Go view Escherichia coli Nissle 1917 AML-0000616 CDS
Automated Process Uncurated Go view Escherichia coli RS218 (NMEC) ACK-0174716 CDS
Automated Process Approved Go view Escherichia coli SE11 AFS-0000544 CDS
Automated Process Approved Go view Escherichia coli SMS-3-5 AFT-0000551 CDS
Person Approved Go view Escherichia coli Sakai (EHEC) ACA-0130462 glxR CDS
Automated Process Uncurated Go view Escherichia coli TW14588 (EHEC) BBK-0005209 CDS
Automated Process Approved Go view Escherichia coli UTI89 (UPEC) AEA-0000539 ybbQ CDS
Automated Process Uncurated Go view Salmonella Agona SL483 BBX-0004744 CDS
Person Uncurated Go view Salmonella Choleraesuis SC-B67 ADB-0000651 glxR CDS
Automated Process Uncurated Go view Salmonella Dublin CT_02021853 BCB-0004844 CDS
Automated Process Uncurated Go view Salmonella Enteritidis P125109 BCF-0001698 glxR CDS
Automated Process Uncurated Go view Salmonella Gallinarum 287/91 BCG-0001657 glxR CDS
Automated Process Uncurated Go view Salmonella Hadar RI_05P066 BBT-0005608 CDS
Automated Process Uncurated Go view Salmonella Heidelberg SL476 BBV-0004992 CDS
Automated Process Uncurated Go view Salmonella Heidelberg SL486 BBW-0004351 CDS
Automated Process Uncurated Go view Salmonella Kentucky CDC 191 BBZ-0005969 CDS
Automated Process Uncurated Go view Salmonella Kentucky CVM29188 BBP-0009012 CDS
Automated Process Uncurated Go view Salmonella Newport SL254 BBQ-0004943 CDS
Automated Process Uncurated Go view Salmonella Newport SL317 BBR-0007081 CDS
Automated Process Uncurated Go view Salmonella Paratyphi A AKU_12601 BCH-0002219 CDS
Person Uncurated Go view Salmonella Paratyphi A ATCC 9150 ADA-0002203 CDS
Automated Process Uncurated Go view Salmonella Paratyphi B SPB7 BCC-0003057 CDS
Automated Process Uncurated Go view Salmonella Saintpaul SARA23 BBN-0005231 CDS
Automated Process Uncurated Go view Salmonella Saintpaul SARA29 BBM-0006236 CDS
Person Approved Go view Salmonella Typhi CT18 ABX-0106408 garR CDS
Person Uncurated Go view Salmonella Typhi Ty2 ABS-0084055 garR CDS
Automated Process Uncurated Go view Salmonella Typhimurium 14028S AJR-0000610 glxR CDS
Person Uncurated Go view Salmonella Typhimurium LT2 [T] ABU-0092140 glxR CDS
Automated Process Uncurated Go view Salmonella Virchow SL491 BBS-0008963 CDS
Automated Process Uncurated Go view Salmonella Weltevreden SL484 BBU-0005306 CDS
Automated Process Uncurated Go view Salmonella enterica CVM23701 BBL-0004908 CDS
Automated Process Uncurated Go view Shigella dysenteriae 1012 BAA-0005151 CDS
Automated Process Uncurated Go view Yersinia intermedia ATCC 29909 [T] AEH-0003295 garR_2 CDS
Experimental to toptop
SelectSetNameSetDetailsNotes
stringent responsetranscriptional profile of the stringent responseNone
Recombinant heat-shock dataexpression data for recombinant strain under heat shockThese data are from the Harcum laboratory. (Jeremy Glasner)
Suppressor tRNA expressionexperiment comparing transcript levels in cells with and without suppressor tRNA expressionThese data were reported in the paper: Herring and Blattner. 2004. Global transcriptional effects of a suppressor tRNA and the inactivation of the regulator frmR. J. Bacteriol. 186(20):6714-20. Link to Abstract (Jeremy Glasner)
Recombinant E. coli expressionexperiment comparing expression of wild-type E. coli with the same strain harboring a plasmid that expresses protein when induced with IPTG These data were reported in the paper: F. T. Haddadin, S. W. Harcum (2005) Transcriptome profiles for high-cell-density recombinant and wild-type Escherichia coli, Biotechnology and Bioengineering, 90:127-153. Link to Abstract (Jeremy Glasner)
Aerobic shiftAerobic shiftThese data were reported in the paper: Covert MW, Knight EM, Reed JL, Herrgard MJ, Palsson BO. 2004. Integrating high-throughput and computational data elucidates bacterial networks. Nature. 2004 May 6;429(6987):92-6. Link to Abstract (Jeremy Glasner)
CalibratorCalibrated microarray experiments (50 hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
AffyData1Affymetrix Experiments (data from 41 chip hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
Context Table to toptop

Listed below are features that lie nearby this feature. Features encoded in multiple intervals may appear more than once in the table. Features that span the origin will have a left endpoint greater than the right endpoint.

Features overlapping the region 531586 to 542464
FeatureIDNameFeature TypeStrandLeft EndRight EndRelationship
ABE-0000001sourceforward14641652Contains
ABE-0001742allSCDScomplement531295532221Upstream
ABE-0001747allACDSforward532451532933Upstream
ABE-0001750allRCDSforward533011533826Upstream
ABE-0285849allZncRNAforward533629533863Upstream
ABE-0001754gclCDSforward533916535697Upstream
ABE-0001756hyiCDSforward535710536486Upstream
ABE-0001759glxRCDSforward536586537464Matches
ABE-0001764ybbWCDSforward537633539087Downstream
ABE-0001768allBCDSforward539147540508Downstream
ABE-0001771ybbYCDSforward540565541866Downstream
ABE-0001773glxKCDSforward541888543033Downstream
Release Notes to toptop
All MG1655 annotations and sequence data are publicly available, and investigators can use these data in publications without contacting the genome curators. This version of the sequence was the source of GenBank record U00096.3. Ongoing annotation updates to that GenBank record are being generated from a collaboration that includes ASAP, EcoGene, the Coli Genetic Stock Center, EcoliHub, EcoCyc, RegulonDB and UniProtKB/Swiss-Prot.