Escherichia coli K-12 MG1655
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Working With: Genome: Escherichia coli K-12 MG1655 Version: v3

ABE-0002185 (cobC) - Escherichia coli K-12 MG1655 - Feature Annotation

ASAP ID
ABE-0002185 showshow history
Names
cobC phpB JW0633 ECK0631 b0638
Product
putative adenosylcobalamin phosphatase/alpha-ribazole phosphatase
Type
CDS
Location
# Contig Strand Left Right Length (b.p.) Length (a.a.)
1 Chromosome complement 669296 669907 612 204
Sequence

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Context

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Protein Families to toptop
Author Approval Family Annotated
Automated Process Approved IPR013078 (IPR013078 Histidine phosphatase superfamily, clade-1) Apr 2008
Automated Process Approved IPR001345 (IPR001345 Phosphoglycerate/bisphosphoglycerate mutase, active site) Apr 2008
Automated Process Approved IPR017578 (IPR017578 Alpha-ribazole phosphatase, CobC) Jul 2018
Automated Process Approved IPR029033 (IPR029033 Histidine phosphatase superfamily) Jul 2018
Automated Process Approved PF00300 (PF00300 Histidine phosphatase superfamily (branch 1)) Jul 2018
Gene Ontology to toptop
Author Approval Type Annotation Evidence Annotated
Person Approved GO biological process GO:0009236 cobalamin biosynthetic process Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Approved GO biological process GO:0008152 metabolic process GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR001345
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO molecular function GO:0043755 alpha-ribazole phosphatase activity GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR017578
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved GO molecular function GO:0003824 catalytic activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR001345
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Annotations to toptop
Author Approval Type Annotation Evidence Annotated
Nomenclature
Person Approved name cobC Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved synonym ECK0631 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved synonym phpB Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Jan 2006
Person Approved synonym JW0633 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved locus tag b0638 Unique Identifier - Origin: Guy Plunkett III, guy@genome.wisc.edu May 2004
Product
Person Uncurated product putative adenosylcobalamin phosphatase/alpha-ribazole phosphatase Published Annotation - EcoCyc Accession Number: G6349
Reference: Escherichia coli K-12 MG1655 		Oct 2021
Person Uncurated alternate product name putative alpha-ribazole-5'-Pphosphatase (cobalamin biosynthesis) Published Annotation - Database Name: GenProtEC Jan 2006
Person Approved alternate product name predicted alpha-ribazole-5'-P phosphatase Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved alternate product name homolog of Salmonella cobC, a phosphohistidine protein Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Jan 2006
Protein Family
Automated Process Approved protein family IPR013078 Histidine phosphatase superfamily, clade-1 Protein Sequence Similarity - InterPro Domain: IPR013078
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family IPR029033 Histidine phosphatase superfamily Protein Sequence Similarity - InterPro Domain: IPR029033
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved protein family PF00300 Histidine phosphatase superfamily (branch 1) Protein Sequence Similarity - PFAM Model Name: PF00300
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved protein family IPR001345 Phosphoglycerate/bisphosphoglycerate mutase, active site Protein Sequence Similarity - InterPro Domain: IPR001345
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family IPR017578 Alpha-ribazole phosphatase, CobC Protein Sequence Similarity - InterPro Domain: IPR017578
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Other
Person Approved EC number 3.1.3.73 Published Annotation - Swiss-Prot Accession Number: P52086 Feb 2006
Person Uncurated MultiFun 1.5.3.13 (metabolism; building block biosynthesis; cofactor, small molecule carrier; cobalamin (Vitamin B12)) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Automated Process Approved codon start 1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref GeneID:945246 Published Annotation - Entrez Gene Database ID: 945246
Reference: Escherichia coli K-12 MG1655 		Jun 2009
Person Approved db xref UniProtKB:P52086 Published Annotation - Swiss-Prot Accession Number: P52086 Jan 2005
Automated Process Approved db xref GI:1786857 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref UniProtKB/Swiss-Prot:P52086 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref ASAP:ABE-0002185 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref EcoGene:EG13240 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Person Approved function putative regulator; Biosynthesis of cofactors, carriers: Cobalamin Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Oct 1998
Automated Process Approved note homolog of Salmonella cobC, a phosphohistidine protein Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved protein id AAC73739.1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Uncurated subcellular localization Unknown Predicted by PSORTb - PSORTb Final_Score: 2.00
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Person Uncurated subsystem component of in silico model iJR904 Experimental - PubMed ID: 12952533
Reference: Escherichia coli K-12 MG1655 		Feb 2009
Person Uncurated subsystem component of in silico model iMC1010 Experimental - PubMed ID: 15129285
Reference: Escherichia coli K-12 MG1655 		Mar 2009
Person Uncurated subsystem component of in silico model the E-matrix Experimental - PubMed ID: 19282977
Reference: Escherichia coli K-12 MG1655 		Mar 2009
Person Uncurated subsystem component of in silico model iAF1260 Experimental - PubMed ID: 17593909
Reference: Escherichia coli K-12 MG1655 		Jan 2009
Automated Process Approved transl table 11 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Gene Ontology
Automated Process Approved GO biological process GO:0008152 metabolic process GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR001345
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Person Approved GO biological process GO:0009236 cobalamin biosynthetic process Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Uncurated GO molecular function GO:0043755 alpha-ribazole phosphatase activity GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR017578
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved GO molecular function GO:0003824 catalytic activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR001345
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Comparative to toptop
Author Approval Details Genome Feature Name Type
Member
Automated Process Uncurated Go view OrthoMCL (14 enterobacteria) AMM-0004293 CDS
Automated Process Uncurated Go view OrthoMCL (205 gammaproteobacteria) APP-0002783 cobC CDS
Automated Process Uncurated Go view OrthoMCL (307 Enterobacteriaceae) ATM-0002871 cobC CDS
Automated Process Uncurated Go view OrthoMCL (42 Serratia) BEZ-0007511 cobC CDS
Automated Process Uncurated Go view OrthoMCL (UW draft) CQJ-0002631 cobC CDS
Ortholog
Automated Process Uncurated Go view Citrobacter amalonaticus ATCC 25405 [T] AUW-0001459 cobC_2 CDS
Automated Process Uncurated Go view Citrobacter freundii ATCC 8090 [T] AVI-0001989 cobC_2 CDS
Automated Process Uncurated Go view Escherichia albertii TW07627 AFX-0000308 cobC CDS
Automated Process Uncurated Go view Escherichia coli 101-1 (EAEC) BAB-0009280 cobC CDS
Automated Process Approved Go view Escherichia coli 536 (UPEC) AEF-0000672 CDS
Automated Process Uncurated Go view Escherichia coli 53638 (EIEC) ADP-0005884 cobC CDS
Automated Process Approved Go view Escherichia coli APEC O1 (APEC) AEG-0000574 phpB CDS
Automated Process Approved Go view Escherichia coli ATCC 11775 [T] AMC-0003708 cobC CDS
Automated Process Approved Go view Escherichia coli ATCC 8739 AEM-0008953 CDS
Automated Process Uncurated Go view Escherichia coli B171 (EPEC) ADN-0010723 cobC CDS
Person Uncurated Go view Escherichia coli B7A (ETEC) ADK-0009103 CDS
Person Approved Go view Escherichia coli CFT073 (UPEC) ABR-0076805 cobC CDS
Automated Process Uncurated Go view Escherichia coli DEC7E (UM-IGS draft) CFX-0000690 cobC CDS
Automated Process Uncurated Go view Escherichia coli DEC9A (UM-IGS draft) CFY-0000798 cobC CDS
Automated Process Uncurated Go view Escherichia coli E110019 (EPEC) ADM-0007511 cobC CDS
Automated Process Uncurated Go view Escherichia coli E22 (EPEC) ADL-0006988 cobC CDS
Automated Process Approved Go view Escherichia coli E2348/69 (EPEC) BCI-0000562 cobC CDS
Automated Process Approved Go view Escherichia coli E24377A (ETEC) ADO-0005111 cobC CDS
Automated Process Uncurated Go view Escherichia coli EC4024 (EHEC) BBI-0005933 CDS
Automated Process Uncurated Go view Escherichia coli EC4042 (EHEC) BBA-0010899 cobC CDS
Automated Process Uncurated Go view Escherichia coli EC4045 (EHEC) BBB-0008479 cobC CDS
Automated Process Uncurated Go view Escherichia coli EC4076 (EHEC) BAZ-0005745 cobC CDS
Automated Process Approved Go view Escherichia coli EC4115 (EHEC) BAS-0005567 cobC CDS
Automated Process Uncurated Go view Escherichia coli EC4196 (EHEC) BAX-0010186 cobC CDS
Automated Process Uncurated Go view Escherichia coli EC4401 (EHEC) BAV-0010177 cobC CDS
Automated Process Uncurated Go view Escherichia coli EC4486 (EHEC) BAU-0006513 cobC CDS
Automated Process Uncurated Go view Escherichia coli EC4501 (EHEC) BAT-0010240 cobC CDS
Automated Process Uncurated Go view Escherichia coli EC508 (EHEC) BBJ-0010168 cobC CDS
Automated Process Uncurated Go view Escherichia coli EC869 (EHEC) BBC-0006790 cobC CDS
Person Approved Go view Escherichia coli EDL933 (EHEC) ABH-0024625 cobC CDS
Automated Process Approved Go view Escherichia coli F11 (UPEC) ADQ-0009236 cobC CDS
Automated Process Approved Go view Escherichia coli HS ADR-0005371 cobC CDS
Automated Process Uncurated Go view Escherichia coli J96 (UPEC) CQK-0000935 CDS
Person Uncurated Go view Escherichia coli K-12 DH10B AEC-0000632 cobC CDS
Person Approved Go view Escherichia coli K-12 W3110 ADY-0000648 cobC CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR68 CGA-0000863 CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR71 CGB-0000889 CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR8 CFZ-0000827 CDS
Automated Process Uncurated Go view Escherichia coli Nissle 1917 AML-0000722 CDS
Automated Process Uncurated Go view Escherichia coli RS218 (NMEC) ACK-0174819 CDS
Automated Process Approved Go view Escherichia coli SE11 AFS-0000717 CDS
Automated Process Approved Go view Escherichia coli SMS-3-5 AFT-0000657 cobC CDS
Person Approved Go view Escherichia coli Sakai (EHEC) ACA-0130570 cobC CDS
Automated Process Uncurated Go view Escherichia coli TW14588 (EHEC) BBK-0005321 CDS
Automated Process Approved Go view Escherichia coli UTI89 (UPEC) AEA-0000643 phpB CDS
Person Uncurated Go view Klebsiella pneumoniae subsp. pneumoniae MGH 78578 AEP-0000672 phpB CDS
Person Uncurated Go view Photorhabdus luminescens subsp. laumondii TTO1 [T] ACD-0143682 cobC CDS
Automated Process Uncurated Go view Salmonella Agona SL483 BBX-0004864 cobC CDS
Automated Process Uncurated Go view Salmonella Arizonae CDC 346-86 BCD-0002406 CDS
Person Uncurated Go view Salmonella Choleraesuis SC-B67 ADB-0000798 cobC CDS
Automated Process Uncurated Go view Salmonella Dublin CT_02021853 BCB-0005020 cobC CDS
Automated Process Uncurated Go view Salmonella Enteritidis P125109 BCF-0002057 cobC CDS
Automated Process Uncurated Go view Salmonella Gallinarum 287/91 BCG-0002002 cobC CDS
Automated Process Uncurated Go view Salmonella Hadar RI_05P066 BBT-0008748 cobC CDS
Automated Process Uncurated Go view Salmonella Heidelberg SL476 BBV-0005124 cobC CDS
Automated Process Uncurated Go view Salmonella Heidelberg SL486 BBW-0004481 cobC CDS
Automated Process Uncurated Go view Salmonella Javiana GA_MM04042433 BCA-0007913 cobC CDS
Automated Process Uncurated Go view Salmonella Kentucky CDC 191 BBZ-0006096 cobC CDS
Automated Process Uncurated Go view Salmonella Kentucky CVM29188 BBP-0004267 cobC CDS
Automated Process Uncurated Go view Salmonella Newport SL254 BBQ-0005070 cobC CDS
Automated Process Uncurated Go view Salmonella Newport SL317 BBR-0007257 cobC CDS
Automated Process Uncurated Go view Salmonella Paratyphi A AKU_12601 BCH-0002106 CDS
Person Uncurated Go view Salmonella Paratyphi A ATCC 9150 ADA-0002091 cobC CDS
Automated Process Uncurated Go view Salmonella Paratyphi B SPB7 BCC-0002920 CDS
Automated Process Uncurated Go view Salmonella Saintpaul SARA23 BBN-0005360 cobC CDS
Automated Process Uncurated Go view Salmonella Saintpaul SARA29 BBM-0006115 cobC CDS
Automated Process Uncurated Go view Salmonella Schwarzengrund CVM19633 BBO-0004893 cobC CDS
Automated Process Uncurated Go view Salmonella Schwarzengrund SL480 BBY-0005976 cobC CDS
Person Uncurated Go view Salmonella Typhi CT18 ABX-0106638 cobC CDS
Person Uncurated Go view Salmonella Typhi Ty2 ABS-0083938 cobC CDS
Automated Process Uncurated Go view Salmonella Typhimurium 14028S AJR-0000752 cobC CDS
Person Uncurated Go view Salmonella Typhimurium LT2 [T] ABU-0092495 cobC CDS
Automated Process Uncurated Go view Salmonella Virchow SL491 BBS-0008830 cobC CDS
Automated Process Uncurated Go view Salmonella Weltevreden SL484 BBU-0006578 cobC CDS
Automated Process Uncurated Go view Salmonella enterica CVM23701 BBL-0005035 cobC CDS
Person Uncurated Go view Shewanella oneidensis MR-1 ACY-0264586 CDS
Automated Process Uncurated Go view Shigella dysenteriae 1012 BAA-0007238 cobC CDS
Person Approved Go view Shigella flexneri 2457T ABQ-0071661 phpB CDS
Person Approved Go view Shigella flexneri 301 ABT-0086993 phpB CDS
Automated Process Approved Go view Shigella flexneri 8401 BAG-0000723 phpB CDS
Person Uncurated Go view Shigella sonnei 046 ADD-0000639 phpB CDS
Person Uncurated Go view Xenorhabdus nematophila ATCC 19061 [T] ADW-0002038 cobC CDS
Automated Process Uncurated Go view Yersinia bercovieri ATCC 43970 [T] AEK-0000510 CDS
Automated Process Uncurated Go view Yersinia enterocolitica 8081 BAH-0007786 cobC CDS
Automated Process Uncurated Go view Yersinia frederiksenii ATCC 33641 [T] AEI-0000446 cobC CDS
Automated Process Uncurated Go view Yersinia intermedia ATCC 29909 [T] AEH-0002885 cobC CDS
Automated Process Uncurated Go view Yersinia mollaretii ATCC 43969 [T] AEJ-0001260 CDS
Automated Process Uncurated Go view Yokenella regensburgei ATCC 43003 APO-0009978 CDS
Automated Process Uncurated Go view Yokenella regensburgei ATCC 49455 [T] AMG-0001763 cobC CDS
Experimental to toptop
SelectSetNameSetDetailsNotes
stringent responsetranscriptional profile of the stringent responseNone
Recombinant heat-shock dataexpression data for recombinant strain under heat shockThese data are from the Harcum laboratory. (Jeremy Glasner)
Suppressor tRNA expressionexperiment comparing transcript levels in cells with and without suppressor tRNA expressionThese data were reported in the paper: Herring and Blattner. 2004. Global transcriptional effects of a suppressor tRNA and the inactivation of the regulator frmR. J. Bacteriol. 186(20):6714-20. Link to Abstract (Jeremy Glasner)
Recombinant E. coli expressionexperiment comparing expression of wild-type E. coli with the same strain harboring a plasmid that expresses protein when induced with IPTG These data were reported in the paper: F. T. Haddadin, S. W. Harcum (2005) Transcriptome profiles for high-cell-density recombinant and wild-type Escherichia coli, Biotechnology and Bioengineering, 90:127-153. Link to Abstract (Jeremy Glasner)
Aerobic shiftAerobic shiftThese data were reported in the paper: Covert MW, Knight EM, Reed JL, Herrgard MJ, Palsson BO. 2004. Integrating high-throughput and computational data elucidates bacterial networks. Nature. 2004 May 6;429(6987):92-6. Link to Abstract (Jeremy Glasner)
CalibratorCalibrated microarray experiments (50 hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
AffyData1Affymetrix Experiments (data from 41 chip hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
Strains to toptop

Strains with mutations in this feature.

Strain NameStrain TypeStrain InformationStrain RequestFeatureIDNameMutation DetailsExperiments Using StrainSubmitter
FB20217mutantTn5 InsertionRequest the StrainABE-0002185cobCphpB::Tn5KAN-2 at position 420 in Minus orientation ,- pKD460Blattner Laboratory
Context Table to toptop

Listed below are features that lie nearby this feature. Features encoded in multiple intervals may appear more than once in the table. Features that span the origin will have a left endpoint greater than the right endpoint.

Features overlapping the region 664296 to 674907
FeatureIDNameFeature TypeStrandLeft EndRight EndRelationship
ABE-0000001sourceforward14641652Contains
ABE-0002171rlpACDScomplement664102665190Downstream
ABE-0002173mrdBCDScomplement665201666313Downstream
ABE-0002178mrdACDScomplement666316668217Downstream
ABE-0002180rlmHCDScomplement668248668715Downstream
ABE-0002183rsfSCDScomplement668719669036Downstream
ABE-0002185cobCCDScomplement669296669907Matches
ABE-0002187nadDCDScomplement669931670572Upstream
ABE-0002192holACDScomplement670574671605Upstream
ABE-0002194lptECDScomplement671605672186Upstream
ABE-0002196leuSCDScomplement672201674783Upstream
Release Notes to toptop
All MG1655 annotations and sequence data are publicly available, and investigators can use these data in publications without contacting the genome curators. This version of the sequence was the source of GenBank record U00096.3. Ongoing annotation updates to that GenBank record are being generated from a collaboration that includes ASAP, EcoGene, the Coli Genetic Stock Center, EcoliHub, EcoCyc, RegulonDB and UniProtKB/Swiss-Prot.