Escherichia coli K-12 MG1655
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Working With: Genome: Escherichia coli K-12 MG1655 Version: v3

ABE-0003370 (torC) - Escherichia coli K-12 MG1655 - Feature Annotation

ASAP ID
ABE-0003370 showshow history
Names
torC JW0981 ECK0987 b0996
Product
cytochrome c menaquinol dehydrogenase
Type
CDS
Location
# Contig Strand Left Right Length (b.p.) Length (a.a.)
1 Chromosome forward 1058084 1059256 1173 391
Sequence

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Context

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Protein Families to toptop
Author Approval Family Annotated
Automated Process Approved IPR009154 (IPR009154 Membrane-bound tetrahaem cytochrome TorC/YecK) Apr 2008
Automated Process Approved IPR005126 (IPR005126 NapC/NirT cytochrome c, N-terminal) Apr 2008
Automated Process Approved IPR011031 (IPR011031 Multihaem cytochrome) Apr 2008
Automated Process Approved IPR036280 (IPR036280 Multiheme cytochrome superfamily) Jul 2018
Automated Process Approved PF03264 (PF03264 NapC/NirT cytochrome c family, N-terminal region) Jul 2018
Gene Ontology to toptop
Author Approval Type Annotation Evidence Annotated
Automated Process Approved GO biological process GO:0006118 (OBSOLETE) electron transport GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR009154
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Person Uncurated GO biological process GO:0009061 anaerobic respiration Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Person Uncurated GO biological process GO:0006350 (DEPRECATED) transcription Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Person Uncurated GO biological process GO:0017004 cytochrome complex assembly Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Approved GO cellular component GO:0016021 integral component of membrane GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR009154
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO cellular component GO:0009276 Gram-negative-bacterium-type cell wall GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR009154
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO cellular component GO:0005886 plasma membrane GO Inferred from Electronic Annotation - PubMed ID: 15501914
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Person Uncurated GO cellular component GO:0042597 periplasmic space Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Approved GO molecular function GO:0009055 electron transfer activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR009154
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO molecular function GO:0020037 heme binding GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR009154
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Person Uncurated GO molecular function GO:0016564 (OBSOLETE) transcription repressor activity Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Person Approved GO molecular function GO:0009055 electron transfer activity Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Approved GO molecular function GO:0005506 iron ion binding GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR009154
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Annotations to toptop
Author Approval Type Annotation Evidence Annotated
Nomenclature
Person Approved name torC Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Oct 1998
Person Approved synonym ECK0987 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved synonym JW0981 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved locus tag b0996 Unique Identifier - Origin: Guy Plunkett III, guy@genome.wisc.edu May 2004
Product
Person Uncurated product cytochrome c menaquinol dehydrogenase Published Annotation - EcoCyc Accession Number: EG11815
Reference: Escherichia coli K-12 MG1655 		Oct 2021
Person Uncurated alternate product name cytochrome c-type protein in TMAO respiration; with TorA, also negativer regulator of tor operon Published Annotation - Database Name: GenProtEC Jan 2006
Person Approved alternate product name trimethylamine N-oxide reductase, cytochrome c-type subunit Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Jan 2006
Person Approved alternate product name trimethylamine N-oxide (TMAO) reductase I, cytochrome c-type subunit Published Annotation - PubMed ID: 16397293 Jan 2006
Protein Family
Automated Process Approved protein family IPR011031 Multihaem cytochrome Protein Sequence Similarity - InterPro Domain: IPR011031
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family IPR036280 Multiheme cytochrome superfamily Protein Sequence Similarity - InterPro Domain: IPR036280
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved protein family IPR009154 Membrane-bound tetrahaem cytochrome TorC/YecK Protein Sequence Similarity - InterPro Domain: IPR009154
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family PF03264 NapC/NirT cytochrome c family, N-terminal region Protein Sequence Similarity - PFAM Model Name: PF03264
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved protein family IPR005126 NapC/NirT cytochrome c, N-terminal Protein Sequence Similarity - InterPro Domain: IPR005126
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Other
Person Uncurated MultiFun 1.3.7 (metabolism; energy metabolism, carbon; anaerobic respiration) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Person Uncurated MultiFun 2.2.2 (information transfer; RNA related; transcription related) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Person Uncurated MultiFun 1.4.3 (metabolism; energy production/transport; electron carrier) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Person Uncurated MultiFun 1.6.15.1 (metabolism; macromolecules (cellular constituent) biosynthesis; large molecule carriers; cytochromes) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Person Uncurated MultiFun 7.2 (location of gene products; periplasmic space) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Person Uncurated MultiFun 3.3.1 (regulation; genetic unit regulated; operon) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Person Uncurated MultiFun 3.1.2.3 (regulation; type of regulation; transcriptional level; repressor) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Automated Process Approved codon start 1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref ASAP:ABE-0003370 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref EcoGene:EG11815 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Person Approved db xref UniProtKB:P33226 Published Annotation - Swiss-Prot Accession Number: P33226 Jan 2005
Automated Process Approved db xref GI:1787230 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref GeneID:946252 Published Annotation - Entrez Gene Database ID: 946252
Reference: Escherichia coli K-12 MG1655 		Jun 2009
Automated Process Approved db xref UniProtKB/Swiss-Prot:P33226 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Person Approved function enzyme; Energy metabolism, carbon: Anaerobic respiration Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Oct 1998
Automated Process Approved note trimethylamine N-oxide reductase, cytochrome c-type subunit; GO_component: GO:0042597 - periplasmic space; GO_function: GO:0009055 - electron carrier activity; GO_function: GO:0016564 - transcription repressor activity; GO_process: GO:0009061 - anaerobic respiration; GO_process: GO:0017004 - cytochrome complex assembly; GO_process: GO:0006350 - transcription Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved protein id AAC74081.1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Uncurated subcellular localization Cytoplasmic Membrane Predicted by PSORTb - PSORTb Final_Score: 10.00
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Person Uncurated subsystem component of in silico model iMC1010 Experimental - PubMed ID: 15129285
Reference: Escherichia coli K-12 MG1655 		Mar 2009
Person Uncurated subsystem component of in silico model iJR904 Experimental - PubMed ID: 12952533
Reference: Escherichia coli K-12 MG1655 		Feb 2009
Person Uncurated subsystem component of in silico model iAF1260 Experimental - PubMed ID: 17593909
Reference: Escherichia coli K-12 MG1655 		Jan 2009
Automated Process Approved transl table 11 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Gene Ontology
Automated Process Approved GO biological process GO:0006118 (OBSOLETE) electron transport GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR009154
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Person Uncurated GO biological process GO:0009061 anaerobic respiration Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Person Uncurated GO biological process GO:0006350 (DEPRECATED) transcription Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Person Uncurated GO biological process GO:0017004 cytochrome complex assembly Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Approved GO cellular component GO:0009276 Gram-negative-bacterium-type cell wall GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR009154
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO cellular component GO:0016021 integral component of membrane GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR009154
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO cellular component GO:0005886 plasma membrane GO Inferred from Electronic Annotation - PubMed ID: 15501914
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Person Uncurated GO cellular component GO:0042597 periplasmic space Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Person Approved GO molecular function GO:0009055 electron transfer activity Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Approved GO molecular function GO:0009055 electron transfer activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR009154
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO molecular function GO:0020037 heme binding GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR009154
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Person Uncurated GO molecular function GO:0016564 (OBSOLETE) transcription repressor activity Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Approved GO molecular function GO:0005506 iron ion binding GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR009154
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Comparative to toptop
Author Approval Details Genome Feature Name Type
Member
Automated Process Uncurated Go view OrthoMCL (14 enterobacteria) AMM-0006679 CDS
Automated Process Uncurated Go view OrthoMCL (205 gammaproteobacteria) APP-0003073 torC CDS
Automated Process Uncurated Go view OrthoMCL (307 Enterobacteriaceae) ATM-0003328 torC CDS
Automated Process Uncurated Go view OrthoMCL (42 Serratia) BEZ-0006358 torC CDS
Automated Process Uncurated Go view OrthoMCL (UW draft) CQJ-0003042 torC CDS
Ortholog
Automated Process Uncurated Go view Citrobacter freundii ATCC 8090 [T] AVI-0001888 torY_1 CDS
Automated Process Uncurated Go view Escherichia albertii TW07627 AFX-0003615 torC CDS
Automated Process Uncurated Go view Escherichia coli 101-1 (EAEC) BAB-0007287 torC CDS
Automated Process Approved Go view Escherichia coli 536 (UPEC) AEF-0001003 CDS
Automated Process Uncurated Go view Escherichia coli 53638 (EIEC) ADP-0005484 torC CDS
Automated Process Approved Go view Escherichia coli APEC O1 (APEC) AEG-0000924 torC CDS
Automated Process Approved Go view Escherichia coli ATCC 11775 [T] AMC-0003381 torC CDS
Automated Process Approved Go view Escherichia coli ATCC 8739 AEM-0008444 CDS
Automated Process Uncurated Go view Escherichia coli B171 (EPEC) ADN-0008009 torC CDS
Automated Process Uncurated Go view Escherichia coli B7A (ETEC) ADK-0007120 pseudogene
Person Approved Go view Escherichia coli CFT073 (UPEC) ABR-0077226 torC CDS
Automated Process Uncurated Go view Escherichia coli DEC7E (UM-IGS draft) CFX-0001080 torC CDS
Automated Process Uncurated Go view Escherichia coli DEC9A (UM-IGS draft) CFY-0001325 torC CDS
Automated Process Uncurated Go view Escherichia coli E110019 (EPEC) ADM-0009455 torC CDS
Automated Process Uncurated Go view Escherichia coli E22 (EPEC) ADL-0008291 torC CDS
Automated Process Approved Go view Escherichia coli E2348/69 (EPEC) BCI-0001097 torC CDS
Automated Process Approved Go view Escherichia coli E24377A (ETEC) ADO-0005556 torC CDS
Automated Process Uncurated Go view Escherichia coli EC4024 (EHEC) BBI-0005071 CDS
Automated Process Uncurated Go view Escherichia coli EC4042 (EHEC) BBA-0009939 torC CDS
Automated Process Uncurated Go view Escherichia coli EC4045 (EHEC) BBB-0008979 torC CDS
Automated Process Uncurated Go view Escherichia coli EC4076 (EHEC) BAZ-0007584 torC CDS
Automated Process Uncurated Go view Escherichia coli EC4113 (EHEC) BAY-0005568 torC CDS
Automated Process Approved Go view Escherichia coli EC4115 (EHEC) BAS-0006072 torC CDS
Automated Process Uncurated Go view Escherichia coli EC4196 (EHEC) BAX-0006342 torC CDS
Automated Process Uncurated Go view Escherichia coli EC4206 (EHEC) BAW-0009840 torC CDS
Automated Process Uncurated Go view Escherichia coli EC4401 (EHEC) BAV-0006273 torC CDS
Automated Process Uncurated Go view Escherichia coli EC4486 (EHEC) BAU-0006927 torC CDS
Automated Process Uncurated Go view Escherichia coli EC4501 (EHEC) BAT-0008804 torC CDS
Automated Process Uncurated Go view Escherichia coli EC508 (EHEC) BBJ-0008349 torC CDS
Automated Process Uncurated Go view Escherichia coli EC869 (EHEC) BBC-0007805 torC CDS
Person Approved Go view Escherichia coli EDL933 (EHEC) ABH-0025226 torC CDS
Automated Process Approved Go view Escherichia coli F11 (UPEC) ADQ-0007465 torC CDS
Automated Process Approved Go view Escherichia coli HS ADR-0005784 torC CDS
Automated Process Uncurated Go view Escherichia coli J96 (UPEC) CQK-0001191 CDS
Person Uncurated Go view Escherichia coli K-12 DH10B AEC-0000958 torC CDS
Person Approved Go view Escherichia coli K-12 W3110 ADY-0001007 torC CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR68 CGA-0001296 CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR71 CGB-0001290 CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR8 CFZ-0001246 CDS
Automated Process Uncurated Go view Escherichia coli Nissle 1917 AML-0001084 CDS
Automated Process Uncurated Go view Escherichia coli RS218 (NMEC) ACK-0175219 CDS
Automated Process Approved Go view Escherichia coli SE11 AFS-0001084 CDS
Automated Process Approved Go view Escherichia coli SMS-3-5 AFT-0002127 torC CDS
Person Approved Go view Escherichia coli Sakai (EHEC) ACA-0131072 torC CDS
Automated Process Uncurated Go view Escherichia coli TW14588 (EHEC) BBK-0003466 CDS
Person Approved Go view Escherichia coli UTI89 (UPEC) AEA-0001063 torC CDS
Automated Process Uncurated Go view Salmonella Agona SL483 BBX-0008218 torC CDS
Automated Process Uncurated Go view Salmonella Arizonae CDC 346-86 BCD-0004007 CDS
Person Approved Go view Salmonella Choleraesuis SC-B67 ADB-0004374 torC CDS
Automated Process Uncurated Go view Salmonella Dublin CT_02021853 BCB-0008458 torC CDS
Automated Process Uncurated Go view Salmonella Enteritidis P125109 BCF-0011977 torC CDS
Automated Process Uncurated Go view Salmonella Gallinarum 287/91 BCG-0011032 torC CDS
Automated Process Uncurated Go view Salmonella Hadar RI_05P066 BBT-0005037 torC CDS
Automated Process Uncurated Go view Salmonella Heidelberg SL476 BBV-0008513 torC CDS
Automated Process Uncurated Go view Salmonella Heidelberg SL486 BBW-0005863 torC CDS
Automated Process Uncurated Go view Salmonella Javiana GA_MM04042433 BCA-0005937 torC CDS
Automated Process Uncurated Go view Salmonella Kentucky CDC 191 BBZ-0007689 torC CDS
Automated Process Uncurated Go view Salmonella Kentucky CVM29188 BBP-0007607 torC CDS
Automated Process Uncurated Go view Salmonella Newport SL254 BBQ-0008461 torC CDS
Automated Process Uncurated Go view Salmonella Newport SL317 BBR-0006391 torC CDS
Automated Process Uncurated Go view Salmonella Paratyphi A AKU_12601 BCH-0003710 CDS
Person Approved Go view Salmonella Paratyphi A ATCC 9150 ADA-0003672 torC CDS
Automated Process Uncurated Go view Salmonella Paratyphi B SPB7 BCC-0004778 CDS
Automated Process Uncurated Go view Salmonella Saintpaul SARA23 BBN-0008634 torC CDS
Automated Process Uncurated Go view Salmonella Saintpaul SARA29 BBM-0004354 torC CDS
Automated Process Uncurated Go view Salmonella Schwarzengrund CVM19633 BBO-0008102 torC CDS
Automated Process Uncurated Go view Salmonella Schwarzengrund SL480 BBY-0004911 torC CDS
Person Uncurated Go view Salmonella Typhi CT18 ABX-0113342 torC pseudogene
Person Approved Go view Salmonella Typhi Ty2 ABS-0085421 torC CDS
Automated Process Uncurated Go view Salmonella Typhimurium 14028S AJR-0004621 torC CDS
Person Approved Go view Salmonella Typhimurium LT2 [T] ABU-0101806 torC CDS
Automated Process Uncurated Go view Salmonella Virchow SL491 BBS-0005381 torC CDS
Automated Process Uncurated Go view Salmonella Weltevreden SL484 BBU-0004803 torC CDS
Automated Process Uncurated Go view Salmonella enterica CVM23701 BBL-0006629 torC CDS
Person Uncurated Go view Shewanella oneidensis MR-1 ACY-0264798 torC CDS
Person Approved Go view Shigella boydii 227 ADV-0002479 torC CDS
Automated Process Uncurated Go view Shigella dysenteriae 1012 BAA-0004896 torC CDS
Person Uncurated Go view Shigella dysenteriae 197 ADU-0001090 torC pseudogene
Person Approved Go view Shigella flexneri 2457T ABQ-0072105 torC CDS
Person Approved Go view Shigella flexneri 301 ABT-0087350 torC CDS
Automated Process Approved Go view Shigella flexneri 8401 BAG-0001066 torC CDS
Person Approved Go view Shigella sonnei 046 ADD-0001078 torC CDS
Person Approved Go view Vibrio cholerae N16961 ADH-0001766 VC1693 CDS
Experimental to toptop
SelectSetNameSetDetailsNotes
stringent responsetranscriptional profile of the stringent responseNone
Recombinant heat-shock dataexpression data for recombinant strain under heat shockThese data are from the Harcum laboratory. (Jeremy Glasner)
Suppressor tRNA expressionexperiment comparing transcript levels in cells with and without suppressor tRNA expressionThese data were reported in the paper: Herring and Blattner. 2004. Global transcriptional effects of a suppressor tRNA and the inactivation of the regulator frmR. J. Bacteriol. 186(20):6714-20. Link to Abstract (Jeremy Glasner)
Recombinant E. coli expressionexperiment comparing expression of wild-type E. coli with the same strain harboring a plasmid that expresses protein when induced with IPTG These data were reported in the paper: F. T. Haddadin, S. W. Harcum (2005) Transcriptome profiles for high-cell-density recombinant and wild-type Escherichia coli, Biotechnology and Bioengineering, 90:127-153. Link to Abstract (Jeremy Glasner)
Aerobic shiftAerobic shiftThese data were reported in the paper: Covert MW, Knight EM, Reed JL, Herrgard MJ, Palsson BO. 2004. Integrating high-throughput and computational data elucidates bacterial networks. Nature. 2004 May 6;429(6987):92-6. Link to Abstract (Jeremy Glasner)
CalibratorCalibrated microarray experiments (50 hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
AffyData1Affymetrix Experiments (data from 41 chip hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
Context Table to toptop

Listed below are features that lie nearby this feature. Features encoded in multiple intervals may appear more than once in the table. Features that span the origin will have a left endpoint greater than the right endpoint.

Features overlapping the region 1053084 to 1064256
FeatureIDNameFeature TypeStrandLeft EndRight EndRelationship
ABE-0000001sourceforward14641652Contains
ABE-0003351yccMCDScomplement10522891053362Upstream
ABE-0003354torSCDScomplement10534341056178Upstream
ABE-0003360torTCDSforward10562611057289Upstream
ABE-0003362torRCDScomplement10572621057954Upstream
ABE-0003370torCCDSforward10580841059256Matches
ABE-0003372torACDSforward10592561061802Overlaps Downstream
ABE-0003374torDCDSforward10617991062398Downstream
ABE-0285418repeat_regionforward10624071062540Downstream
ABE-0003377cbpMCDScomplement10625501062855Downstream
ABE-0003379cbpACDScomplement10628551063775Downstream
ABE-0003384yccECDSforward10640361065292Downstream
Release Notes to toptop
All MG1655 annotations and sequence data are publicly available, and investigators can use these data in publications without contacting the genome curators. This version of the sequence was the source of GenBank record U00096.3. Ongoing annotation updates to that GenBank record are being generated from a collaboration that includes ASAP, EcoGene, the Coli Genetic Stock Center, EcoliHub, EcoCyc, RegulonDB and UniProtKB/Swiss-Prot.