Escherichia coli K-12 MG1655
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Working With: Genome: Escherichia coli K-12 MG1655 Version: v3

ABE-0004973 (gadC) - Escherichia coli K-12 MG1655 - Feature Annotation

ASAP ID
ABE-0004973 showshow history
Names
gadC acsA xasA JW1487 ECK1486 b1492
Product
L-glutamate:4-aminobutyrate antiporter
Type
CDS
Location
# Contig Strand Left Right Length (b.p.) Length (a.a.)
1 Chromosome complement 1568954 1570489 1536 512
Sequence

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Context

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Protein Families to toptop
Author Approval Family Annotated
Automated Process Approved IPR004841 (IPR004841 Amino acid permease/ SLC12A domain) Apr 2008
Automated Process Approved IPR002293 (IPR002293 Amino acid/polyamine transporter I) Apr 2008
Automated Process Approved IPR004759 (IPR004759 Glutamate:g-aminobutyrate antiporter) Apr 2008
Automated Process Approved PF13520 (PF13520 Amino acid permease) Jul 2018
Gene Ontology to toptop
Author Approval Type Annotation Evidence Annotated
Automated Process Approved GO biological process GO:0006810 transport GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR004841
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO biological process GO:0055085 transmembrane transport GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR002293
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved GO biological process GO:0006865 amino acid transport GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR002293
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO cellular component GO:0016021 integral component of membrane GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR004759
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO cellular component GO:0016020 membrane GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR004841
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO cellular component GO:0005886 plasma membrane GO Inferred from Electronic Annotation - PubMed ID: 15501914
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Person Uncurated GO cellular component GO:0019866 organelle inner membrane Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Uncurated GO molecular function GO:0022857 transmembrane transporter activity GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR002293
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved GO molecular function GO:0015171 amino acid transmembrane transporter activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR002293
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO molecular function GO:0015359 (DEPRECATED) amino acid permease activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR004759
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Annotations to toptop
Author Approval Type Annotation Evidence Annotated
Nomenclature
Person Approved name gadC Experimental - PubMed ID: 8682809
Reference: Escherichia coli 		Oct 2005
Person Approved synonym ECK1486 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved synonym JW1487 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved synonym xasA Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Jan 2006
Automated Process Approved synonym acsA Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Person Approved locus tag b1492 Unique Identifier - Origin: Guy Plunkett III, guy@genome.wisc.edu May 2004
Product
Person Uncurated product L-glutamate:4-aminobutyrate antiporter Published Annotation - EcoCyc Accession Number: G6786
Reference: Escherichia coli K-12 MG1655 		Oct 2021
Person Approved alternate product name predicted glutamate:gamma-aminobutyric acid antiporter Published Annotation - PubMed ID: 16397293 Jan 2006
Automated Process Approved alternate product name glutamate:gamma-aminobutyric acid antiporter Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Protein Family
Automated Process Approved protein family IPR004759 Glutamate:g-aminobutyrate antiporter Protein Sequence Similarity - InterPro Domain: IPR004759
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family PF13520 Amino acid permease Protein Sequence Similarity - PFAM Model Name: PF13520
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved protein family IPR002293 Amino acid/polyamine transporter I Protein Sequence Similarity - InterPro Domain: IPR002293
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family IPR004841 Amino acid permease/ SLC12A domain Protein Sequence Similarity - InterPro Domain: IPR004841
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Other
Person Uncurated MultiFun 4.2.A.3 (transport; Electrochemical potential driven transporters; Porters (Uni-, Sym- and Antiporters); The Amino Acid-Polyamine-Choline (APC) Family) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Person Uncurated MultiFun 6.1 (cell structure; membrane) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Person Uncurated MultiFun 7.3 (location of gene products; inner membrane) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Person Uncurated MultiFun 4.S.74 (transport; substrate; glutamate/aminobutyric acid) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Automated Process Approved codon start 1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref EcoGene:EG12456 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref ASAP:ABE-0004973 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref UniProtKB/Swiss-Prot:P63235 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref GeneID:946057 Published Annotation - Entrez Gene Database ID: 946057
Reference: Escherichia coli K-12 MG1655 		Jun 2009
Person Approved db xref UniProtKB:P63235 Published Annotation - Swiss-Prot Accession Number: P63235 Jan 2006
Automated Process Approved db xref GI:1787768 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved note acid sensitivity protein, putative transporter; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved protein id AAC74565.1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Person Approved regulation expression regulated by acetate; expression is induced by acetate Experimental - PubMed ID: 11244055
Reference: Escherichia coli ATCC43888 (EHEC) 		Nov 2005
Automated Process Uncurated subcellular localization Cytoplasmic Membrane Predicted by PSORTb - PSORTb Final_Score: 10.00
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Person Uncurated subsystem component of in silico model iMC1010 Experimental - PubMed ID: 15129285
Reference: Escherichia coli K-12 MG1655 		Mar 2009
Person Uncurated subsystem component of in silico model iJR904 Experimental - PubMed ID: 12952533
Reference: Escherichia coli K-12 MG1655 		Feb 2009
Person Uncurated subsystem component of in silico model iAF1260 Experimental - PubMed ID: 17593909
Reference: Escherichia coli K-12 MG1655 		Jan 2009
Automated Process Approved transl table 11 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Gene Ontology
Automated Process Approved GO biological process GO:0006810 transport GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR004841
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO biological process GO:0055085 transmembrane transport GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR002293
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved GO biological process GO:0006865 amino acid transport GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR002293
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Person Uncurated GO cellular component GO:0019866 organelle inner membrane Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Uncurated GO cellular component GO:0005886 plasma membrane GO Inferred from Electronic Annotation - PubMed ID: 15501914
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Automated Process Approved GO cellular component GO:0016021 integral component of membrane GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR004759
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO cellular component GO:0016020 membrane GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR004841
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO molecular function GO:0015359 (DEPRECATED) amino acid permease activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR004759
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO molecular function GO:0015171 amino acid transmembrane transporter activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR002293
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO molecular function GO:0022857 transmembrane transporter activity GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR002293
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Comparative to toptop
Author Approval Details Genome Feature Name Type
Member
Automated Process Uncurated Go view OrthoMCL (14 enterobacteria) AMM-0006725 CDS
Automated Process Uncurated Go view OrthoMCL (205 gammaproteobacteria) APP-0002794 gadC CDS
Automated Process Uncurated Go view OrthoMCL (307 Enterobacteriaceae) ATM-0002981 gadC CDS
Automated Process Uncurated Go view OrthoMCL (42 Serratia) BEZ-0006630 gadC CDS
Automated Process Uncurated Go view OrthoMCL (UW draft) CQJ-0002669 gadC CDS
Ortholog
Automated Process Uncurated Go view Buttiauxella agrestis ATCC 33320 [T] APC-0000407 gadC CDS
Automated Process Uncurated Go view Escherichia albertii TW07627 AFX-0003971 gadC CDS
Automated Process Uncurated Go view Escherichia coli 101-1 (EAEC) BAB-0005500 gadC CDS
Automated Process Approved Go view Escherichia coli 536 (UPEC) AEF-0001500 CDS
Automated Process Uncurated Go view Escherichia coli 53638 (EIEC) ADP-0010090 gadC CDS
Automated Process Approved Go view Escherichia coli APEC O1 (APEC) AEG-0001458 xasA CDS
Automated Process Approved Go view Escherichia coli ATCC 11775 [T] AMC-0005114 gadC CDS
Automated Process Approved Go view Escherichia coli ATCC 8739 AEM-0007915 CDS
Automated Process Uncurated Go view Escherichia coli B171 (EPEC) ADN-0005357 gadC CDS
Automated Process Uncurated Go view Escherichia coli B7A (ETEC) ADK-0005060 CDS
Person Approved Go view Escherichia coli CFT073 (UPEC) ABR-0078037 gadC CDS
Automated Process Uncurated Go view Escherichia coli DEC7E (UM-IGS draft) CFX-0001665 gadC CDS
Automated Process Uncurated Go view Escherichia coli DEC9A (UM-IGS draft) CFY-0001922 xasA CDS
Automated Process Uncurated Go view Escherichia coli E110019 (EPEC) ADM-0005243 gadC CDS
Automated Process Uncurated Go view Escherichia coli E22 (EPEC) ADL-0007986 gadC CDS
Automated Process Approved Go view Escherichia coli E2348/69 (EPEC) BCI-0001732 gadC CDS
Automated Process Approved Go view Escherichia coli E24377A (ETEC) ADO-0006120 gadC CDS
Automated Process Uncurated Go view Escherichia coli EC4024 (EHEC) BBI-0003364 CDS
Automated Process Uncurated Go view Escherichia coli EC4042 (EHEC) BBA-0005483 gadC CDS
Automated Process Uncurated Go view Escherichia coli EC4045 (EHEC) BBB-0009848 gadC CDS
Automated Process Uncurated Go view Escherichia coli EC4076 (EHEC) BAZ-0008028 gadC CDS
Automated Process Uncurated Go view Escherichia coli EC4113 (EHEC) BAY-0007037 gadC CDS
Automated Process Approved Go view Escherichia coli EC4115 (EHEC) BAS-0006945 gadC CDS
Automated Process Uncurated Go view Escherichia coli EC4196 (EHEC) BAX-0006913 gadC CDS
Automated Process Uncurated Go view Escherichia coli EC4206 (EHEC) BAW-0011420 gadC CDS
Automated Process Uncurated Go view Escherichia coli EC4401 (EHEC) BAV-0008087 gadC CDS
Automated Process Uncurated Go view Escherichia coli EC4486 (EHEC) BAU-0008415 gadC CDS
Automated Process Uncurated Go view Escherichia coli EC4501 (EHEC) BAT-0007003 gadC CDS
Automated Process Uncurated Go view Escherichia coli EC508 (EHEC) BBJ-0007108 gadC CDS
Automated Process Uncurated Go view Escherichia coli EC869 (EHEC) BBC-0008763 gadC CDS
Person Approved Go view Escherichia coli EDL933 (EHEC) ABH-0025990 gadC CDS
Automated Process Approved Go view Escherichia coli F11 (UPEC) ADQ-0007960 gadC CDS
Automated Process Approved Go view Escherichia coli HS ADR-0006253 gadC CDS
Automated Process Uncurated Go view Escherichia coli J96 (UPEC) CQK-0001897 CDS
Person Uncurated Go view Escherichia coli K-12 DH10B AEC-0001401 gadC CDS
Person Approved Go view Escherichia coli K-12 W3110 ADY-0001533 gadC CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR68 CGA-0001747 gadC CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR71 CGB-0001801 gadC CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR8 CFZ-0001708 gadC CDS
Automated Process Uncurated Go view Escherichia coli Nissle 1917 AML-0001723 CDS
Automated Process Uncurated Go view Escherichia coli RS218 (NMEC) ACK-0175858 CDS
Automated Process Approved Go view Escherichia coli SE11 AFS-0001611 CDS
Automated Process Approved Go view Escherichia coli SMS-3-5 AFT-0001680 gadC CDS
Person Approved Go view Escherichia coli Sakai (EHEC) ACA-0132067 gadC CDS
Automated Process Uncurated Go view Escherichia coli TW14588 (EHEC) BBK-0002021 CDS
Automated Process Approved Go view Escherichia coli UTI89 (UPEC) AEA-0001713 xasA CDS
Person Uncurated Go view Hafnia alvei ATCC 13337 [T] AMD-0000242 gadC CDS
Person Approved Go view Shigella boydii 227 ADV-0001727 xasA CDS
Automated Process Approved Go view Shigella boydii BS512 ADJ-0007164 gadC CDS
Automated Process Uncurated Go view Shigella dysenteriae 1012 BAA-0004144 gadC CDS
Person Approved Go view Shigella dysenteriae 197 ADU-0001858 xasA CDS
Person Approved Go view Shigella flexneri 2457T ABQ-0072963 xasA CDS
Person Approved Go view Shigella flexneri 301 ABT-0088039 xasA CDS
Automated Process Approved Go view Shigella flexneri 8401 BAG-0001846 xasA CDS
Person Approved Go view Shigella sonnei 046 ADD-0001776 gadC CDS
Experimental to toptop
SelectSetNameSetDetailsNotes
stringent responsetranscriptional profile of the stringent responseNone
Recombinant heat-shock dataexpression data for recombinant strain under heat shockThese data are from the Harcum laboratory. (Jeremy Glasner)
Suppressor tRNA expressionexperiment comparing transcript levels in cells with and without suppressor tRNA expressionThese data were reported in the paper: Herring and Blattner. 2004. Global transcriptional effects of a suppressor tRNA and the inactivation of the regulator frmR. J. Bacteriol. 186(20):6714-20. Link to Abstract (Jeremy Glasner)
Recombinant E. coli expressionexperiment comparing expression of wild-type E. coli with the same strain harboring a plasmid that expresses protein when induced with IPTG These data were reported in the paper: F. T. Haddadin, S. W. Harcum (2005) Transcriptome profiles for high-cell-density recombinant and wild-type Escherichia coli, Biotechnology and Bioengineering, 90:127-153. Link to Abstract (Jeremy Glasner)
Aerobic shiftAerobic shiftThese data were reported in the paper: Covert MW, Knight EM, Reed JL, Herrgard MJ, Palsson BO. 2004. Integrating high-throughput and computational data elucidates bacterial networks. Nature. 2004 May 6;429(6987):92-6. Link to Abstract (Jeremy Glasner)
CalibratorCalibrated microarray experiments (50 hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
AffyData1Affymetrix Experiments (data from 41 chip hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
Context Table to toptop

Listed below are features that lie nearby this feature. Features encoded in multiple intervals may appear more than once in the table. Features that span the origin will have a left endpoint greater than the right endpoint.

Features overlapping the region 1563954 to 1575489
FeatureIDNameFeature TypeStrandLeft EndRight EndRelationship
ABE-0000001sourceforward14641652Contains
ABE-0004963dosPCDScomplement15633341565733Downstream
ABE-0004965dosCCDScomplement15657581567140Downstream
ABE-0285781yddYCDScomplement15671781567219Downstream
ABE-0004970digHCDScomplement15675041568823Downstream
ABE-0004973gadCCDScomplement15689541570489Matches
ABE-0004976gadBCDScomplement15706451572045Upstream
ABE-0004979pqqLCDScomplement15724071575202Upstream
ABE-0004982yddBCDScomplement15752471577619Upstream
Release Notes to toptop
All MG1655 annotations and sequence data are publicly available, and investigators can use these data in publications without contacting the genome curators. This version of the sequence was the source of GenBank record U00096.3. Ongoing annotation updates to that GenBank record are being generated from a collaboration that includes ASAP, EcoGene, the Coli Genetic Stock Center, EcoliHub, EcoCyc, RegulonDB and UniProtKB/Swiss-Prot.