Escherichia coli K-12 MG1655
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Working With: Genome: Escherichia coli K-12 MG1655 Version: v3

ABE-0005364 (folM) - Escherichia coli K-12 MG1655 - Feature Annotation

ASAP ID
ABE-0005364 showshow history
Names
folM ydgB JW1598 ECK1601 b1606
Product
dihydrofolate reductase isozyme
Type
CDS
Location
# Contig Strand Left Right Length (b.p.) Length (a.a.)
1 Chromosome forward 1680976 1681698 723 241
Sequence

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Context

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Protein Families to toptop
Author Approval Family Annotated
Automated Process Approved IPR002198 (IPR002198 (DEPRECATED) Short-chain dehydrogenase/reductase SDR) Apr 2008
Automated Process Approved IPR002347 (IPR002347 Short-chain dehydrogenase/reductase SDR) Apr 2008
Automated Process Approved IPR036291 (IPR036291 NAD(P)-binding domain superfamily) Jul 2018
Automated Process Approved PF13561 (PF13561 Enoyl-(Acyl carrier protein) reductase) Jul 2018
Gene Ontology to toptop
Author Approval Type Annotation Evidence Annotated
Automated Process Approved GO biological process GO:0008152 metabolic process GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR002198
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO molecular function GO:0016491 oxidoreductase activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR002198
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Annotations to toptop
Author Approval Type Annotation Evidence Annotated
Nomenclature
Person Approved name folM Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved synonym ECK1601 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved synonym ydgB Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Jan 2006
Person Approved synonym JW1598 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved locus tag b1606 Unique Identifier - Origin: Guy Plunkett III, guy@genome.wisc.edu May 2004
Product
Person Approved product dihydrofolate reductase isozyme Published Annotation - PubMed ID: 16397293 Jan 2006
Person Uncurated alternate product name putative oxidoreductase, NAD(P)-binding Published Annotation - Database Name: GenProtEC Jan 2006
Person Approved alternate product name putative oxidoreductase Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Jan 2006
Automated Process Approved alternate product name dihydromonapterin reductase, NADPH-dependent; dihydrofolate reductase isozyme Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Protein Family
Automated Process Approved protein family IPR002198 (DEPRECATED) Short-chain dehydrogenase/reductase SDR Protein Sequence Similarity - InterPro Domain: IPR002198
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family IPR036291 NAD(P)-binding domain superfamily Protein Sequence Similarity - InterPro Domain: IPR036291
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved protein family IPR002347 Short-chain dehydrogenase/reductase SDR Protein Sequence Similarity - InterPro Domain: IPR002347
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family PF13561 Enoyl-(Acyl carrier protein) reductase Protein Sequence Similarity - PFAM Model Name: PF13561
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Other
Automated Process Approved EC number 1.5.1.3 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Person Approved EC number 1.-.-.- Published Annotation - Swiss-Prot Accession Number: P0AFS3 Feb 2006
Automated Process Approved codon start 1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref UniProtKB/Swiss-Prot:P0AFS3 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref GI:1787891 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Person Approved db xref UniProtKB:P0AFS3 Published Annotation - Swiss-Prot Accession Number: P0AFS3 Jan 2006
Automated Process Approved db xref ASAP:ABE-0005364 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref GeneID:949096 Published Annotation - Entrez Gene Database ID: 949096
Reference: Escherichia coli K-12 MG1655 		Jun 2009
Automated Process Approved db xref EcoGene:EG13189 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved function enzyme; tetrahydromonapterin synthesis Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved note putative oxidoreductase Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved protein id AAC74678.1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Uncurated subcellular localization Unknown Predicted by PSORTb - PSORTb Final_Score: 2.00
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Person Uncurated subsystem component of in silico model iAF1260 Experimental - PubMed ID: 17593909
Reference: Escherichia coli K-12 MG1655 		Jan 2009
Automated Process Approved transl table 11 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Gene Ontology
Automated Process Approved GO biological process GO:0008152 metabolic process GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR002198
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO molecular function GO:0016491 oxidoreductase activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR002198
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Comparative to toptop
Author Approval Details Genome Feature Name Type
Member
Automated Process Uncurated Go view OrthoMCL (14 enterobacteria) AMM-0003255 CDS
Automated Process Uncurated Go view OrthoMCL (205 gammaproteobacteria) APP-0003325 folM CDS
Automated Process Uncurated Go view OrthoMCL (307 Enterobacteriaceae) ATM-0003065 folM CDS
Automated Process Uncurated Go view OrthoMCL (42 Serratia) BEZ-0002470 folM CDS
Automated Process Uncurated Go view OrthoMCL (UW draft) CQJ-0003032 folM CDS
Ortholog
Automated Process Uncurated Go view Buttiauxella agrestis ATCC 33320 [T] APC-0001936 folM CDS
Automated Process Uncurated Go view Cedecea davisae ATCC 33431 [T] ALZ-0002222 CDS
Automated Process Approved Go view Citrobacter amalonaticus ATCC 25405 [T] AUW-0002176 folM CDS
Automated Process Approved Go view Citrobacter freundii ATCC 8090 [T] AVI-0002821 folM CDS
Automated Process Uncurated Go view Enterobacter cloacae subsp. cloacae ATCC 13047 [T] (AToL DRAFT) AMB-0002453 CDS
Automated Process Uncurated Go view Escherichia albertii TW07627 AFX-0004153 CDS
Automated Process Uncurated Go view Escherichia coli 101-1 (EAEC) BAB-0005636 CDS
Automated Process Approved Go view Escherichia coli 536 (UPEC) AEF-0001562 CDS
Automated Process Uncurated Go view Escherichia coli 53638 (EIEC) ADP-0010172 CDS
Automated Process Approved Go view Escherichia coli APEC O1 (APEC) AEG-0001529 ydgB CDS
Automated Process Approved Go view Escherichia coli ATCC 11775 [T] AMC-0002782 CDS
Automated Process Approved Go view Escherichia coli ATCC 8739 AEM-0007748 CDS
Automated Process Uncurated Go view Escherichia coli B171 (EPEC) ADN-0005442 CDS
Automated Process Uncurated Go view Escherichia coli B7A (ETEC) ADK-0006034 CDS
Person Approved Go view Escherichia coli CFT073 (UPEC) ABR-0078113 folM CDS
Automated Process Uncurated Go view Escherichia coli DEC7E (UM-IGS draft) CFX-0001809 folM CDS
Automated Process Uncurated Go view Escherichia coli DEC9A (UM-IGS draft) CFY-0002089 CDS
Automated Process Uncurated Go view Escherichia coli E110019 (EPEC) ADM-0008803 CDS
Automated Process Uncurated Go view Escherichia coli E22 (EPEC) ADL-0008719 CDS
Automated Process Approved Go view Escherichia coli E2348/69 (EPEC) BCI-0001805 folM CDS
Automated Process Approved Go view Escherichia coli E24377A (ETEC) ADO-0006251 CDS
Automated Process Uncurated Go view Escherichia coli EC4024 (EHEC) BBI-0001786 CDS
Automated Process Uncurated Go view Escherichia coli EC4042 (EHEC) BBA-0005695 CDS
Automated Process Uncurated Go view Escherichia coli EC4045 (EHEC) BBB-0010003 CDS
Automated Process Uncurated Go view Escherichia coli EC4076 (EHEC) BAZ-0009947 CDS
Automated Process Uncurated Go view Escherichia coli EC4113 (EHEC) BAY-0008686 CDS
Automated Process Approved Go view Escherichia coli EC4115 (EHEC) BAS-0007156 CDS
Automated Process Uncurated Go view Escherichia coli EC4196 (EHEC) BAX-0008436 CDS
Automated Process Uncurated Go view Escherichia coli EC4206 (EHEC) BAW-0010953 CDS
Automated Process Uncurated Go view Escherichia coli EC4401 (EHEC) BAV-0009382 CDS
Automated Process Uncurated Go view Escherichia coli EC4486 (EHEC) BAU-0010558 CDS
Automated Process Uncurated Go view Escherichia coli EC4501 (EHEC) BAT-0009252 CDS
Automated Process Uncurated Go view Escherichia coli EC869 (EHEC) BBC-0009705 CDS
Person Approved Go view Escherichia coli EDL933 (EHEC) ABH-0026393 folM CDS
Automated Process Approved Go view Escherichia coli F11 (UPEC) ADQ-0009604 folM CDS
Automated Process Approved Go view Escherichia coli HS ADR-0006356 CDS
Automated Process Uncurated Go view Escherichia coli J96 (UPEC) CQK-0002007 CDS
Person Uncurated Go view Escherichia coli K-12 DH10B AEC-0001508 folM CDS
Person Approved Go view Escherichia coli K-12 W3110 ADY-0001648 folM CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR68 CGA-0001919 CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR71 CGB-0001923 CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR8 CFZ-0002306 CDS
Automated Process Uncurated Go view Escherichia coli Nissle 1917 AML-0001803 CDS
Automated Process Uncurated Go view Escherichia coli RS218 (NMEC) ACK-0175951 CDS
Automated Process Approved Go view Escherichia coli SE11 AFS-0001756 CDS
Automated Process Approved Go view Escherichia coli SMS-3-5 AFT-0001592 CDS
Person Approved Go view Escherichia coli Sakai (EHEC) ACA-0132293 folM CDS
Automated Process Uncurated Go view Escherichia coli TW14588 (EHEC) BBK-0004273 CDS
Automated Process Approved Go view Escherichia coli UTI89 (UPEC) AEA-0001801 ydgB CDS
Person Uncurated Go view Hafnia alvei ATCC 13337 [T] AMD-0002873 CDS
Person Uncurated Go view Klebsiella pneumoniae subsp. pneumoniae MGH 78578 AEP-0001527 ydgB CDS
Automated Process Uncurated Go view Leclercia adecarboxylata ATCC 23216 [T] AME-0004363 CDS
Automated Process Uncurated Go view Pectobacterium brasiliensis 1692 AED-0001120 CDS
Person Uncurated Go view Pectobacterium carotovorum WPP14 ADT-0001725 CDS
Automated Process Uncurated Go view Pectobacterium parmentieri WPP163 AFJ-0003614 CDS
Automated Process Uncurated Go view Pectobacterium sp. PC1 AFL-0007205 CDS
Person Uncurated Go view Pseudomonas syringae pv. tomato DC3000 ADG-0001212 CDS
Automated Process Uncurated Go view Serratia marcescens subsp. marcescens ATCC 13880 [T] AMF-0003210 CDS
Person Uncurated Go view Shewanella oneidensis MR-1 ACY-0264327 CDS
Person Approved Go view Shigella boydii 227 ADV-0001688 ydgB CDS
Automated Process Approved Go view Shigella boydii BS512 ADJ-0007201 CDS
Automated Process Uncurated Go view Shigella dysenteriae 1012 BAA-0004276 CDS
Person Uncurated Go view Shigella dysenteriae 197 ADU-0001785 ydgB CDS
Person Approved Go view Shigella flexneri 2457T ABQ-0072845 ydgB CDS
Person Approved Go view Shigella flexneri 301 ABT-0087938 ydgB CDS
Automated Process Approved Go view Shigella flexneri 8401 BAG-0001728 ydgB CDS
Person Approved Go view Shigella sonnei 046 ADD-0001683 folM CDS
Automated Process Uncurated Go view Yokenella regensburgei ATCC 43003 APO-0013987 CDS
Automated Process Uncurated Go view Yokenella regensburgei ATCC 49455 [T] AMG-0003718 CDS
Molecular Interactions to toptop
Author Approval Feature Name Technique Evidence Comment Annotated
Person Approved ABE-0005364 folM lambda repressor assay Doodle - bnumber: b1606 Oct 2003
Experimental to toptop
SelectSetNameSetDetailsNotes
stringent responsetranscriptional profile of the stringent responseNone
Recombinant heat-shock dataexpression data for recombinant strain under heat shockThese data are from the Harcum laboratory. (Jeremy Glasner)
Suppressor tRNA expressionexperiment comparing transcript levels in cells with and without suppressor tRNA expressionThese data were reported in the paper: Herring and Blattner. 2004. Global transcriptional effects of a suppressor tRNA and the inactivation of the regulator frmR. J. Bacteriol. 186(20):6714-20. Link to Abstract (Jeremy Glasner)
Recombinant E. coli expressionexperiment comparing expression of wild-type E. coli with the same strain harboring a plasmid that expresses protein when induced with IPTG These data were reported in the paper: F. T. Haddadin, S. W. Harcum (2005) Transcriptome profiles for high-cell-density recombinant and wild-type Escherichia coli, Biotechnology and Bioengineering, 90:127-153. Link to Abstract (Jeremy Glasner)
Aerobic shiftAerobic shiftThese data were reported in the paper: Covert MW, Knight EM, Reed JL, Herrgard MJ, Palsson BO. 2004. Integrating high-throughput and computational data elucidates bacterial networks. Nature. 2004 May 6;429(6987):92-6. Link to Abstract (Jeremy Glasner)
CalibratorCalibrated microarray experiments (50 hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
AffyData1Affymetrix Experiments (data from 41 chip hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
Context Table to toptop

Listed below are features that lie nearby this feature. Features encoded in multiple intervals may appear more than once in the table. Features that span the origin will have a left endpoint greater than the right endpoint.

Features overlapping the region 1675976 to 1686698
FeatureIDNameFeature TypeStrandLeft EndRight EndRelationship
ABE-0000001sourceforward14641652Contains
ABE-0005352pntBCDScomplement16749721676360Upstream
ABE-0005354pntACDScomplement16763711677903Upstream
ABE-0005359ydgHCDSforward16784271679371Upstream
ABE-0005362ydgICDSforward16795571680939Upstream
ABE-0005364folMCDSforward16809761681698Matches
ABE-0005366ydgCCDScomplement16816951682030Overlaps Downstream
ABE-0005370rstACDSforward16821591682878Downstream
ABE-0005372rstBCDSforward16828821684183Downstream
ABE-0005378tusCDSforward16842591685188Downstream
ABE-0005380fumCCDScomplement16851851686588Downstream
Release Notes to toptop
All MG1655 annotations and sequence data are publicly available, and investigators can use these data in publications without contacting the genome curators. This version of the sequence was the source of GenBank record U00096.3. Ongoing annotation updates to that GenBank record are being generated from a collaboration that includes ASAP, EcoGene, the Coli Genetic Stock Center, EcoliHub, EcoCyc, RegulonDB and UniProtKB/Swiss-Prot.