Escherichia coli K-12 MG1655
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Working With: Genome: Escherichia coli K-12 MG1655 Version: v3

ABE-0005419 (hdhA) - Escherichia coli K-12 MG1655 - Feature Annotation

ASAP ID
ABE-0005419 showshow history
Names
hdhA hsd JW1611 ECK1614 hsdH b1619
Product
7-alpha-hydroxysteroid dehydrogenase
Type
CDS
Location
# Contig Strand Left Right Length (b.p.) Length (a.a.)
1 Chromosome complement 1697273 1698040 768 256
Sequence

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Context

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Protein Families to toptop
Author Approval Family Annotated
Automated Process Approved IPR002198 (IPR002198 (DEPRECATED) Short-chain dehydrogenase/reductase SDR) Apr 2008
Automated Process Approved IPR002347 (IPR002347 Short-chain dehydrogenase/reductase SDR) Apr 2008
Automated Process Approved IPR036291 (IPR036291 NAD(P)-binding domain superfamily) Jul 2018
Automated Process Approved PF13561 (PF13561 Enoyl-(Acyl carrier protein) reductase) Jul 2018
Gene Ontology to toptop
Author Approval Type Annotation Evidence Annotated
Automated Process Approved GO biological process GO:0008152 metabolic process GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR002198
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO cellular component GO:0005737 cytoplasm GO Inferred from Electronic Annotation - PubMed ID: 15501914
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Person Uncurated GO cellular component GO:0005737 cytoplasm Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Approved GO molecular function GO:0016491 oxidoreductase activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR002198
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Annotations to toptop
Author Approval Type Annotation Evidence Annotated
Nomenclature
Person Approved name hdhA Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Oct 1998
Person Approved synonym hsdH Published Sequence Analysis - PubMed ID: 9729611 Aug 2003
Person Approved synonym JW1611 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved synonym ECK1614 Published Annotation - PubMed ID: 16397293 Jan 2006
Automated Process Approved synonym hsd Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Person Approved locus tag b1619 Unique Identifier - Origin: Guy Plunkett III, guy@genome.wisc.edu May 2004
Product
Person Uncurated product 7-alpha-hydroxysteroid dehydrogenase Published Annotation - PubMed ID: 16397293
Reference: Escherichia coli K-12 		Oct 2021
Person Uncurated alternate product name 7alpha-hydroxysteroid dehydrogenase, NAD-dependent Published Annotation - Database Name: GenProtEC Jan 2006
Person Approved alternate product name NAD-dependent 7alpha-hydroxysteroid dehydrogenase, dehydroxylation of bile acids Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Jan 2006
Protein Family
Automated Process Approved protein family IPR002198 (DEPRECATED) Short-chain dehydrogenase/reductase SDR Protein Sequence Similarity - InterPro Domain: IPR002198
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family IPR002347 Short-chain dehydrogenase/reductase SDR Protein Sequence Similarity - InterPro Domain: IPR002347
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family IPR036291 NAD(P)-binding domain superfamily Protein Sequence Similarity - InterPro Domain: IPR036291
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved protein family PF13561 Enoyl-(Acyl carrier protein) reductase Protein Sequence Similarity - PFAM Model Name: PF13561
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Other
Person Approved EC number 1.1.1.159 Published Annotation - Swiss-Prot Accession Number: P0AET8 Feb 2006
Person Uncurated MultiFun 7.1 (location of gene products; cytoplasm) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Person Uncurated MultiFun 1.7.1 (metabolism; central intermediary metabolism; unassigned reversible reactions) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Automated Process Approved codon start 1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref GI:1787905 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref GeneID:946151 Published Annotation - Entrez Gene Database ID: 946151
Reference: Escherichia coli K-12 MG1655 		Jun 2009
Automated Process Approved db xref UniProtKB/Swiss-Prot:P0AET8 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref ASAP:ABE-0005419 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Person Approved db xref UniProtKB:P0AET8 Published Annotation - Swiss-Prot Accession Number: P0AET8 Jan 2006
Automated Process Approved db xref EcoGene:EG10425 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Person Approved function enzyme; Central intermediary metabolism: Pool, multipurpose conversions Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Oct 1998
Automated Process Approved note NAD-dependent 7alpha-hydroxysteroid dehydrogenase, dehydroxylation of bile acids; GO_component: GO:0005737 - cytoplasm Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved protein id AAC74691.1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Uncurated subcellular localization Cytoplasmic Predicted by PSORTb - PSORTb Final_Score: 9.26
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Automated Process Approved transl table 11 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Gene Ontology
Automated Process Approved GO biological process GO:0008152 metabolic process GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR002198
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO cellular component GO:0005737 cytoplasm GO Inferred from Electronic Annotation - PubMed ID: 15501914
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Person Uncurated GO cellular component GO:0005737 cytoplasm Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Approved GO molecular function GO:0016491 oxidoreductase activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR002198
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Comparative to toptop
Author Approval Details Genome Feature Name Type
Member
Automated Process Uncurated Go view OrthoMCL (205 gammaproteobacteria) APP-0003944 hdhA CDS
Automated Process Uncurated Go view OrthoMCL (307 Enterobacteriaceae) ATM-0004030 hdhA CDS
Automated Process Uncurated Go view OrthoMCL (UW draft) CQJ-0003587 hdhA CDS
Ortholog
Automated Process Uncurated Go view Escherichia albertii TW07627 AFX-0004162 CDS
Automated Process Uncurated Go view Escherichia coli 101-1 (EAEC) BAB-0005649 CDS
Automated Process Approved Go view Escherichia coli 536 (UPEC) AEF-0001575 CDS
Automated Process Uncurated Go view Escherichia coli 53638 (EIEC) ADP-0010185 CDS
Automated Process Approved Go view Escherichia coli APEC O1 (APEC) AEG-0001542 hdhA CDS
Automated Process Approved Go view Escherichia coli ATCC 11775 [T] AMC-0002769 CDS
Automated Process Approved Go view Escherichia coli ATCC 8739 AEM-0007731 CDS
Automated Process Uncurated Go view Escherichia coli B171 (EPEC) ADN-0005455 CDS
Automated Process Uncurated Go view Escherichia coli B7A (ETEC) ADK-0006021 hdhA CDS
Person Approved Go view Escherichia coli CFT073 (UPEC) ABR-0078126 hdhA CDS
Person Uncurated Go view Escherichia coli DEC7E (UM-IGS draft) CFX-0001822 hdhA pseudogene
Automated Process Uncurated Go view Escherichia coli E110019 (EPEC) ADM-0008816 CDS
Automated Process Uncurated Go view Escherichia coli E22 (EPEC) ADL-0008732 CDS
Automated Process Approved Go view Escherichia coli E2348/69 (EPEC) BCI-0001818 hdhA CDS
Automated Process Approved Go view Escherichia coli E24377A (ETEC) ADO-0006264 CDS
Automated Process Uncurated Go view Escherichia coli EC4024 (EHEC) BBI-0001802 CDS
Automated Process Uncurated Go view Escherichia coli EC4042 (EHEC) BBA-0005710 CDS
Automated Process Uncurated Go view Escherichia coli EC4045 (EHEC) BBB-0010018 CDS
Automated Process Uncurated Go view Escherichia coli EC4076 (EHEC) BAZ-0009962 CDS
Automated Process Uncurated Go view Escherichia coli EC4113 (EHEC) BAY-0008673 CDS
Automated Process Approved Go view Escherichia coli EC4115 (EHEC) BAS-0007171 CDS
Automated Process Uncurated Go view Escherichia coli EC4196 (EHEC) BAX-0008449 CDS
Automated Process Uncurated Go view Escherichia coli EC4206 (EHEC) BAW-0010937 CDS
Automated Process Uncurated Go view Escherichia coli EC4401 (EHEC) BAV-0009366 CDS
Automated Process Uncurated Go view Escherichia coli EC4486 (EHEC) BAU-0010573 CDS
Automated Process Uncurated Go view Escherichia coli EC4501 (EHEC) BAT-0009237 CDS
Automated Process Uncurated Go view Escherichia coli EC508 (EHEC) BBJ-0008593 CDS
Automated Process Uncurated Go view Escherichia coli EC869 (EHEC) BBC-0009720 CDS
Person Approved Go view Escherichia coli EDL933 (EHEC) ABH-0026408 hdhA CDS
Automated Process Approved Go view Escherichia coli F11 (UPEC) ADQ-0008635 hdhA CDS
Automated Process Approved Go view Escherichia coli HS ADR-0006369 CDS
Automated Process Uncurated Go view Escherichia coli J96 (UPEC) CQK-0002020 CDS
Person Uncurated Go view Escherichia coli K-12 DH10B AEC-0001521 hdhA CDS
Person Approved Go view Escherichia coli K-12 W3110 ADY-0001661 hdhA CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR68 CGA-0001906 CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR71 CGB-0001974 CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR8 CFZ-0002293 CDS
Automated Process Uncurated Go view Escherichia coli Nissle 1917 AML-0001816 CDS
Automated Process Uncurated Go view Escherichia coli RS218 (NMEC) ACK-0175966 CDS
Automated Process Approved Go view Escherichia coli SE11 AFS-0001769 CDS
Automated Process Approved Go view Escherichia coli SMS-3-5 AFT-0001579 CDS
Person Approved Go view Escherichia coli Sakai (EHEC) ACA-0132308 hdhA CDS
Automated Process Uncurated Go view Escherichia coli TW14588 (EHEC) BBK-0004258 CDS
Automated Process Approved Go view Escherichia coli UTI89 (UPEC) AEA-0001814 hdhA CDS
Person Approved Go view Shigella boydii 227 ADV-0001675 hdhA CDS
Automated Process Approved Go view Shigella boydii BS512 ADJ-0007215 CDS
Person Approved Go view Shigella dysenteriae 197 ADU-0002124 hdhA CDS
Person Uncurated Go view Shigella flexneri 2457T ABQ-0072861 hdhA pseudogene
Person Uncurated Go view Shigella flexneri 301 ABT-0087954 CDS
Person Uncurated Go view Shigella sonnei 046 ADD-0001670 hdhA CDS
Molecular Interactions to toptop
Author Approval Feature Name Technique Evidence Comment Annotated
Person Approved ABE-0005419 hdhA lambda repressor assay Doodle - bnumber: b1619 Oct 2003
Experimental to toptop
SelectSetNameSetDetailsNotes
stringent responsetranscriptional profile of the stringent responseNone
Recombinant heat-shock dataexpression data for recombinant strain under heat shockThese data are from the Harcum laboratory. (Jeremy Glasner)
Suppressor tRNA expressionexperiment comparing transcript levels in cells with and without suppressor tRNA expressionThese data were reported in the paper: Herring and Blattner. 2004. Global transcriptional effects of a suppressor tRNA and the inactivation of the regulator frmR. J. Bacteriol. 186(20):6714-20. Link to Abstract (Jeremy Glasner)
Recombinant E. coli expressionexperiment comparing expression of wild-type E. coli with the same strain harboring a plasmid that expresses protein when induced with IPTG These data were reported in the paper: F. T. Haddadin, S. W. Harcum (2005) Transcriptome profiles for high-cell-density recombinant and wild-type Escherichia coli, Biotechnology and Bioengineering, 90:127-153. Link to Abstract (Jeremy Glasner)
Aerobic shiftAerobic shiftThese data were reported in the paper: Covert MW, Knight EM, Reed JL, Herrgard MJ, Palsson BO. 2004. Integrating high-throughput and computational data elucidates bacterial networks. Nature. 2004 May 6;429(6987):92-6. Link to Abstract (Jeremy Glasner)
AffyData1Affymetrix Experiments (data from 41 chip hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
Context Table to toptop

Listed below are features that lie nearby this feature. Features encoded in multiple intervals may appear more than once in the table. Features that span the origin will have a left endpoint greater than the right endpoint.

Features overlapping the region 1692273 to 1703040
FeatureIDNameFeature TypeStrandLeft EndRight EndRelationship
ABE-0000001sourceforward14641652Contains
ABE-0005405uidCCDScomplement16915861692851Downstream
ABE-0005407uidBCDScomplement16928901694263Downstream
ABE-0005410uidACDScomplement16942601696071Downstream
ABE-0005415uidRCDScomplement16964621697052Downstream
ABE-0005419hdhACDScomplement16972731698040Matches
ABE-0005421malICDScomplement16981521699180Upstream
ABE-0005429malXCDSforward16993551700947Upstream
ABE-0005432malYCDSforward17009571702129Upstream
ABE-0005435addCDSforward17022331703234Upstream
Release Notes to toptop
All MG1655 annotations and sequence data are publicly available, and investigators can use these data in publications without contacting the genome curators. This version of the sequence was the source of GenBank record U00096.3. Ongoing annotation updates to that GenBank record are being generated from a collaboration that includes ASAP, EcoGene, the Coli Genetic Stock Center, EcoliHub, EcoCyc, RegulonDB and UniProtKB/Swiss-Prot.