Escherichia coli K-12 MG1655
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Working With: Genome: Escherichia coli K-12 MG1655 Version: v3

ABE-0005429 (malX) - Escherichia coli K-12 MG1655 - Feature Annotation

ASAP ID
ABE-0005429 showshow history
Names
malX JW1613 ECK1616 b1621
Product
PTS system maltose- and glucose-specific EIICB component
Type
CDS
Location
# Contig Strand Left Right Length (b.p.) Length (a.a.)
1 Chromosome forward 1699355 1700947 1593 531
Sequence

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Context

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Protein Families to toptop
Author Approval Family Annotated
Automated Process Approved IPR001996 (IPR001996 Phosphotransferase system, IIB component, type 1) Apr 2008
Automated Process Approved IPR004719 (IPR004719 Phosphotransferase system, maltose/glucose-specific subfamily IIC component) Apr 2008
Automated Process Approved IPR011535 (IPR011535 (DEPRECATED) Phosphotransferase system, glucose-like IIB component) Apr 2008
Automated Process Approved IPR013013 (IPR013013 Phosphotransferase system, EIIC component, type 1) Apr 2008
Automated Process Approved IPR003352 (IPR003352 Phosphotransferase system, EIIC) Apr 2008
Automated Process Approved IPR011301 (IPR011301 PTS system, maltose/glucose-specific IIBC component) Apr 2008
Automated Process Approved IPR018113 (IPR018113 Phosphotransferase system EIIB, cysteine phosphorylation site) Jul 2018
Automated Process Approved IPR036878 (IPR036878 Glucose permease domain IIB) Jul 2018
Automated Process Approved PF00367 (PF00367 phosphotransferase system, EIIB) Jul 2018
Automated Process Approved PF02378 (PF02378 Phosphotransferase system, EIIC) Jul 2018
Gene Ontology to toptop
Author Approval Type Annotation Evidence Annotated
Person Uncurated GO biological process GO:0016052 carbohydrate catabolic process Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Approved GO biological process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR001996
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO biological process GO:0006810 transport GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR001996
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO cellular component GO:0016021 integral component of membrane GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR004719
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Uncurated GO cellular component GO:0005886 plasma membrane GO Inferred from Electronic Annotation - PubMed ID: 15501914
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Automated Process Approved GO cellular component GO:0016020 membrane GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR001996
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO molecular function GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR018113, IPR003352, IPR004719, IPR001996, IPR011301, IPR036878
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved GO molecular function GO:0005351 carbohydrate:proton symporter activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR001996
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Annotations to toptop
Author Approval Type Annotation Evidence Annotated
Nomenclature
Person Approved name malX Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Oct 1998
Person Approved synonym JW1613 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved synonym ECK1616 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved locus tag b1621 Unique Identifier - Origin: Guy Plunkett III, guy@genome.wisc.edu May 2004
Product
Person Approved product PTS system maltose- and glucose-specific EIICB component Published Annotation - Swiss-Prot Accession Number: P19642
Reference: Escherichia coli K-12 		Feb 2008
Automated Process Approved alternate product name fused maltose and glucose-specific PTS enzymes: IIB component, IIC component Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Protein Family
Automated Process Approved protein family IPR011535 (DEPRECATED) Phosphotransferase system, glucose-like IIB component Protein Sequence Similarity - InterPro Domain: IPR011535
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family IPR001996 Phosphotransferase system, IIB component, type 1 Protein Sequence Similarity - InterPro Domain: IPR001996
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family IPR036878 Glucose permease domain IIB Protein Sequence Similarity - InterPro Domain: IPR036878
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved protein family IPR004719 Phosphotransferase system, maltose/glucose-specific subfamily IIC component Protein Sequence Similarity - InterPro Domain: IPR004719
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family PF02378 Phosphotransferase system, EIIC Protein Sequence Similarity - PFAM Model Name: PF02378
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved protein family IPR018113 Phosphotransferase system EIIB, cysteine phosphorylation site Protein Sequence Similarity - InterPro Domain: IPR018113
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved protein family IPR011301 PTS system, maltose/glucose-specific IIBC component Protein Sequence Similarity - InterPro Domain: IPR011301
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family IPR003352 Phosphotransferase system, EIIC Protein Sequence Similarity - InterPro Domain: IPR003352
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family IPR013013 Phosphotransferase system, EIIC component, type 1 Protein Sequence Similarity - InterPro Domain: IPR013013
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family PF00367 phosphotransferase system, EIIB Protein Sequence Similarity - PFAM Model Name: PF00367
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Other
Person Approved EC number 2.7.1.69 Published Annotation - Swiss-Prot Accession Number: P19642 Feb 2006
Person Uncurated MultiFun 4.4.A.1 (transport; Group Translocators; Phosphotransferase Systems (PEP-dependent PTS); The PTS Glucose-Glucoside (Glc) Family) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Person Uncurated MultiFun 4.S.72 (transport; substrate; glucose/maltose) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Person Uncurated MultiFun 1.1.1 (metabolism; carbon utilization; carbon compounds) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Automated Process Approved codon start 1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref GI:1787908 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Person Approved db xref UniProtKB:P19642 Published Annotation - Swiss-Prot Accession Number: P19642 Jan 2005
Automated Process Approved db xref UniProtKB/Swiss-Prot:P19642 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref ASAP:ABE-0005429 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref EcoGene:EG10563 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref GeneID:946009 Published Annotation - Entrez Gene Database ID: 946009
Reference: Escherichia coli K-12 MG1655 		Jun 2009
Person Approved function transport; Transport of small molecules: Carbohydrates, organic acids, alcohols Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Oct 1998
Automated Process Approved note PTS system, maltose and glucose-specific IIABC component; GO_process: GO:0016052 - carbohydrate catabolic process Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Person Approved note includes maltose and glucose permease IIC component, and maltose- and glucose-specific phosphotransferase enzyme IIB component Published Annotation - Swiss-Prot Accession Number: P19642
Reference: Escherichia coli K-12 		Feb 2008
Automated Process Approved protein id AAC74693.1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Uncurated subcellular localization Cytoplasmic Membrane Predicted by PSORTb - PSORTb Final_Score: 10.00
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Person Uncurated subsystem component of in silico model iAF1260 Experimental - PubMed ID: 17593909
Reference: Escherichia coli K-12 MG1655 		Jan 2009
Person Uncurated subsystem component of in silico model iJR904 Experimental - PubMed ID: 12952533
Reference: Escherichia coli K-12 MG1655 		Feb 2009
Person Uncurated subsystem component of in silico model iMC1010 Experimental - PubMed ID: 15129285
Reference: Escherichia coli K-12 MG1655 		Mar 2009
Automated Process Approved transl table 11 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Gene Ontology
Person Uncurated GO biological process GO:0016052 carbohydrate catabolic process Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Approved GO biological process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR001996
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO biological process GO:0006810 transport GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR001996
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO cellular component GO:0005886 plasma membrane GO Inferred from Electronic Annotation - PubMed ID: 15501914
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Automated Process Uncurated GO cellular component GO:0016021 integral component of membrane GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR004719
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved GO cellular component GO:0016020 membrane GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR001996
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO molecular function GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR018113, IPR003352, IPR004719, IPR001996, IPR011301, IPR036878
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved GO molecular function GO:0005351 carbohydrate:proton symporter activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR001996
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Comparative to toptop
Author Approval Details Genome Feature Name Type
Member
Automated Process Uncurated Go view OrthoMCL (14 enterobacteria) AMM-0004204 CDS
Automated Process Uncurated Go view OrthoMCL (205 gammaproteobacteria) APP-0002884 malX CDS
Automated Process Uncurated Go view OrthoMCL (307 Enterobacteriaceae) ATM-0002442 malX CDS
Automated Process Uncurated Go view OrthoMCL (42 Serratia) BEZ-0002425 malX CDS
Automated Process Uncurated Go view OrthoMCL (UW draft) CQJ-0002424 malX CDS
Ortholog
Automated Process Uncurated Go view Buttiauxella agrestis ATCC 33320 [T] APC-0001925 CDS
Automated Process Uncurated Go view Cedecea davisae ATCC 33431 [T] ALZ-0002231 CDS
Automated Process Approved Go view Citrobacter amalonaticus ATCC 25405 [T] AUW-0002166 ptsG_4 CDS
Automated Process Approved Go view Citrobacter freundii ATCC 8090 [T] AVI-0002805 ptsG_3 CDS
Automated Process Uncurated Go view Escherichia albertii TW07627 AFX-0004165 malX CDS
Automated Process Uncurated Go view Escherichia coli 101-1 (EAEC) BAB-0005651 malX CDS
Automated Process Approved Go view Escherichia coli 536 (UPEC) AEF-0001577 CDS
Automated Process Uncurated Go view Escherichia coli 53638 (EIEC) ADP-0010187 malX CDS
Automated Process Approved Go view Escherichia coli APEC O1 (APEC) AEG-0001544 malX CDS
Automated Process Approved Go view Escherichia coli ATCC 11775 [T] AMC-0002767 CDS
Person Uncurated Go view Escherichia coli ATCC 8739 AEM-0007729 malX pseudogene
Automated Process Uncurated Go view Escherichia coli B171 (EPEC) ADN-0005457 malX CDS
Automated Process Uncurated Go view Escherichia coli B7A (ETEC) ADK-0006019 CDS
Person Approved Go view Escherichia coli CFT073 (UPEC) ABR-0078128 malX CDS
Automated Process Uncurated Go view Escherichia coli DEC7E (UM-IGS draft) CFX-0001825 CDS
Automated Process Uncurated Go view Escherichia coli DEC9A (UM-IGS draft) CFY-0002105 CDS
Automated Process Uncurated Go view Escherichia coli E110019 (EPEC) ADM-0008818 malX CDS
Automated Process Uncurated Go view Escherichia coli E22 (EPEC) ADL-0008734 malX CDS
Automated Process Approved Go view Escherichia coli E2348/69 (EPEC) BCI-0001820 malX CDS
Automated Process Approved Go view Escherichia coli E24377A (ETEC) ADO-0006266 malX CDS
Automated Process Uncurated Go view Escherichia coli EC4024 (EHEC) BBI-0001804 CDS
Automated Process Uncurated Go view Escherichia coli EC4042 (EHEC) BBA-0005712 malX CDS
Automated Process Uncurated Go view Escherichia coli EC4045 (EHEC) BBB-0010020 malX CDS
Automated Process Uncurated Go view Escherichia coli EC4076 (EHEC) BAZ-0009964 malX CDS
Automated Process Uncurated Go view Escherichia coli EC4113 (EHEC) BAY-0008671 malX CDS
Automated Process Approved Go view Escherichia coli EC4115 (EHEC) BAS-0007173 malX CDS
Automated Process Uncurated Go view Escherichia coli EC4196 (EHEC) BAX-0008451 malX CDS
Automated Process Uncurated Go view Escherichia coli EC4206 (EHEC) BAW-0010935 malX CDS
Automated Process Uncurated Go view Escherichia coli EC4401 (EHEC) BAV-0009364 malX CDS
Automated Process Uncurated Go view Escherichia coli EC4486 (EHEC) BAU-0010575 malX CDS
Automated Process Uncurated Go view Escherichia coli EC4501 (EHEC) BAT-0009235 malX CDS
Automated Process Uncurated Go view Escherichia coli EC508 (EHEC) BBJ-0008595 malX CDS
Automated Process Uncurated Go view Escherichia coli EC869 (EHEC) BBC-0009722 malX CDS
Person Approved Go view Escherichia coli EDL933 (EHEC) ABH-0026410 malX CDS
Automated Process Approved Go view Escherichia coli F11 (UPEC) ADQ-0008633 malX_1 CDS
Automated Process Approved Go view Escherichia coli HS ADR-0006371 malX CDS
Automated Process Uncurated Go view Escherichia coli J96 (UPEC) CQK-0002022 CDS
Person Uncurated Go view Escherichia coli K-12 DH10B AEC-0001523 malX CDS
Person Approved Go view Escherichia coli K-12 W3110 ADY-0001663 malX CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR68 CGA-0001904 CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR71 CGB-0001976 CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR8 CFZ-0002291 CDS
Automated Process Uncurated Go view Escherichia coli Nissle 1917 AML-0001818 CDS
Person Uncurated Go view Escherichia coli RS218 (NMEC) ACK-0179616 CDS
Automated Process Approved Go view Escherichia coli SE11 AFS-0001771 CDS
Automated Process Approved Go view Escherichia coli SMS-3-5 AFT-0001577 malX CDS
Person Approved Go view Escherichia coli Sakai (EHEC) ACA-0132310 malX CDS
Automated Process Uncurated Go view Escherichia coli TW14588 (EHEC) BBK-0004256 CDS
Automated Process Approved Go view Escherichia coli UTI89 (UPEC) AEA-0001816 malX CDS
Automated Process Uncurated Go view Ewingella americana ATCC 33852 [T] AMA-0001609 CDS
Person Uncurated Go view Hafnia alvei ATCC 13337 [T] AMD-0002927 CDS
Person Uncurated Go view Klebsiella pneumoniae subsp. pneumoniae MGH 78578 AEP-0001516 malX CDS
Automated Process Uncurated Go view Leclercia adecarboxylata ATCC 23216 [T] AME-0004349 CDS
Automated Process Uncurated Go view Pantoea agglomerans IG1 APM-0001180 CDS
Automated Process Uncurated Go view Pantoea agglomerans SL1-M5 ALY-0003920 CDS
Automated Process Uncurated Go view Pantoea sp. At-9b AGM-0009513 CDS
Automated Process Uncurated Go view Pantoea sp. aB AJV-0002593 CDS
Automated Process Uncurated Go view Salmonella Arizonae CDC 346-86 BCD-0001571 CDS
Automated Process Uncurated Go view Salmonella Javiana GA_MM04042433 BCA-0004977 malX CDS
Automated Process Approved Go view Salmonella Schwarzengrund CVM19633 BBO-0005650 malX CDS
Automated Process Uncurated Go view Salmonella Schwarzengrund SL480 BBY-0004982 malX CDS
Person Uncurated Go view Salmonella Typhi CT18 ABX-0108378 malX pseudogene
Person Uncurated Go view Salmonella Typhimurium LT2 [T] ABU-0094892 malX pseudogene
Automated Process Uncurated Go view Serratia marcescens subsp. marcescens ATCC 13880 [T] AMF-0003534 CDS
Person Approved Go view Shigella boydii 227 ADV-0001670 malX CDS
Automated Process Approved Go view Shigella boydii BS512 ADJ-0007218 malX CDS
Person Uncurated Go view Shigella dysenteriae 197 ADU-0002129 malX CDS
Person Approved Go view Shigella flexneri 2457T ABQ-0072866 malX CDS
Person Approved Go view Shigella flexneri 301 ABT-0087956 malX CDS
Automated Process Approved Go view Shigella flexneri 8401 BAG-0001746 malX CDS
Person Approved Go view Shigella sonnei 046 ADD-0001665 malX CDS
Automated Process Uncurated Go view Yersinia bercovieri ATCC 43970 [T] AEK-0002781 CDS
Automated Process Uncurated Go view Yersinia enterocolitica 8081 BAH-0005920 malX CDS
Automated Process Uncurated Go view Yersinia frederiksenii ATCC 33641 [T] AEI-0003000 malX_1 CDS
Automated Process Uncurated Go view Yersinia intermedia ATCC 29909 [T] AEH-0000604 malX_1 CDS
Automated Process Uncurated Go view Yersinia mollaretii ATCC 43969 [T] AEJ-0000407 CDS
Automated Process Uncurated Go view Yokenella regensburgei ATCC 43003 APO-0014035 CDS
Automated Process Uncurated Go view Yokenella regensburgei ATCC 49455 [T] AMG-0003706 CDS
Experimental to toptop
SelectSetNameSetDetailsNotes
stringent responsetranscriptional profile of the stringent responseNone
Recombinant heat-shock dataexpression data for recombinant strain under heat shockThese data are from the Harcum laboratory. (Jeremy Glasner)
Suppressor tRNA expressionexperiment comparing transcript levels in cells with and without suppressor tRNA expressionThese data were reported in the paper: Herring and Blattner. 2004. Global transcriptional effects of a suppressor tRNA and the inactivation of the regulator frmR. J. Bacteriol. 186(20):6714-20. Link to Abstract (Jeremy Glasner)
Recombinant E. coli expressionexperiment comparing expression of wild-type E. coli with the same strain harboring a plasmid that expresses protein when induced with IPTG These data were reported in the paper: F. T. Haddadin, S. W. Harcum (2005) Transcriptome profiles for high-cell-density recombinant and wild-type Escherichia coli, Biotechnology and Bioengineering, 90:127-153. Link to Abstract (Jeremy Glasner)
Aerobic shiftAerobic shiftThese data were reported in the paper: Covert MW, Knight EM, Reed JL, Herrgard MJ, Palsson BO. 2004. Integrating high-throughput and computational data elucidates bacterial networks. Nature. 2004 May 6;429(6987):92-6. Link to Abstract (Jeremy Glasner)
CalibratorCalibrated microarray experiments (50 hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
AffyData1Affymetrix Experiments (data from 41 chip hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
Strains to toptop

Strains with mutations in this feature.

Strain NameStrain TypeStrain InformationStrain RequestFeatureIDNameMutation DetailsExperiments Using StrainSubmitter
FB20394mutantTn5 InsertionRequest the StrainABE-0005429malXmalX::Tn5KAN-2 at position 1263 in Plus orientation ,+ pKD460Blattner Laboratory
Context Table to toptop

Listed below are features that lie nearby this feature. Features encoded in multiple intervals may appear more than once in the table. Features that span the origin will have a left endpoint greater than the right endpoint.

Features overlapping the region 1694355 to 1705947
FeatureIDNameFeature TypeStrandLeft EndRight EndRelationship
ABE-0000001sourceforward14641652Contains
ABE-0005410uidACDScomplement16942601696071Upstream
ABE-0005415uidRCDScomplement16964621697052Upstream
ABE-0005419hdhACDScomplement16972731698040Upstream
ABE-0005421malICDScomplement16981521699180Upstream
ABE-0005429malXCDSforward16993551700947Matches
ABE-0005432malYCDSforward17009571702129Downstream
ABE-0005435addCDSforward17022331703234Downstream
ABE-0005437ydgJCDScomplement17032681704308Downstream
ABE-0285730matS18protein_bindforward17040021704014Downstream
ABE-0047212blrCDSforward17045511704676Downstream
ABE-0005443cnuCDSforward17049491705164Downstream
ABE-0005447ydgKCDSforward17052501705690Downstream
ABE-0005450rsxACDSforward17057671706348Downstream
Release Notes to toptop
All MG1655 annotations and sequence data are publicly available, and investigators can use these data in publications without contacting the genome curators. This version of the sequence was the source of GenBank record U00096.3. Ongoing annotation updates to that GenBank record are being generated from a collaboration that includes ASAP, EcoGene, the Coli Genetic Stock Center, EcoliHub, EcoCyc, RegulonDB and UniProtKB/Swiss-Prot.