Escherichia coli K-12 MG1655
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Working With: Genome: Escherichia coli K-12 MG1655 Version: v3

ABE-0006616 (cobU) - Escherichia coli K-12 MG1655 - Feature Annotation

ASAP ID
ABE-0006616 showshow history
Names
cobU JW1971 ECK1988 b1993
Product
cobinamide kinase/cobinamide phosphate guanylyltransferase
Type
CDS
Location
# Contig Strand Left Right Length (b.p.) Length (a.a.)
1 Chromosome complement 2065219 2065764 546 182
Sequence

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Context

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Protein Families to toptop
Author Approval Family Annotated
Automated Process Approved IPR003203 (IPR003203 Cobinamide kinase/cobinamide phosphate guanyltransferase) Apr 2008
Automated Process Approved IPR027417 (IPR027417 P-loop containing nucleoside triphosphate hydrolase) Jul 2018
Automated Process Approved PF02283 (PF02283 Cobinamide kinase / cobinamide phosphate guanyltransferase) Jul 2018
Gene Ontology to toptop
Author Approval Type Annotation Evidence Annotated
Automated Process Uncurated GO biological process GO:0051188 (OBSOLETE) cofactor biosynthetic process GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR003203
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Person Approved GO biological process GO:0009236 cobalamin biosynthetic process Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Uncurated GO cellular component GO:0005737 cytoplasm GO Inferred from Electronic Annotation - PubMed ID: 15501914
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Automated Process Uncurated GO molecular function GO:0043752 adenosylcobinamide kinase activity GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR003203
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Uncurated GO molecular function GO:0000166 nucleotide binding GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR003203
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Annotations to toptop
Author Approval Type Annotation Evidence Annotated
Nomenclature
Person Approved name cobU Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Oct 1998
Person Approved synonym JW1971 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved synonym ECK1988 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved locus tag b1993 Unique Identifier - Origin: Guy Plunkett III, guy@genome.wisc.edu May 2004
Product
Person Uncurated product cobinamide kinase/cobinamide phosphate guanylyltransferase Published Annotation - PubMed ID: 16397293
Reference: Escherichia coli K-12 		Oct 2021
Person Uncurated alternate product name bifunctional: cobinamide kinase; cobinamide phosphate guanylyltransferase Published Annotation - Database Name: GenProtEC Jan 2006
Person Approved alternate product name cobinamide kinase/cobinamide phosphate guanylyltransferase Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Jan 2006
Automated Process Approved alternate product name bifunctional cobinamide kinase/ cobinamide phosphate guanylyltransferase Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Protein Family
Automated Process Approved protein family IPR027417 P-loop containing nucleoside triphosphate hydrolase Protein Sequence Similarity - InterPro Domain: IPR027417
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved protein family IPR003203 Cobinamide kinase/cobinamide phosphate guanyltransferase Protein Sequence Similarity - InterPro Domain: IPR003203
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family PF02283 Cobinamide kinase / cobinamide phosphate guanyltransferase Protein Sequence Similarity - PFAM Model Name: PF02283
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Other
Person Approved EC number 2.7.7.62 Published Annotation - Swiss-Prot Accession Number: P0AE76 Feb 2006
Person Approved EC number 2.7.1.156 Published Annotation - Swiss-Prot Accession Number: P0AE76 Feb 2006
Person Uncurated MultiFun 1.5.3.13 (metabolism; building block biosynthesis; cofactor, small molecule carrier; cobalamin (Vitamin B12)) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Automated Process Approved codon start 1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref ASAP:ABE-0006616 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Person Approved db xref UniProtKB:P0AE76 Published Annotation - Swiss-Prot Accession Number: P0AE76 Jan 2006
Automated Process Approved db xref GeneID:946519 Published Annotation - Entrez Gene Database ID: 946519
Reference: Escherichia coli K-12 MG1655 		Jun 2009
Automated Process Approved db xref GI:1788302 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref UniProtKB/Swiss-Prot:P0AE76 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref EcoGene:EG13238 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Person Approved function enzyme; Biosynthesis of cofactors, carriers: Cobalamin Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Oct 1998
Automated Process Approved note cobinamide kinase/cobinamide phosphate guanylyltransferase Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved protein id AAC75054.1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Uncurated subcellular localization Cytoplasmic Predicted by PSORTb - PSORTb Final_Score: 8.96
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Person Uncurated subsystem component of in silico model iAF1260 Experimental - PubMed ID: 17593909
Reference: Escherichia coli K-12 MG1655 		Jan 2009
Person Uncurated subsystem component of in silico model iJR904 Experimental - PubMed ID: 12952533
Reference: Escherichia coli K-12 MG1655 		Feb 2009
Person Uncurated subsystem component of in silico model iMC1010 Experimental - PubMed ID: 15129285
Reference: Escherichia coli K-12 MG1655 		Mar 2009
Automated Process Approved transl table 11 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Gene Ontology
Automated Process Uncurated GO biological process GO:0051188 (OBSOLETE) cofactor biosynthetic process GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR003203
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Person Approved GO biological process GO:0009236 cobalamin biosynthetic process Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Uncurated GO cellular component GO:0005737 cytoplasm GO Inferred from Electronic Annotation - PubMed ID: 15501914
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Automated Process Uncurated GO molecular function GO:0043752 adenosylcobinamide kinase activity GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR003203
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Uncurated GO molecular function GO:0000166 nucleotide binding GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR003203
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Comparative to toptop
Author Approval Details Genome Feature Name Type
Member
Automated Process Uncurated Go view OrthoMCL (14 enterobacteria) AMM-0004295 CDS
Automated Process Uncurated Go view OrthoMCL (205 gammaproteobacteria) APP-0002707 cobU CDS
Automated Process Uncurated Go view OrthoMCL (307 Enterobacteriaceae) ATM-0002830 cobU CDS
Automated Process Uncurated Go view OrthoMCL (42 Serratia) BEZ-0007596 cobU CDS
Automated Process Uncurated Go view OrthoMCL (UW draft) CQJ-0002650 cobU CDS
Ortholog
Automated Process Approved Go view Citrobacter amalonaticus ATCC 25405 [T] AUW-0002834 cobU CDS
Automated Process Approved Go view Citrobacter freundii ATCC 8090 [T] AVI-0003510 cobU CDS
Automated Process Uncurated Go view Escherichia coli 101-1 (EAEC) BAB-0004942 cobU CDS
Automated Process Approved Go view Escherichia coli 536 (UPEC) AEF-0002009 CDS
Automated Process Uncurated Go view Escherichia coli 53638 (EIEC) ADP-0009426 cobU CDS
Automated Process Approved Go view Escherichia coli APEC O1 (APEC) AEG-0001928 cobU CDS
Automated Process Approved Go view Escherichia coli ATCC 11775 [T] AMC-0002393 CDS
Automated Process Approved Go view Escherichia coli ATCC 8739 AEM-0007281 CDS
Automated Process Uncurated Go view Escherichia coli B171 (EPEC) ADN-0008429 cobU CDS
Automated Process Uncurated Go view Escherichia coli B7A (ETEC) ADK-0008044 CDS
Person Approved Go view Escherichia coli CFT073 (UPEC) ABR-0078610 cobU CDS
Automated Process Uncurated Go view Escherichia coli DEC7E (UM-IGS draft) CFX-0002286 cobU CDS
Automated Process Uncurated Go view Escherichia coli DEC9A (UM-IGS draft) CFY-0002626 cobP CDS
Automated Process Uncurated Go view Escherichia coli E110019 (EPEC) ADM-0010423 cobU CDS
Automated Process Uncurated Go view Escherichia coli E22 (EPEC) ADL-0006320 cobU CDS
Automated Process Approved Go view Escherichia coli E2348/69 (EPEC) BCI-0002264 cobU CDS
Automated Process Approved Go view Escherichia coli E24377A (ETEC) ADO-0006712 cobU CDS
Automated Process Uncurated Go view Escherichia coli EC4024 (EHEC) BBI-0006001 CDS
Automated Process Uncurated Go view Escherichia coli EC4042 (EHEC) BBA-0006238 cobU CDS
Automated Process Uncurated Go view Escherichia coli EC4045 (EHEC) BBB-0010520 cobU CDS
Automated Process Uncurated Go view Escherichia coli EC4076 (EHEC) BAZ-0010600 cobU CDS
Automated Process Uncurated Go view Escherichia coli EC4113 (EHEC) BAY-0009656 cobU CDS
Automated Process Uncurated Go view Escherichia coli EC4196 (EHEC) BAX-0009702 cobU CDS
Automated Process Uncurated Go view Escherichia coli EC4206 (EHEC) BAW-0010428 cobU CDS
Automated Process Uncurated Go view Escherichia coli EC4401 (EHEC) BAV-0010321 cobU CDS
Automated Process Uncurated Go view Escherichia coli EC4486 (EHEC) BAU-0009736 cobU CDS
Automated Process Uncurated Go view Escherichia coli EC4501 (EHEC) BAT-0009618 cobU CDS
Automated Process Uncurated Go view Escherichia coli EC508 (EHEC) BBJ-0009690 cobU CDS
Automated Process Uncurated Go view Escherichia coli EC869 (EHEC) BBC-0010441 cobU CDS
Person Approved Go view Escherichia coli EDL933 (EHEC) ABH-0026878 cobU CDS
Automated Process Approved Go view Escherichia coli F11 (UPEC) ADQ-0004778 cobU CDS
Automated Process Approved Go view Escherichia coli HS ADR-0006791 cobU CDS
Automated Process Uncurated Go view Escherichia coli J96 (UPEC) CQK-0002492 cobU CDS
Person Uncurated Go view Escherichia coli K-12 DH10B AEC-0001869 cobU CDS
Person Approved Go view Escherichia coli K-12 W3110 ADY-0002045 cobU CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR68 CGA-0001980 CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR71 CGB-0002392 CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR8 CFZ-0001889 CDS
Automated Process Uncurated Go view Escherichia coli Nissle 1917 AML-0002324 cobU CDS
Automated Process Uncurated Go view Escherichia coli RS218 (NMEC) ACK-0176459 cobU CDS
Automated Process Approved Go view Escherichia coli SE11 AFS-0002317 CDS
Automated Process Approved Go view Escherichia coli SMS-3-5 AFT-0001130 cobU CDS
Person Approved Go view Escherichia coli Sakai (EHEC) ACA-0132788 cobU CDS
Automated Process Uncurated Go view Escherichia coli TW14588 (EHEC) BBK-0004681 CDS
Automated Process Approved Go view Escherichia coli UTI89 (UPEC) AEA-0002238 cobU CDS
Person Uncurated Go view Klebsiella pneumoniae subsp. pneumoniae MGH 78578 AEP-0003192 cobU CDS
Person Uncurated Go view Photorhabdus luminescens subsp. laumondii TTO1 [T] ACD-0143689 cobU CDS
Person Uncurated Go view Pseudomonas syringae pv. tomato DC3000 ADG-0001744 cobP CDS
Automated Process Uncurated Go view Salmonella Agona SL483 BBX-0006309 CDS
Automated Process Uncurated Go view Salmonella Arizonae CDC 346-86 BCD-0000906 CDS
Person Uncurated Go view Salmonella Choleraesuis SC-B67 ADB-0002387 cobU CDS
Automated Process Uncurated Go view Salmonella Dublin CT_02021853 BCB-0006620 CDS
Automated Process Uncurated Go view Salmonella Enteritidis P125109 BCF-0006434 cobU CDS
Automated Process Uncurated Go view Salmonella Gallinarum 287/91 BCG-0006113 cobU CDS
Automated Process Uncurated Go view Salmonella Hadar RI_05P066 BBT-0004401 CDS
Automated Process Uncurated Go view Salmonella Heidelberg SL476 BBV-0006602 CDS
Automated Process Uncurated Go view Salmonella Heidelberg SL486 BBW-0005902 CDS
Automated Process Uncurated Go view Salmonella Javiana GA_MM04042433 BCA-0006347 CDS
Automated Process Uncurated Go view Salmonella Kentucky CDC 191 BBZ-0003983 CDS
Automated Process Uncurated Go view Salmonella Kentucky CVM29188 BBP-0005729 CDS
Automated Process Uncurated Go view Salmonella Newport SL254 BBQ-0006557 CDS
Automated Process Uncurated Go view Salmonella Newport SL317 BBR-0007716 CDS
Automated Process Uncurated Go view Salmonella Paratyphi A AKU_12601 BCH-0000854 CDS
Person Uncurated Go view Salmonella Paratyphi A ATCC 9150 ADA-0000853 cobU CDS
Automated Process Uncurated Go view Salmonella Paratyphi B SPB7 BCC-0001096 CDS
Automated Process Uncurated Go view Salmonella Saintpaul SARA23 BBN-0006791 CDS
Automated Process Uncurated Go view Salmonella Saintpaul SARA29 BBM-0008265 CDS
Automated Process Uncurated Go view Salmonella Schwarzengrund CVM19633 BBO-0006267 CDS
Automated Process Uncurated Go view Salmonella Schwarzengrund SL480 BBY-0007951 CDS
Person Approved Go view Salmonella Typhi CT18 ABX-0109454 cobU CDS
Person Uncurated Go view Salmonella Typhi Ty2 ABS-0082569 cobU CDS
Automated Process Uncurated Go view Salmonella Typhimurium 14028S AJR-0002510 cobU CDS
Person Approved Go view Salmonella Typhimurium LT2 [T] ABU-0096481 cobU CDS
Automated Process Uncurated Go view Salmonella Virchow SL491 BBS-0007268 CDS
Automated Process Uncurated Go view Salmonella Weltevreden SL484 BBU-0004779 CDS
Automated Process Uncurated Go view Salmonella enterica CVM23701 BBL-0005290 CDS
Person Uncurated Go view Shewanella oneidensis MR-1 ACY-0264592 cobU CDS
Automated Process Uncurated Go view Shigella boydii BS512 ADJ-0006358 CDS
Automated Process Uncurated Go view Shigella dysenteriae 1012 BAA-0003776 cobU CDS
Person Approved Go view Shigella dysenteriae 197 ADU-0002581 cobU CDS
Person Uncurated Go view Shigella flexneri 2457T ABQ-0073282 cobU pseudogene
Person Uncurated Go view Shigella flexneri 301 ABT-0088348 cobU CDS
Automated Process Approved Go view Shigella flexneri 8401 BAG-0002215 cobU CDS
Person Approved Go view Shigella sonnei 046 ADD-0002258 cobU CDS
Person Uncurated Go view Vibrio cholerae N16961 ADH-0001311 VC1239 CDS
Person Uncurated Go view Xenorhabdus nematophila ATCC 19061 [T] ADW-0002036 cobU CDS
Automated Process Uncurated Go view Yersinia bercovieri ATCC 43970 [T] AEK-0000508 CDS
Automated Process Uncurated Go view Yersinia enterocolitica 8081 BAH-0007792 cobU CDS
Automated Process Uncurated Go view Yersinia frederiksenii ATCC 33641 [T] AEI-0000448 cobU CDS
Automated Process Uncurated Go view Yersinia intermedia ATCC 29909 [T] AEH-0002883 cobU CDS
Automated Process Uncurated Go view Yersinia mollaretii ATCC 43969 [T] AEJ-0001262 CDS
Automated Process Uncurated Go view Yokenella regensburgei ATCC 43003 APO-0016191 CDS
Automated Process Uncurated Go view Yokenella regensburgei ATCC 49455 [T] AMG-0003182 CDS
Experimental to toptop
SelectSetNameSetDetailsNotes
stringent responsetranscriptional profile of the stringent responseNone
Recombinant heat-shock dataexpression data for recombinant strain under heat shockThese data are from the Harcum laboratory. (Jeremy Glasner)
Suppressor tRNA expressionexperiment comparing transcript levels in cells with and without suppressor tRNA expressionThese data were reported in the paper: Herring and Blattner. 2004. Global transcriptional effects of a suppressor tRNA and the inactivation of the regulator frmR. J. Bacteriol. 186(20):6714-20. Link to Abstract (Jeremy Glasner)
Recombinant E. coli expressionexperiment comparing expression of wild-type E. coli with the same strain harboring a plasmid that expresses protein when induced with IPTG These data were reported in the paper: F. T. Haddadin, S. W. Harcum (2005) Transcriptome profiles for high-cell-density recombinant and wild-type Escherichia coli, Biotechnology and Bioengineering, 90:127-153. Link to Abstract (Jeremy Glasner)
Aerobic shiftAerobic shiftThese data were reported in the paper: Covert MW, Knight EM, Reed JL, Herrgard MJ, Palsson BO. 2004. Integrating high-throughput and computational data elucidates bacterial networks. Nature. 2004 May 6;429(6987):92-6. Link to Abstract (Jeremy Glasner)
CalibratorCalibrated microarray experiments (50 hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
AffyData1Affymetrix Experiments (data from 41 chip hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
Context Table to toptop

Listed below are features that lie nearby this feature. Features encoded in multiple intervals may appear more than once in the table. Features that span the origin will have a left endpoint greater than the right endpoint.

Features overlapping the region 2060219 to 2070764
FeatureIDNameFeature TypeStrandLeft EndRight EndRelationship
ABE-0000001sourceforward14641652Contains
ABE-0006590cblCDScomplement20599642060914Downstream
ABE-0006594nacCDScomplement20610162061933Downstream
ABE-0006605asnVtRNAforward20622602062335Downstream
ABE-0006607ldtACDScomplement20623912063323Downstream
ABE-0006611cobTCDScomplement20633882064467Downstream
ABE-0006613cobSCDScomplement20644792065222Overlaps Downstream
ABE-0006616cobUCDScomplement20652192065764Matches
ABE-0285237yeeHpseudogenecomplement20660652066154(Interval #2) Upstream
ABE-0006617is_elementforward20661592067353Upstream
ABE-0234210CP4-44prophageforward20661592079031Upstream
ABE-0285478mobile_elementcomplement20661592067353Upstream
ABE-0006619insH6CDScomplement20663052067285Upstream
ABE-0285237yeeHpseudogenecomplement20673542067455(Interval #1) Upstream
ABE-0285479misc_featureforward20673542079031Upstream
ABE-0285238yoeGpseudogenecomplement20674562067892Upstream
ABE-0285239yoeHpseudogenecomplement20682522068419Upstream
ABE-0006626yoeA_1CDSpforward20686352069027Upstream
ABE-0285114yoeApseudogeneforward20686352068940(Interval #1) Upstream
ABE-0006627is_elementforward20689412070271Upstream
ABE-0285480mobile_elementcomplement20689412070271Upstream
ABE-0006629insD-3CDScomplement20689522069857Upstream
ABE-0006631insC-3CDScomplement20698152070180Upstream
ABE-0006636yoeA_2CDSpforward20702442070504Upstream
ABE-0285114yoeApseudogeneforward20702772070470(Interval #2) Upstream
ABE-0006639yeePpseudogeneforward20706602071211Upstream
Release Notes to toptop
All MG1655 annotations and sequence data are publicly available, and investigators can use these data in publications without contacting the genome curators. This version of the sequence was the source of GenBank record U00096.3. Ongoing annotation updates to that GenBank record are being generated from a collaboration that includes ASAP, EcoGene, the Coli Genetic Stock Center, EcoliHub, EcoCyc, RegulonDB and UniProtKB/Swiss-Prot.