Escherichia coli K-12 MG1655
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Working With: Genome: Escherichia coli K-12 MG1655 Version: v3

ABE-0007096 (preT) - Escherichia coli K-12 MG1655 - Feature Annotation

ASAP ID
ABE-0007096 showshow history
Names
preT dpdA preB JW2133 ECK2139 yeiT b2146
Product
NAD-dependent dihydropyrimidine dehydrogenase subunit
Type
CDS
Location
# Contig Strand Left Right Length (b.p.) Length (a.a.)
1 Chromosome forward 2234033 2235271 1239 413
Sequence

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Context

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Protein Families to toptop
Author Approval Family Annotated
Automated Process Approved IPR013027 (IPR013027 (DEPRECATED) FAD-dependent pyridine nucleotide-disulphide oxidoreductase) Apr 2008
Automated Process Approved IPR001327 (IPR001327 (DEPRECATED) Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain) Apr 2008
Automated Process Approved IPR009051 (IPR009051 Alpha-helical ferredoxin) Apr 2008
Automated Process Approved IPR000759 (IPR000759 (DEPRECATED) Adrenodoxin reductase) Apr 2008
Automated Process Approved IPR000103 (IPR000103 (DEPRECATED) Pyridine nucleotide-disulphide oxidoreductase, class-II) Apr 2008
Automated Process Approved IPR023753 (IPR023753 FAD/NAD(P)-binding domain) Jul 2018
Automated Process Approved IPR028261 (IPR028261 Dihydroprymidine dehydrogenase domain II) Jul 2018
Automated Process Approved PF07992 (PF07992 Pyridine nucleotide-disulphide oxidoreductase) Jul 2018
Automated Process Approved PF14691 (PF14691 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster) Jul 2018
Gene Ontology to toptop
Author Approval Type Annotation Evidence Annotated
Automated Process Uncurated GO biological process GO:0055114 (OBSOLETE) oxidation-reduction process GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR023753
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved GO biological process GO:0006118 (OBSOLETE) electron transport GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR000759
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO cellular component GO:0005737 cytoplasm GO Inferred from Electronic Annotation - PubMed ID: 15501914
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Automated Process Uncurated GO molecular function GO:0051536 iron-sulfur cluster binding GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR009051
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved GO molecular function GO:0050660 flavin adenine dinucleotide binding GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR001327
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO molecular function GO:0016491 oxidoreductase activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR001327
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Annotations to toptop
Author Approval Type Annotation Evidence Annotated
Nomenclature
Automated Process Approved name preT Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Person Approved synonym yeiT Published Annotation - Swiss-Prot Accession Number: P76440 Aug 2002
Person Approved synonym ECK2139 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved synonym JW2133 Published Annotation - PubMed ID: 16397293 Jan 2006
Automated Process Approved synonym dpdA Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved synonym preB Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Person Approved locus tag b2146 Unique Identifier - Origin: Guy Plunkett III, guy@genome.wisc.edu May 2004
Product
Person Approved product NAD-dependent dihydropyrimidine dehydrogenase subunit Experimental - PubMed ID: 21169495
Reference: Escherichia coli K-12 W3110 		May 2020
Automated Process Approved alternate product name dihydropyrimidine dehydrogenase, NADH-dependent, subunit N Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Person Approved alternate product name putative oxidoreductase Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Jan 2006
Person Uncurated alternate product name bifunctional: putative glutamate synthase (N-terminal); putative oxidoreductase (C-terminal) Published Annotation - Database Name: GenProtEC Jan 2006
Protein Family
Automated Process Approved protein family IPR001327 (DEPRECATED) Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain Protein Sequence Similarity - InterPro Domain: IPR001327
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family IPR013027 (DEPRECATED) FAD-dependent pyridine nucleotide-disulphide oxidoreductase Protein Sequence Similarity - InterPro Domain: IPR013027
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family IPR009051 Alpha-helical ferredoxin Protein Sequence Similarity - InterPro Domain: IPR009051
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family IPR000759 (DEPRECATED) Adrenodoxin reductase Protein Sequence Similarity - InterPro Domain: IPR000759
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family IPR028261 Dihydroprymidine dehydrogenase domain II Protein Sequence Similarity - InterPro Domain: IPR028261
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved protein family IPR023753 FAD/NAD(P)-binding domain Protein Sequence Similarity - InterPro Domain: IPR023753
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved protein family IPR000103 (DEPRECATED) Pyridine nucleotide-disulphide oxidoreductase, class-II Protein Sequence Similarity - InterPro Domain: IPR000103
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family PF07992 Pyridine nucleotide-disulphide oxidoreductase Protein Sequence Similarity - PFAM Model Name: PF07992
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved protein family PF14691 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Protein Sequence Similarity - PFAM Model Name: PF14691
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Other
Person Approved EC number 1.-.-.- Protein Sequence Similarity - InterPro Domain: IPR009051
Reference: Escherichia coli K-12 MG1655 		Dec 2008
Person Uncurated MultiFun 1.7.1 (metabolism; central intermediary metabolism; unassigned reversible reactions) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Automated Process Approved codon start 1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref EcoGene:EG14074 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref UniProtKB/Swiss-Prot:P76440 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref GeneID:949049 Published Annotation - Entrez Gene Database ID: 949049
Reference: Escherichia coli K-12 MG1655 		Jun 2009
Person Approved db xref UniProtKB:P76440 Published Annotation - Swiss-Prot Accession Number: P76440 Jan 2006
Automated Process Approved db xref GI:1788468 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref ASAP:ABE-0007096 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved function enzyme; pyrimidine metabolism Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved note putative oxidoreductase Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved protein id AAC75207.1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Uncurated subcellular localization Cytoplasmic Predicted by PSORTb - PSORTb Final_Score: 9.97
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Automated Process Approved transl table 11 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Gene Ontology
Automated Process Uncurated GO biological process GO:0055114 (OBSOLETE) oxidation-reduction process GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR023753
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved GO biological process GO:0006118 (OBSOLETE) electron transport GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR000759
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO cellular component GO:0005737 cytoplasm GO Inferred from Electronic Annotation - PubMed ID: 15501914
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Automated Process Approved GO molecular function GO:0050660 flavin adenine dinucleotide binding GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR001327
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO molecular function GO:0051536 iron-sulfur cluster binding GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR009051
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved GO molecular function GO:0016491 oxidoreductase activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR001327
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Comparative to toptop
Author Approval Details Genome Feature Name Type
Member
Automated Process Uncurated Go view OrthoMCL (14 enterobacteria) AMM-0003787 CDS
Automated Process Uncurated Go view OrthoMCL (205 gammaproteobacteria) APP-0003135 yeiT CDS
Automated Process Uncurated Go view OrthoMCL (307 Enterobacteriaceae) ATM-0003572 yeiT CDS
Automated Process Uncurated Go view OrthoMCL (UW draft) CQJ-0003124 preT CDS
Ortholog
Automated Process Approved Go view Citrobacter freundii ATCC 8090 [T] AVI-0003708 gltD_2 CDS
Automated Process Uncurated Go view Escherichia albertii TW07627 AFX-0003419 CDS
Automated Process Uncurated Go view Escherichia coli 101-1 (EAEC) BAB-0005101 CDS
Automated Process Approved Go view Escherichia coli 536 (UPEC) AEF-0002203 CDS
Automated Process Uncurated Go view Escherichia coli 53638 (EIEC) ADP-0009193 CDS
Automated Process Approved Go view Escherichia coli APEC O1 (APEC) AEG-0002097 yeiT CDS
Automated Process Approved Go view Escherichia coli ATCC 11775 [T] AMC-0002181 CDS
Automated Process Approved Go view Escherichia coli ATCC 8739 AEM-0007125 CDS
Automated Process Uncurated Go view Escherichia coli B171 (EPEC) ADN-0006573 CDS
Automated Process Uncurated Go view Escherichia coli B7A (ETEC) ADK-0005473 CDS
Person Approved Go view Escherichia coli CFT073 (UPEC) ABR-0078815 yeiT CDS
Automated Process Uncurated Go view Escherichia coli DEC7E (UM-IGS draft) CFX-0002479 CDS
Automated Process Uncurated Go view Escherichia coli DEC9A (UM-IGS draft) CFY-0002808 CDS
Automated Process Uncurated Go view Escherichia coli E110019 (EPEC) ADM-0009764 CDS
Automated Process Uncurated Go view Escherichia coli E22 (EPEC) ADL-0005763 CDS
Automated Process Approved Go view Escherichia coli E2348/69 (EPEC) BCI-0002437 yeiT CDS
Automated Process Approved Go view Escherichia coli E24377A (ETEC) ADO-0006877 CDS
Automated Process Uncurated Go view Escherichia coli EC4024 (EHEC) BBI-0000505 CDS
Automated Process Uncurated Go view Escherichia coli EC4042 (EHEC) BBA-0006615 CDS
Automated Process Uncurated Go view Escherichia coli EC4045 (EHEC) BBB-0005142 CDS
Automated Process Uncurated Go view Escherichia coli EC4076 (EHEC) BAZ-0006583 CDS
Automated Process Uncurated Go view Escherichia coli EC4113 (EHEC) BAY-0008634 CDS
Automated Process Approved Go view Escherichia coli EC4115 (EHEC) BAS-0008118 CDS
Automated Process Uncurated Go view Escherichia coli EC4196 (EHEC) BAX-0005814 CDS
Automated Process Uncurated Go view Escherichia coli EC4206 (EHEC) BAW-0005902 CDS
Automated Process Uncurated Go view Escherichia coli EC4401 (EHEC) BAV-0009617 CDS
Automated Process Uncurated Go view Escherichia coli EC4486 (EHEC) BAU-0007185 CDS
Automated Process Uncurated Go view Escherichia coli EC4501 (EHEC) BAT-0009356 CDS
Automated Process Uncurated Go view Escherichia coli EC508 (EHEC) BBJ-0008870 CDS
Automated Process Uncurated Go view Escherichia coli EC869 (EHEC) BBC-0009234 CDS
Person Approved Go view Escherichia coli EDL933 (EHEC) ABH-0027123 yeiT CDS
Automated Process Approved Go view Escherichia coli F11 (UPEC) ADQ-0004974 preT CDS
Automated Process Approved Go view Escherichia coli HS ADR-0006954 CDS
Automated Process Uncurated Go view Escherichia coli J96 (UPEC) CQK-0002723 CDS
Person Uncurated Go view Escherichia coli K-12 DH10B AEC-0002018 yeiT CDS
Person Approved Go view Escherichia coli K-12 W3110 ADY-0002212 yeiT CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR68 CGA-0002628 CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR71 CGB-0002572 CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR8 CFZ-0002523 CDS
Automated Process Uncurated Go view Escherichia coli Nissle 1917 AML-0002505 CDS
Automated Process Approved Go view Escherichia coli SE11 AFS-0002453 CDS
Automated Process Approved Go view Escherichia coli SMS-3-5 AFT-0002292 CDS
Person Approved Go view Escherichia coli Sakai (EHEC) ACA-0133046 yeiT CDS
Automated Process Uncurated Go view Escherichia coli TW14588 (EHEC) BBK-0000250 CDS
Automated Process Approved Go view Escherichia coli UTI89 (UPEC) AEA-0002426 yeiT CDS
Automated Process Uncurated Go view Salmonella Agona SL483 BBX-0006501 CDS
Person Uncurated Go view Salmonella Choleraesuis SC-B67 ADB-0002571 yeiT CDS
Automated Process Uncurated Go view Salmonella Dublin CT_02021853 BCB-0006800 CDS
Automated Process Uncurated Go view Salmonella Enteritidis P125109 BCF-0006966 CDS
Automated Process Uncurated Go view Salmonella Gallinarum 287/91 BCG-0006624 CDS
Automated Process Uncurated Go view Salmonella Hadar RI_05P066 BBT-0004202 CDS
Automated Process Uncurated Go view Salmonella Heidelberg SL476 BBV-0006783 CDS
Automated Process Uncurated Go view Salmonella Heidelberg SL486 BBW-0006083 CDS
Automated Process Uncurated Go view Salmonella Javiana GA_MM04042433 BCA-0006539 CDS
Automated Process Uncurated Go view Salmonella Kentucky CDC 191 BBZ-0004182 CDS
Automated Process Uncurated Go view Salmonella Kentucky CVM29188 BBP-0005931 CDS
Automated Process Uncurated Go view Salmonella Newport SL254 BBQ-0006739 CDS
Automated Process Uncurated Go view Salmonella Newport SL317 BBR-0007524 CDS
Automated Process Uncurated Go view Salmonella Paratyphi A AKU_12601 BCH-0000665 CDS
Person Uncurated Go view Salmonella Paratyphi A ATCC 9150 ADA-0000665 CDS
Automated Process Uncurated Go view Salmonella Paratyphi B SPB7 BCC-0000836 CDS
Automated Process Uncurated Go view Salmonella Saintpaul SARA23 BBN-0006971 CDS
Automated Process Uncurated Go view Salmonella Saintpaul SARA29 BBM-0006421 CDS
Automated Process Uncurated Go view Salmonella Schwarzengrund CVM19633 BBO-0006504 CDS
Automated Process Uncurated Go view Salmonella Schwarzengrund SL480 BBY-0005727 CDS
Person Approved Go view Salmonella Typhi CT18 ABX-0109919 CDS
Person Uncurated Go view Salmonella Typhi Ty2 ABS-0082382 CDS
Automated Process Uncurated Go view Salmonella Typhimurium 14028S AJR-0002697 CDS
Person Approved Go view Salmonella Typhimurium LT2 [T] ABU-0096976 CDS
Automated Process Uncurated Go view Salmonella Virchow SL491 BBS-0007090 CDS
Automated Process Uncurated Go view Salmonella Weltevreden SL484 BBU-0004596 CDS
Automated Process Uncurated Go view Salmonella enterica CVM23701 BBL-0005471 CDS
Person Uncurated Go view Shigella boydii 227 ADV-0001087 CDS
Automated Process Approved Go view Shigella boydii BS512 ADJ-0006222 CDS
Automated Process Uncurated Go view Shigella dysenteriae 1012 BAA-0003603 CDS
Person Uncurated Go view Shigella dysenteriae 197 ADU-0002469 CDS
Person Uncurated Go view Shigella flexneri 2457T ABQ-0073489 CDS
Person Uncurated Go view Shigella flexneri 301 ABT-0088499 CDS
Automated Process Uncurated Go view Shigella flexneri 8401 BAG-0002386 CDS
Experimental to toptop
SelectSetNameSetDetailsNotes
stringent responsetranscriptional profile of the stringent responseNone
Recombinant heat-shock dataexpression data for recombinant strain under heat shockThese data are from the Harcum laboratory. (Jeremy Glasner)
Suppressor tRNA expressionexperiment comparing transcript levels in cells with and without suppressor tRNA expressionThese data were reported in the paper: Herring and Blattner. 2004. Global transcriptional effects of a suppressor tRNA and the inactivation of the regulator frmR. J. Bacteriol. 186(20):6714-20. Link to Abstract (Jeremy Glasner)
Recombinant E. coli expressionexperiment comparing expression of wild-type E. coli with the same strain harboring a plasmid that expresses protein when induced with IPTG These data were reported in the paper: F. T. Haddadin, S. W. Harcum (2005) Transcriptome profiles for high-cell-density recombinant and wild-type Escherichia coli, Biotechnology and Bioengineering, 90:127-153. Link to Abstract (Jeremy Glasner)
Aerobic shiftAerobic shiftThese data were reported in the paper: Covert MW, Knight EM, Reed JL, Herrgard MJ, Palsson BO. 2004. Integrating high-throughput and computational data elucidates bacterial networks. Nature. 2004 May 6;429(6987):92-6. Link to Abstract (Jeremy Glasner)
CalibratorCalibrated microarray experiments (50 hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
AffyData1Affymetrix Experiments (data from 41 chip hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
Context Table to toptop

Listed below are features that lie nearby this feature. Features encoded in multiple intervals may appear more than once in the table. Features that span the origin will have a left endpoint greater than the right endpoint.

Features overlapping the region 2229033 to 2240271
FeatureIDNameFeature TypeStrandLeft EndRight EndRelationship
ABE-0000001sourceforward14641652Contains
ABE-0285222yohPCDSforward22289822229065Upstream
ABE-0007074dusCCDScomplement22294382230385Upstream
ABE-0007078yohJCDSforward22306242231022Upstream
ABE-0007080yohKCDSforward22310192231714Upstream
ABE-0007086cddCDSforward22318442232728Upstream
ABE-0285495repeat_regionforward22327362232769Upstream
ABE-0007091sanACDSforward22328782233597Upstream
ABE-0007093yeiSCDSforward22336002233839Upstream
ABE-0007096preTCDSforward22340332235271Matches
ABE-0007098preACDSforward22352652236500Overlaps Downstream
ABE-0285496repeat_regionforward22365342236683Downstream
ABE-0007101mglCCDScomplement22367432237753Downstream
ABE-0007103mglACDScomplement22377692239289Downstream
ABE-0007108mglBCDScomplement22393502240348Downstream
Release Notes to toptop
All MG1655 annotations and sequence data are publicly available, and investigators can use these data in publications without contacting the genome curators. This version of the sequence was the source of GenBank record U00096.3. Ongoing annotation updates to that GenBank record are being generated from a collaboration that includes ASAP, EcoGene, the Coli Genetic Stock Center, EcoliHub, EcoCyc, RegulonDB and UniProtKB/Swiss-Prot.