Escherichia coli K-12 MG1655
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Working With: Genome: Escherichia coli K-12 MG1655 Version: v3

ABE-0007603 (folX) - Escherichia coli K-12 MG1655 - Feature Annotation

ASAP ID
ABE-0007603 showshow history
Names
folX JW2300 ECK2297 b2303
Product
D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase and dihydroneopterin aldolase
Type
CDS
Location
# Contig Strand Left Right Length (b.p.) Length (a.a.)
1 Chromosome forward 2421325 2421687 363 121
Sequence

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Context

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Protein Families to toptop
Author Approval Family Annotated
Automated Process Approved IPR006157 (IPR006157 Dihydroneopterin aldolase/epimerase domain) Apr 2008
Automated Process Approved PF02152 (PF02152 Dihydroneopterin aldolase) Jul 2018
Gene Ontology to toptop
Author Approval Type Annotation Evidence Annotated
Automated Process Approved GO biological process GO:0006760 folic acid-containing compound metabolic process GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR006157
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO cellular component GO:0005737 cytoplasm GO Inferred from Electronic Annotation - PubMed ID: 15501914
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Automated Process Approved GO molecular function GO:0004150 dihydroneopterin aldolase activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR006157
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Annotations to toptop
Author Approval Type Annotation Evidence Annotated
Nomenclature
Person Approved name folX Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Oct 1998
Person Approved synonym ECK2297 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved synonym JW2300 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved locus tag b2303 Unique Identifier - Origin: Guy Plunkett III, guy@genome.wisc.edu May 2004
Product
Person Approved product D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase and dihydroneopterin aldolase Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved alternate product name D-erythro-7,8-dihydroneopterin tri P epimerase Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Jan 2006
Person Uncurated alternate product name D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase (with dihydroneopterin aldolase activity) Published Annotation - Database Name: GenProtEC Jan 2006
Protein Family
Automated Process Approved protein family PF02152 Dihydroneopterin aldolase Protein Sequence Similarity - PFAM Model Name: PF02152
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved protein family IPR006157 Dihydroneopterin aldolase/epimerase domain Protein Sequence Similarity - InterPro Domain: IPR006157
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Other
Automated Process Uncurated EC number 4.1.2.25 Published Annotation - Database Name: EC2GO: GO:0004150
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Person Approved EC number 5.-.-.- Published Annotation - Swiss-Prot Accession Number: P0AC19 Feb 2006
Person Uncurated MultiFun 1.7.1 (metabolism; central intermediary metabolism; unassigned reversible reactions) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Automated Process Approved codon start 1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref EcoGene:EG14263 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Person Approved db xref UniProtKB:P0AC19 Published Annotation - Swiss-Prot Accession Number: P0AC19 Jan 2006
Automated Process Approved db xref GeneID:946781 Published Annotation - Entrez Gene Database ID: 946781
Reference: Escherichia coli K-12 MG1655 		Jun 2009
Automated Process Approved db xref GI:1788641 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref UniProtKB/Swiss-Prot:P0AC19 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref ASAP:ABE-0007603 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Person Approved function enzyme; Central intermediary metabolism: Pool, multipurpose conversions Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Oct 1998
Automated Process Approved note D-erythro-7,8-dihydroneopterin tri P epimerase Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved protein id AAC75363.1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Uncurated subcellular localization Cytoplasmic Predicted by PSORTb - PSORTb Final_Score: 8.96
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Person Uncurated subsystem component of in silico model iAF1260 Experimental - PubMed ID: 17593909
Reference: Escherichia coli K-12 MG1655 		Jan 2009
Automated Process Approved transl table 11 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Gene Ontology
Automated Process Approved GO biological process GO:0006760 folic acid-containing compound metabolic process GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR006157
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO cellular component GO:0005737 cytoplasm GO Inferred from Electronic Annotation - PubMed ID: 15501914
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Automated Process Approved GO molecular function GO:0004150 dihydroneopterin aldolase activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR006157
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Comparative to toptop
Author Approval Details Genome Feature Name Type
Member
Automated Process Uncurated Go view OrthoMCL (14 enterobacteria) AMM-0003291 CDS
Automated Process Uncurated Go view OrthoMCL (205 gammaproteobacteria) APP-0003358 folX CDS
Automated Process Uncurated Go view OrthoMCL (307 Enterobacteriaceae) ATM-0003246 folX CDS
Automated Process Uncurated Go view OrthoMCL (42 Serratia) BEZ-0002071 folX CDS
Automated Process Uncurated Go view OrthoMCL (UW draft) CQJ-0003098 folX CDS
Ortholog
Automated Process Uncurated Go view Brenneria sp. EniD312 AKG-0001340 CDS
Automated Process Uncurated Go view Buttiauxella agrestis ATCC 33320 [T] APC-0003087 folX CDS
Automated Process Uncurated Go view Cedecea davisae ATCC 33431 [T] ALZ-0001000 CDS
Automated Process Approved Go view Citrobacter amalonaticus ATCC 25405 [T] AUW-0003144 folX CDS
Automated Process Approved Go view Citrobacter freundii ATCC 8090 [T] AVI-0003862 folX CDS
Automated Process Uncurated Go view Enterobacter cloacae subsp. cloacae ATCC 13047 [T] (AToL DRAFT) AMB-0003786 CDS
Automated Process Uncurated Go view Escherichia albertii TW07627 AFX-0003225 folX CDS
Automated Process Uncurated Go view Escherichia coli 101-1 (EAEC) BAB-0005268 folX CDS
Automated Process Approved Go view Escherichia coli 536 (UPEC) AEF-0002360 CDS
Automated Process Uncurated Go view Escherichia coli 53638 (EIEC) ADP-0008917 folX CDS
Automated Process Approved Go view Escherichia coli APEC O1 (APEC) AEG-0002250 folX CDS
Automated Process Approved Go view Escherichia coli ATCC 11775 [T] AMC-0002023 CDS
Automated Process Approved Go view Escherichia coli ATCC 8739 AEM-0006938 CDS
Automated Process Uncurated Go view Escherichia coli B171 (EPEC) ADN-0009154 folX CDS
Person Uncurated Go view Escherichia coli B7A (ETEC) ADK-0010097 CDS
Person Approved Go view Escherichia coli CFT073 (UPEC) ABR-0078983 folX CDS
Automated Process Uncurated Go view Escherichia coli DEC7E (UM-IGS draft) CFX-0002659 folX CDS
Automated Process Uncurated Go view Escherichia coli DEC9A (UM-IGS draft) CFY-0003033 folX CDS
Automated Process Uncurated Go view Escherichia coli E110019 (EPEC) ADM-0006582 folX CDS
Automated Process Uncurated Go view Escherichia coli E22 (EPEC) ADL-0005921 folX CDS
Automated Process Approved Go view Escherichia coli E2348/69 (EPEC) BCI-0002590 folX CDS
Automated Process Approved Go view Escherichia coli E24377A (ETEC) ADO-0007031 folX CDS
Automated Process Uncurated Go view Escherichia coli EC4024 (EHEC) BBI-0000672 CDS
Automated Process Uncurated Go view Escherichia coli EC4045 (EHEC) BBB-0005306 folX CDS
Automated Process Uncurated Go view Escherichia coli EC4076 (EHEC) BAZ-0006749 folX CDS
Automated Process Uncurated Go view Escherichia coli EC4113 (EHEC) BAY-0006334 folX CDS
Automated Process Approved Go view Escherichia coli EC4115 (EHEC) BAS-0008283 folX CDS
Automated Process Uncurated Go view Escherichia coli EC4196 (EHEC) BAX-0005648 folX CDS
Automated Process Uncurated Go view Escherichia coli EC4206 (EHEC) BAW-0006069 folX CDS
Automated Process Uncurated Go view Escherichia coli EC4401 (EHEC) BAV-0007001 folX CDS
Automated Process Uncurated Go view Escherichia coli EC4486 (EHEC) BAU-0007351 folX CDS
Automated Process Uncurated Go view Escherichia coli EC508 (EHEC) BBJ-0006231 folX CDS
Automated Process Uncurated Go view Escherichia coli EC869 (EHEC) BBC-0007523 folX CDS
Person Approved Go view Escherichia coli EDL933 (EHEC) ABH-0027276 folX CDS
Automated Process Approved Go view Escherichia coli F11 (UPEC) ADQ-0005140 folX CDS
Automated Process Approved Go view Escherichia coli HS ADR-0007126 folX CDS
Automated Process Uncurated Go view Escherichia coli J96 (UPEC) CQK-0002875 CDS
Person Uncurated Go view Escherichia coli K-12 DH10B AEC-0002168 folX CDS
Person Approved Go view Escherichia coli K-12 W3110 ADY-0002379 folX CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR68 CGA-0002843 CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR71 CGB-0002762 CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR8 CFZ-0002693 CDS
Automated Process Uncurated Go view Escherichia coli Nissle 1917 AML-0002678 folX CDS
Automated Process Uncurated Go view Escherichia coli RS218 (NMEC) ACK-0176840 folX CDS
Automated Process Approved Go view Escherichia coli SE11 AFS-0002602 CDS
Automated Process Approved Go view Escherichia coli SMS-3-5 AFT-0002458 folX CDS
Person Approved Go view Escherichia coli Sakai (EHEC) ACA-0133198 folX CDS
Automated Process Uncurated Go view Escherichia coli TW14588 (EHEC) BBK-0000083 CDS
Automated Process Approved Go view Escherichia coli UTI89 (UPEC) AEA-0002594 folX CDS
Person Uncurated Go view Hafnia alvei ATCC 13337 [T] AMD-0003524 CDS
Person Uncurated Go view Klebsiella pneumoniae subsp. pneumoniae MGH 78578 AEP-0002702 folX CDS
Automated Process Uncurated Go view Leclercia adecarboxylata ATCC 23216 [T] AME-0001037 CDS
Person Approved Go view Pectobacterium atrosepticum SCRI1043 ABL-0063332 folX CDS
Automated Process Uncurated Go view Pectobacterium brasiliensis 1692 AED-0001700 folX CDS
Person Uncurated Go view Pectobacterium carotovorum WPP14 ADT-0001947 folX CDS
Automated Process Uncurated Go view Pectobacterium parmentieri WPP163 AFJ-0000285 folX CDS
Automated Process Uncurated Go view Pectobacterium sp. PC1 AFL-0007821 CDS
Person Uncurated Go view Pseudomonas syringae pv. tomato DC3000 ADG-0001210 folB-2 CDS
Automated Process Uncurated Go view Serratia marcescens subsp. marcescens ATCC 13880 [T] AMF-0002388 CDS
Person Uncurated Go view Shewanella oneidensis MR-1 ACY-0266531 folX CDS
Person Approved Go view Shigella boydii 227 ADV-0002585 folX CDS
Automated Process Approved Go view Shigella boydii BS512 ADJ-0008088 folX CDS
Automated Process Uncurated Go view Shigella dysenteriae 1012 BAA-0005471 folX CDS
Person Approved Go view Shigella dysenteriae 197 ADU-0002872 folX CDS
Person Approved Go view Shigella flexneri 2457T ABQ-0073656 folX CDS
Person Approved Go view Shigella flexneri 301 ABT-0088640 folX CDS
Automated Process Approved Go view Shigella flexneri 8401 BAG-0002539 folX CDS
Person Approved Go view Shigella sonnei 046 ADD-0002581 folX CDS
Person Uncurated Go view Trabulsiella guamensis ATCC 49490 [T] APH-0002320 folX CDS
Automated Process Uncurated Go view Yokenella regensburgei ATCC 43003 APO-0017303 CDS
Automated Process Uncurated Go view Yokenella regensburgei ATCC 49455 [T] AMG-0002943 CDS
Molecular Interactions to toptop
Author Approval Feature Name Technique Evidence Comment Annotated
Person Approved ABE-0007603 folX lambda repressor assay Doodle - bnumber: b2303 Oct 2003
Experimental to toptop
SelectSetNameSetDetailsNotes
stringent responsetranscriptional profile of the stringent responseNone
Recombinant heat-shock dataexpression data for recombinant strain under heat shockThese data are from the Harcum laboratory. (Jeremy Glasner)
Suppressor tRNA expressionexperiment comparing transcript levels in cells with and without suppressor tRNA expressionThese data were reported in the paper: Herring and Blattner. 2004. Global transcriptional effects of a suppressor tRNA and the inactivation of the regulator frmR. J. Bacteriol. 186(20):6714-20. Link to Abstract (Jeremy Glasner)
Recombinant E. coli expressionexperiment comparing expression of wild-type E. coli with the same strain harboring a plasmid that expresses protein when induced with IPTG These data were reported in the paper: F. T. Haddadin, S. W. Harcum (2005) Transcriptome profiles for high-cell-density recombinant and wild-type Escherichia coli, Biotechnology and Bioengineering, 90:127-153. Link to Abstract (Jeremy Glasner)
Aerobic shiftAerobic shiftThese data were reported in the paper: Covert MW, Knight EM, Reed JL, Herrgard MJ, Palsson BO. 2004. Integrating high-throughput and computational data elucidates bacterial networks. Nature. 2004 May 6;429(6987):92-6. Link to Abstract (Jeremy Glasner)
CalibratorCalibrated microarray experiments (50 hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
AffyData1Affymetrix Experiments (data from 41 chip hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
Context Table to toptop

Listed below are features that lie nearby this feature. Features encoded in multiple intervals may appear more than once in the table. Features that span the origin will have a left endpoint greater than the right endpoint.

Features overlapping the region 2416325 to 2426687
FeatureIDNameFeature TypeStrandLeft EndRight EndRelationship
ABE-0000001sourceforward14641652Contains
ABE-0007582ptaCDSforward24147472416891Upstream
ABE-0007585yfcCCDSforward24170812418601Upstream
ABE-0007587yfcDCDScomplement24186342419176Upstream
ABE-0007589yfcECDScomplement24192342419788Upstream
ABE-0007593yfcFCDScomplement24198412420485Upstream
ABE-0007600yfcGCDSforward24206212421268Upstream
ABE-0007603folXCDSforward24213252421687Matches
ABE-0007605yfcHCDSforward24217082422601Downstream
ABE-0007607rpnBCDScomplement24226492423539Downstream
ABE-0007610hisPCDScomplement24237362424509Downstream
ABE-0007613hisMCDScomplement24245172425233Downstream
ABE-0007615hisQCDScomplement24252302425916Downstream
ABE-0007617hisJCDScomplement24260062426788Downstream
Release Notes to toptop
All MG1655 annotations and sequence data are publicly available, and investigators can use these data in publications without contacting the genome curators. This version of the sequence was the source of GenBank record U00096.3. Ongoing annotation updates to that GenBank record are being generated from a collaboration that includes ASAP, EcoGene, the Coli Genetic Stock Center, EcoliHub, EcoCyc, RegulonDB and UniProtKB/Swiss-Prot.