Escherichia coli K-12 MG1655
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Working With: Genome: Escherichia coli K-12 MG1655 Version: v3

ABE-0011019 (frlA) - Escherichia coli K-12 MG1655 - Feature Annotation

ASAP ID
ABE-0011019 showshow history
Names
frlA yhfM JW3333 ECK3358 b3370
Product
fructoselysine/psicoselysine transporter
Type
CDS
Location
# Contig Strand Left Right Length (b.p.) Length (a.a.)
1 Chromosome forward 3499910 3501247 1338 446
Sequence

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View sequence with flanking regions: bases upstream and bases downstream

Context

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Protein Families to toptop
Author Approval Family Annotated
Automated Process Approved IPR002293 (IPR002293 Amino acid/polyamine transporter I) Apr 2008
Automated Process Approved IPR004841 (IPR004841 Amino acid permease/ SLC12A domain) Apr 2008
Automated Process Approved PF13520 (PF13520 Amino acid permease) Jul 2018
Gene Ontology to toptop
Author Approval Type Annotation Evidence Annotated
Automated Process Approved GO biological process GO:0006865 amino acid transport GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR002293
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO biological process GO:0055085 transmembrane transport GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR002293
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved GO biological process GO:0006810 transport GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR004841
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO cellular component GO:0016020 membrane GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR002293
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Person Uncurated GO cellular component GO:0019866 organelle inner membrane Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Uncurated GO cellular component GO:0005886 plasma membrane GO Inferred from Electronic Annotation - PubMed ID: 15501914
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Automated Process Uncurated GO molecular function GO:0022857 transmembrane transporter activity GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR002293
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved GO molecular function GO:0015171 amino acid transmembrane transporter activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR002293
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Annotations to toptop
Author Approval Type Annotation Evidence Annotated
Nomenclature
Person Approved name frlA Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved synonym yhfM Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Jan 2006
Person Approved synonym JW3333 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved synonym ECK3358 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved locus tag b3370 Unique Identifier - Origin: Guy Plunkett III, guy@genome.wisc.edu May 2004
Product
Person Uncurated product fructoselysine/psicoselysine transporter Published Annotation - EcoCyc Accession Number: EG12908
Reference: Escherichia coli K-12 MG1655 		Oct 2021
Person Approved alternate product name putative amino acid/amine transport protein Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Jan 2006
Person Approved alternate product name predicted fructoselysine transporter Published Annotation - PubMed ID: 16397293 Jan 2006
Person Uncurated alternate product name putative methionine transport protein (APC family) Published Annotation - Database Name: GenProtEC Jan 2006
Protein Family
Automated Process Approved protein family IPR004841 Amino acid permease/ SLC12A domain Protein Sequence Similarity - InterPro Domain: IPR004841
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family IPR002293 Amino acid/polyamine transporter I Protein Sequence Similarity - InterPro Domain: IPR002293
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family PF13520 Amino acid permease Protein Sequence Similarity - PFAM Model Name: PF13520
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Other
Person Uncurated MultiFun 6.1 (cell structure; membrane) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Person Uncurated MultiFun 4.2.A.3 (transport; Electrochemical potential driven transporters; Porters (Uni-, Sym- and Antiporters); The Amino Acid-Polyamine-Choline (APC) Family) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Person Uncurated MultiFun 7.3 (location of gene products; inner membrane) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Person Uncurated MultiFun 4.S.118 (transport; substrate; methionine) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Automated Process Approved codon start 1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref EcoGene:EG12908 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref ASAP:ABE-0011019 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Person Approved db xref UniProtKB:P45539 Published Annotation - Swiss-Prot Accession Number: P45539 Jan 2005
Automated Process Approved db xref GeneID:947878 Published Annotation - Entrez Gene Database ID: 947878
Reference: Escherichia coli K-12 MG1655 		Jun 2009
Automated Process Approved db xref GI:87082250 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref UniProtKB/Swiss-Prot:P45539 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Person Approved function putative transport; Not classified Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Oct 1998
Automated Process Approved note putative amino acid/amine transport protein; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved protein id AAC76395.2 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Uncurated subcellular localization Cytoplasmic Membrane Predicted by PSORTb - PSORTb Final_Score: 10.00
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Person Uncurated subsystem component of in silico model iAF1260 Experimental - PubMed ID: 17593909
Reference: Escherichia coli K-12 MG1655 		Jan 2009
Automated Process Approved transl table 11 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Gene Ontology
Automated Process Approved GO biological process GO:0006865 amino acid transport GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR002293
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO biological process GO:0006810 transport GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR004841
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO biological process GO:0055085 transmembrane transport GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR002293
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Person Uncurated GO cellular component GO:0019866 organelle inner membrane Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Approved GO cellular component GO:0016020 membrane GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR002293
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO cellular component GO:0005886 plasma membrane GO Inferred from Electronic Annotation - PubMed ID: 15501914
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Automated Process Approved GO molecular function GO:0015171 amino acid transmembrane transporter activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR002293
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO molecular function GO:0022857 transmembrane transporter activity GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR002293
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Comparative to toptop
Author Approval Details Genome Feature Name Type
Member
Automated Process Uncurated Go view OrthoMCL (205 gammaproteobacteria) APP-0004589 frlA CDS
Automated Process Uncurated Go view OrthoMCL (307 Enterobacteriaceae) ATM-0005003 frlA CDS
Automated Process Uncurated Go view OrthoMCL (42 Serratia) BEZ-0009683 frlA CDS
Automated Process Uncurated Go view OrthoMCL (UW draft) CQJ-0004060 frlA CDS
Ortholog
Automated Process Uncurated Go view Escherichia coli 101-1 (EAEC) BAB-0008812 CDS
Automated Process Uncurated Go view Escherichia coli 53638 (EIEC) ADP-0007726 CDS
Automated Process Approved Go view Escherichia coli ATCC 8739 AEM-0005720 CDS
Automated Process Uncurated Go view Escherichia coli B171 (EPEC) ADN-0006387 CDS
Automated Process Uncurated Go view Escherichia coli B7A (ETEC) ADK-0008808 FrlA CDS
Automated Process Uncurated Go view Escherichia coli DEC7E (UM-IGS draft) CFX-0003851 CDS
Automated Process Uncurated Go view Escherichia coli DEC9A (UM-IGS draft) CFY-0004498 yhfM CDS
Automated Process Uncurated Go view Escherichia coli E110019 (EPEC) ADM-0007143 CDS
Automated Process Uncurated Go view Escherichia coli E22 (EPEC) ADL-0005383 CDS
Automated Process Approved Go view Escherichia coli E24377A (ETEC) ADO-0008274 CDS
Automated Process Uncurated Go view Escherichia coli EC4024 (EHEC) BBI-0004635 CDS
Automated Process Uncurated Go view Escherichia coli EC4042 (EHEC) BBA-0008022 CDS
Automated Process Uncurated Go view Escherichia coli EC4045 (EHEC) BBB-0006535 CDS
Automated Process Uncurated Go view Escherichia coli EC4076 (EHEC) BAZ-0006081 CDS
Automated Process Uncurated Go view Escherichia coli EC4113 (EHEC) BAY-0009919 CDS
Automated Process Approved Go view Escherichia coli EC4115 (EHEC) BAS-0009516 CDS
Automated Process Uncurated Go view Escherichia coli EC4196 (EHEC) BAX-0005427 CDS
Automated Process Uncurated Go view Escherichia coli EC4206 (EHEC) BAW-0007331 CDS
Automated Process Uncurated Go view Escherichia coli EC4401 (EHEC) BAV-0005114 CDS
Automated Process Uncurated Go view Escherichia coli EC4486 (EHEC) BAU-0005183 CDS
Automated Process Uncurated Go view Escherichia coli EC4501 (EHEC) BAT-0005024 CDS
Automated Process Uncurated Go view Escherichia coli EC869 (EHEC) BBC-0005509 CDS
Person Approved Go view Escherichia coli EDL933 (EHEC) ABH-0028388 frlA CDS
Automated Process Approved Go view Escherichia coli HS ADR-0008254 CDS
Person Uncurated Go view Escherichia coli K-12 DH10B AEC-0003138 frlA CDS
Person Approved Go view Escherichia coli K-12 W3110 ADY-0003999 frlA CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR71 CGB-0003999 CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR8 CFZ-0003937 CDS
Automated Process Approved Go view Escherichia coli SE11 AFS-0003703 CDS
Person Approved Go view Escherichia coli Sakai (EHEC) ACA-0134293 frlA CDS
Automated Process Uncurated Go view Escherichia coli TW14588 (EHEC) BBK-0002564 CDS
Person Approved Go view Shigella boydii 227 ADV-0003670 yhfM CDS
Automated Process Uncurated Go view Shigella boydii BS512 ADJ-0009167 CDS
Person Uncurated Go view Shigella flexneri 2457T ABQ-0075688 frlA pseudogene
Person Approved Go view Shigella sonnei 046 ADD-0003816 frlA CDS
Experimental to toptop
SelectSetNameSetDetailsNotes
stringent responsetranscriptional profile of the stringent responseNone
Recombinant heat-shock dataexpression data for recombinant strain under heat shockThese data are from the Harcum laboratory. (Jeremy Glasner)
Suppressor tRNA expressionexperiment comparing transcript levels in cells with and without suppressor tRNA expressionThese data were reported in the paper: Herring and Blattner. 2004. Global transcriptional effects of a suppressor tRNA and the inactivation of the regulator frmR. J. Bacteriol. 186(20):6714-20. Link to Abstract (Jeremy Glasner)
Recombinant E. coli expressionexperiment comparing expression of wild-type E. coli with the same strain harboring a plasmid that expresses protein when induced with IPTG These data were reported in the paper: F. T. Haddadin, S. W. Harcum (2005) Transcriptome profiles for high-cell-density recombinant and wild-type Escherichia coli, Biotechnology and Bioengineering, 90:127-153. Link to Abstract (Jeremy Glasner)
Aerobic shiftAerobic shiftThese data were reported in the paper: Covert MW, Knight EM, Reed JL, Herrgard MJ, Palsson BO. 2004. Integrating high-throughput and computational data elucidates bacterial networks. Nature. 2004 May 6;429(6987):92-6. Link to Abstract (Jeremy Glasner)
CalibratorCalibrated microarray experiments (50 hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
AffyData1Affymetrix Experiments (data from 41 chip hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
Strains to toptop

Strains with mutations in this feature.

Strain NameStrain TypeStrain InformationStrain RequestFeatureIDNameMutation DetailsExperiments Using StrainSubmitter
FB21138mutantTn5 InsertionRequest the StrainABE-0011019frlAyhfM::Tn5KAN-I-SceI at position 469 in Plus orientation ,- pKD465Blattner Laboratory
FB21139mutantTn5 InsertionRequest the StrainABE-0011019frlAyhfM::Tn5KAN-I-SceI at position 469 in Plus orientation ,+ pKD460Blattner Laboratory
Context Table to toptop

Listed below are features that lie nearby this feature. Features encoded in multiple intervals may appear more than once in the table. Features that span the origin will have a left endpoint greater than the right endpoint.

Features overlapping the region 3494910 to 3506247
FeatureIDNameFeature TypeStrandLeft EndRight EndRelationship
ABE-0000001sourceforward14641652Contains
ABE-0011003nirBCDSforward34940113496554Upstream
ABE-0011005nirDCDSforward34965513496877Upstream
ABE-0011008nirCCDSforward34970033497809Upstream
ABE-0011010cysGCDSforward34978283499201Upstream
ABE-0011016yhfLCDSforward34994483499615Upstream
ABE-0011019frlACDSforward34999103501247Matches
ABE-0011021frlBCDSforward35012683502290Downstream
ABE-0174114frlCCDSforward35023403503170Downstream
ABE-0011029frlDCDSforward35031673503952Downstream
ABE-0011031frlRCDSforward35040523504783Downstream
ABE-0285599repeat_regionforward35047863504821Downstream
ABE-0011035yhfSCDScomplement35049353506020Downstream
ABE-0011037yhfTCDScomplement35060323507336Downstream
Release Notes to toptop
All MG1655 annotations and sequence data are publicly available, and investigators can use these data in publications without contacting the genome curators. This version of the sequence was the source of GenBank record U00096.3. Ongoing annotation updates to that GenBank record are being generated from a collaboration that includes ASAP, EcoGene, the Coli Genetic Stock Center, EcoliHub, EcoCyc, RegulonDB and UniProtKB/Swiss-Prot.