Escherichia coli K-12 MG1655
Working With: Genome: Escherichia coli K-12 MG1655 Version: v3

ABE-0011650 (xylH) - Escherichia coli K-12 MG1655 - Feature Annotation

ASAP ID
ABE-0011650 showshow history
Names
xylH JW3540 ECK3557 b3568
Product
membrane component of an ABC superfamily D-xylose transporter
Type
CDS
Location
# Contig Strand Left Right Length (b.p.) Length (a.a.)
1 Chromosome forward 3733720 3734901 1182 394
Sequence

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View sequence with flanking regions: bases upstream and bases downstream

Context

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Protein Families to toptop
Author Approval Family Annotated
Automated Process Approved IPR001851 (IPR001851 ABC transporter, permease) Apr 2008
Automated Process Approved PF02653 (PF02653 Branched-chain amino acid transport system / permease component) Jul 2018
Gene Ontology to toptop
Author Approval Type Annotation Evidence Annotated
Person Uncurated GO biological process GO:0016052 carbohydrate catabolic process Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Uncurated GO biological process GO:0055085 transmembrane transport GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR001851
Reference: Escherichia coli K-12 MG1655
Jul 2018
Automated Process Approved GO biological process GO:0006810 transport GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR001851
Reference: Escherichia coli K-12 MG1655
Apr 2008
Automated Process Approved GO cellular component GO:0016020 membrane GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR001851
Reference: Escherichia coli K-12 MG1655
Apr 2008
Person Uncurated GO cellular component GO:0019866 organelle inner membrane Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Uncurated GO cellular component GO:0005886 plasma membrane GO Inferred from Electronic Annotation - PubMed ID: 15501914
Reference: Escherichia coli K-12 MG1655
Feb 2008
Automated Process Uncurated GO molecular function GO:0022857 transmembrane transporter activity GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR001851
Reference: Escherichia coli K-12 MG1655
Jul 2018
Automated Process Approved GO molecular function GO:0005215 transporter activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR001851
Reference: Escherichia coli K-12 MG1655
Apr 2008
Annotations to toptop
Author Approval Type Annotation Evidence Annotated
Nomenclature
Person Approved name xylH Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655
Oct 1998
Person Approved synonym JW3540 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved synonym ECK3557 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved locus tag b3568 Unique Identifier - Origin: Guy Plunkett III, guy@genome.wisc.edu May 2004
Product
Person Approved product membrane component of an ABC superfamily D-xylose transporter Published Annotation - PubMed ID: 16397293
Reference: Escherichia coli K-12
Mar 2008
Person Uncurated alternate product name D-xylose transport permease (ABC superfamily, membrane) Published Annotation - Database Name: GenProtEC Jan 2006
Person Approved alternate product name putative xylose transport, membrane component Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655
Jan 2006
Automated Process Approved alternate product name D-xylose ABC transporter permease subunit Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655
Oct 2013
Protein Family
Automated Process Approved protein family PF02653 Branched-chain amino acid transport system / permease component Protein Sequence Similarity - PFAM Model Name: PF02653
Reference: Escherichia coli K-12 MG1655
Jul 2018
Automated Process Approved protein family IPR001851 ABC transporter, permease Protein Sequence Similarity - InterPro Domain: IPR001851
Reference: Escherichia coli K-12 MG1655
Apr 2008
Other
Person Approved EC number 3.6.3.17 Published Annotation - Swiss-Prot Accession Number: P0AGI4 Feb 2006
Person Uncurated MultiFun 4.3.A.1.m (transport; Primary Active Transporters; Pyrophosphate Bond (ATP, GTP, P2) Hydrolysis-driven Active Transporters; The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases; ABC superfamily, membrane component) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Person Uncurated MultiFun 6.1 (cell structure; membrane) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Person Uncurated MultiFun 4.S.50 (transport; substrate; D-xylose) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Person Uncurated MultiFun 1.1.1 (metabolism; carbon utilization; carbon compounds) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Person Uncurated MultiFun 7.3 (location of gene products; inner membrane) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Automated Process Approved codon start 1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655
Oct 2013
Automated Process Approved db xref GI:1789992 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655
Oct 2013
Automated Process Approved db xref GeneID:948083 Published Annotation - Entrez Gene Database ID: 948083
Reference: Escherichia coli K-12 MG1655
Jun 2009
Automated Process Approved db xref UniProtKB/Swiss-Prot:P0AGI4 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655
Oct 2013
Automated Process Approved db xref ASAP:ABE-0011650 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655
Oct 2013
Automated Process Approved db xref EcoGene:EG12276 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655
Oct 2013
Person Approved db xref UniProtKB:P0AGI4 Published Annotation - Swiss-Prot Accession Number: P0AGI4 Jan 2006
Person Approved function putative transport; Not classified Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655
Oct 1998
Automated Process Approved note putative xylose transport, membrane component; membrane component of ABC superfamily; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane; GO_process: GO:0016052 - carbohydrate catabolic process Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655
Oct 2013
Automated Process Approved protein id AAC76592.1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655
Oct 2013
Automated Process Uncurated subcellular localization Cytoplasmic Membrane Predicted by PSORTb - PSORTb Final_Score: 10.00
Reference: Escherichia coli K-12 MG1655
Feb 2008
Person Uncurated subsystem component of in silico model iAF1260 Experimental - PubMed ID: 17593909
Reference: Escherichia coli K-12 MG1655
Jan 2009
Person Uncurated subsystem component of in silico model iMC1010 Experimental - PubMed ID: 15129285
Reference: Escherichia coli K-12 MG1655
Mar 2009
Person Uncurated subsystem component of in silico model iJR904 Experimental - PubMed ID: 12952533
Reference: Escherichia coli K-12 MG1655
Feb 2009
Automated Process Approved transl table 11 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655
Oct 2013
Gene Ontology
Person Uncurated GO biological process GO:0016052 carbohydrate catabolic process Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Uncurated GO biological process GO:0055085 transmembrane transport GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR001851
Reference: Escherichia coli K-12 MG1655
Jul 2018
Automated Process Approved GO biological process GO:0006810 transport GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR001851
Reference: Escherichia coli K-12 MG1655
Apr 2008
Person Uncurated GO cellular component GO:0019866 organelle inner membrane Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Approved GO cellular component GO:0016020 membrane GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR001851
Reference: Escherichia coli K-12 MG1655
Apr 2008
Automated Process Uncurated GO cellular component GO:0005886 plasma membrane GO Inferred from Electronic Annotation - PubMed ID: 15501914
Reference: Escherichia coli K-12 MG1655
Feb 2008
Automated Process Uncurated GO molecular function GO:0022857 transmembrane transporter activity GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR001851
Reference: Escherichia coli K-12 MG1655
Jul 2018
Automated Process Approved GO molecular function GO:0005215 transporter activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR001851
Reference: Escherichia coli K-12 MG1655
Apr 2008
Comparative to toptop
Author Approval Details Genome Feature Name Type
Member
Automated Process Uncurated Go view OrthoMCL (14 enterobacteria) AMM-0002086 CDS
Automated Process Uncurated Go view OrthoMCL (205 gammaproteobacteria) APP-0002604 xylH CDS
Automated Process Uncurated Go view OrthoMCL (307 Enterobacteriaceae) ATM-0002566 xylH CDS
Automated Process Uncurated Go view OrthoMCL (42 Serratia) BEZ-0003720 xylH CDS
Automated Process Uncurated Go view OrthoMCL (UW draft) CQJ-0002765 xylH CDS
Ortholog
Automated Process Uncurated Go view Brenneria sp. EniD312 AKG-0001075 CDS
Automated Process Uncurated Go view Buttiauxella agrestis ATCC 33320 [T] APC-0004208 CDS
Automated Process Uncurated Go view Cedecea davisae ATCC 33431 [T] ALZ-0004220 CDS
Automated Process Approved Go view Citrobacter amalonaticus ATCC 25405 [T] AUW-0000200 rbsC_1 CDS
Automated Process Uncurated Go view Dickeya chrysanthemi Ech1591 AFK-0004455 CDS
Person Uncurated Go view Dickeya dadantii 3937 ABF-0016099 xylH CDS
Automated Process Uncurated Go view Dickeya parazeae Ech586 AGC-0004175 CDS
Automated Process Uncurated Go view Escherichia coli 101-1 (EAEC) BAB-0004735 xylH CDS
Automated Process Approved Go view Escherichia coli 536 (UPEC) AEF-0003710 CDS
Automated Process Uncurated Go view Escherichia coli 53638 (EIEC) ADP-0007503 xylH CDS
Automated Process Approved Go view Escherichia coli APEC O1 (APEC) AEG-0003629 xylH CDS
Automated Process Approved Go view Escherichia coli ATCC 11775 [T] AMC-0000607 CDS
Automated Process Approved Go view Escherichia coli ATCC 8739 AEM-0005484 CDS
Automated Process Uncurated Go view Escherichia coli B171 (EPEC) ADN-0006972 xylH CDS
Automated Process Uncurated Go view Escherichia coli B7A (ETEC) ADK-0005284 CDS
Person Approved Go view Escherichia coli CFT073 (UPEC) ABR-0080565 xylH CDS
Automated Process Uncurated Go view Escherichia coli DEC7E (UM-IGS draft) CFX-0004077 CDS
Automated Process Uncurated Go view Escherichia coli DEC9A (UM-IGS draft) CFY-0005064 xylH CDS
Automated Process Uncurated Go view Escherichia coli E110019 (EPEC) ADM-0006896 xylH CDS
Automated Process Uncurated Go view Escherichia coli E22 (EPEC) ADL-0005151 xylH CDS
Automated Process Approved Go view Escherichia coli E2348/69 (EPEC) BCI-0004064 xylH CDS
Automated Process Approved Go view Escherichia coli E24377A (ETEC) ADO-0008497 xylH CDS
Automated Process Uncurated Go view Escherichia coli EC4024 (EHEC) BBI-0004893 CDS
Automated Process Uncurated Go view Escherichia coli EC4042 (EHEC) BBA-0008275 xylH CDS
Automated Process Uncurated Go view Escherichia coli EC4045 (EHEC) BBB-0006790 xylH CDS
Automated Process Uncurated Go view Escherichia coli EC4076 (EHEC) BAZ-0006337 xylH CDS
Automated Process Uncurated Go view Escherichia coli EC4113 (EHEC) BAY-0005089 xylH CDS
Automated Process Approved Go view Escherichia coli EC4115 (EHEC) BAS-0009778 xylH CDS
Automated Process Uncurated Go view Escherichia coli EC4196 (EHEC) BAX-0005171 xylH CDS
Automated Process Uncurated Go view Escherichia coli EC4206 (EHEC) BAW-0007590 xylH CDS
Automated Process Uncurated Go view Escherichia coli EC4401 (EHEC) BAV-0005375 xylH CDS
Automated Process Uncurated Go view Escherichia coli EC4486 (EHEC) BAU-0005440 xylH CDS
Automated Process Uncurated Go view Escherichia coli EC4501 (EHEC) BAT-0005282 xylH CDS
Automated Process Uncurated Go view Escherichia coli EC508 (EHEC) BBJ-0005169 xylH CDS
Automated Process Uncurated Go view Escherichia coli EC869 (EHEC) BBC-0005768 xylH CDS
Person Approved Go view Escherichia coli EDL933 (EHEC) ABH-0028638 xylH CDS
Automated Process Approved Go view Escherichia coli F11 (UPEC) ADQ-0005380 xylH CDS
Automated Process Approved Go view Escherichia coli HS ADR-0008460 xylH CDS
Automated Process Uncurated Go view Escherichia coli J96 (UPEC) CQK-0004291 CDS
Person Uncurated Go view Escherichia coli K-12 DH10B AEC-0003324 xylH CDS
Person Approved Go view Escherichia coli K-12 W3110 ADY-0003797 xylH CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR68 CGA-0004222 CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR71 CGB-0004222 CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR8 CFZ-0004041 CDS
Automated Process Uncurated Go view Escherichia coli Nissle 1917 AML-0004099 CDS
Automated Process Uncurated Go view Escherichia coli RS218 (NMEC) ACK-0178244 CDS
Automated Process Approved Go view Escherichia coli SE11 AFS-0003915 CDS
Automated Process Approved Go view Escherichia coli SMS-3-5 AFT-0003888 xylH CDS
Person Approved Go view Escherichia coli Sakai (EHEC) ACA-0134524 xylH CDS
Automated Process Uncurated Go view Escherichia coli TW14588 (EHEC) BBK-0002816 CDS
Automated Process Approved Go view Escherichia coli UTI89 (UPEC) AEA-0004118 xylH CDS
Person Uncurated Go view Klebsiella pneumoniae subsp. pneumoniae MGH 78578 AEP-0003980 xylH CDS
Automated Process Uncurated Go view Leclercia adecarboxylata ATCC 23216 [T] AME-0002583 CDS
Automated Process Uncurated Go view Musicola paradisiaca Ech703 AGA-0004450 CDS
Automated Process Uncurated Go view Pantoea agglomerans IG1 APM-0003146 CDS
Automated Process Uncurated Go view Pantoea agglomerans SL1-M5 ALY-0003335 CDS
Automated Process Uncurated Go view Pantoea ananatis AJ13355 AOV-0003282 xylH CDS
Automated Process Uncurated Go view Pantoea ananatis B1-9 APL-0000710 CDS
Automated Process Uncurated Go view Pantoea ananatis LMG 20103 AKB-0000043 xylH CDS
Automated Process Uncurated Go view Pantoea ananatis PA13 APK-0000049 CDS
Automated Process Uncurated Go view Pantoea sp. At-9b AGM-0007817 CDS
Automated Process Uncurated Go view Pantoea sp. aB AJV-0003485 CDS
Automated Process Uncurated Go view Pantoea stewartii DC283 ACV-0287098 xylH CDS
Automated Process Uncurated Go view Pantoea vagans C9-1 ALK-0007035 xylH CDS
Person Uncurated Go view Pectobacterium atrosepticum SCRI1043 ABL-0060301 xylH CDS
Automated Process Uncurated Go view Pectobacterium brasiliensis 1692 AED-0000072 xylH CDS
Person Uncurated Go view Pectobacterium carotovorum WPP14 ADT-0001238 xylH CDS
Automated Process Uncurated Go view Pectobacterium parmentieri WPP163 AFJ-0000209 xylH CDS
Automated Process Uncurated Go view Pectobacterium sp. PC1 AFL-0009461 CDS
Person Uncurated Go view Pseudomonas syringae pv. tomato DC3000 ADG-0003054 xylH CDS
Person Approved Go view Shigella boydii 227 ADV-0003903 xylH CDS
Automated Process Approved Go view Shigella boydii BS512 ADJ-0009375 xylH CDS
Automated Process Uncurated Go view Shigella dysenteriae 1012 BAA-0003163 xylH CDS
Person Approved Go view Shigella flexneri 2457T ABQ-0075442 xylH CDS
Person Approved Go view Shigella flexneri 301 ABT-0089836 xylH CDS
Person Uncurated Go view Trabulsiella guamensis ATCC 49490 [T] APH-0003404 CDS
Automated Process Uncurated Go view Yersinia bercovieri ATCC 43970 [T] AEK-0000163 CDS
Automated Process Uncurated Go view Yersinia enterocolitica 8081 BAH-0011875 CDS
Automated Process Uncurated Go view Yersinia frederiksenii ATCC 33641 [T] AEI-0002360 xylH CDS
Automated Process Uncurated Go view Yersinia intermedia ATCC 29909 [T] AEH-0002644 xylH CDS
Automated Process Uncurated Go view Yersinia mollaretii ATCC 43969 [T] AEJ-0000689 CDS
Person Uncurated Go view Yersinia pestis 91001 (biovar Microtus) ACQ-0242472 araH12 CDS
Automated Process Uncurated Go view Yersinia pestis Angola (biovar Pestoides) ADI-0008283 CDS
Automated Process Uncurated Go view Yersinia pestis Antiqua (biovar Antiqua) BAE-0004917 CDS
Automated Process Uncurated Go view Yersinia pestis B42003004 (biovar Antiqua) BAL-0007264 CDS
Automated Process Uncurated Go view Yersinia pestis CA88-4125 (biovar Orientalis) BAF-0003366 CDS
Person Uncurated Go view Yersinia pestis CO92 (biovar Orientalis) ABY-0128920 CDS
Automated Process Uncurated Go view Yersinia pestis E1979001 (biovar Antiqua) BAM-0005829 CDS
Automated Process Uncurated Go view Yersinia pestis F1991016 (biovar Orientalis) BAQ-0007201 CDS
Automated Process Uncurated Go view Yersinia pestis FV-1 (biovar Orientalis) BAK-0001876 CDS
Automated Process Uncurated Go view Yersinia pestis IP275 (biovar Orientalis) BAC-0006147 CDS
Automated Process Uncurated Go view Yersinia pestis K1973002 (biovar Mediaevalis) BAO-0006932 CDS
Person Uncurated Go view Yersinia pestis KIM (biovar Mediaevalis) ABI-0033853 xylH CDS
Automated Process Uncurated Go view Yersinia pestis MG05-1020 (biovar Orientalis) BAP-0006721 CDS
Automated Process Uncurated Go view Yersinia pestis Nepal516 (biovar Antiqua) BAD-0004424 CDS
Automated Process Uncurated Go view Yersinia pestis Pestoides F (biovar Pestoides) BAI-0004537 CDS
Automated Process Uncurated Go view Yersinia pestis UG05-0454 (biovar Antiqua) BAN-0007866 CDS
Automated Process Uncurated Go view Yersinia pseudotuberculosis IP31758 ADS-0008138 CDS
Person Uncurated Go view Yersinia pseudotuberculosis IP32953 ACZ-0004008 xylH CDS
Automated Process Uncurated Go view Yersinia pseudotuberculosis PB1/+ AFV-0004880 CDS
Automated Process Uncurated Go view Yersinia pseudotuberculosis YPIII AFW-0000073 CDS
Automated Process Uncurated Go view Yokenella regensburgei ATCC 43003 APO-0004656 CDS
Automated Process Uncurated Go view Yokenella regensburgei ATCC 49455 [T] AMG-0001148 CDS
Experimental to toptop
SelectSetNameSetDetailsNotes
stringent responsetranscriptional profile of the stringent responseNone
Recombinant heat-shock dataexpression data for recombinant strain under heat shockThese data are from the Harcum laboratory. (Jeremy Glasner)
Suppressor tRNA expressionexperiment comparing transcript levels in cells with and without suppressor tRNA expressionThese data were reported in the paper: Herring and Blattner. 2004. Global transcriptional effects of a suppressor tRNA and the inactivation of the regulator frmR. J. Bacteriol. 186(20):6714-20. Link to Abstract (Jeremy Glasner)
Recombinant E. coli expressionexperiment comparing expression of wild-type E. coli with the same strain harboring a plasmid that expresses protein when induced with IPTG These data were reported in the paper: F. T. Haddadin, S. W. Harcum (2005) Transcriptome profiles for high-cell-density recombinant and wild-type Escherichia coli, Biotechnology and Bioengineering, 90:127-153. Link to Abstract (Jeremy Glasner)
Aerobic shiftAerobic shiftThese data were reported in the paper: Covert MW, Knight EM, Reed JL, Herrgard MJ, Palsson BO. 2004. Integrating high-throughput and computational data elucidates bacterial networks. Nature. 2004 May 6;429(6987):92-6. Link to Abstract (Jeremy Glasner)
CalibratorCalibrated microarray experiments (50 hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
AffyData1Affymetrix Experiments (data from 41 chip hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)

Strains to toptop

Strains with mutations in this feature.

Strain NameStrain TypeStrain InformationStrain RequestFeatureIDNameMutation DetailsExperiments Using StrainSubmitter
FB21293mutantTn5 InsertionRequest the StrainABE-0011650xylHxylH::Tn5KAN-I-SceI at position 938 in Plus orientation ,- pKD465Blattner Laboratory
FB23526mutantTn5 InsertionRequest the StrainABE-0011650xylHxylH::Tn5KAN-I-SceI at position 938 in Plus orientation ,+ pKD460Blattner Laboratory
Context Table to toptop

Listed below are features that lie nearby this feature. Features encoded in multiple intervals may appear more than once in the table. Features that span the origin will have a left endpoint greater than the right endpoint.

Features overlapping the region 3728720 to 3739901
FeatureIDNameFeature TypeStrandLeft EndRight EndRelationship
ABE-0000001sourceforward14641652Contains
ABE-0011637xylBCDScomplement37279173729371Upstream
ABE-0285848xylZncRNAcomplement37293863729545Upstream
ABE-0011639xylACDScomplement37294433730765Upstream
ABE-0011646xylFCDSforward37311313732123Upstream
ABE-0011648xylGCDSforward37322013733742Overlaps Upstream
ABE-0011650xylHCDSforward37337203734901Matches
ABE-0011652xylRCDSforward37349793736157Downstream
ABE-0285620repeat_regionforward37361543736324Downstream
ABE-0011655baxCDScomplement37363533737177Downstream
ABE-0285772baxLCDScomplement37371773737203Downstream
ABE-0011668malSCDSforward37374973739527Downstream
ABE-0011671avtACDSforward37397053740958Downstream
Release Notes to toptop
All MG1655 annotations and sequence data are publicly available, and investigators can use these data in publications without contacting the genome curators. This version of the sequence was the source of GenBank record U00096.3. Ongoing annotation updates to that GenBank record are being generated from a collaboration that includes ASAP, EcoGene, the Coli Genetic Stock Center, EcoliHub, EcoCyc, RegulonDB and UniProtKB/Swiss-Prot.