Escherichia coli K-12 MG1655
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Working With: Genome: Escherichia coli K-12 MG1655 Version: v3

ABE-0013530 (cadB) - Escherichia coli K-12 MG1655 - Feature Annotation

ASAP ID
ABE-0013530 showshow history
Names
cadB JW4093 ECK4126 b4132
Product
lysine:cadaverine antiporter
Type
CDS
Location
# Contig Strand Left Right Length (b.p.) Length (a.a.)
1 Chromosome complement 4358697 4360031 1335 445
Sequence

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View sequence with flanking regions: bases upstream and bases downstream

Context

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Protein Families to toptop
Author Approval Family Annotated
Automated Process Approved IPR004754 (IPR004754 Amino acid antiporter) Apr 2008
Automated Process Approved IPR002293 (IPR002293 Amino acid/polyamine transporter I) Apr 2008
Automated Process Approved IPR004841 (IPR004841 Amino acid permease/ SLC12A domain) Apr 2008
Automated Process Approved PF13520 (PF13520 Amino acid permease) Jul 2018
Gene Ontology to toptop
Author Approval Type Annotation Evidence Annotated
Person Uncurated GO biological process GO:0009089 lysine biosynthetic process via diaminopimelate Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Uncurated GO biological process GO:0055085 transmembrane transport GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR002293
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved GO biological process GO:0006810 transport GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR004841
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO biological process GO:0006865 amino acid transport GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR004754
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO cellular component GO:0016020 membrane GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR002293
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO cellular component GO:0016021 integral component of membrane GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR004754
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO cellular component GO:0005886 plasma membrane GO Inferred from Electronic Annotation - PubMed ID: 15501914
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Person Uncurated GO cellular component GO:0019866 organelle inner membrane Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Uncurated GO molecular function GO:0022857 transmembrane transporter activity GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR002293
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved GO molecular function GO:0005279 (DEPRECATED) amino acid-polyamine transporter activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR004754
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO molecular function GO:0015171 amino acid transmembrane transporter activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR002293
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Annotations to toptop
Author Approval Type Annotation Evidence Annotated
Nomenclature
Person Approved name cadB Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Oct 1998
Person Approved synonym ECK4126 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved synonym JW4093 Published Annotation - PubMed ID: 16397293 Jan 2006
Person Approved locus tag b4132 Unique Identifier - Origin: Guy Plunkett III, guy@genome.wisc.edu May 2004
Product
Person Uncurated product lysine:cadaverine antiporter Published Annotation - EcoCyc Accession Number: EG10132
Reference: Escherichia coli K-12 MG1655 		Oct 2021
Person Uncurated alternate product name lysine/cadaverine transport protein (APC family) Published Annotation - Database Name: GenProtEC Jan 2006
Person Approved alternate product name transport of lysine/cadaverine Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Jan 2006
Person Approved alternate product name predicted lysine/cadaverine transporter Published Annotation - PubMed ID: 16397293 Jan 2006
Protein Family
Automated Process Approved protein family IPR004754 Amino acid antiporter Protein Sequence Similarity - InterPro Domain: IPR004754
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family IPR004841 Amino acid permease/ SLC12A domain Protein Sequence Similarity - InterPro Domain: IPR004841
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved protein family PF13520 Amino acid permease Protein Sequence Similarity - PFAM Model Name: PF13520
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved protein family IPR002293 Amino acid/polyamine transporter I Protein Sequence Similarity - InterPro Domain: IPR002293
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Other
Person Uncurated MultiFun 4.2.A.3 (transport; Electrochemical potential driven transporters; Porters (Uni-, Sym- and Antiporters); The Amino Acid-Polyamine-Choline (APC) Family) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Person Uncurated MultiFun 1.5.1.7 (metabolism; building block biosynthesis; amino acids; lysine, diaminopimelate) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Person Uncurated MultiFun 6.1 (cell structure; membrane) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Person Uncurated MultiFun 4.S.26 (transport; substrate; cadaverine/lysine) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Person Uncurated MultiFun 7.3 (location of gene products; inner membrane) Published Annotation - MultiFun Database Name: MultiFun Feb 2002
Automated Process Approved codon start 1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref ASAP:ABE-0013530 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref EcoGene:EG10132 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Person Approved db xref UniProtKB:P0AAE8 Published Annotation - Swiss-Prot Accession Number: P0AAE8 Jan 2006
Automated Process Approved db xref UniProtKB/Swiss-Prot:P0AAE8 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref GI:1790575 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved db xref GeneID:948654 Published Annotation - Entrez Gene Database ID: 948654
Reference: Escherichia coli K-12 MG1655 		Jun 2009
Person Approved function transport; Transport of small molecules: Amino acids, amines Published Annotation - GenBank Accession Number: U00096
Reference: Escherichia coli MG1655 		Oct 1998
Automated Process Approved note transport of lysine/cadaverine; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane; GO_process: GO:0009089 - lysine biosynthetic process via diaminopimelate Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Approved protein id AAC77093.1 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Automated Process Uncurated subcellular localization Cytoplasmic Membrane Predicted by PSORTb - PSORTb Final_Score: 10.00
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Person Uncurated subsystem component of in silico model iJR904 Experimental - PubMed ID: 12952533
Reference: Escherichia coli K-12 MG1655 		Feb 2009
Person Uncurated subsystem component of in silico model iMC1010 Experimental - PubMed ID: 15129285
Reference: Escherichia coli K-12 MG1655 		Mar 2009
Person Uncurated subsystem component of in silico model iAF1260 Experimental - PubMed ID: 17593909
Reference: Escherichia coli K-12 MG1655 		Jan 2009
Automated Process Approved transl table 11 Published Annotation - GenBank Accession Number: U00096.3
Reference: Escherichia coli K-12 MG1655 		Oct 2013
Gene Ontology
Automated Process Uncurated GO biological process GO:0055085 transmembrane transport GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR002293
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved GO biological process GO:0006810 transport GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR004841
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO biological process GO:0006865 amino acid transport GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR004754
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Person Uncurated GO biological process GO:0009089 lysine biosynthetic process via diaminopimelate Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Person Uncurated GO cellular component GO:0019866 organelle inner membrane Ontology Mapping - Source and Dest Ontology: MultiFun to GO Mar 2004
Automated Process Uncurated GO cellular component GO:0005886 plasma membrane GO Inferred from Electronic Annotation - PubMed ID: 15501914
Reference: Escherichia coli K-12 MG1655 		Feb 2008
Automated Process Approved GO cellular component GO:0016020 membrane GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR002293
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO cellular component GO:0016021 integral component of membrane GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR004754
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Uncurated GO molecular function GO:0022857 transmembrane transporter activity GO Inferred from Electronic Annotation - Database Name:Identifier: InterPro2GO: IPR002293
Reference: Escherichia coli K-12 MG1655 		Jul 2018
Automated Process Approved GO molecular function GO:0015171 amino acid transmembrane transporter activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR002293
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Automated Process Approved GO molecular function GO:0005279 (DEPRECATED) amino acid-polyamine transporter activity GO Inferred from Electronic Annotation - Database Name:Identifier: INTERPRO:IPR004754
Reference: Escherichia coli K-12 MG1655 		Apr 2008
Comparative to toptop
Author Approval Details Genome Feature Name Type
Member
Automated Process Uncurated Go view OrthoMCL (14 enterobacteria) AMM-0006907 CDS
Automated Process Uncurated Go view OrthoMCL (205 gammaproteobacteria) APP-0002993 cadB CDS
Automated Process Uncurated Go view OrthoMCL (307 Enterobacteriaceae) ATM-0003072 cadB CDS
Automated Process Uncurated Go view OrthoMCL (42 Serratia) BEZ-0003616 cadB CDS
Automated Process Uncurated Go view OrthoMCL (UW draft) CQJ-0002929 cadB CDS
Ortholog
Automated Process Uncurated Go view Escherichia albertii TW07627 AFX-0001508 CDS
Automated Process Uncurated Go view Escherichia coli 101-1 (EAEC) BAB-0006420 CDS
Automated Process Approved Go view Escherichia coli 536 (UPEC) AEF-0004427 CDS
Automated Process Uncurated Go view Escherichia coli 53638 (EIEC) ADP-0006832 CDS
Automated Process Approved Go view Escherichia coli APEC O1 (APEC) AEG-0004212 cadB CDS
Automated Process Approved Go view Escherichia coli ATCC 11775 [T] AMC-0004669 CDS
Automated Process Approved Go view Escherichia coli ATCC 8739 AEM-0010041 CDS
Automated Process Uncurated Go view Escherichia coli B171 (EPEC) ADN-0006350 CDS
Automated Process Uncurated Go view Escherichia coli B7A (ETEC) ADK-0005730 CDS
Person Approved Go view Escherichia coli CFT073 (UPEC) ABR-0081347 cadB CDS
Automated Process Uncurated Go view Escherichia coli DEC7E (UM-IGS draft) CFX-0004804 CDS
Automated Process Uncurated Go view Escherichia coli DEC9A (UM-IGS draft) CFY-0005403 CDS
Automated Process Uncurated Go view Escherichia coli E110019 (EPEC) ADM-0006222 CDS
Automated Process Uncurated Go view Escherichia coli E22 (EPEC) ADL-0006684 CDS
Automated Process Approved Go view Escherichia coli E2348/69 (EPEC) BCI-0004756 cadB CDS
Automated Process Approved Go view Escherichia coli E24377A (ETEC) ADO-0009124 CDS
Automated Process Uncurated Go view Escherichia coli EC4024 (EHEC) BBI-0003195 CDS
Automated Process Uncurated Go view Escherichia coli EC4042 (EHEC) BBA-0008974 CDS
Automated Process Uncurated Go view Escherichia coli EC4045 (EHEC) BBB-0007488 CDS
Automated Process Uncurated Go view Escherichia coli EC4076 (EHEC) BAZ-0007133 CDS
Automated Process Uncurated Go view Escherichia coli EC4113 (EHEC) BAY-0006191 CDS
Automated Process Approved Go view Escherichia coli EC4115 (EHEC) BAS-0010478 CDS
Automated Process Uncurated Go view Escherichia coli EC4196 (EHEC) BAX-0007148 CDS
Automated Process Uncurated Go view Escherichia coli EC4206 (EHEC) BAW-0008292 CDS
Automated Process Uncurated Go view Escherichia coli EC4401 (EHEC) BAV-0007266 CDS
Automated Process Uncurated Go view Escherichia coli EC4486 (EHEC) BAU-0005843 CDS
Automated Process Uncurated Go view Escherichia coli EC4501 (EHEC) BAT-0006591 CDS
Automated Process Uncurated Go view Escherichia coli EC508 (EHEC) BBJ-0005941 CDS
Automated Process Uncurated Go view Escherichia coli EC869 (EHEC) BBC-0005113 CDS
Person Approved Go view Escherichia coli EDL933 (EHEC) ABH-0029309 cadB CDS
Automated Process Approved Go view Escherichia coli F11 (UPEC) ADQ-0008542 cadB_2 CDS
Automated Process Approved Go view Escherichia coli HS ADR-0009061 CDS
Automated Process Uncurated Go view Escherichia coli J96 (UPEC) CQK-0004744 CDS
Person Uncurated Go view Escherichia coli K-12 DH10B AEC-0003821 cadB CDS
Person Approved Go view Escherichia coli K-12 W3110 ADY-0004222 cadB CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR68 CGA-0004720 CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR71 CGB-0004855 CDS
Automated Process Uncurated Go view Escherichia coli MOD1-ECOR8 CFZ-0004532 CDS
Automated Process Uncurated Go view Escherichia coli Nissle 1917 AML-0004792 cadB CDS
Automated Process Uncurated Go view Escherichia coli RS218 (NMEC) ACK-0178962 cadB CDS
Automated Process Approved Go view Escherichia coli SE11 AFS-0004532 CDS
Automated Process Approved Go view Escherichia coli SMS-3-5 AFT-0004593 CDS
Person Approved Go view Escherichia coli Sakai (EHEC) ACA-0135226 cadB CDS
Automated Process Uncurated Go view Escherichia coli TW14588 (EHEC) BBK-0003388 CDS
Automated Process Approved Go view Escherichia coli UTI89 (UPEC) AEA-0004738 cadB CDS
Person Uncurated Go view Klebsiella pneumoniae subsp. pneumoniae MGH 78578 AEP-0000501 cadB CDS
Automated Process Uncurated Go view Salmonella Agona SL483 BBX-0006884 CDS
Automated Process Uncurated Go view Salmonella Arizonae CDC 346-86 BCD-0000331 CDS
Person Uncurated Go view Salmonella Choleraesuis SC-B67 ADB-0002992 cadB CDS
Automated Process Uncurated Go view Salmonella Dublin CT_02021853 BCB-0007195 CDS
Automated Process Uncurated Go view Salmonella Enteritidis P125109 BCF-0008261 cadB CDS
Automated Process Uncurated Go view Salmonella Gallinarum 287/91 BCG-0007840 cadB CDS
Automated Process Uncurated Go view Salmonella Hadar RI_05P066 BBT-0005955 CDS
Automated Process Uncurated Go view Salmonella Heidelberg SL476 BBV-0007183 CDS
Automated Process Uncurated Go view Salmonella Heidelberg SL486 BBW-0007067 CDS
Automated Process Uncurated Go view Salmonella Javiana GA_MM04042433 BCA-0006990 CDS
Automated Process Uncurated Go view Salmonella Kentucky CDC 191 BBZ-0006550 CDS
Automated Process Uncurated Go view Salmonella Kentucky CVM29188 BBP-0006326 CDS
Automated Process Uncurated Go view Salmonella Newport SL254 BBQ-0007121 CDS
Automated Process Uncurated Go view Salmonella Newport SL317 BBR-0008014 CDS
Automated Process Uncurated Go view Salmonella Paratyphi A AKU_12601 BCH-0000310 CDS
Person Uncurated Go view Salmonella Paratyphi A ATCC 9150 ADA-0000308 cadB CDS
Automated Process Uncurated Go view Salmonella Paratyphi B SPB7 BCC-0000376 CDS
Automated Process Uncurated Go view Salmonella Saintpaul SARA23 BBN-0007363 CDS
Automated Process Uncurated Go view Salmonella Saintpaul SARA29 BBM-0004818 CDS
Automated Process Uncurated Go view Salmonella Schwarzengrund CVM19633 BBO-0006874 CDS
Automated Process Uncurated Go view Salmonella Schwarzengrund SL480 BBY-0007517 CDS
Person Uncurated Go view Salmonella Typhi CT18 ABX-0110951 cadB CDS
Person Uncurated Go view Salmonella Typhi Ty2 ABS-0082010 cadB CDS
Automated Process Uncurated Go view Salmonella Typhimurium 14028S AJR-0003142 cadB CDS
Person Uncurated Go view Salmonella Typhimurium LT2 [T] ABU-0098117 cadB CDS
Automated Process Uncurated Go view Salmonella Virchow SL491 BBS-0006710 CDS
Automated Process Uncurated Go view Salmonella Weltevreden SL484 BBU-0007711 CDS
Automated Process Uncurated Go view Salmonella enterica CVM23701 BBL-0006893 CDS
Automated Process Uncurated Go view Serratia marcescens subsp. marcescens ATCC 13880 [T] AMF-0001919 CDS
Person Uncurated Go view Shigella flexneri 2457T ABQ-0075887 CDS
Person Uncurated Go view Shigella flexneri 301 ABT-0090495 CDS
Automated Process Uncurated Go view Shigella flexneri 8401 BAG-0004557 cadB CDS
Person Uncurated Go view Vibrio cholerae N16961 ADH-0000296 VC0280 CDS
Automated Process Uncurated Go view Yokenella regensburgei ATCC 43003 APO-0007681 CDS
Automated Process Uncurated Go view Yokenella regensburgei ATCC 49455 [T] AMG-0002323 CDS
Experimental to toptop
SelectSetNameSetDetailsNotes
stringent responsetranscriptional profile of the stringent responseNone
Recombinant heat-shock dataexpression data for recombinant strain under heat shockThese data are from the Harcum laboratory. (Jeremy Glasner)
Suppressor tRNA expressionexperiment comparing transcript levels in cells with and without suppressor tRNA expressionThese data were reported in the paper: Herring and Blattner. 2004. Global transcriptional effects of a suppressor tRNA and the inactivation of the regulator frmR. J. Bacteriol. 186(20):6714-20. Link to Abstract (Jeremy Glasner)
Recombinant E. coli expressionexperiment comparing expression of wild-type E. coli with the same strain harboring a plasmid that expresses protein when induced with IPTG These data were reported in the paper: F. T. Haddadin, S. W. Harcum (2005) Transcriptome profiles for high-cell-density recombinant and wild-type Escherichia coli, Biotechnology and Bioengineering, 90:127-153. Link to Abstract (Jeremy Glasner)
Aerobic shiftAerobic shiftThese data were reported in the paper: Covert MW, Knight EM, Reed JL, Herrgard MJ, Palsson BO. 2004. Integrating high-throughput and computational data elucidates bacterial networks. Nature. 2004 May 6;429(6987):92-6. Link to Abstract (Jeremy Glasner)
CalibratorCalibrated microarray experiments (50 hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
AffyData1Affymetrix Experiments (data from 41 chip hybridizations)This data was used in the paper: Allen et al., J. Bacteriol. 185(21):6392-9 (Jeremy Glasner)
Strains to toptop

Strains with mutations in this feature.

Strain NameStrain TypeStrain InformationStrain RequestFeatureIDNameMutation DetailsExperiments Using StrainSubmitter
FB21693mutantTn5 InsertionRequest the StrainABE-0013530cadBcadB::Tn5KAN-I-SceI at position 537 in Minus orientation ,- pKD465Blattner Laboratory
FB21694mutantTn5 InsertionRequest the StrainABE-0013530cadBcadB::Tn5KAN-I-SceI at position 537 in Minus orientation ,+ pKD460Blattner Laboratory
Context Table to toptop

Listed below are features that lie nearby this feature. Features encoded in multiple intervals may appear more than once in the table. Features that span the origin will have a left endpoint greater than the right endpoint.

Features overlapping the region 4353697 to 4365031
FeatureIDNameFeature TypeStrandLeft EndRight EndRelationship
ABE-0000001sourceforward14641652Contains
ABE-0013520lysUCDScomplement43532004354717Downstream
ABE-0013524dtpCCDScomplement43549544356411Downstream
ABE-0013526cadACDScomplement43564704358617Downstream
ABE-0013530cadBCDScomplement43586974360031Matches
ABE-0013532cadCCDScomplement43603964361934Upstream
ABE-0285247yjdQpseudogenecomplement43621944362361Upstream
ABE-0013535pheUtRNAcomplement43625514362626Upstream
ABE-0013537yjdCCDScomplement43627334363308Upstream
ABE-0013539dsbDCDScomplement43633454365042Upstream
ABE-0013544cutACDScomplement43650184365356Upstream
Release Notes to toptop
All MG1655 annotations and sequence data are publicly available, and investigators can use these data in publications without contacting the genome curators. This version of the sequence was the source of GenBank record U00096.3. Ongoing annotation updates to that GenBank record are being generated from a collaboration that includes ASAP, EcoGene, the Coli Genetic Stock Center, EcoliHub, EcoCyc, RegulonDB and UniProtKB/Swiss-Prot.