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Report for CCDS2326.2 (current version)

CCDS Status Species Chrom. Gene CCDS Release NCBI Annotation Release Ensembl Annotation Release Links
2326.2 Public Homo sapiens 2 PLCL1 24 110 108 CCDS HistoryNCBI Gene:5334Re-query CCDS DB by CCDS ID:2326.2Re-query CCDS DB by GeneID:5334See the combined annotation on chromosome 2 in Sequence Viewer

Public Note for CCDS 2326.1
The coding region has been updated to represent an alternative 5' splicing pattern, which results in an extended N-terminus that is more supported by available conservation and protein data. The previous representation was based on the mRNA D42108.1, but this would be a nonsense-mediated mRNA decay (NMD) candidate if the homology-supported upstream AUG start codon (strong Kozak signal) was used, and it is thus unlikely that translation would initiate from the annotated downstream AUG (weaker Kozak signal). There are no full-length mRNAs representing the updated transcript in human, but the updated 5' end is supported by the partial human ESTs DA193701.1 and DB284706.1, and by the full-length rat transcript D45920.1.

Public since: CCDS release 1, NCBI annotation release 35.1, Ensembl annotation release 23

Review status: Reviewed (by RefSeq, Havana and CCDS collaboration)

Sequence IDs included in CCDS 2326.2

Original Current Source Nucleotide ID Protein ID MANE Status in CCDS Seq. Status Links
Original member Current member EBI ENST00000428675.6 ENSP00000402861.1 MANE Select Accepted alive Link to Ensembl Transcript Viewer:ENST00000428675.6Link to Ensembl Protein Viewer:ENSP00000402861.1Re-query CCDS DB by Nucleotide ID:ENST00000428675Re-query CCDS DB by Protein ID:ENSP00000402861
Original member Current member NCBI NM_006226.4 NP_006217.3 MANE Select Accepted alive Link to Nucleotide Sequence:NM_006226.4Link to Protein Sequence:NP_006217.3Re-query CCDS DB by Nucleotide ID:NM_006226Re-query CCDS DB by Protein ID:NP_006217Link to BLAST:NP_006217.3

RefSeq Length Related UniProtKB/SwissProt Length Identity Gaps Mismatches
NP_006217.3 1095 Q15111-1 1095 100% 0 0

Chromosomal Locations for CCDS 2326.2

Assembly GRCh38.p14 (GCF_000001405.40)

On '+' strand of Chromosome 2 (NC_000002.12)
Genome Browser links: Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 2Link to Ensembl Genome Browser on chromosome 2See the combined annotation on chromosome 2 in Sequence Viewer

Chromosome Start Stop Links
2 197805100 197805339 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 2Link to Ensembl Genome Browser on chromosome 2
2 198083758 198086232 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 2Link to Ensembl Genome Browser on chromosome 2
2 198088858 198089061 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 2Link to Ensembl Genome Browser on chromosome 2
2 198101285 198101360 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 2Link to Ensembl Genome Browser on chromosome 2
2 198103827 198103936 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 2Link to Ensembl Genome Browser on chromosome 2
2 198146780 198146962 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 2Link to Ensembl Genome Browser on chromosome 2

CCDS Sequence Data
Blue highlighting indicates alternating exons.
Red highlighting indicates amino acids encoded across a splice junction.
 
Mouse over the nucleotide or protein sequence below and click on the highlighted codon or residue to select the pair.

Nucleotide Sequence (3288 nt):
ATGGCCGAGGGCGCGGCCGGCAGGGAGGATCCGGCGCCGCCCGACGCGGCGGGGGGCGAAGACGACCCCC
GAGTGGGCCCGGATGCCGCCGGGGACTGCGTGACGGCGGCCTCTGGGGGCCGGATGAGGGACCGTCGCAG
CGGGGTCGCACTGCCAGGCGCCGCGGGGACCCCAGCGGACAGCGAGGCGGGCCTCCTGGAGGCAGCACGG
GCGACCCCCCGGCGCAGCAGCATCATCAAGGATCCTTCAAACCAAAAATGTGGTGGAAGAAAGAAAACCG
TGTCTTTCAGCAGCATGCCATCGGAAAAGAAAATTAGCAGTGCAAATGACTGCATCAGCTTCATGCAAGC
TGGCTGTGAGTTGAAGAAAGTCCGGCCAAATTCTCGCATTTACAACCGTTTTTTCACTCTGGACACAGAC
CTTCAAGCTCTTCGCTGGGAACCTTCAAAGAAAGACCTCGAGAAAGCCAAGCTTGATATTTCTGCCATAA
AAGAGATCAGACTGGGGAAAAACACGGAAACATTTAGAAACAATGGCCTTGCTGACCAGATCTGTGAGGA
CTGTGCCTTTTCCATACTCCACGGGGAAAACTATGAGTCTCTGGACCTAGTTGCCAATTCAGCAGATGTG
GCAAACATCTGGGTGTCTGGGTTACGGTACCTGGTTTCTCGAAGTAAGCAGCCTCTTGATTTTATGGAGG
GCAACCAGAACACACCACGGTTCATGTGGTTGAAAACAGTGTTTGAAGCAGCAGATGTTGATGGGAATGG
GATTATGTTGGAAGACACCTCTGTAGAGTTAATAAAACAACTCAACCCTACTCTGAAGGAAGCCAAGATC
AGGTTAAAGTTTAAAGAAATCCAGAAGAGCAAGGAAAAACTAACCACCCGCGTGACCGAAGAGGAATTTT
GTGAAGCTTTTTGTGAACTTTGCACCAGGCCAGAAGTGTATTTCTTACTTGTACAGATATCTAAAAACAA
AGAATATTTGGATGCCAATGATCTCATGCTCTTTTTAGAAGCTGAGCAAGGAGTCACCCATATCACCGAG
GATATATGCTTAGACATCATAAGGAGATACGAACTTTCTGAAGAGGGACGTCAAAAAGGGTTTCTTGCAA
TTGATGGCTTTACCCAGTATTTATTGTCATCAGAATGTGACATTTTTGATCCTGAGCAAAAGAAGGTTGC
CCAAGATATGACCCAGCCATTATCTCACTACTATATCAATGCCTCTCATAACACCTATCTAATAGAAGAC
CAGTTCAGGGGGCCAGCTGACATCAATGGGTACATTAGAGCTTTGAAAATGGGCTGTCGAAGCGTTGAAC
TCGATGTAAGTGATGGTTCAGATAATGAACCAATCCTTTGTAATCGAAATAACATGACAACCCATGTTTC
CTTTCGAAGTGTCATAGAGGTAATAAATAAATTTGCCTTTGTTGCTTCTGAATACCCACTCATTCTTTGC
TTGGGAAATCACTGCTCCTTGCCGCAGCAGAAGGTAATGGCTCAACAGATGAAAAAGGTCTTTGGCAATA
AACTCTATACTGAAGCACCTTTGCCCTCAGAATCCTACCTCCCATCACCAGAAAAATTAAAAAGAATGAT
CATTGTGAAAGGAAAGAAGTTGCCTTCTGATCCAGATGTGTTAGAAGGAGAAGTAACAGATGAAGATGAA
GAAGCTGAAATGTCTCGAAGGATGTCGGTAGATTACAATGGTGAGCAGAAGCAAATCCGACTCTGTAGGG
AGCTCTCTGATTTGGTGTCTATTTGTAAATCTGTTCAATACAGGGATTTTGAACTATCTATGAAAAGCCA
AAACTATTGGGAAATGTGTTCATTTAGTGAAACAGAGGCCAGCCGCATTGCAAATGAGTACCCAGAGGAT
TTTGTTAATTATAATAAGAAGTTCTTATCAAGAATCTATCCAAGTGCCATGAGGATCGATTCCAGTAACT
TGAATCCACAGGACTTTTGGAATTGTGGCTGTCAGATTGTAGCAATGAATTTTCAGACTCCGGGTCCAAT
GATGGACCTTCACACGGGCTGGTTTCTTCAAAACGGGGGATGTGGTTATGTTCTAAGGCCGTCTATAATG
CGAGATGAAGTTTCTTACTTCAGCGCAAATACAAAGGGCATTCTACCTGGGGTGTCTCCTCTAGCTCTTC
ATATCAAGATCATCAGTGGTCAGAATTTCCCAAAGCCCAAGGGAGCTTGTGCCAAAGGGGATGTCATAGA
TCCCTATGTTTGTATAGAGATACACGGAATTCCAGCGGATTGTTCGGAACAAAGAACTAAAACTGTACAG
CAAAACAGTGATAATCCTATTTTTGATGAAACTTTTGAGTTCCAAGTAAACCTACCTGAGCTGGCCATGA
TCCGTTTTGTTGTTCTGGATGATGACTACATTGGGGATGAGTTTATAGGGCAATATACGATACCATTTGA
ATGTTTGCAGCCTGGATATCGGCATGTTCCCCTGCGTTCTTTTGTGGGTGACATCATGGAGCACGTAACC
CTTTTTGTCCACATAGCAATAACTAATCGAAGTGGAGGAGGAAAGGCACAGAAGCGCAGTCTTTCAGTGA
GAATGGGGAAGAAAGTTCGGGAATATACCATGCTCAGGAATATCGGTCTTAAAACCATTGATGACATCTT
TAAAATAGCGGTTCATCCATTACGAGAAGCCATAGATATGAGAGAAAATATGCAGAATGCAATCGTGTCT
ATTAAGGAACTATGTGGACTCCCTCCAATTGCCAGTCTGAAGCAGTGCCTGTTAACTCTGTCATCTCGGC
TCATCACCAGTGACAATACTCCTTCAGTCTCACTTGTGATGAAAGACAGCTTTCCTTACCTGGAGCCTCT
GGGTGCAATTCCAGATGTGCAGAAAAAGATGCTGACTGCTTATGATCTGATGATTCAAGAGAGCCGGTTT
CTCATAGAAATGGCGGACACAGTCCAGGAAAAGATTGTACAGTGTCAGAAAGCAGGGATGGAGTTCCATG
AAGAACTTCATAATTTGGGGGCAAAAGAAGGCTTGAAGGGAAGAAAACTCAACAAAGCAACTGAGAGCTT
TGCTTGGAACATTACAGTATTGAAGGGCCAAGGAGATCTGTTGAAGAATGCCAAGAATGAAGCTATAGAA
AACATGAAGCAGATCCAGCTGGCATGCCTGTCCTGTGGACTGAGTAAAGCCCCCAGCAGCAGTGCTGAGG
CCAAGAGCAAGCGCAGCCTGGAAGCCATAGAGGAGAAGGAAAGTAGTGAGGAGAATGGGAAGCTGTGA

Translation (1095 aa):
MAEGAAGREDPAPPDAAGGEDDPRVGPDAAGDCVTAASGGRMRDRRSGVALPGAAGTPADSEAGLLEAAR
ATPRRSSIIKDPSNQKCGGRKKTVSFSSMPSEKKISSANDCISFMQAGCELKKVRPNSRIYNRFFTLDTD
LQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADV
ANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEAKI
RLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHITE
DICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIED
QFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRSVIEVINKFAFVASEYPLILC
LGNHCSLPQQKVMAQQMKKVFGNKLYTEAPLPSESYLPSPEKLKRMIIVKGKKLPSDPDVLEGEVTDEDE
EAEMSRRMSVDYNGEQKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPED
FVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIM
RDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEIHGIPADCSEQRTKTVQ
QNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVT
LFVHIAITNRSGGGKAQKRSLSVRMGKKVREYTMLRNIGLKTIDDIFKIAVHPLREAIDMRENMQNAIVS
IKELCGLPPIASLKQCLLTLSSRLITSDNTPSVSLVMKDSFPYLEPLGAIPDVQKKMLTAYDLMIQESRF
LIEMADTVQEKIVQCQKAGMEFHEELHNLGAKEGLKGRKLNKATESFAWNITVLKGQGDLLKNAKNEAIE
NMKQIQLACLSCGLSKAPSSSAEAKSKRSLEAIEEKESSEENGKL


Links Key
 Links to:   History report
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 Re-query CCDS DB by:   CCDS ID
  Gene ID
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 Genome Browser Links:   Ensembl Genome Browser
  NCBI Sequence Viewer
  UCSC Genome Browser
  VEGA Genome Browser

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