CHEBI:17158 - methylglyoxal

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ChEBI Name methylglyoxal ChEBI ID CHEBI:17158 Definition A 2-oxo aldehyde derived from propanal. Stars This entity has been manually annotated by the ChEBI Team. Secondary ChEBI IDs CHEBI:6875, CHEBI:11643, CHEBI:14599, CHEBI:25303 Supplier Information ChemicalBook:CB1157969, eMolecules:528934, ZINC000001532681 Download Molfile XML SDF Find compounds which contain this structure Find compounds which resemble this structure Take structure to the Advanced Search Wikipedia License Methylglyoxal (MGO) is the organic compound with the formula CH3C(O)CHO. It is a reduced derivative of pyruvic acid. It is a reactive compound that is implicated in the biology of diabetes. Methylglyoxal is produced industrially by degradation of carbohydrates using overexpressed methylglyoxal synthase. Read full article at Wikipedia Formula C3H4O2 Net Charge 0 Average Mass 72.06266 Monoisotopic Mass 72.02113 InChI InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 InChIKey AIJULSRZWUXGPQ-UHFFFAOYSA-N SMILES [H]C(=O)C(C)=O Metabolite of Species Details Mus musculus (NCBI:txid10090) Source: BioModels - MODEL1507180067 See: PubMed Saccharomyces cerevisiae (NCBI:txid4932) Source: yeast.sf.net See: PubMed Escherichia coli (NCBI:txid562) See: PubMed Homo sapiens (NCBI:txid9606) See: DOI Roles Classification Biological Role(s): Escherichia coli metabolite Any bacterial metabolite produced during a metabolic reaction in Escherichia coli. Saccharomyces cerevisiae metabolite Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae ). human metabolite Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens). mouse metabolite Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus). View more via ChEBI Ontology ChEBI Ontology Outgoing methylglyoxal (CHEBI:17158) has role Escherichia coli metabolite (CHEBI:76971) methylglyoxal (CHEBI:17158) has role Saccharomyces cerevisiae metabolite (CHEBI:75772) methylglyoxal (CHEBI:17158) has role human metabolite (CHEBI:77746) methylglyoxal (CHEBI:17158) has role mouse metabolite (CHEBI:75771) methylglyoxal (CHEBI:17158) is a 2-oxo aldehyde (CHEBI:27659) methylglyoxal (CHEBI:17158) is a propanals (CHEBI:26282) Incoming mitoguazone (CHEBI:43996) has functional parent methylglyoxal (CHEBI:17158) IUPAC Name 2-oxopropanal Synonyms Sources 1,2-propanedione NIST Chemistry WebBook 2-Ketopropionaldehyde KEGG COMPOUND 2-Oxopropanal KEGG COMPOUND 2-oxopropionaldehyde ChemIDplus acetylformaldehyde ChemIDplus acetylformyl NIST Chemistry WebBook α-ketopropionaldehyde NIST Chemistry WebBook CH3COCHO NIST Chemistry WebBook Methylglyoxal KEGG COMPOUND methylglyoxal UniProt Pyruvaldehyde KEGG COMPOUND Pyruvic aldehyde KEGG COMPOUND Manual Xrefs Databases C00007562 KNApSAcK C00546 KEGG COMPOUND Methylglyoxal Wikipedia View more database links Registry Numbers Types Sources 78-98-8 CAS Registry Number ChemIDplus 78-98-8 CAS Registry Number NIST Chemistry WebBook 906750 Reaxys Registry Number Reaxys Citations Last Modified 08 August 2018

General Comment 2011-01-26 Formed endogenously in numerous reactions, it modifies Arg and Lys residues in proteins, forming advanced glycation end-products which are associated with complications of diabetes and some neurodegenerative diseases.