quinolinic acid (CHEBI:16675)

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ChEBI Name	quinolinic acid

ChEBI ID	CHEBI:16675

Definition	A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.

Stars	This entity has been manually annotated by the ChEBI Team.

Secondary ChEBI IDs	CHEBI:26418, CHEBI:44529, CHEBI:8663

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Formula

C7H5NO4

Net Charge

Average Mass

167.11890

Monoisotopic Mass

167.02186

InChI

InChI=1S/C7H5NO4/c9-6(10)4-2-1-3-8-5(4)7(11)12/h1-3H,(H,9,10)(H,11,12)

InChIKey

GJAWHXHKYYXBSV-UHFFFAOYSA-N

SMILES

OC(=O)c1cccnc1C(O)=O

Metabolite of Species	Details
Mus musculus (NCBI:txid10090)	See: PubMed
Mus musculus (NCBI:txid10090)	Source: BioModels - MODEL1507180067 See: PubMed
Escherichia coli (NCBI:txid562)	See: PubMed
Homo sapiens (NCBI:txid9606)	See: PubMed

Roles Classification
Chemical Role(s):	Bronsted acid A molecular entity capable of donating a hydron to an acceptor (Bronsted base). (via oxoacid )

Biological Role(s):	Escherichia coli metabolite Any bacterial metabolite produced during a metabolic reaction in Escherichia coli. NMDA receptor agonist An excitatory amino acid agonist which binds to NMDA receptors and triggers a response. human metabolite Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens). mouse metabolite Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).

Application(s):	NMDA receptor agonist An excitatory amino acid agonist which binds to NMDA receptors and triggers a response.

ChEBI Ontology
Outgoing	quinolinic acid (CHEBI:16675) has role Escherichia coli metabolite (CHEBI:76971) quinolinic acid (CHEBI:16675) has role human metabolite (CHEBI:77746) quinolinic acid (CHEBI:16675) has role mouse metabolite (CHEBI:75771) quinolinic acid (CHEBI:16675) has role NMDA receptor agonist (CHEBI:64571) quinolinic acid (CHEBI:16675) is a pyridinedicarboxylic acid (CHEBI:36112) quinolinic acid (CHEBI:16675) is conjugate acid of quinolinate (CHEBI:132942) quinolinic acid (CHEBI:16675) is conjugate acid of quinolinate(1−) (CHEBI:46828)

Incoming	quinolinate (CHEBI:132942) is conjugate base of quinolinic acid (CHEBI:16675) quinolinate(1−) (CHEBI:46828) is conjugate base of quinolinic acid (CHEBI:16675)

IUPAC Name

pyridine-2,3-dicarboxylic acid

Last Modified

08 August 2016