CHEBI:17997 - dinitrogen

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ChEBI Name dinitrogen
ChEBI ID CHEBI:17997
Definition An elemental molecule consisting of two trivalently-bonded nitrogen atoms.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:43128, CHEBI:7593, CHEBI:13388, CHEBI:14660, CHEBI:25365
Supplier Information ChemicalBook:CB5320664, eMolecules:2726126, Selleckchem:sn-38, ZINC000004099013
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SN-38 is an antineoplastic drug. It is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor) but has 1000 times more activity than irinotecan itself. In vitro cytotoxicity assays show that the potency of SN-38 relative to irinotecan varies from 2- to 2000-fold. SN38 is formed via hydrolysis of irinotecan by carboxylesterases and metabolized via glucuronidation by UGT1A1. The variant of UGT1A1 in ~10% of Caucasians which leads to poor metabolism of SN-38 predicts irinotecan toxicity, as it is then less easily excreted from the body in its SN-38 glucuronide form. SN-38 and its glucuronide are lost into the bile and intestines. It can cause the symptoms of diarrhoea and myelosuppression experienced by ~25% of the patients administered irinotecan.
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Formula N2
Net Charge 0
Average Mass 28.01348
Monoisotopic Mass 28.00615
InChI InChI=1S/N2/c1-2
InChIKey IJGRMHOSHXDMSA-UHFFFAOYSA-N
SMILES N#N
Roles Classification
Biological Role(s): food packaging gas
A food additive that is a (generally inert) gas which is used to envelop foodstuffs during packing and so protect them from unwanted chemical reactions such as food spoilage or oxidation during subsequent transport and storage. The term includes propellant gases, used to expel foods from a container.
food propellant
A propellant that is used to expel foods from an aerosol container.
Application(s): food packaging gas
A food additive that is a (generally inert) gas which is used to envelop foodstuffs during packing and so protect them from unwanted chemical reactions such as food spoilage or oxidation during subsequent transport and storage. The term includes propellant gases, used to expel foods from a container.
food propellant
A propellant that is used to expel foods from an aerosol container.
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ChEBI Ontology
Outgoing dinitrogen (CHEBI:17997) has role food packaging gas (CHEBI:77974)
dinitrogen (CHEBI:17997) has role food propellant (CHEBI:78017)
dinitrogen (CHEBI:17997) is a diatomic nitrogen (CHEBI:33266)
dinitrogen (CHEBI:17997) is a elemental molecule (CHEBI:25362)
dinitrogen (CHEBI:17997) is a gas molecular entity (CHEBI:138675)
dinitrogen (CHEBI:17997) is conjugate base of diazynium (CHEBI:30102)
Incoming diazynium (CHEBI:30102) is conjugate acid of dinitrogen (CHEBI:17997)
IUPAC Name
dinitrogen
Synonyms Sources
molecular nitrogen ChEBI
N2 KEGG COMPOUND
N2 IUPAC
N2 UniProt
N≡N ChEBI
Nitrogen KEGG COMPOUND
Manual Xrefs Databases
4251 DrugCentral
C00697 KEGG COMPOUND
D00083 KEGG DRUG
HDZ PDBeChem
HMDB0001371 HMDB
Nitrogen Wikipedia
NITROGEN-MOLECULE MetaCyc
View more database links
Registry Numbers Types Sources
150 Gmelin Registry Number Gmelin
15940095 Reaxys Registry Number Reaxys
7727-37-9 CAS Registry Number KEGG COMPOUND
7727-37-9 CAS Registry Number NIST Chemistry WebBook
7727-37-9 CAS Registry Number ChemIDplus
Citations Types Sources
18334638 PubMed citation Europe PMC
22237545 PubMed citation Europe PMC
Last Modified
13 October 2017