| Deoxyuridine (dU) is a compound and a nucleoside. It belongs to a class of compounds known as Pyrimidine 2'-deoxyribonucleosides and closely resembles the chemical composition of uridine but without the presence of the 2' hydroxyl group. Idoxuridine and Trifluridine are variants of deoxyuridine used as antiviral drugs. They are similar enough to be incorporated as part of DNA replication, but they possess side groups on the uracil component (an iodine and a CF3 group, respectively), that prevent base pairing. A known use of dU is as a precursor in the synthesis of Edoxudine.
This compound exists in all living organisms and can become part of DNA in both prokaryotic and eukaryotic cells through two mechanisms. The first is the removal of an amino group from cytosine to result in uracil and the second is the non-intentional incorporation of pyrimidine where thymine belongs in the DNA, resulting in dUMP.
UMP synthase deficiency is a metabolic disorder in humans that involves deoxyuridine. Deoxyuridine can be toxic. It has also been found in several foods, which makes it a useful indicator for diseases through consumption of those foods. |
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Homo sapiens
(NCBI:txid9606)
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See:
DOI
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antioxidant
A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
electron donor
A molecular entity that can transfer an electron to another molecular entity.
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human metabolite
Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
food packaging gas
A food additive that is a (generally inert) gas which is used to envelop foodstuffs during packing and so protect them from unwanted chemical reactions such as food spoilage or oxidation during subsequent transport and storage. The term includes propellant gases, used to expel foods from a container.
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fuel
An energy-rich substance that can be transformed with release of usable energy.
food packaging gas
A food additive that is a (generally inert) gas which is used to envelop foodstuffs during packing and so protect them from unwanted chemical reactions such as food spoilage or oxidation during subsequent transport and storage. The term includes propellant gases, used to expel foods from a container.
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View more via ChEBI Ontology
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dihydrogen
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ChEBI
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E 949
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ChEBI
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E-949
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ChEBI
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E949
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ChEBI
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H2
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KEGG COMPOUND
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H2
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IUPAC
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H2
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UniProt
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Hydrogen
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KEGG COMPOUND
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molecular hydrogen
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ChEBI
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1333-74-0
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CAS Registry Number
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KEGG COMPOUND
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1333-74-0
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CAS Registry Number
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ChemIDplus
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1333-74-0
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CAS Registry Number
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NIST Chemistry WebBook
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3
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Gmelin Registry Number
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Gmelin
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3587189
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Reaxys Registry Number
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Reaxys
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15303745
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PubMed citation
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Europe PMC
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16517646
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PubMed citation
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Europe PMC
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18706888
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PubMed citation
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Europe PMC
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19905000
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PubMed citation
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Europe PMC
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19908827
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PubMed citation
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Europe PMC
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20568549
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PubMed citation
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Europe PMC
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24171421
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PubMed citation
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Europe PMC
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