CHEBI:18344 - kynurenic acid

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name kynurenic acid
ChEBI ID CHEBI:18344
Definition A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:20378, CHEBI:1841, CHEBI:14495
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Formula C10H7NO3
Net Charge 0
Average Mass 189.16750
Monoisotopic Mass 189.04259
InChI InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)
InChIKey HCZHHEIFKROPDY-UHFFFAOYSA-N
SMILES OC(=O)c1cc(O)c2ccccc2n1
Metabolite of Species Details
Saccharomyces cerevisiae (NCBI:txid4932) Source: yeast.sf.net See: PubMed
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): Saccharomyces cerevisiae metabolite
Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae ).
G-protein-coupled receptor agonist
An agonist that binds to and activates G-protein-coupled receptors
NMDA receptor antagonist
Any substance that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs.
nicotinic antagonist
An antagonist at the nicotinic cholinergic receptor.
human metabolite
Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
Application(s): nicotinic antagonist
An antagonist at the nicotinic cholinergic receptor.
neuroprotective agent
Any compound that can be used for the treatment of neurodegenerative disorders.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing kynurenic acid (CHEBI:18344) has role Saccharomyces cerevisiae metabolite (CHEBI:75772)
kynurenic acid (CHEBI:18344) has role G-protein-coupled receptor agonist (CHEBI:70998)
kynurenic acid (CHEBI:18344) has role human metabolite (CHEBI:77746)
kynurenic acid (CHEBI:18344) has role neuroprotective agent (CHEBI:63726)
kynurenic acid (CHEBI:18344) has role nicotinic antagonist (CHEBI:48878)
kynurenic acid (CHEBI:18344) has role NMDA receptor antagonist (CHEBI:60643)
kynurenic acid (CHEBI:18344) is a monohydroxyquinoline (CHEBI:38775)
kynurenic acid (CHEBI:18344) is a quinolinemonocarboxylic acid (CHEBI:26512)
kynurenic acid (CHEBI:18344) is conjugate acid of kynurenate (CHEBI:58454)
Incoming 4-hydroxy-8-methoxyquinaldic acid (CHEBI:2323) has functional parent kynurenic acid (CHEBI:18344)
7,8-dihydro-7,8-dihydroxykynurenic acid (CHEBI:17109) has functional parent kynurenic acid (CHEBI:18344)
7,8-dihydroxykynurenic acid (CHEBI:17508) has functional parent kynurenic acid (CHEBI:18344)
kynurenate (CHEBI:58454) is conjugate base of kynurenic acid (CHEBI:18344)
IUPAC Name
4-hydroxyquinoline-2-carboxylic acid
Synonyms Sources
4-Hydroxy-2-chinolincarbonsäure ChEBI
4-Hydroxy-2-quinolinecarboxylic acid KEGG COMPOUND
4-hydroxy-2-quinolinecarboxylic acid ChEBI
4-hydroxyquinaldic acid ChemIDplus
4-hydroxyquinaldinic acid ChemIDplus
Kynurenate KEGG COMPOUND
Kynurenic acid KEGG COMPOUND
Kynurensäure ChEBI
Manual Xrefs Databases
C00026453 KNApSAcK
C00026494 KNApSAcK
C01717 KEGG COMPOUND
HMDB0000715 HMDB
KYA PDBeChem
KYNURENATE MetaCyc
Kynurenic_acid Wikipedia
LSM-24962 LINCS
View more database links
Registry Numbers Types Sources
147451 Reaxys Registry Number Reaxys
147451 Beilstein Registry Number Beilstein
492-27-3 CAS Registry Number KEGG COMPOUND
492-27-3 CAS Registry Number ChemIDplus
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Last Modified
22 April 2016