3-hydroxykynurenamine (CHEBI:27421)

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ChEBI Name	3-hydroxykynurenamine

ChEBI ID	CHEBI:27421

Definition	A hydroxykynurenamine that is kynurenamine carrying a hydroxy group at position 3. It is a metabolite of tryptophan that exhibits antiinflammatory and immunomodulatory properties.

Stars	This entity has been manually annotated by the ChEBI Team.

Secondary ChEBI IDs	CHEBI:1546, CHEBI:20074

Supplier Information	ChemicalBook:CB9204599, ChemicalBook:CB31011930, eMolecules:477227

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Formula

C9H12N2O2

Net Charge

Average Mass

180.207

Monoisotopic Mass

180.08988

InChI

InChI=1S/C9H12N2O2/c10-5-4-7(12)6-2-1-3-8(13)9(6)11/h1-3,13H,4-5,10-11H2

InChIKey

ODOPEICAGBYCFH-UHFFFAOYSA-N

SMILES

NCCC(=O)C1=CC=CC(O)=C1N

Metabolite of Species	Details
Mus musculus (NCBI:txid10090)	Source: BioModels - MODEL1507180067 See: PubMed
Homo sapiens (NCBI:txid9606)	Found in lymph (UBERON:0002391). See: PubMed

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	immunomodulator Biologically active substance whose activity affects or plays a role in the functioning of the immune system. human metabolite Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).

Application(s):	anti-inflammatory agent Any compound that has anti-inflammatory effects. immunomodulator Biologically active substance whose activity affects or plays a role in the functioning of the immune system.

ChEBI Ontology
Outgoing	3-hydroxykynurenamine (CHEBI:27421) has role anti-inflammatory agent (CHEBI:67079) 3-hydroxykynurenamine (CHEBI:27421) has role human metabolite (CHEBI:77746) 3-hydroxykynurenamine (CHEBI:27421) has role immunomodulator (CHEBI:50846) 3-hydroxykynurenamine (CHEBI:27421) is a hydroxykynurenamine (CHEBI:24705) 3-hydroxykynurenamine (CHEBI:27421) is a phenols (CHEBI:33853)

IUPAC Name

3-amino-1-(2-amino-3-hydroxyphenyl)propan-1-one

Synonym	Source
3-hydroxy-kynurenamine	ChEBI

Citations

Last Modified

29 June 2022