CHEBI:15971 - L-histidine

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name L-histidine
ChEBI ID CHEBI:15971
ChEBI ASCII Name L-histidine
Definition The L-enantiomer of the amino acid histidine.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:43239, CHEBI:43114, CHEBI:43190, CHEBI:43048, CHEBI:6240, CHEBI:13117, CHEBI:21324
Supplier Information No supplier information found for this compound.
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Histidine (symbol His or H) is an essential amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated –NH3+ form under biological conditions), a carboxylic acid group (which is in the deprotonated –COO− form under biological conditions), and an imidazole side chain (which is partially protonated), classifying it as a positively charged amino acid at physiological pH. Initially thought essential only for infants, it has now been shown in longer-term studies to be essential for adults also. It is encoded by the codons CAU and CAC. Histidine was first isolated by Albrecht Kossel and Sven Gustaf Hedin in 1896. The name stems from its discovery in tissue, from ἱστός histós "tissue". It is also a precursor to histamine, a vital inflammatory agent in immune responses. The acyl radical is histidyl.
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Formula C6H9N3O2
Net Charge 0
Average Mass 155.15468
Monoisotopic Mass 155.06948
InChI InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1
InChIKey HNDVDQJCIGZPNO-YFKPBYRVSA-N
SMILES N[C@@H](Cc1c[nH]cn1)C(O)=O
Metabolite of Species Details
Mus musculus (NCBI:txid10090) Source: BioModels - MODEL1507180067 See: PubMed
Chlamydomonas reinhardtii (NCBI:txid3055) See: PubMed
Saccharomyces cerevisiae (NCBI:txid4932) See: PubMed
Saccharomyces cerevisiae (NCBI:txid4932) Source: yeast.sf.net See: PubMed
Escherichia coli (NCBI:txid562) See: PubMed
Escherichia coli (NCBI:txid562) See: PubMed
Homo sapiens (NCBI:txid9606) See: DOI
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): micronutrient
Any nutrient required in small quantities by organisms throughout their life in order to orchestrate a range of physiological functions.
algal metabolite
Any eukaryotic metabolite produced during a metabolic reaction in algae including unicellular organisms like chlorella and diatoms to multicellular organisms like giant kelps and brown algae.
mouse metabolite
Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
Saccharomyces cerevisiae metabolite
Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae ).
Escherichia coli metabolite
Any bacterial metabolite produced during a metabolic reaction in Escherichia coli.
human metabolite
Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
metabolite
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
(via histidine )
Application(s): nutraceutical
A product in capsule, tablet or liquid form that provide essential nutrients, such as a vitamin, an essential mineral, a protein, an herb, or similar nutritional substance.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing L-histidine (CHEBI:15971) has role Escherichia coli metabolite (CHEBI:76971)
L-histidine (CHEBI:15971) has role Saccharomyces cerevisiae metabolite (CHEBI:75772)
L-histidine (CHEBI:15971) has role algal metabolite (CHEBI:84735)
L-histidine (CHEBI:15971) has role human metabolite (CHEBI:77746)
L-histidine (CHEBI:15971) has role micronutrient (CHEBI:27027)
L-histidine (CHEBI:15971) has role mouse metabolite (CHEBI:75771)
L-histidine (CHEBI:15971) has role nutraceutical (CHEBI:50733)
L-histidine (CHEBI:15971) is a L-α-amino acid (CHEBI:15705)
L-histidine (CHEBI:15971) is a histidine (CHEBI:27570)
L-histidine (CHEBI:15971) is a proteinogenic amino acid (CHEBI:83813)
L-histidine (CHEBI:15971) is conjugate acid of L-histidinate(1−) (CHEBI:32510)
L-histidine (CHEBI:15971) is conjugate base of L-histidinium(1+) (CHEBI:32513)
L-histidine (CHEBI:15971) is enantiomer of D-histidine (CHEBI:27947)
L-histidine (CHEBI:15971) is tautomer of L-histidine zwitterion (CHEBI:57595)
Incoming α-methyl-L-histidine (CHEBI:189415) has functional parent L-histidine (CHEBI:15971)
Nα-(L-γ-glutamyl)-hercynyl-L-cysteine sulfoxide (CHEBI:83290) has functional parent L-histidine (CHEBI:15971)
Nα-(L-γ-glutamyl)-hercynyl-L-selenocysteine (CHEBI:83292) has functional parent L-histidine (CHEBI:15971)
L-histidine derivative (CHEBI:84076) has functional parent L-histidine (CHEBI:15971)
Ala-Gly-His (CHEBI:73348) has functional parent L-histidine (CHEBI:15971)
Ala-Leu-Leu-His (CHEBI:73365) has functional parent L-histidine (CHEBI:15971)
Ala-Val-Asp-His (CHEBI:73383) has functional parent L-histidine (CHEBI:15971)
Asn-Gly-Pro-His (CHEBI:176851) has functional parent L-histidine (CHEBI:15971)
Asn-His (CHEBI:73424) has functional parent L-histidine (CHEBI:15971)
Asn-Lys-His-His (CHEBI:176852) has functional parent L-histidine (CHEBI:15971)
Asn-Trp-Cys-His (CHEBI:73415) has functional parent L-histidine (CHEBI:15971)
Asp-His (CHEBI:73451) has functional parent L-histidine (CHEBI:15971)
cyclo(L-His-L-Pro) (CHEBI:90039) has functional parent L-histidine (CHEBI:15971)
Cys-Cys-His-His (CHEBI:73456) has functional parent L-histidine (CHEBI:15971)
Cys-Met-Phe-His (CHEBI:138508) has functional parent L-histidine (CHEBI:15971)
Gly-His (CHEBI:73515) has functional parent L-histidine (CHEBI:15971)
His-His (CHEBI:74051) has functional parent L-histidine (CHEBI:15971)
His-Ile (CHEBI:141437) has functional parent L-histidine (CHEBI:15971)
His-Phe (CHEBI:141438) has functional parent L-histidine (CHEBI:15971)
Ile-His (CHEBI:73520) has functional parent L-histidine (CHEBI:15971)
Leu-Asn-His (CHEBI:73530) has functional parent L-histidine (CHEBI:15971)
Phe-His (CHEBI:73634) has functional parent L-histidine (CHEBI:15971)
Ser-His (CHEBI:73651) has functional parent L-histidine (CHEBI:15971)
Thr-Ala-His (CHEBI:73656) has functional parent L-histidine (CHEBI:15971)
Thr-His (CHEBI:73663) has functional parent L-histidine (CHEBI:15971)
Tyr-His (CHEBI:73695) has functional parent L-histidine (CHEBI:15971)
Val-His (CHEBI:73700) has functional parent L-histidine (CHEBI:15971)
L-histidinium(1+) (CHEBI:32513) is conjugate acid of L-histidine (CHEBI:15971)
L-histidinate(1−) (CHEBI:32510) is conjugate base of L-histidine (CHEBI:15971)
D-histidine (CHEBI:27947) is enantiomer of L-histidine (CHEBI:15971)
Nπ-L-histidino group (CHEBI:32516) is substituent group from L-histidine (CHEBI:15971)
Nτ-L-histidino group (CHEBI:32517) is substituent group from L-histidine (CHEBI:15971)
N2-L-histidino group (CHEBI:32515) is substituent group from L-histidine (CHEBI:15971)
L-histidine residue (CHEBI:29979) is substituent group from L-histidine (CHEBI:15971)
L-histidyl group (CHEBI:32514) is substituent group from L-histidine (CHEBI:15971)
L-histidine zwitterion (CHEBI:57595) is tautomer of L-histidine (CHEBI:15971)
IUPAC Names
(2S)-2-amino-3-(1H-imidazol-4-yl)propanoic acid
L-histidine
Synonyms Sources
(S)-4-(2-Amino-2-carboxyethyl)imidazole DrugBank
(S)-α-amino-1H-Imidazole-4-propanoic acid NIST Chemistry WebBook
(S)-alpha-Amino-1H-imidazole-4-propionic acid KEGG COMPOUND
H ChEBI
His ChEBI
HISTIDINE PDBeChem
L-(−)-histidine NIST Chemistry WebBook
L-Histidin ChEBI
L-Histidine KEGG COMPOUND
Manual Xrefs Databases
C00001363 KNApSAcK
C00135 KEGG COMPOUND
D00032 KEGG DRUG
DB00117 DrugBank
ECMDB00177 ECMDB
HIS PDBeChem
HIS MetaCyc
HMDB0000177 HMDB
L-histidine Wikipedia
YMDB00369 YMDB
View more database links
Registry Numbers Types Sources
71-00-1 CAS Registry Number KEGG COMPOUND
71-00-1 CAS Registry Number ChemIDplus
71-00-1 CAS Registry Number NIST Chemistry WebBook
83042 Gmelin Registry Number Gmelin
84088 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
15206581 PubMed citation Europe PMC
21608102 PubMed citation Europe PMC
21719207 PubMed citation Europe PMC
22324399 PubMed citation Europe PMC
22415677 PubMed citation Europe PMC
22517640 PubMed citation Europe PMC
Last Modified
20 January 2022