CHEBI:17544 - hydrogencarbonate

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ChEBI Name hydrogencarbonate
ChEBI ID CHEBI:17544
Definition The carbon oxoanion resulting from the removal of a proton from carbonic acid.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:22863, CHEBI:40961, CHEBI:5589, CHEBI:13363
Supplier Information ChemicalBook:CB1413658, ChemicalBook:CB24796965, ChemicalBook:CB61261439, eMolecules:27677450, eMolecules:474380, ZINC000013550868
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Paracetamol, or acetaminophen, is a non-opioid analgesic and antipyretic agent used to treat fever and mild to moderate pain. It is a widely available over-the-counter drug sold under various brand names, including Tylenol and Panadol. Paracetamol relieves pain in both acute mild migraine and episodic tension headache. At a standard dose, paracetamol slightly reduces fever; it is inferior to ibuprofen in that respect, and the benefits of its use for fever are unclear, particularly in the context of fever of viral origins. The aspirin/paracetamol/caffeine combination also helps with both conditions where the pain is mild and is recommended as a first-line treatment for them. Paracetamol is effective for post-surgical pain, but it is inferior to ibuprofen. The paracetamol/ibuprofen combination provides further increase in potency and is superior to either drug alone. The pain relief paracetamol provides in osteoarthritis is small and clinically insignificant. The evidence in its favor for the use in low back pain, cancer pain, and neuropathic pain is insufficient. In the short term, paracetamol is safe and effective when used as directed. Short term adverse effects are uncommon and similar to ibuprofen, but paracetamol is typically safer than nonsteroidal anti-inflammatory drugs (NSAIDs) for long-term use. Paracetamol is also often used in patients who cannot tolerate NSAIDs like ibuprofen. Chronic consumption of paracetamol may result in a drop in hemoglobin level, indicating possible gastrointestinal bleeding, and abnormal liver function tests. The recommended maximum daily dose for an adult is three to four grams. Higher doses may lead to toxicity, including liver failure. Paracetamol poisoning is the foremost cause of acute liver failure in the Western world, and accounts for most drug overdoses in the United States, the United Kingdom, Australia, and New Zealand. Paracetamol was first made in 1878 by Harmon Northrop Morse or possibly in 1852 by Charles Frédéric Gerhardt. It is the most commonly used medication for pain and fever in both the United States and Europe. It is on the World Health Organization's List of Essential Medicines. Paracetamol is available as a generic medication, with brand names including Tylenol and Panadol among others. In 2022, it was the 114th most commonly prescribed medication in the United States, with more than 5 million prescriptions.
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Formula CHO3
Net Charge -1
Average Mass 61.01684
Monoisotopic Mass 60.99312
InChI InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-1
InChIKey BVKZGUZCCUSVTD-UHFFFAOYSA-M
SMILES OC([O-])=O
Metabolite of Species Details
Mus musculus (NCBI:txid10090) Source: BioModels - MODEL1507180067 See: PubMed
Saccharomyces cerevisiae (NCBI:txid4932) Source: yeast.sf.net See: PubMed
Escherichia coli (NCBI:txid562) See: PubMed
Homo sapiens (NCBI:txid9606) See: DOI
Roles Classification
Biological Role(s): Escherichia coli metabolite
Any bacterial metabolite produced during a metabolic reaction in Escherichia coli.
Saccharomyces cerevisiae metabolite
Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae ).
human metabolite
Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
mouse metabolite
Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
cofactor
An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group).
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ChEBI Ontology
Outgoing hydrogencarbonate (CHEBI:17544) has role Escherichia coli metabolite (CHEBI:76971)
hydrogencarbonate (CHEBI:17544) has role Saccharomyces cerevisiae metabolite (CHEBI:75772)
hydrogencarbonate (CHEBI:17544) has role cofactor (CHEBI:23357)
hydrogencarbonate (CHEBI:17544) has role human metabolite (CHEBI:77746)
hydrogencarbonate (CHEBI:17544) has role mouse metabolite (CHEBI:75771)
hydrogencarbonate (CHEBI:17544) is a carbon oxoanion (CHEBI:35604)
hydrogencarbonate (CHEBI:17544) is conjugate acid of carbonate (CHEBI:41609)
hydrogencarbonate (CHEBI:17544) is conjugate base of carbonic acid (CHEBI:28976)
Incoming potassium hydrogencarbonate (CHEBI:81862) has part hydrogencarbonate (CHEBI:17544)
sodium hydrogencarbonate (CHEBI:32139) has part hydrogencarbonate (CHEBI:17544)
hydrogen (13C)carbonate (CHEBI:140315) is a hydrogencarbonate (CHEBI:17544)
carbonic acid (CHEBI:28976) is conjugate acid of hydrogencarbonate (CHEBI:17544)
carbonate (CHEBI:41609) is conjugate base of hydrogencarbonate (CHEBI:17544)
IUPAC Names
hydrogen(trioxidocarbonate)(1−)
hydrogencarbonate
hydrogencarbonate(1−)
hydrogentrioxocarbonate(1−)
hydrogentrioxocarbonate(IV)
hydroxidodioxidocarbonate(1−)
Synonyms Sources
[CO2(OH)] IUPAC
Acid carbonate KEGG COMPOUND
Bicarbonate KEGG COMPOUND
BICARBONATE ION PDBeChem
HCO3 IUPAC
HCO3- KEGG COMPOUND
hydrogen carbonate PDBeChem
Hydrogencarbonate KEGG COMPOUND
hydrogencarbonate UniProt
Manual Xrefs Databases
BCT PDBeChem
Bicarbonate Wikipedia
C00288 KEGG COMPOUND
HCO3 MetaCyc
HMDB0000595 HMDB
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Registry Numbers Types Sources
3903504 Beilstein Registry Number Beilstein
49249 Gmelin Registry Number Gmelin
71-52-3 CAS Registry Number ChemIDplus
Citations Types Sources
17215880 PubMed citation Europe PMC
17505962 PubMed citation Europe PMC
18439416 PubMed citation Europe PMC
28732801 PubMed citation Europe PMC
29150416 PubMed citation Europe PMC
29460248 PubMed citation Europe PMC
29466234 PubMed citation Europe PMC
4208463 PubMed citation Europe PMC
Last Modified
30 August 2023