CHEBI:15346 - coenzyme A

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ChEBI Name coenzyme A
ChEBI ID CHEBI:15346
Definition A thiol comprising a panthothenate unit in phosphoric anhydride linkage with a 3',5'-adenosine diphosphate unit; and an aminoethanethiol unit.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:741566, CHEBI:41631, CHEBI:41597, CHEBI:3771, CHEBI:13294, CHEBI:13295, CHEBI:13298, CHEBI:23355
Supplier Information ZINC000008551087
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Coenzyme A (CoA, SHCoA, CoASH) is a coenzyme, notable for its role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric acid cycle. All genomes sequenced to date encode enzymes that use coenzyme A as a substrate, and around 4% of cellular enzymes use it (or a thioester) as a substrate. In humans, CoA biosynthesis requires cysteine, pantothenate (vitamin B5), and adenosine triphosphate (ATP). In its acetyl form, coenzyme A is a highly versatile molecule, serving metabolic functions in both the anabolic and catabolic pathways. Acetyl-CoA is utilised in the post-translational regulation and allosteric regulation of pyruvate dehydrogenase and carboxylase to maintain and support the partition of pyruvate synthesis and degradation.
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Formula C21H36N7O16P3S
Net Charge 0
Average Mass 767.53540
Monoisotopic Mass 767.11521
InChI InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/t11-,14-,15-,16+,20-/m1/s1
InChIKey RGJOEKWQDUBAIZ-IBOSZNHHSA-N
SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)n1cnc2c(N)ncnc12)[C@@H](O)C(=O)NCCC(=O)NCCS
Metabolite of Species Details
Mus musculus (NCBI:txid10090) Source: BioModels - MODEL1507180067 See: PubMed
Escherichia coli (NCBI:txid562) See: PubMed
Roles Classification
Biological Role(s): Escherichia coli metabolite
Any bacterial metabolite produced during a metabolic reaction in Escherichia coli.
mouse metabolite
Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
coenzyme
A low-molecular-weight, non-protein organic compound participating in enzymatic reactions as dissociable acceptor or donor of chemical groups or electrons.
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ChEBI Ontology
Outgoing coenzyme A (CHEBI:15346) has functional parent 3'-phosphate-adenosine-5'-diphosphate (CHEBI:44672)
coenzyme A (CHEBI:15346) has role Escherichia coli metabolite (CHEBI:76971)
coenzyme A (CHEBI:15346) has role coenzyme (CHEBI:23354)
coenzyme A (CHEBI:15346) has role mouse metabolite (CHEBI:75771)
coenzyme A (CHEBI:15346) is a 6-aminopurines (CHEBI:20706)
coenzyme A (CHEBI:15346) is a nucleotide derivative (CHEBI:231540)
coenzyme A (CHEBI:15346) is a secondary carboxamide (CHEBI:140325)
coenzyme A (CHEBI:15346) is a thiol (CHEBI:29256)
coenzyme A (CHEBI:15346) is conjugate acid of coenzyme A(4−) (CHEBI:57287)
Incoming γ-butyrobetainyl-CoA (CHEBI:61517) has functional parent coenzyme A (CHEBI:15346)
(1-hydroxycyclohexyl)acetyl-CoA (CHEBI:15448) has functional parent coenzyme A (CHEBI:15346)
(2,3,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA (CHEBI:27866) has functional parent coenzyme A (CHEBI:15346)
(2-trans,6-cis)-dodeca-2,6-dienoyl-CoA (CHEBI:28387) has functional parent coenzyme A (CHEBI:15346)
(2E,4Z)-deca-2,4-dienoyl-CoA (CHEBI:29119) has functional parent coenzyme A (CHEBI:15346)
(3S)-citryl-CoA (CHEBI:15459) has functional parent coenzyme A (CHEBI:15346)
(3Z,6Z)-dodecadienoyl-CoA (CHEBI:28002) has functional parent coenzyme A (CHEBI:15346)
(E)-4-(trimethylammonio)but-2-enoyl-CoA (CHEBI:61123) has functional parent coenzyme A (CHEBI:15346)
(E,E)-piperonyl-CoA (CHEBI:15464) has functional parent coenzyme A (CHEBI:15346)
(R)-methylmalonyl-CoA (CHEBI:15465) has functional parent coenzyme A (CHEBI:15346)
(R)-phenyllactoyl-CoA (CHEBI:11010) has functional parent coenzyme A (CHEBI:15346)
(S)-3-hydroxyhexanoyl-CoA (CHEBI:28276) has functional parent coenzyme A (CHEBI:15346)
(S)-methylmalonyl-CoA (CHEBI:15466) has functional parent coenzyme A (CHEBI:15346)
2'-(5''-phosphoribosyl)-3'-dephospho-CoA (CHEBI:65338) has functional parent coenzyme A (CHEBI:15346)
2'-(5-triphosphoribosyl)-3'-dephospho-CoA (CHEBI:11392) has functional parent coenzyme A (CHEBI:15346)
2-amino-5-oxocyclohex-1-enecarbonyl-CoA (CHEBI:18206) has functional parent coenzyme A (CHEBI:15346)
2-benzylsuccinyl-CoA (CHEBI:22746) has functional parent coenzyme A (CHEBI:15346)
2-furoyl-CoA (CHEBI:15474) has functional parent coenzyme A (CHEBI:15346)
2-methylbutanoyl-CoA (CHEBI:15477) has functional parent coenzyme A (CHEBI:15346)
3'-dephospho-CoA (CHEBI:15468) has functional parent coenzyme A (CHEBI:15346)
3,4,4-trimethylhepta-2,5-dienoyl-CoA (CHEBI:23608) has functional parent coenzyme A (CHEBI:15346)
3,4-dihydro-7-methoxy-2-methylene-3-oxo-2H-1,4-benzoxazine-5-carbonyl-CoA (CHEBI:1373) has functional parent coenzyme A (CHEBI:15346)
3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA (CHEBI:15480) has functional parent coenzyme A (CHEBI:15346)
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA (CHEBI:15483) has functional parent coenzyme A (CHEBI:15346)
3-hydroxy-3-methylbutyl-CoA (CHEBI:27874) has functional parent coenzyme A (CHEBI:15346)
3-isopropenylpimeloyl-CoA (CHEBI:37439) has functional parent coenzyme A (CHEBI:15346)
3-methylbut-3-enoyl-CoA (CHEBI:28188) has functional parent coenzyme A (CHEBI:15346)
3-oxooctadecanoyl-CoA (CHEBI:50571) has functional parent coenzyme A (CHEBI:15346)
4,8,12-trimethyltridecanoyl-CoA (CHEBI:15495) has functional parent coenzyme A (CHEBI:15346)
5-hydroxythiophene-2-carbonyl-CoA (CHEBI:15502) has functional parent coenzyme A (CHEBI:15346)
6-hydroxycyclohex-1-ene-1-carbonyl-CoA (CHEBI:15505) has functional parent coenzyme A (CHEBI:15346)
6-hydroxyhex-3-enoyl-CoA (CHEBI:49281) has functional parent coenzyme A (CHEBI:15346)
6-oxocyclohex-1-ene-1-carbonyl-CoA (CHEBI:28168) has functional parent coenzyme A (CHEBI:15346)
cis-dodec-3-enoyl-CoA (CHEBI:27989) has functional parent coenzyme A (CHEBI:15346)
cis-geranoyl-CoA (CHEBI:15523) has functional parent coenzyme A (CHEBI:15346)
cis-tetradec-11-enoyl-CoA (CHEBI:15461) has functional parent coenzyme A (CHEBI:15346)
cis-tetradec-3-enoyl-CoA (CHEBI:62014) has functional parent coenzyme A (CHEBI:15346)
N-methylanthraniloyl-CoA (CHEBI:30305) has functional parent coenzyme A (CHEBI:15346)
O3-(phosphoribosyl dephospho-CoA)-L-serine (CHEBI:21979) has functional parent coenzyme A (CHEBI:15346)
S-alkyl-CoA (CHEBI:62204) has functional parent coenzyme A (CHEBI:15346)
S-nitroso-coenzyme A (CHEBI:229721) has functional parent coenzyme A (CHEBI:15346)
trans-3-methylglutaconyl-CoA (CHEBI:15488) has functional parent coenzyme A (CHEBI:15346)
trans-4-carboxybut-2-enoyl-CoA (CHEBI:15497) has functional parent coenzyme A (CHEBI:15346)
trans-dec-2-enoyl-CoA (CHEBI:10723) has functional parent coenzyme A (CHEBI:15346)
trans-dodec-2-enoyl-CoA (CHEBI:15471) has functional parent coenzyme A (CHEBI:15346)
trans-feruloyl-CoA (CHEBI:15511) has functional parent coenzyme A (CHEBI:15346)
trans-hex-2-enoyl-CoA (CHEBI:28706) has functional parent coenzyme A (CHEBI:15346)
trans-oct-2-enoyl-CoA (CHEBI:27537) has functional parent coenzyme A (CHEBI:15346)
trans-tetradec-11-enoyl-CoA (CHEBI:15460) has functional parent coenzyme A (CHEBI:15346)
trans-tetradec-2-enoyl-CoA (CHEBI:27721) has functional parent coenzyme A (CHEBI:15346)
acetyl-CoA (CHEBI:15351) has functional parent coenzyme A (CHEBI:15346)
acryloyl-CoA (CHEBI:15513) has functional parent coenzyme A (CHEBI:15346)
acyl-CoA (CHEBI:17984) has functional parent coenzyme A (CHEBI:15346)
alk-2-enoyl-CoA (CHEBI:15469) has functional parent coenzyme A (CHEBI:15346)
but-2-enoyl-CoA (CHEBI:36926) has functional parent coenzyme A (CHEBI:15346)
butyryl-CoA (CHEBI:15517) has functional parent coenzyme A (CHEBI:15346)
cinnamoyl-CoA (CHEBI:15463) has functional parent coenzyme A (CHEBI:15346)
citramalyl-CoA (CHEBI:15457) has functional parent coenzyme A (CHEBI:15346)
CoA-glutathione (CHEBI:17586) has functional parent coenzyme A (CHEBI:15346)
cyclohexa-1,4-diene-1-carbonyl-CoA (CHEBI:28443) has functional parent coenzyme A (CHEBI:15346)
cyclohexa-1,5-diene-1-carbonyl-CoA (CHEBI:15520) has functional parent coenzyme A (CHEBI:15346)
cyclohexa-2,5-diene-1-carbonyl-CoA (CHEBI:27610) has functional parent coenzyme A (CHEBI:15346)
decanoyl-CoA (CHEBI:28493) has functional parent coenzyme A (CHEBI:15346)
deoxycholoyl-CoA (CHEBI:50111) has functional parent coenzyme A (CHEBI:15346)
farnesoyl-CoA (CHEBI:28562) has functional parent coenzyme A (CHEBI:15346)
feruloyl-CoA (CHEBI:14261) has functional parent coenzyme A (CHEBI:15346)
glutaryl-CoA (CHEBI:15524) has functional parent coenzyme A (CHEBI:15346)
heptanoyl-CoA (CHEBI:37283) has functional parent coenzyme A (CHEBI:15346)
hexanoyl-CoA (CHEBI:27540) has functional parent coenzyme A (CHEBI:15346)
icosanoyl-CoA (CHEBI:15527) has functional parent coenzyme A (CHEBI:15346)
indol-3-ylacetyl-CoA (CHEBI:12755) has functional parent coenzyme A (CHEBI:15346)
isobutyryl-CoA (CHEBI:15479) has functional parent coenzyme A (CHEBI:15346)
itaconyl-CoA (CHEBI:15528) has functional parent coenzyme A (CHEBI:15346)
linoleoyl-CoA (CHEBI:15530) has functional parent coenzyme A (CHEBI:15346)
malonyl-CoA (CHEBI:15531) has functional parent coenzyme A (CHEBI:15346)
malonyl-CoA lithium salt (CHEBI:232859) has functional parent coenzyme A (CHEBI:15346)
methacrylyl-CoA (CHEBI:27754) has functional parent coenzyme A (CHEBI:15346)
myristoyl-CoA (CHEBI:15532) has functional parent coenzyme A (CHEBI:15346)
n-propionyl-CoA lithium salt (CHEBI:233091) has functional parent coenzyme A (CHEBI:15346)
nonanoyl-CoA (CHEBI:27770) has functional parent coenzyme A (CHEBI:15346)
oleoyl-CoA (CHEBI:15534) has functional parent coenzyme A (CHEBI:15346)
palmitoyl-CoA (CHEBI:15525) has functional parent coenzyme A (CHEBI:15346)
pent-2-enoyl-CoA (CHEBI:27962) has functional parent coenzyme A (CHEBI:15346)
pentanoyl-CoA (CHEBI:15536) has functional parent coenzyme A (CHEBI:15346)
phenylglyoxylyl-CoA (CHEBI:50117) has functional parent coenzyme A (CHEBI:15346)
phytanoyl-CoA (CHEBI:15538) has functional parent coenzyme A (CHEBI:15346)
pimeloyl-CoA (CHEBI:15504) has functional parent coenzyme A (CHEBI:15346)
propionyl-CoA (CHEBI:15539) has functional parent coenzyme A (CHEBI:15346)
sinapoyl-CoA (CHEBI:15540) has functional parent coenzyme A (CHEBI:15346)
succinyl-CoA (CHEBI:15380) has functional parent coenzyme A (CHEBI:15346)
sulfoacetyl-CoA (CHEBI:61992) has functional parent coenzyme A (CHEBI:15346)
tetracosanoyl-CoA (CHEBI:52974) has functional parent coenzyme A (CHEBI:15346)
tetradecenoyl-CoA (CHEBI:26900) has functional parent coenzyme A (CHEBI:15346)
thiophene-2-carbonyl-CoA (CHEBI:15542) has functional parent coenzyme A (CHEBI:15346)
vinylacetyl-CoA (CHEBI:15543) has functional parent coenzyme A (CHEBI:15346)
coenzyme A(4−) (CHEBI:57287) is conjugate base of coenzyme A (CHEBI:15346)
IUPAC Name
3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl] dihydrogen diphosphate}
Synonyms Sources
3'-phosphoadenosine-(5')diphospho(4')pantatheine ChEBI
[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R)-3-hydroxy-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)-2,2-dimethyl-4-oxobutyl dihydrogen diphosphate ChEBI
CoA KEGG COMPOUND
CoA-SH KEGG COMPOUND
CoASH ChEBI
Coenzym A ChEBI
Coenzyme A KEGG COMPOUND
COENZYME A PDBeChem
HSCoA ChEBI
Koenzym A ChEBI
Manual Xrefs Databases
C00007258 KNApSAcK
C00010 KEGG COMPOUND
COA PDBeChem
Coenzyme_A Wikipedia
COZ PDBeChem
DB01992 DrugBank
View more database links
Registry Numbers Types Sources
77809 Beilstein Registry Number Beilstein
85-61-0 CAS Registry Number ChemIDplus
Citations
Last Modified
06 June 2024
General Comment
2024-06-03 Coenzyme A is a universal carrier of acyl groups, notable for its rôle in the synthesis and oxidation of fatty acids and the oxidation of pyruvate in the citric (tricarboxylic) acid cycle.