colchicine (CHEBI:23359)

ChEBI > Main

Main

ChEBI Ontology

Automatic Xrefs

Reactions

Pathways

Models

ChEBI Name	colchicine

ChEBI ID	CHEBI:23359

Definition	An alkaloid that is a carbotricyclic compound comprising 5,6,7,9-tetrahydrobenzo[a]heptalene having four methoxy substituents at the 1-, 2-, 3- and 10-positions as well as an oxo group at the 9-position and an acetamido group at the 7-position. It has been isolated from the plants belonging to genus Colchicum.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Formula

C22H25NO6

Net Charge

Average Mass

399.43704

Monoisotopic Mass

399.16819

InChI

InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)

InChIKey

IAKHMKGGTNLKSZ-UHFFFAOYSA-N

SMILES

COc1cc2CCC(NC(C)=O)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC

Roles Classification
Biological Role(s):	plant metabolite Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. microtubule-destabilising agent Any substance that interacts with tubulin to inhibit polymerisation of microtubules. metabolite Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. (via alkaloid )

ChEBI Ontology
Outgoing	colchicine (CHEBI:23359) has role microtubule-destabilising agent (CHEBI:61951) colchicine (CHEBI:23359) has role plant metabolite (CHEBI:76924) colchicine (CHEBI:23359) is a acetamides (CHEBI:22160) colchicine (CHEBI:23359) is a alkaloid (CHEBI:22315) colchicine (CHEBI:23359) is a aromatic ether (CHEBI:35618) colchicine (CHEBI:23359) is a carbotricyclic compound (CHEBI:38032)

Incoming	(R)-colchicine (CHEBI:51074) is a colchicine (CHEBI:23359) (S)-colchicine (CHEBI:27882) is a colchicine (CHEBI:23359)

IUPAC Name

N-(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide

Last Modified

25 February 2016