S-Adenosyl methionine (SAM), also known under the commercial names of SAMe, SAM-e, or AdoMet, is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. Although these anabolic reactions occur throughout the body, most SAM is produced and consumed in the liver. More than 40 methyl transfers from SAM are known, to various substrates such as nucleic acids, proteins, lipids and secondary metabolites. It is made from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase. SAM was first discovered by Giulio Cantoni in 1952.
In bacteria, SAM is bound by the SAM riboswitch, which regulates genes involved in methionine or cysteine biosynthesis. In eukaryotic cells, SAM serves as a regulator of a variety of processes including DNA, tRNA, and rRNA methylation; immune response; amino acid metabolism; transsulfuration; and more. In plants, SAM is crucial to the biosynthesis of ethylene, an important plant hormone and signaling molecule. |
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MYMOFIZGZYHOMD-UHFFFAOYSA-N |
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Saccharomyces cerevisiae
(NCBI:txid4932)
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Source: yeast.sf.net
See:
PubMed
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Homo sapiens
(NCBI:txid9606)
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See:
DOI
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oxidising agent
A substance that removes electrons from another reactant in a redox reaction.
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Saccharomyces cerevisiae metabolite
Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae ).
human metabolite
Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
micronutrient
Any nutrient required in small quantities by organisms throughout their life in order to orchestrate a range of physiological functions.
nutrient
A nutrient is a food component that an organism uses to survive and grow.
food packaging gas
A food additive that is a (generally inert) gas which is used to envelop foodstuffs during packing and so protect them from unwanted chemical reactions such as food spoilage or oxidation during subsequent transport and storage. The term includes propellant gases, used to expel foods from a container.
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anti-inflammatory drug
A substance that reduces or suppresses inflammation.
reagent
A substance used in a chemical reaction to detect, measure, examine, or produce other substances.
food packaging gas
A food additive that is a (generally inert) gas which is used to envelop foodstuffs during packing and so protect them from unwanted chemical reactions such as food spoilage or oxidation during subsequent transport and storage. The term includes propellant gases, used to expel foods from a container.
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[OO]
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MolBase
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dioxygène
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ChEBI
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Disauerstoff
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ChEBI
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E 948
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ChEBI
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E-948
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ChEBI
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E948
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ChEBI
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molecular oxygen
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ChEBI
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O2
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O2
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O2
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UniProt
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Oxygen
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OXYGEN MOLECULE
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PDBeChem
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485
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Gmelin Registry Number
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Gmelin
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7782-44-7
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7782-44-7
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NIST Chemistry WebBook
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7782-44-7
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10906528
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16977326
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Europe PMC
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18210929
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18638417
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19840863
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7710549
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Europe PMC
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9463773
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PubMed citation
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Europe PMC
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