CHEBI:2718 - angiotensin I

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name angiotensin I
ChEBI ID CHEBI:2718
Definition A ten amino acid peptide formed by renin cleavage of angiotensinogen. Angiotensin I has no direct biological function except that high levels can stimulate catecholamine production. It is metabolized to its biologically active byproduct angiotensin II, a potent vasoconstrictor, by angiotensin converting enzyme (ACE) through cleavage of the two terminal amino acids.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C62H89N17O14
Net Charge 0
Average Mass 1296.499
Monoisotopic Mass 1295.67749
InChI InChI=1S/C62H89N17O14/c1-7-35(6)51(78-56(87)44(25-37-17-19-40(80)20-18-37)74-58(89)50(34(4)5)77-53(84)42(15-11-21-68-62(64)65)71-52(83)41(63)28-49(81)82)59(90)75-46(27-39-30-67-32-70-39)60(91)79-22-12-16-48(79)57(88)73-43(24-36-13-9-8-10-14-36)54(85)72-45(26-38-29-66-31-69-38)55(86)76-47(61(92)93)23-33(2)3/h8-10,13-14,17-20,29-35,41-48,50-51,80H,7,11-12,15-16,21-28,63H2,1-6H3,(H,66,69)(H,67,70)(H,71,83)(H,72,85)(H,73,88)(H,74,89)(H,75,90)(H,76,86)(H,77,84)(H,78,87)(H,81,82)(H,92,93)(H4,64,65,68)/t35-,41-,42-,43-,44-,45-,46-,47-,48-,50-,51-/m0/s1
InChIKey ORWYRWWVDCYOMK-HBZPZAIKSA-N
SMILES [C@H](NC([C@H](CC(O)=O)N)=O)(CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@@H](CCC1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC3=CNC=N3)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)=O)CC4=CN=CN4)=O)[C@H](CC)C)=O)CC5=CC=C(C=C5)O)=O)C(C)C)=O
Metabolite of Species Details
Homo sapiens (NCBI:txid9606) Found in blood plasma (BTO_0000131). See: PubMed
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): neurotransmitter agent
A substance used for its pharmacological action on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.
human metabolite
Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
hormone
Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.
(via peptide hormone )
Application(s): neurotransmitter agent
A substance used for its pharmacological action on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing angiotensin I (CHEBI:2718) has role human metabolite (CHEBI:77746)
angiotensin I (CHEBI:2718) has role neurotransmitter agent (CHEBI:35942)
angiotensin I (CHEBI:2718) is a angiotensin (CHEBI:48433)
angiotensin I (CHEBI:2718) is tautomer of angiotensin I dizwitterion (CHEBI:147350)
Incoming angiotensin I dizwitterion (CHEBI:147350) is tautomer of angiotensin I (CHEBI:2718)
IUPAC Name
L-α-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidyl-L-leucine
Synonyms Sources
angiotensin I KEGG COMPOUND
Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu MetaCyc
D-R-V-Y-I-H-P-F-H-L ChEBI
DRVYIHPFHL ChEBI
L-Asp-L-Arg-L-Val-L-Tyr-L-Ile-L-His-L-Pro-L-Phe-L-His-L-Leu ChEBI
pepsitensin ChemIDplus
proangiotensin ChemIDplus
Manual Xrefs Databases
C00873 KEGG COMPOUND
CPD-13004 MetaCyc
HMDB0061196 HMDB
WO2009040072 Patent
View more database links
Registry Number Type Source
9041-90-1 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
20026757 PubMed citation Europe PMC
31746507 PubMed citation Europe PMC
32028998 PubMed citation Europe PMC
32238693 PubMed citation Europe PMC
836506 PubMed citation Europe PMC
Last Modified
09 April 2020