| Thyrotropin-releasing hormone (TRH) is a hypophysiotropic hormone produced by neurons in the hypothalamus that stimulates the release of thyroid-stimulating hormone (TSH) and prolactin from the anterior pituitary.
TRH has been used clinically for the treatment of spinocerebellar degeneration and disturbance of consciousness in humans. Its pharmaceutical form is called protirelin (INN) (). |
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InChI=1S/C16H22N6O4/c17- 14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1 |
| XNSAINXGIQZQOO-SRVKXCTJSA-N |
| NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1 |
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Homo sapiens
(NCBI:txid9606)
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See:
DOI
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Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
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human metabolite
Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
hormone
Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.
(via peptide hormone )
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View more via ChEBI Ontology
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5-oxo-L-prolyl-L-histidyl-L-prolinamide
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L-Pyroglutamyl-L-histidyl-L-prolineamide
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ChemIDplus
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Protirelin
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KEGG COMPOUND
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Thyroliberin
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KEGG COMPOUND
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Thyrotropic releasing hormone
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ChemIDplus
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Thyrotropic-releasing factor
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ChemIDplus
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Thyrotropin releasing hormone
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KEGG COMPOUND
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Thyrotropin-releasing factor
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ChemIDplus
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TRH
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KEGG COMPOUND
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TSH-releasing factor
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HMDB
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TSH-releasing hormone
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HMDB
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24305-27-9
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CAS Registry Number
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ChemIDplus
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903432
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Reaxys Registry Number
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Reaxys
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