CHEBI:28265 - coenzyme F430

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ChEBI Name coenzyme F430
ChEBI ID CHEBI:28265
ChEBI ASCII Name coenzyme F430
Definition A nickel tetrapyrrole found only in methanogenic Archaea. It is the prosthetic group of the enzyme methyl coenzyme M reductase which catalyses the release of methane in the final step of methanogenesis.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:49592, CHEBI:3808, CHEBI:23352
Supplier Information ChemicalBook:CB5778186, eMolecules:474232
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Carbon dioxide is a chemical compound with the chemical formula CO2. It is made up of molecules that each have one carbon atom covalently double bonded to two oxygen atoms. It is found in a gas state at room temperature and at normally-encountered concentrations it is odorless. As the source of carbon in the carbon cycle, atmospheric CO2 is the primary carbon source for life on Earth. In the air, carbon dioxide is transparent to visible light but absorbs infrared radiation, acting as a greenhouse gas. Carbon dioxide is soluble in water and is found in groundwater, lakes, ice caps, and seawater. It is a trace gas in Earth's atmosphere at 421 parts per million (ppm), or about 0.042% (as of May 2022) having risen from pre-industrial levels of 280 ppm or about 0.028%. Burning fossil fuels is the main cause of these increased CO2 concentrations, which are the primary cause of climate change. Its concentration in Earth's pre-industrial atmosphere since late in the Precambrian was regulated by organisms and geological features. Plants, algae and cyanobacteria use energy from sunlight to synthesize carbohydrates from carbon dioxide and water in a process called photosynthesis, which produces oxygen as a waste product. In turn, oxygen is consumed and CO2 is released as waste by all aerobic organisms when they metabolize organic compounds to produce energy by respiration. CO2 is released from organic materials when they decay or combust, such as in forest fires. When carbon dioxide dissolves in water, it forms carbonate and mainly bicarbonate (HCO−3), which causes ocean acidification as atmospheric CO2 levels increase. Carbon dioxide is 53% more dense than dry air, but is long lived and thoroughly mixes in the atmosphere. About half of excess CO2 emissions to the atmosphere are absorbed by land and ocean carbon sinks. These sinks can become saturated and are volatile, as decay and wildfires result in the CO2 being released back into the atmosphere. CO2, or the carbon it holds, is eventually sequestered (stored for the long term) in rocks and organic deposits like coal, petroleum and natural gas. Nearly all CO2 produced by humans goes into the atmosphere. Less than 1% of CO2 produced annually is put to commercial use, mostly in the fertilizer industry and in the oil and gas industry for enhanced oil recovery. Other commercial applications include food and beverage production, metal fabrication, cooling, fire suppression and stimulating plant growth in greenhouses.: 3 
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Formula C42H51N6NiO13
Net Charge +1
Average Mass 906.582
Monoisotopic Mass 905.28620
InChI InChI=1S/C42H52N6O13.Ni/c1-40(16-30(43)50)22(5-9-33(54)55)27-15-42-41(2,17-31(51)48-42)23(6-10-34(56)57)26(47-42)13-24-20(11-35(58)59)19(4-8-32(52)53)39(45-24)37-28(49)7-3-18-21(12-36(60)61)25(46-38(18)37)14-29(40)44-27;/h13,18-23,25,27H,3-12,14-17H2,1-2H3,(H9,43,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61);/q;+2/p-1/t18-,19-,20-,21-,22+,23+,25+,27-,40-,41-,42-;/m0./s1
InChIKey XLFIRMYGVLUNOY-SXMZNAGASA-M
SMILES [C@H]12[C@H]([C@@](CC(N)=O)(C)C3=[N+]1[Ni-2]45[N+]=6[C@H](C3)[C@H]([C@@H]7CCC(C(C67)=C8N5C(=CC9=[N+]4[C@]%10(C2)[C@@]([C@@H]9CCC(O)=O)(C)CC(N%10)=O)[C@H]([C@@H]8CCC(O)=O)CC(O)=O)=O)CC(O)=O)CCC(O)=O
Roles Classification
Biological Role(s): cofactor
An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group).
prosthetic group
A tightly bound, specific nonpolypeptide unit in a protein determining and involved in its biological activity.
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ChEBI Ontology
Outgoing coenzyme F430 (CHEBI:28265) has role cofactor (CHEBI:23357)
coenzyme F430 (CHEBI:28265) has role prosthetic group (CHEBI:26348)
coenzyme F430 (CHEBI:28265) is a nickel tetrapyrrole (CHEBI:25519)
coenzyme F430 (CHEBI:28265) is conjugate acid of coenzyme F430(4−) (CHEBI:60540)
Incoming coenzyme F430(4−) (CHEBI:60540) is conjugate base of coenzyme F430 (CHEBI:28265)
IUPAC Name
{3,3',3''-[5-(2-amino-2-oxoethyl)-18,29-bis(carboxymethyl)-5,23-dimethyl-14,25-dioxo-9,26,27,28,30-pentaazaheptacyclo[19.5.1.13,6.18,11.116,19.01,23.010,15]triaconta-6(30),9,15,19,21(27)-pentaene-4,17,22-triyl-κ4N9,N27,N28,N30]tripropanoato}nickel
Synonyms Sources
Coenzyme F430 KEGG COMPOUND
cofactor F430 ChEBI
cofactor F430 ChEBI
F(430) ChemIDplus
FACTOR 430 PDBeChem
Factor F430 ChemIDplus
Factor F430 KEGG COMPOUND
Manual Xrefs Databases
C05777 KEGG COMPOUND
Cofactor_F430 Wikipedia
F43 PDBeChem
MOL000059 COMe
View more database links
Registry Numbers Types Sources
20949 Gmelin Registry Number Gmelin
73145-13-8 CAS Registry Number ChemIDplus
9610411 Beilstein Registry Number Beilstein
Last Modified
26 July 2019