2-nitropropane (CHEBI:16037)

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ChEBI Name	2-nitropropane

ChEBI ID	CHEBI:16037

Definition	A secondary nitroalkane that is propane in which a hydrogen at position 2 has been replaced by a nitro group. Mainly used as a solvent (b.p. 120°C).

Stars	This entity has been manually annotated by the ChEBI Team.

Secondary ChEBI IDs	CHEBI:44443, CHEBI:1226, CHEBI:11632, CHEBI:19727

Supplier Information	ZINC000003938704

Download	Molfile XML SDF

Wikipedia	License
Levothyroxine, also known as L-thyroxine, is a synthetic form of the thyroid hormone thyroxine (T4). It is used to treat thyroid hormone deficiency (hypothyroidism), including a severe form known as myxedema coma. It may also be used to treat and prevent certain types of thyroid tumors. It is not indicated for weight loss. Levothyroxine is taken orally (by mouth) or given by intravenous injection. Levothyroxine has a half-life of 7.5 days when taken daily, so about six weeks is required for it to reach a steady level in the blood. Side effects from excessive doses include weight loss, trouble tolerating heat, sweating, anxiety, trouble sleeping, tremor, and fast heart rate. Use is not recommended in people who have had a recent heart attack. Use during pregnancy has been found to be safe. Dosing should be based on regular measurements of thyroid-stimulating hormone (TSH) and T4 levels in the blood. Much of the effect of levothyroxine is following its conversion to triiodothyronine (T3). Levothyroxine was first made in 1927. It is on the World Health Organization's List of Essential Medicines. Levothyroxine is available as a generic medication. In 2022, it was the fourth most commonly prescribed medication in the United States, with more than 82 million prescriptions.
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Formula

C3H7NO2

Net Charge

Average Mass

89.09322

Monoisotopic Mass

89.04768

InChI

InChI=1S/C3H7NO2/c1-3(2)4(5)6/h3H,1-2H3

InChIKey

FGLBSLMDCBOPQK-UHFFFAOYSA-N

SMILES

CC(C)[N+]([O-])=O

Roles Classification
Chemical Role(s):	polar aprotic solvent A solvent with a comparatively high relative permittivity (or dielectric constant), greater than ca. 15, and a sizable permanent dipole moment, that cannot donate suitably labile hydrogen atoms to form strong hydrogen bonds.

Biological Role(s):	hepatotoxic agent A role played by a chemical compound exhibiting itself through the ability to induce damage to the liver in animals. carcinogenic agent A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquistion of tumoral capabilities. xenobiotic A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.

Application(s):	polar aprotic solvent A solvent with a comparatively high relative permittivity (or dielectric constant), greater than ca. 15, and a sizable permanent dipole moment, that cannot donate suitably labile hydrogen atoms to form strong hydrogen bonds.

ChEBI Ontology
Outgoing	2-nitropropane (CHEBI:16037) has role carcinogenic agent (CHEBI:50903) 2-nitropropane (CHEBI:16037) has role hepatotoxic agent (CHEBI:50908) 2-nitropropane (CHEBI:16037) has role polar aprotic solvent (CHEBI:48358) 2-nitropropane (CHEBI:16037) has role xenobiotic (CHEBI:35703) 2-nitropropane (CHEBI:16037) is a secondary nitroalkane (CHEBI:139218)

IUPAC Name

2-nitropropane

Citations

Last Modified

13 December 2017