Estrone (E1), also spelled oestrone, is a steroid, a weak estrogen, and a minor female sex hormone. It is one of three major endogenous estrogens, the others being estradiol and estriol. Estrone, as well as the other estrogens, are synthesized from cholesterol and secreted mainly from the gonads, though they can also be formed from adrenal androgens in adipose tissue. Relative to estradiol, both estrone and estriol have far weaker activity as estrogens. Estrone can be converted into estradiol, and serves mainly as a precursor or metabolic intermediate of estradiol. It is both a precursor and metabolite of estradiol.
In addition to its role as a natural hormone, estrone has been used as a medication, for instance in menopausal hormone therapy; for information on estrone as a medication, see the estrone (medication) article. |
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DRTQHJPVMGBUCF-XVFCMESISA-N |
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O |
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Mus musculus
(NCBI:txid10090)
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Source: BioModels - MODEL1507180067
See:
PubMed
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Daphnia magna
(NCBI:txid35525)
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See:
Mixtures of similarly acting compounds in Daphnia magna: From gene to metabolite and beyondTine Vandenbrouck, Oliver A.H. Jones, Nathalie Dom, Julian L. Griffin, Wim De CoenEnvironment International 36 (2010) 254-268
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Saccharomyces cerevisiae
(NCBI:txid4932)
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Source: yeast.sf.net
See:
PubMed
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Escherichia coli
(NCBI:txid562)
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See:
PubMed
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Homo sapiens
(NCBI:txid9606)
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See:
DOI
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human metabolite
Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
drug metabolite
fundamental metabolite
Any metabolite produced by all living cells.
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View more via ChEBI Ontology
1-β-D-ribofuranosylpyrimidine-2,4(1H,3H)-dione
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ChEBI
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1-β-D-ribofuranosyluracil
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HMDB
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β-Uridine
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HMDB
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u
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ChEBI
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Urd
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CBN
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Uridin
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ChemIDplus
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Uridine
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KEGG COMPOUND
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URIDINE
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PDBeChem
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uridine
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UniProt
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397474
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Gmelin Registry Number
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Gmelin
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58-96-8
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CAS Registry Number
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ChemIDplus
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754904
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Reaxys Registry Number
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Reaxys
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