imipramine (CHEBI:47499)

ChEBI > Main

Main

ChEBI Ontology

Automatic Xrefs

Reactions

Pathways

Models

ChEBI Name	imipramine

ChEBI ID	CHEBI:47499

Definition	A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.

Stars	This entity has been manually annotated by the ChEBI Team.

Secondary ChEBI IDs	CHEBI:47498, CHEBI:5881

Supplier Information

Download	Molfile XML SDF

more structures >>

Wikipedia	License

Read full article at Wikipedia

Formula

C19H24N2

Net Charge

Average Mass

280.40734

Monoisotopic Mass

280.19395

InChI

InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3

InChIKey

BCGWQEUPMDMJNV-UHFFFAOYSA-N

SMILES

CN(C)CCCN1c2ccccc2CCc2ccccc12

Roles Classification
Biological Role(s):	adrenergic uptake inhibitor Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. EC 3.4.21.26 (prolyl oligopeptidase) inhibitor Any EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of prolyl oligopeptidase (EC 3.4.21.26).

Application(s):	adrenergic uptake inhibitor Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.

ChEBI Ontology
Outgoing	imipramine (CHEBI:47499) has parent hydride 5H-dibenzo[b,f]azepine (CHEBI:47802) imipramine (CHEBI:47499) has role adrenergic uptake inhibitor (CHEBI:35640) imipramine (CHEBI:47499) has role antidepressant (CHEBI:35469) imipramine (CHEBI:47499) has role EC 3.4.21.26 (prolyl oligopeptidase) inhibitor (CHEBI:76779) imipramine (CHEBI:47499) is a dibenzoazepine (CHEBI:47804)

Incoming	clomipramine (CHEBI:47780) has functional parent imipramine (CHEBI:47499) trimipramine (CHEBI:9738) has functional parent imipramine (CHEBI:47499) imipramine hydrochloride (CHEBI:5882) has part imipramine (CHEBI:47499)

IUPAC Name

3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine

Synonyms	Sources
10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine	NIST Chemistry WebBook
3-(5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE	PDBeChem
5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine	NIST Chemistry WebBook
Imipramin	ChEBI
Imipramine	KEGG COMPOUND
imizine	NIST Chemistry WebBook
N-(γ-dimethylaminopropyl)iminodibenzyl	NIST Chemistry WebBook

Citation	Type	Source
20825390	PubMed citation	Europe PMC

Last Modified

22 February 2017