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| Estradiol (E2), also called oestrogen, oestradiol, is an estrogen steroid hormone and the major female sex hormone. It is involved in the regulation of female reproductive cycles such as estrous and menstrual cycles. Estradiol is responsible for the development of female secondary sexual characteristics such as the breasts, widening of the hips and a female pattern of fat distribution. It is also important in the development and maintenance of female reproductive tissues such as the mammary glands, uterus and vagina during puberty, adulthood and pregnancy. It also has important effects in many other tissues including bone, fat, skin, liver, and the brain.
Though estradiol levels in males are much lower than in females, estradiol has important roles in males as well. Apart from humans and other mammals, estradiol is also found in most vertebrates and crustaceans, insects, fish, and other animal species.
Estradiol is produced within the follicles of the ovaries and in other tissues including the testicles, the adrenal glands, fat, liver, the breasts, and the brain. Estradiol is produced in the body from cholesterol through a series of reactions and intermediates. The major pathway involves the formation of androstenedione, which is then converted by aromatase into estrone and is subsequently converted into estradiol. Alternatively, androstenedione can be converted into testosterone, which can then be converted into estradiol. Upon menopause in females, production of estrogens by the ovaries stops and estradiol levels decrease to very low levels.
In addition to its role as a natural hormone, estradiol is used as a medication, for instance in menopausal hormone therapy, and feminizing hormone therapy for transgender women and other genderqueer individuals; for information on estradiol as a medication, see the estradiol (medication) article. |
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Read full article at Wikipedia
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InChI=1S/C18H24O2/c1- 18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 |
| VOXZDWNPVJITMN-ZBRFXRBCSA-N |
| [H][C@]12CC[C@]3(C)[C@@H](O)CC[C@@]3([H])[C@]1([H])CCc1cc(O)ccc21 |
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Mus musculus
(NCBI:txid10090)
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Source: BioModels - MODEL1507180067
See:
PubMed
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Daphnia magna
(NCBI:txid35525)
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See:
Changes in the Metabolic Elimination Profile of Testosterone Following Exposure of the Crustacean Daphnia magna to TributyltinGerald A. LeBlanc and James B. McLachlanEcotoxicology and Environmental Safety 45, 296-303 (2000)
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Homo sapiens
(NCBI:txid9606)
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See:
DOI
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estrogen
A hormone that stimulates or controls the development and maintenance of female sex characteristics in mammals by binding to oestrogen receptors. The oestrogens are named for their importance in the oestrous cycle. The oestrogens that occur naturally in the body, notably estrone, estradiol, estriol, and estetrol are steroids. Other compounds with oestrogenic activity are produced by plants (phytoestrogens) and fungi (mycoestrogens); synthetic compounds with oestrogenic activity are known as xenoestrogens.
(via estradiol )
Daphnia magna metabolite
A Daphnia metabolite produced by the species Daphnia magna.
human metabolite
Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
(via estradiol )
EC 1.2.3.1 (aldehyde oxidase) inhibitor
An EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor which interferes with the action of aldehyde oxidase (EC 1.2.3.1).
mouse metabolite
Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
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geroprotector
Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.
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View more via ChEBI Ontology
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estra-1,3,5(10)-triene-3,17β-diol
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(17β)-estra-1,3,5(10)-triene-3,17-diol
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ChemIDplus
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17beta oestradiol
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ChEBI
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17β-estra-1,3,5(10)-triene-3,17-diol
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NIST Chemistry WebBook
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17β-estradiol
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UniProt
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17β-estradiol
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NIST Chemistry WebBook
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17β-oestradiol
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NIST Chemistry WebBook
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beta-Estradiol
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KEGG COMPOUND
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cis-estradiol
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NIST Chemistry WebBook
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Estradiol
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KEGG COMPOUND
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ESTRADIOL
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PDBeChem
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Estradiol-17beta
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KEGG COMPOUND
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Estradiol-17beta
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KEGG COMPOUND
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1057
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DrugCentral
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5554
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ChemSpider
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C00951
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KEGG COMPOUND
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D00105
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KEGG DRUG
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DB00783
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DrugBank
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EST
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PDBeChem
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Estradiol
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Wikipedia
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HMDB0000151
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HMDB
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LMST02010001
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LIPID MAPS
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LSM-2421
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LINCS
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| View more database links |
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1914275
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Reaxys Registry Number
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Reaxys
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290805
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Gmelin Registry Number
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Gmelin
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50-28-2
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CAS Registry Number
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KEGG COMPOUND
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50-28-2
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CAS Registry Number
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ChemIDplus
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50-28-2
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CAS Registry Number
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NIST Chemistry WebBook
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