ketanserin (CHEBI:6123)

ChEBI > Main

Main

ChEBI Ontology

Automatic Xrefs

Reactions

Pathways

Models

ChEBI Name	ketanserin

ChEBI ID	CHEBI:6123

Definition	A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

more structures >>

Wikipedia	License

Read full article at Wikipedia

Formula

C22H22FN3O3

Net Charge

Average Mass

395.42680

Monoisotopic Mass

395.16452

InChI

InChI=1S/C22H22FN3O3/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29)

InChIKey

FPCCSQOGAWCVBH-UHFFFAOYSA-N

SMILES

Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2ccccc2c1=O

Roles Classification
Biological Role(s):	EC 3.4.21.26 (prolyl oligopeptidase) inhibitor Any EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of prolyl oligopeptidase (EC 3.4.21.26). alpha-adrenergic antagonist An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.

Application(s):	antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. alpha-adrenergic antagonist An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.

ChEBI Ontology
Outgoing	ketanserin (CHEBI:6123) has role α-adrenergic antagonist (CHEBI:37890) ketanserin (CHEBI:6123) has role antihypertensive agent (CHEBI:35674) ketanserin (CHEBI:6123) has role cardiovascular drug (CHEBI:35554) ketanserin (CHEBI:6123) has role EC 3.4.21.26 (prolyl oligopeptidase) inhibitor (CHEBI:76779) ketanserin (CHEBI:6123) has role serotonergic antagonist (CHEBI:48279) ketanserin (CHEBI:6123) is a aromatic ketone (CHEBI:76224) ketanserin (CHEBI:6123) is a organofluorine compound (CHEBI:37143) ketanserin (CHEBI:6123) is a piperidines (CHEBI:26151) ketanserin (CHEBI:6123) is a quinazolines (CHEBI:38530) ketanserin (CHEBI:6123) is conjugate base of ketanserin(1+) (CHEBI:183638)

Incoming	ketanserin(1+) (CHEBI:183638) is conjugate acid of ketanserin (CHEBI:6123)

IUPAC Name

3-{2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl}quinazoline-2,4(1H,3H)-dione

Synonyms	Sources
3-[2-[4-(4-fluorobenzoyl)-1-piperidyl]ethyl]-1H-quinazoline-2,4-dione	IUPHAR
Ketanserin	KEGG COMPOUND

Last Modified

09 November 2021