CHEBI:68437 - 5,6,7,8-tetrahydrofolate(2−)

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ChEBI Name 5,6,7,8-tetrahydrofolate(2−)
ChEBI ID CHEBI:68437
ChEBI ASCII Name 5,6,7,8-tetrahydrofolate(2-)
Definition A dicarboxylic acid anion arising from deprotonation of both carboxylic acid functions of 5,6,7,8-tetrahydrofolic acid; major structure at pH 7.3
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Anne Morgat
Supplier Information ZINC000095627837
Download Molfile XML SDF
Formula C19H21N7O6
Net Charge -2
Average Mass 443.41330
Monoisotopic Mass 443.15643
InChI InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11?,12-/m0/s1
InChIKey MSTNYGQPCMXVAQ-KIYNQFGBSA-L
SMILES Nc1nc2NCC(CNc3ccc(cc3)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)Nc2c(=O)[nH]1
Roles Classification
Biological Role(s): water-soluble vitamin (role)
Any vitamin that dissolves in water and readily absorbed into tissues for immediate use. Unlike the fat-soluble vitamins, they are not stored in the body and need to be replenished regularly in the diet and will rarely accumulate to toxic levels since they are quickly excreted from the body via urine.
(via B vitamin )
Application(s): nutraceutical
A product in capsule, tablet or liquid form that provide essential nutrients, such as a vitamin, an essential mineral, a protein, an herb, or similar nutritional substance.
(via B vitamin )
View more via ChEBI Ontology
ChEBI Ontology
Outgoing 5,6,7,8-tetrahydrofolate(2−) (CHEBI:68437) is a dicarboxylic acid dianion (CHEBI:28965)
5,6,7,8-tetrahydrofolate(2−) (CHEBI:68437) is a tetrahydrofolate (CHEBI:67016)
5,6,7,8-tetrahydrofolate(2−) (CHEBI:68437) is conjugate base of 5,6,7,8-tetrahydrofolic acid (CHEBI:20506)
Incoming 5-methyltetrahydrofolate(2−) (CHEBI:189667) has functional parent 5,6,7,8-tetrahydrofolate(2−) (CHEBI:68437)
5,6,7,8-tetrahydrofolic acid (CHEBI:20506) is conjugate acid of 5,6,7,8-tetrahydrofolate(2−) (CHEBI:68437)
IUPAC Name
(2S)-2-[(4-{[(2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl)amino]pentanedioate
Synonym Source
5,6,7,8-tetrahydrofolate UniProt
Registry Number Type Source
21098913 Reaxys Registry Number Reaxys
Last Modified
14 February 2022