ChemSpider 2D Image | ANGIOTENSIN 1-7 | C41H62N12O11

ANGIOTENSIN 1-7

  • Molecular FormulaC41H62N12O11
  • Average mass899.005 Da
  • Monoisotopic mass898.466125 Da
  • ChemSpider ID110354

  • defined stereocentres - 8 of 8 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

51833-78-4 [RN]
ANGIOTENSIN 1-7
Angiotensin I/II (1-7)
Ile(5)-angiotensin II (1-7) dizwitterion
L-Proline, L-α-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl- [ACD/Index Name]
L-α-Asparagyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolin [German] [ACD/IUPAC Name]
L-α-Aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline [ACD/IUPAC Name]
L-α-Aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline [French] [ACD/IUPAC Name]
UNII:IJ3FUK8MOF
(2S)-1-[(2S)-2-[(2S,3S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-AMINO-3-CARBOXYPROPANAMIDO]-5-[(DIAMINOMETHYLIDENE)AMINO]PENTANAMIDO]-3-METHYLBUTANAMIDO]-3-(4-HYDROXYPHENYL)PROPANAMIDO]-3-METHYLPENTANAMIDO]-3-(3H-IMIDAZOL-4-YL)PROPANOYL]PYRROLIDINE-2-CARBOXYLIC ACID
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

39386-80-6; 51833-78-4 [DBID]
8753045 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Chemical Class:

      An angiotensin compound consisting of the linear heptapeptide sequence <stereo>L</stereo>-Asp-<stereo>L</stereo>-Arg-<stereo>L</stereo>-Val-<stereo>L</stereo>-Tyr-<stereo>L</stereo>-Ile-<stereo>L</ste reo>-His-<stereo>L</stereo>-Pro. ChEBI CHEBI:55438, CHEBI:58922
      An angiotensin compound consisting of the linear heptapeptide sequence L-Asp-L-Arg-L-Val-L-Tyr-L-Ile-L-His-L-Pro. ChEBI CHEBI:55438
      Dizwitterionic form of Ile(5)-angiotensin II (1-7) having both carboxy groups deprotonated and the aspartyl amino group and arginine side-chain protonated. ChEBI CHEBI:58922
      Dizwitterionic form of Ile<smallsup>5</smallsup>-angiotensin II (1-7) having both carboxy groups deprotonated and the aspartyl amino group and arginine side-chain protonated. ChEBI CHEBI:55438, CHEBI:58922

    • Bio Activity:

      7-TM Receptors Tocris Bioscience 1562
      Angiotensin (1-7) is a endogenous peptide fragment which can induces vasorelaxation through release of NO and prostaglandins, perhaps through activation of a non-AT1, non-AT2 receptor, Mas.; IC50 value:; Target: ; in vitro: Treatment with Ang-(1-7) reversed MGA-induced cellular hypertrophy and myofibroblast transition evidenced by reduced immunostaining and protein expression of ?-smooth muscle actin (?-SMA) [0.4?0.1 vs. MedChem Express HY-12403
      Angiotensin Receptor MedChem Express HY-12403
      Angiotensin Receptors Tocris Bioscience 1562
      Endogenous peptide fragment. Induces vasorelaxation through release of NO and prostaglandins, perhaps through activation of a non-AT1, non-AT2 receptor, Mas. Counteracts the vasoconstrictive and proli ferative effects of angiotensin II and stimulates vasopressin (anti-diuretic hormone) release in vivo. Tocris Bioscience 1562
      Endogenous peptide fragment. Induces vasorelaxation through release of NO and prostaglandins, perhaps through activation of a non-AT1, non-AT2 receptor, Mas. Counteracts the vasoconstrictive and proliferative effects of angiotensin II and stimulates vasopressin (anti-diuretic hormone) release in vivo. Tocris Bioscience 1562
      GPCR/G protein MedChem Express HY-12403
      GPCR/G protein; MedChem Express HY-12403
      Peptide Receptors Tocris Bioscience 1562
      Vasorelaxant peptide Tocris Bioscience 1562

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.5±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.666
Molar Refractivity: 226.6±0.5 cm3
#H bond acceptors: 23
#H bond donors: 15
#Freely Rotating Bonds: 26
#Rule of 5 Violations: 3
ACD/LogP: 0.24
ACD/LogD (pH 5.5): -4.64
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): -3.81
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 1.00
Polar Surface Area: 377 Å2
Polarizability: 89.8±0.5 10-24cm3
Surface Tension: 63.2±7.0 dyne/cm
Molar Volume: 609.7±7.0 cm3

Click to predict properties on the Chemicalize site


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