Abstract
This paper investigates the influence of the Raf Kinase In- hibitor Protein (RKIP) on the Extracellular signal Regulated Kinase (ERK) signaling pathway through mathematical modeling and simula- tion. Using nonlinear ordinary differential equations to represent bio- chemical reactions in the pathway, we suggest a technique for parameter estimation, utilizing time series data of proteins involved in the signal- ing pathway. The mathematical model allows the simulation the sensi- tivity of the ERK pathway to variations of initial RKIP and ERK-PP (phosphorylated ERK) concentrations along with time. Throughout the simulation study, we can qualitatively validate the proposed mathemati- cal model compared with experimental results.
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Kwang-Hyun, C., Sung-Young, S., Hyun-Woo, K., Wolkenhauer, O., McFerran, B., Kolch, W. (2003). Mathematical Modeling of the Influence of RKIP on the ERK Signaling Pathway. In: Priami, C. (eds) Computational Methods in Systems Biology. CMSB 2003. Lecture Notes in Computer Science, vol 2602. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-36481-1_11
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DOI: https://doi.org/10.1007/3-540-36481-1_11
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