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Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Hanan L. Messiha conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper.

Edward Kent performed the experiments, analyzed the data, wrote the paper.

Naglis Malys conceived and designed the experiments, performed the experiments, contributed reagents/materials/analysis tools, wrote the paper.

Kathleen M. Carroll performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper.

Pedro Mendes conceived and designed the experiments, wrote the paper.

Kieran Smallbone conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper.

Grant Disclosures

The following grant information was disclosed by the authors:

BBSRC and EPSRC grant BB/C008219, Pfizer and BBSRC grant BB/G529859,

EU FP7 grant 289434,

BBSRC grants BB/J019259 and BB/K019783,

NIH grant R01-GM080219

Data Deposition

The following information was supplied regarding the deposition of related data:

BioModels database, MODEL1311290000

BioModels database, MODEL1311290001

Funding

We thank the BBSRC and EPSRC for their financial support of this work (grant BB/C008219/1) through the Manchester Centre for Integrative Systems Biology. EK was funded by Pfizer Inc. and BBSRC (grant BB/G529859). KS and PM are grateful for the financial support of the EU FP7 project BioPreDyn (grant 289434). PM was also funded by BBSRC (grants BB/J019259 and BB/K019783) and NIH (R01-GM080219). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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