KEGG   ENZYME: 1.12.1.5
Entry
EC 1.12.1.5                 Enzyme                                 
Name
hydrogen dehydrogenase [NAD(P)+];
hydrogenase II (ambiguous)
Class
Oxidoreductases;
Acting on hydrogen as donor;
With NAD+ or NADP+ as acceptor
Sysname
hydrogen:NAD(P)+ oxidoreductase
Reaction(IUBMB)
H2 + NAD(P)+ = H+ + NAD(P)H [RN:R00700 R07181]
Reaction(KEGG)
R00700 R07181
Substrate
H2 [CPD:C00282];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
H+ [CPD:C00080];
NADH [CPD:C00004];
NADPH [CPD:C00005]
Comment
A nickel, iron, iron-sulfur protein. The enzyme from the archaeon Pyrococcus furiosus is part of a heterotetrameric complex where the alpha and delta subunits function as a hydrogenase while the beta and gamma subunits function as sulfur reductase (EC 1.12.98.4, sulfhydrogenase). Different from EC 1.12.1.3, hydrogen dehydrogenase (NADP+).
History
EC 1.12.1.5 created 2013
Orthology
K17993  sulfhydrogenase subunit alpha
K17994  sulfhydrogenase subunit delta
Genes
PFU: PF0893 PF0894 PF1331 PF1332
PFI: PFC_03675 PFC_03680 PFC_05870 PFC_05875
PHO: PH1292(PH1292) PH1294(PH1294)
PAB: PAB0640(hydD-2) PAB0641(hydA-2) PAB1786 PAB1787
PYN: PNA2_1551 PNA2_1553 PNA2_1665 PNA2_1666
PYA: PYCH_00040 PYCH_00050 PYCH_08370 PYCH_08380
PYS: Py04_0892 Py04_0893 Py04_1129 Py04_1130
PYC: TQ32_02785 TQ32_02790 TQ32_03115 TQ32_03120
TKO: TK2069 TK2070
TON: TON_0052 TON_0053 TON_0534 TON_0535
TSI: TSIB_0284 TSIB_0285 TSIB_1522 TSIB_1523
TBA: TERMP_00069 TERMP_00070 TERMP_00536 TERMP_00537
THE: GQS_02470 GQS_02475 GQS_04985 GQS_04990
THA: TAM4_296 TAM4_701 TAM4_99
THM: CL1_0143 CL1_0144 CL1_0643 CL1_0644
TLT: OCC_03062 OCC_03067 OCC_12216 OCC_12221
THS: TES1_0166 TES1_0167
TNU: BD01_0437 BD01_0438 BD01_2067 BD01_2068
TEU: TEU_09725 TEU_09730
TGY: X802_03245 X802_03250 X802_07560 X802_07565
THV: ADU37_CDS02170 ADU37_CDS02180 ADU37_CDS16280 ADU37_CDS16290
TCH: CHITON_0949 CHITON_0950 CHITON_1019 CHITON_1020
TPEP: A0127_05275 A0127_05280 A0127_07135 A0127_07140
TPIE: A7C91_06185 A7C91_06190 A7C91_08725 A7C91_08730
TGG: A3K92_08480 A3K92_08485
TCE: A3L02_00965 A3L02_00970 A3L02_02385 A3L02_02390
TBS: A3L01_00920 A3L01_00925 A3L01_03415 A3L01_03420
THH: CDI07_00920 CDI07_00925 CDI07_03355 CDI07_03360
TSL: A3L11_04675 A3L11_04680 A3L11_07375 A3L11_07380
TTD: A3L14_02375 A3L14_02380 A3L14_05100 A3L14_05105
TPRF: A3L09_05685 A3L09_05690 A3L09_05740 A3L09_05745
TRL: A3L10_03150 A3L10_03155 A3L10_05635 A3L10_05640
TPAF: A3L08_06480 A3L08_06485
THY: A3L12_05480 A3L12_05485
TIC: FH039_02775 FH039_02780 FH039_05970 FH039_05975
TCQ: TIRI35C_0406(shyA) TIRI35C_0407(shyD) TIRI35C_0918(hydA) TIRI35C_0919(hydD)
THEM: FPV09_03375 FPV09_03380 FPV09_06575 FPV09_06580
THEI: K1720_00335 K1720_00340 K1720_04545 K1720_04550
PPAC: PAP_01490 PAP_01495 PAP_03250 PAP_03255
KCR: Kcr_0321 Kcr_0322
BARB: AOA66_1503(shyD) AOA66_1504(hydA)
 » show all
Reference
1  [PMID:10714990]
  Authors
Ma K, Weiss R, Adams MW
  Title
Characterization of hydrogenase II from the hyperthermophilic archaeon Pyrococcus furiosus and assessment of its role in sulfur reduction.
  Journal
J Bacteriol 182:1864-71 (2000)
DOI:10.1128/JB.182.7.1864-1871.2000
  Sequence
[pfu:PF1332 PF1331]
Other DBs
ExplorEnz - The Enzyme Database: 1.12.1.5
IUBMB Enzyme Nomenclature: 1.12.1.5
ExPASy - ENZYME nomenclature database: 1.12.1.5
BRENDA, the Enzyme Database: 1.12.1.5

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Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG REACTION (2)   
Gene (147)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (145)   
Protein sequence (159)   
   UniProt (26)   
   SWISS-PROT (2)   
   RefSeq(pep) (131)   
DNA sequence (97)   
   RefSeq(nuc) (81)   
   GenBank (8)   
   EMBL (8)   
Protein domain (8)   
   InterPro (8)   
All databases (419)   

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