Entry
Name
ferredoxin hydrogenase;
H2 oxidizing hydrogenase;
H2 producing hydrogenase [ambiguous];
bidirectional hydrogenase;
hydrogen-lyase [ambiguous];
hydrogenase (ferredoxin);
hydrogenase I;
hydrogenase II;
hydrogenlyase [ambiguous];
uptake hydrogenase [ambiguous]
Class
Oxidoreductases;
Acting on hydrogen as donor;
With an iron-sulfur protein as acceptor
BRITE hierarchy
Sysname
hydrogen:ferredoxin oxidoreductase
Reaction(IUBMB)
H2 + 2 oxidized ferredoxin = 2 reduced ferredoxin + 2 H+ [RN:
R00019 ]
Reaction(KEGG)
Substrate
Product
Comment
Contains iron-sulfur clusters. The enzymes from some sources contains nickel. Can use molecular hydrogen for the reduction of a variety of substances.
History
EC 1.12.7.2 created 1961 as EC 1.98.1.1, transferred 1965 to EC 1.12.1.1, transferred 1972 to EC 1.12.7.1, transferred 1978 to EC 1.18.3.1, transferred 1984 to EC 1.18.99.1, transferred 2002 to EC 1.12.7.2
Orthology
K00533 ferredoxin hydrogenase large subunit
K00534 ferredoxin hydrogenase small subunit
K06441 ferredoxin hydrogenase gamma subunit
K18016 membrane-bound hydrogenase subunit alpha
K18017 membrane-bound hydrogenase subunit beta
K18023 membrane-bound hydrogenase subunit mbhJ
Genes
SON : SO_3920(hydA) SO_3921(hydB)
SHE : Shewmr4_3250 Shewmr4_3251
SHN : Shewana3_0710 Shewana3_0711
SHF : CEQ32_19975 CEQ32_19980
SBJ : CF168_17235 CF168_17240
SCAA : TUM17387_33930(hydA) TUM17387_33940(hydB)
SXM : MKD32_03735(hydB) MKD32_03740(hydA)
SCHK : GII14_05570 GII14_19195 GII14_19200
SDEO : D0436_04965(hydB) D0436_04970(hydA)
SWS : I6J16_02785 I6J16_10810 I6J16_10815
RLAC : QMO75_14150 QMO75_14155
ALI : AZOLI_p20532(cooL1) AZOLI_p40581(cooL2)
CRX : CRECT_1405 CRECT_1406
CMED : FE773_04180 FE773_06940
PPD : Ppro_0594 Ppro_2783 Ppro_2791 Ppro_3524 Ppro_3525
DDS : Ddes_1502 Ddes_1503 Ddes_1882
DFI : AXF13_01430 AXF13_01435 AXF13_11600
DPG : DESPIGER_1380 DESPIGER_1381 DESPIGER_2247
DEF : CNY67_02785 CNY67_09530 CNY67_09535
PSYF : N1030_15410 N1030_15415
DSB : LN040_08630 LN040_08635
DCB : C3Y92_14580 C3Y92_14585
DDE : Dde_0081 Dde_0082 Dde_2280 Dde_2281
DMS : E8L03_18925 E8L03_18930
DSA : Desal_1332 Desal_1333
DHY : DESAM_22768(hydB) DESAM_22769(hydA)
DAS : Daes_0301 Daes_0302 Daes_0598 Daes_0599
PPRF : DPRO_0997(hndD) DPRO_0999(hydA) DPRO_1000(hydB)
PSEF : PSDVSF_31430 PSDVSF_31440(hydA_2)
PPOR : JCM14722_10470(hydA)
PNW : SYK_30860 SYK_30870(hydA)
DSX : GD604_04685 GD604_04690
DSD : GD606_03045 GD606_03050 GD606_05420 GD606_05425
PBIZ : LWC08_02130(nuoB) LWC08_02370(nuoB) LWC08_11100 LWC08_11105
DVU : DVU_1769(hydA) DVU_1770(hydB) DVU_1771(hydC) DVU_2288
DVL : Dvul_0967 Dvul_1384 Dvul_1385 Dvul_1386
DVG : Deval_1527 Deval_1528 Deval_1529 Deval_2122
DOA : AXF15_03285 AXF15_03290
THEW : TDMWS_19700(hydB) TDMWS_19710(hydA)
DEK : DSLASN_44700(hydA_1) DSLASN_44710(hydB_1) DSLASN_44720(hydA_2) DSLASN_44730(hydB_2)
DTI : Desti_5160 Desti_5161
TID : Thein_0497 Thein_0498
CRW : CROST_002350 CROST_028220(ndhI_1)
CFB : CLFE_000670 CLFE_026720(ndhI_2)
CAUN : CLAUR_002770(ndhI_1) CLAUR_027730
SARJ : HH195_03980 HH195_07660 HH195_10480
SRI : SELR_07900(hydA) SELR_07910(hydB)
TNR : Thena_0637 Thena_1518 Thena_1519
EPO : Epro_0038(nuoC) Epro_0039(echE)
ACO : Amico_1264 Amico_1265 Amico_1266
TLI : Tlie_1201 Tlie_1202 Tlie_1203
AMO : Anamo_1448 Anamo_1449 Anamo_1450
PPIO : CE91St28_20420 CE91St28_20430 CE91St28_20440
PYY : RAH42_03875 RAH42_03880 RAH42_03885
ARAM : KAR29_07960 KAR29_07970(nuoB)
DTE : Dester_0139 Dester_0140
KPF : IX53_06775 IX53_06785
CPO : COPRO5265_0922 COPRO5265_0933
TYE : THEYE_A0988 THEYE_A1725 THEYE_A1726
BANA : BARAN1_0180(MbhJ) BARAN1_0181(MbhK) BARAN1_0182(MbhL)
BIH : BIP78_0245 BIP78_0246 BIP78_0247
PFU : PF1432 PF1433 PF1434
PFI : PFC_06385 PFC_06390 PFC_06395
PHO : PH1434(PH1434) PH1435(PH1435) PH1437(PH1437)
PAB : PAB1890 PAB1891 PAB1892
PYN : PNA2_0024 PNA2_0025 PNA2_0026
PYA : PYCH_11320 PYCH_11330 PYCH_11340
PYS : Py04_1314 Py04_1315 Py04_1316
PYC : TQ32_09910 TQ32_09915 TQ32_09920
TKO : TK2089 TK2090 TK2091
TON : TON_1024 TON_1591 TON_1592 TON_1593
TGA : TGAM_0036(mbhL) TGAM_0037(mbhK) TGAM_0038(mbhJ)
TSI : TSIB_1284 TSIB_1285 TSIB_1286 TSIB_1298 TSIB_1299 TSIB_1300
TBA : TERMP_01146 TERMP_01473 TERMP_01474 TERMP_01475 TERMP_01487 TERMP_01488 TERMP_01489
THE : GQS_07460 GQS_07465 GQS_07470 GQS_07530 GQS_07535 GQS_07540
THA : TAM4_1143 TAM4_1158 TAM4_1377
THM : CL1_1131 CL1_1132 CL1_1133
TLT : OCC_08599 OCC_08604 OCC_08609 OCC_08669 OCC_08674 OCC_08679
THS : TES1_1204 TES1_1453 TES1_1454 TES1_1455 TES1_1467 TES1_1468 TES1_1469
TNU : BD01_1882 BD01_1883 BD01_1884
TEU : TEU_02000 TEU_02005 TEU_02010
TGY : X802_04245 X802_04250 X802_04255
THV : ADU37_CDS05850 ADU37_CDS05860 ADU37_CDS05870 ADU37_CDS05990 ADU37_CDS06000 ADU37_CDS06010
TCH : CHITON_1644 CHITON_1645 CHITON_1646
TPEP : A0127_05340 A0127_05345 A0127_05350
TPIE : A7C91_04180 A7C91_04185
TGG : A3K92_08545 A3K92_08550 A3K92_08555
TCE : A3L02_07790 A3L02_07795 A3L02_07800
TBS : A3L01_08715 A3L01_08720 A3L01_08725 A3L01_08785 A3L01_08790 A3L01_08795
THH : CDI07_08695 CDI07_08700 CDI07_08705 CDI07_08765 CDI07_08770 CDI07_08775
TSL : A3L11_02185 A3L11_02190 A3L11_02195 A3L11_02255 A3L11_02260 A3L11_02265
TTD : A3L14_11280 A3L14_11285 A3L14_11290 A3L14_11350 A3L14_11355 A3L14_11360
TPRF : A3L09_01690 A3L09_01695 A3L09_01700
TRL : A3L10_08195 A3L10_08200 A3L10_08205 A3L10_08265 A3L10_08270 A3L10_08275
TPAF : A3L08_01780 A3L08_01785 A3L08_01790
THY : A3L12_04505 A3L12_04510 A3L12_04515
TIC : FH039_00320(nuoB) FH039_00325 FH039_00330 FH039_00390 FH039_00395 FH039_00400
TCQ : TIRI35C_2081(mbhJ) TIRI35C_2082(mbhK) TIRI35C_2083(mbhL) TIRI35C_2095(mbhJ) TIRI35C_2096 TIRI35C_2097(mbhL)
THEM : FPV09_08550 FPV09_08555 FPV09_08560 FPV09_08620 FPV09_08625 FPV09_08630
THEI : K1720_09530 K1720_09535 K1720_09540 K1720_09600 K1720_09605 K1720_09610
PPAC : PAP_01140 PAP_01145 PAP_01150 PAP_01210 PAP_01215 PAP_01220
MHU : Mhun_2588 Mhun_2589 Mhun_2590
MRTJ : KHC33_03665 KHC33_03670 KHC33_03675
MLA : Mlab_0957 Mlab_0958 Mlab_0959
MPI : Mpet_1573 Mpet_1574 Mpet_1575
MEFW : F1737_06400 F1737_06405 F1737_06410
MOU : OU421_00930 OU421_00940
MESB : L1S32_02060 L1S32_02065 L1S32_02070
HALA : Hrd1104_02775 Hrd1104_02780
MEAM : MU439_05905 MU439_05910 MU439_05915
MEAE : QEN48_04235 QEN48_04240 QEN48_04245
ABI : Aboo_0673 Aboo_0674 Aboo_0675
ACF : AciM339_1163 AciM339_1164 AciM339_1165
DFD : Desfe_0340 Desfe_1141
DMU : Desmu_0053 Desmu_0818
TAG : Tagg_0051 Tagg_0624 Tagg_0625
IAG : Igag_1912 Igag_1913 Igag_1914
THG : TCELL_1276 TCELL_1277
BARC : AOA65_1904(mbhK) AOA65_1922(mbhL) AOA65_1923(mbhJ)
» show all
Taxonomy
Reference
1
Authors
Shug, A.L., Wilson, P.W., Green, D.E. and Mahler, H.R.
Title
The role of molybdenum and flavin in hydrogenase.
Journal
J Am Chem Soc 76:3355-3356 (1954)
Reference
2
Authors
Tagawa, K. and Arnon, D.I.
Title
Ferredoxin as electron carriers in photosynthesis and in the bioogical production and consumption of hydrogen gas.
Journal
Nature (Lond) 195:537-543 (1962)
Reference
3
Authors
Valentine, R.C., Mortenson, L.E. and Carnahan, J.E.
Title
The hydrogenase system of Clostridium pasteurianum.
Journal
J Biol Chem 238:1141-1144 (1963)
Reference
Authors
Zumft WG, Mortenson LE.
Title
The nitrogen-fixing complex of bacteria.
Journal
Reference
Authors
Adams MW.
Title
The structure and mechanism of iron-hydrogenases.
Journal
Reference
Authors
Peters JW, Lanzilotta WN, Lemon BJ, Seefeldt LC
Title
X-ray crystal structure of the Fe-only hydrogenase (CpI) from Clostridium pasteurianum to 1.8 angstrom resolution.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.12.7.2
ExPASy - ENZYME nomenclature database: 1.12.7.2
UM-BBD (Biocatalysis/Biodegradation Database): 1.12.7.2