Entry
Name
NAD(P)+ transhydrogenase;
soluble transhydrogenase;
pyridine nucleotide transhydrogenase;
transhydrogenase (ambiguous);
nicotinamide adenine dinucleotide (phosphate) transhydrogenase (ambiguous);
NAD+ transhydrogenase (ambiguous);
NADH transhydrogenase (misleading);
nicotinamide nucleotide transhydrogenase (ambiguous);
NADPH-NAD+ transhydrogenase (ambiguous);
pyridine nucleotide transferase (ambiguous);
NADPH-NAD+ oxidoreductase (ambiguous);
NADH-NADP+-transhydrogenase (ambiguous);
NADPH:NAD+ transhydrogenase;
H+-Thase (ambiguous);
non-energy-linked transhydrogenase (ambiguous);
sthA (gene name)
Class
Oxidoreductases;
Acting on NADH or NADPH;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
NADPH:NAD+ oxidoreductase
Reaction(IUBMB)
NADPH + NAD+ = NADP+ + NADH [RN:
R00112 ]
Reaction(KEGG)
Substrate
Product
Comment
A flavoprotein (FAD). The main function of the enzyme is to oxidize excess of NADPH, forming NADH that supplies electrons to the respiratory chain. cf. EC
7.1.1.1 , proton-translocating NAD(P)+ transhydrogenase. This entry stands for enzymes whose stereo-specificity with respect to NADPH is not known. [cf. EC
1.6.1.1 , NAD(P)+ transhydrogenase (Si-specific)].
History
EC 1.6.1.3 created 2013
Reference
Authors
KEISTER DL, SAN PIETRO A, STOLZENBACH FE
Title
Pyridine nucleotide transhydrogenase from spinach. I. Purification and properties.
Journal
J Biol Chem 235:2989-96 (1960)
Reference
Authors
Sauer U, Canonaco F, Heri S, Perrenoud A, Fischer E
Title
The soluble and membrane-bound transhydrogenases UdhA and PntAB have divergent functions in NADPH metabolism of Escherichia coli.
Journal
Reference
3
Authors
Zhao, H., Wang, P., Huang, E., Ge, Y. and Zhu, G.
Title
Physiologic roles of soluble pyridine nucleotide transhydrogenase in Escherichia coli as determined by homologous recombination.
Journal
Ann Microbiol 58:275-280 (2008)
Reference
Authors
Cao Z, Song P, Xu Q, Su R, Zhu G.
Title
Overexpression and biochemical characterization of soluble pyridine nucleotide transhydrogenase from Escherichia coli.
Journal
Reference
Authors
Partipilo M, Yang G, Mascotti ML, Wijma HJ, Slotboom DJ, Fraaije MW.
Title
A conserved sequence motif in the Escherichia coli soluble FAD-containing pyridine nucleotide transhydrogenase is important for reaction efficiency.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 1.6.1.3
ExPASy - ENZYME nomenclature database: 1.6.1.3
BRENDA, the Enzyme Database: 1.6.1.3