Entry
Name
methylene-fatty-acyl-phospholipid synthase;
unsaturated-phospholipid methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (methenylating)
Reaction(IUBMB)
S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid [RN:
R03410 ]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
phospholipid olefinic fatty acid [CPD:
C01229 ]
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
phospholipid methylene fatty acid [CPD:
C04215 ]
Comment
The enzyme transfers a methyl group to the 10-position of a Delta-olefinic acyl chain in phosphatidylglycerol or phosphatidylinositol or, more slowly, phosphatidylethanolamine; subsequent proton transfer produces a 10-methylene group (cf. EC
2.1.1.79 cyclopropane-fatty-acyl-phospholipid synthase).
History
EC 2.1.1.16 created 1972, modified 1986
Reference
Authors
Akamatsu Y, Law JH.
Title
Enzymatic alkylenation of phospholipid fatty acid chains by extracts of Mycobacterium phlei.
Journal
J Biol Chem 245:701-8 (1970)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.16
ExPASy - ENZYME nomenclature database: 2.1.1.16