KEGG ENZYME: 3.2.2.6

ENZYME: 3.2.2.6

Entry

EC 3.2.2.6                  Enzyme

Name

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase;
NAD+ nucleosidase;
NADase (ambiguous);
DPNase (ambiguous);
DPN hydrolase (ambiguous);
NAD hydrolase (ambiguous);
nicotinamide adenine dinucleotide nucleosidase (ambiguous);
NAD glycohydrolase (misleading);
NAD nucleosidase (ambiguous);
nicotinamide adenine dinucleotide glycohydrolase (misleading);
CD38 (gene name);
BST1 (gene name)

Class

Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds

Sysname

NAD+ glycohydrolase (cyclic ADP-ribose-forming)

Reaction(IUBMB)

NAD+ + H2O = ADP-D-ribose + nicotinamide (overall reaction) [RN:R00102];
(1a) NAD+ = cyclic ADP-ribose + nicotinamide [RN:R10629];
(1b) cyclic ADP-ribose + H2O = ADP-D-ribose [RN:R10630]

Reaction(KEGG)

R00102 R10629 R10630

Substrate

NAD+ [CPD:C00003];
H2O [CPD:C00001];
cyclic ADP-ribose [CPD:C13050]

Product

ADP-D-ribose [CPD:C00301];
nicotinamide [CPD:C00153];
cyclic ADP-ribose [CPD:C13050]

Comment

This multiunctional enzyme acts on NAD+, catalysing both the synthesis and hydrolysis of cyclic ADP-ribose, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyses EC 2.4.99.20, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase. It is also able to act on beta-nicotinamide D-ribonucleotide. cf. EC 3.2.2.5, NAD+ glycohydrolase.

History

EC 3.2.2.6 created 1961, modified 2004, modified 2014, modified 2018

Pathway

ec00760

Nicotinate and nicotinamide metabolism

ec01100

Metabolic pathways

Orthology

K01242

ADP-ribosyl cyclase 1

K18152

ADP-ribosyl cyclase 2

Genes

HSA:	683(BST1) 952(CD38)

PTR:	461126(BST1) 745433(CD38)

PPS:	100972434(BST1) 100974952(CD38)

GGO:	101145401(BST1) 101149825(CD38)

PON:	100174150(BST1) 100457558(CD38)

NLE:	100606064(BST1) 100606960(CD38)

HMH:	116456838(CD38) 116456971(BST1)

MCC:	714399(CD38) 722848(BST1)

MCF:	101926698(BST1) 102126394(CD38)

MTHB:

126955270 126955271

MNI:	105487906(CD38) 105487910(BST1)

CSAB:

103246326(CD38) 103246328(BST1)

CATY:

105579036(CD38) 105579041(BST1)

PANU:

101017008(BST1) 101022305(CD38)

TGE:	112624454(CD38) 112625503(BST1)

MLEU:

105542530(CD38) 105542551(BST1)

RRO:	104658167(BST1) 104658170(CD38)

RBB:	108531741(CD38) 108531746(BST1)

TFN:	117085172(BST1) 117085174(CD38)

PTEH:

111539163(BST1) 111539166(CD38)

CANG:

105516574(CD38) 105516575(BST1)

CJC:	100387937(CD38) 100402445(BST1)

SBQ:	101035567(BST1) 101036203(CD38)

CIMI:

108282733(BST1) 108282737(CD38)

CSYR:

103269336(BST1)

MMUR:

105856078(CD38) 105856080(BST1)

LCAT:

123637314(BST1) 123637315(CD38)

PCOQ:

105805514(BST1) 105805529(CD38)

OGA:	100948063(CD38) 100949639(BST1)

MMU:	12182(Bst1) 12494(Cd38)

MCAL:

110294333(Bst1) 110294426(Cd38)

MPAH:

110330967(Cd38) 110330979(Bst1)

RNO:	25668(Cd38) 81506(Bst1)

MCOC:

116070677(Bst1) 116070680(Cd38)

ANU:	117701559 117712457(Cd38) 117712864(Bst1)

MUN:	110559148(Cd38) 110559149(Bst1)

CGE:	100773187(Cd38) 100773468(Bst1)

MAUA:

101825392(Cd38) 101829693(Bst1)

PROB:

127233691(Bst1) 127233692(Cd38)

PLEU:

114687856 114709224(Bst1) 114709225(Cd38)

MORG:

121436384(Cd38) 121436585(Bst1)

MFOT:

126506474 126506475

AAMP:

119803349(Bst1) 119804718(Cd38)

NGI:	103728882(Cd38) 103728884(Bst1)

HGL:	101713685(Bst1) 101720283(Cd38)

CPOC:

100726264(Bst1) 100726537(Cd38) 100735470 106026535

CCAN:

109691561(Cd38) 109691564(Bst1)

DORD:

105980149(Bst1) 105980338(Cd38)

DSP:	122104071(Bst1) 122104097(Cd38)

PLOP:

125364481(Bst1) 125364801(Cd38)

NCAR:

124994506 124994678

MMMA:

107139141(Bst1) 107139142(Cd38)

OCU:	100009409(CD38) 100351817

OPI:	101533232(CD38) 101533472(BST1)

TUP:	102468679(BST1) 102480083(CD38)

GVR:	103601094(CD38) 103606370(BST1)

CFA:	403756(CD38)

CLUD:

112653383(CD38) 125752080(BST1)

VVP:	112919977(BST1) 112919984(CD38)

VLG:	121489283(BST1) 121489687(CD38)

NPO:	129510115(CD38) 129510478(BST1)

AML:	100463977(BST1) 100481326(CD38)

UMR:	103658313(BST1) 103658362(CD38)

UAH:	113266702(BST1) 113266704(CD38)

UAR:	123775810(BST1) 123775823(CD38)

ELK:	111149117 111149296

LLV:	125093560 125093561

MPUF:

101684892(BST1) 101685175(CD38)

MNP:	132004743(BST1) 132004751(CD38)

MLK:	131825764(CD38) 131825787(BST1)

NVS:	122890459(CD38) 122890462(BST1)

ORO:	101364829(CD38) 101365133(BST1)

EJU:	114196716(CD38) 114198536(BST1)

ZCA:	113924284(CD38) 113924929(BST1)

MLX:	118010687(CD38) 118010690(BST1)

NSU:	110571283(CD38) 110581065(BST1)

LWW:	102748690(CD38) 102748987(BST1)

FCA:	101101052(BST1) 101101308(CD38)

PYU:	121038074(CD38) 121038087(BST1)

PCOO:

112858650(BST1) 112858986(CD38)

PBG:	122479020(CD38) 122479021(BST1)

PVIV:

125164260(CD38) 125164330(BST1)

LRUF:

124520126 124521280

PTG:	102955186(CD38) 102962771(BST1)

PPAD:

109269635(CD38) 109269636(BST1)

PUC:	125922651 125922652

AJU:	106975627 106975653

HHV:	120237985(CD38) 120237994(BST1)

BTA:	327677(CD38) 616757(BST1)

BOM:	102271683(BST1) 102273331(CD38)

BIU:	109560088(BST1) 109560687(CD38)

BBUB:

102400853(BST1) 102401480(CD38)

BBIS:

104982242 105001132(CD38) 105001197(BST1)

CHX:	102169848(BST1) 102172881(CD38)

OAS:	101116575(BST1) 105614340 114115250

BTAX:

128049684(BST1) 128049963(CD38)

ODA:	120861630(CD38) 120861770(BST1)

CCAD:

122428274(CD38) 122428330(BST1)

SSC:	100511702(CD38) 100625942(BST1)

CFR:	102508026(CD38) 102508256(BST1)

CBAI:

105083238(BST1) 105083239(CD38)

CDK:	105098338(BST1) 105098339(CD38)

VPC:	102538089(BST1) 102538359(CD38)

BACU:

103000954(BST1) 103020545(CD38)

BMUS:

118895218(CD38) 118895232(BST1)

LVE:	103087769(CD38) 103088314(BST1)

OOR:	101284537(CD38) 101284786(BST1)

DLE:	111171401(CD38) 111171425(BST1)

PCAD:

102981972(CD38) 102982819(BST1)

PSIU:

116754512(CD38) 116754525(BST1)

NASI:

112397560(CD38) 112397568(BST1)

ECB:	100068959(CD38) 100068968(BST1)

EPZ:	103565758(BST1) 103565759(CD38)

EAI:	106827091(CD38) 106827092(BST1)

MYB:	102252244(CD38) 102252530(BST1)

MYD:	102759158(CD38) 102770056(BST1)

MMYO:

118666927(BST1) 118666935(CD38)

MLF:	102434861(CD38) 102437542(BST1)

PKL:	118708737(CD38) 118725690(BST1)

EFUS:

103294529(CD38) 103294530(BST1)

DRO:	112316691(BST1) 112316692(CD38)

SHON:

118986595(CD38) 118989556(BST1)

AJM:	119035514(CD38) 119035581(BST1)

PDIC:

114491309(CD38) 114493375(BST1)

PHAS:

123815823(CD38) 123815824(BST1)

MMF:	118615378(BST1) 118641660(CD38)

PPAM:

129077456(BST1) 129077688(CD38)

HAI:	109372167(CD38) 109372831(BST1)

RFQ:	117021922 117021923 117022444(BST1)

PALE:

102884937(BST1) 102889755(CD38)

PGIG:

120582708(BST1) 120582820(CD38)

PVP:	105295961(BST1) 105295966(CD38)

RAY:	107507351(CD38) 107507352(BST1)

MJV:	108403411(BST1) 108408183(CD38)

TOD:	119260627 119260628 119260630 119260888(BST1) 119261103 119261298

SARA:

101539895(BST1) 101540160(CD38)

LAV:	100659997(BST1) 100660287(CD38)

TMU:	101346112 101346368

ETF:	101649299 101649935 101650242(CD38)

DNM:	101429299(BST1) 101429735(CD38)

MDO:	100015733(BST1) 103094598(CD38)

GAS:	123252450(BST1) 123252910(CD38)

SHR:	100915627(BST1) 105751033(CD38)

AFZ:	127540591 127541917

PCW:	110212831(BST1) 110212844(CD38)

OAA:	100074315(CD38) 100079912(BST1)

GGA:	422827(CD38) 422828(BST1)

PCOC:

116225809(BST1) 116225812

MGP:	100546297 100548136(CD38)

CJO:	107313950(BST1) 107313951(CD38)

TPAI:

128080133 128080300(BST1)

LMUT:

125691785 125691786

NMEL:

110398571(CD38) 110398576

ACYG:

106035386(BST1)

CATA:

118259455 118259458

AFUL:

116489206 116489217(CD38)

TGU:	100224783(BST1) 101232999(CD38)

LSR:	110484008 110484039

SCAN:

103824309(BST1) 103824319

PMOA:

120497359 120497360(CD38)

OTC:	121335091 121335188

PRUF:

121348778(BST1) 121365982(CD38)

GFR:	102032481(BST1) 102032646(CD38)

FAB:	101808664(BST1) 101813225(CD38)

OMA:	130252738(CD38) 130252873(BST1)

PHI:	102100836(CD38) 102101014

PMAJ:

107203272 107203546

CCAE:

111928170 111928172

CCW:	104690721 104690901(CD38)

CBRC:

103625592(CD38) 103625593

ETL:	114061133(BST1) 114061141

ZAB:	102061886 102065942

ACHL:

103810025(BST1) 103810718(CD38)

SVG:	106857245(BST1) 106857250(CD38)

MMEA:

130578391 130578393

HRT:	120753271 120753523

FPG:	101912278(CD38) 101917967(BST1)

FCH:	102048375 102048871

CLV:	102089855(BST1)

EGZ:	104134476(BST1) 104134477(CD38)

NNI:	104010763(CD38) 104010764(BST1)

PCRI:

104026992(CD38) 104030339(BST1)

PLET:

104613827(CD38) 104619105(BST1)

EHS:	104508986(BST1) 104515266(CD38)

PCAO:

104040776(BST1) 104051866(CD38)

ACUN:

113479380 113479383(BST1)

TALA:

104357985(CD38) 104360998(BST1)

PADL:

103916996(CD38) 103916997(BST1)

AFOR:

103898760 103898761

ACHC:

115341987(BST1) 115342015(CD38)

HALD:

104312688(BST1) 104325930(CD38)

HLE:	104837598(CD38) 104837599(BST1)

AGEN:

126034359 126034378

GCL:	127015977 127016135

CCRI:

104161112(CD38) 104163056(BST1)

CSTI:

104549352(CD38)

CMAC:

104473039(CD38) 104475413(BST1)

MUI:	104534000(CD38) 104536118(BST1)

BREG:

104629678(CD38) 104631650(BST1)

FGA:	104080203(CD38)

GSTE:

104263570(BST1) 104263989(CD38)

LDI:	104340997(CD38) 104353367(BST1)

MNB:	103776747(BST1) 103781749(CD38)

OHA:	104329232(BST1) 104329258(CD38)

NNT:	104412272(CD38)

SHAB:

115610662(BST1) 115610663(CD38)

DPUB:

104309172(BST1) 104309173(CD38)

PGUU:

104458293(CD38) 104461953(BST1)

ACAR:

104523532 104523533

CPEA:

104393586(CD38) 104393587(BST1)

AVIT:

104267215(CD38) 104272885(BST1)

CVF:	104288764(BST1) 104288765(CD38)

RTD:	128910295 128910395

CUCA:

104067702(BST1) 104067733(CD38)

TEO:	104376417(BST1) 104376962(CD38)

BRHI:

104499290(CD38) 104500705(BST1)

AAM:	106498697 106498751

AROW:

112970832 112970833

NPD:	112958511 112958546

TGT:	104569372(BST1) 104580413(CD38)

DNE:	112996520 112996530

SCAM:

104143028(BST1) 104143030(CD38)

ASN:	102376962(BST1)

AMJ:	102559494(BST1)

CPOO:

109322214(BST1) 109322366(CD38)

GGN:	109303956 109304108

PSS:	102444728(BST1) 102444963(CD38)

CMY:	102933631(BST1) 102933862(CD38)

CCAY:

125636146(BST1) 125636147(CD38)

DCC:	119855170(BST1) 119855171(CD38)

CPIC:

101935271 101935553

TST:	117878308 117878553

CABI:

116821059(CD38) 116821061(BST1)

MRV:	120405962 120405963

ACS:	100566030(cd38)

ASAO:

132776366

PVT:	110085956(CD38)

SUND:

121932151(CD38)

PBI:

103059310

PMUR:

107292463

CTIG:

120300466

TSR:	106543891(CD38)

PGUT:

117660712

APRI:

131203278

PTEX:

113435891

VKO:	123017189(CD38)

PMUA:

114604446

PRAF:

128420836

ZVI:	118084020(CD38)

HCG:

128326526

GJA:	107120012(CD38)

STOW:

125439720

EMC:

129343506

XLA:	100036901(cd38.L) 101027297(bst1.L)

XTR:	101733556 496666(cd38)

NPR:	108799310(BST1) 108799313

RTEM:

120924334(CD38) 120924335

BBUF:

120990331 120990332

BGAR:

122931523 122940253(BST1)

MUO:	115461420(BST1) 115462162

GSH:

117367099

DRE:

101886891

SANH:

107693813

SGH:

107568972

CAUA:

113075268

CGIB:

128013116

PTET:

122337612

LROH:

127158671

OMC:

131533699

PPRM:

120495013

MASI:

127413750 127418175

TROS:

130550411

TDW:	130412881 130412937

MANU:

129425951 129426525

IPU:	108256685 108259605

IFU:	128599833 128602611

PHYP:

113532851 113546708

SMEO:

124375480 124380174

TFD:	113634204 113659789

TVC:	132838678 132840406

AMEX:

103029242

CMAO:

118798758 118798957

EEE:	113582404 113582405

CHAR:

105894086 105900065 105902689 105902690

TRU:	101074837 101075059 105418447

TFS:	130514094 130514096 130514097 130514099 130514100 130520404 130520406 130520895 130521000 130521379

TNG:	GSTEN00025533G001 GSTEN00025534G001

LCO:	104933795 104933796 104933803

NCC:	104942392 104946571 104946574

TBEN:

117496890 117497347 117498409 117498413

CGOB:

115025235 115025547 115025767

PGEO:

117465503 117465889 117465962

GACU:

117544669 117544769 117544771

EMAC:

134858086 134858088 134858089

ELY:	117264480 117264955 117265032 117265088

EFO:	125882281 125882284 125882285

PLEP:

121940397 121960727 121961001

SLUC:

116048591 116048593 116048594 116048595

ECRA:

117937835 117937841

ESP:	116672165 116672166

PFLV:

114549402 114549422 114549480 114549609

GAT:	120811807 120811890 120811891

PPUG:

119198455 119198456 119198459

AFB:	129110584 129111088

CLUM:

117749414 117749895

PSWI:

130206161 130206628

MSAM:

119912040 119912049

SCHU:

122866627 122866628 122866631

CUD:	121527044 121527105 121527134 121527530 121527535 121527555 121527566 121527740

ALAT:

119008641 119008766 119008934 119009095 119013827

MZE:	101478770 101479062 101479335

ONL:	100696855 100709482 100710024 102077908 102078110 106098852 109194449

OAU:	116329626 116329633 116329643 120441989 120442012 120442076

OLA:	101168159 101168658 101168676

OML:	112151048 112151449

CSAI:

133423196 133423198 133423381 133445545

XMA:	102227962 102228215 106699822

XCO:	114136499 114136564 114137010

XHE:	116711401 116711499 116711986

PRET:

103456798 103456800 103456801

PFOR:

103147559 103147560 103147569

PLAI:

106951163 106951164 106951165

PMEI:

106912836 106912857 106912868

GAF:	122823991 122823992

PPRL:

129352091 129352097 129352104

CVG:	107085442 107085455 107099405 107099407

CTUL:

119798421 119798436 119798439

GMU:	124857890 124858222 124858405

NFU:	107382594 107382595

KMR:	108230245 108230355 108230372

ALIM:

106515510 106515511

NWH:	119426679 119426680

AOCE:

111587679 111587684

MCEP:

124996073 125024413

CSEM:

103377367 103377368

POV:	109629467 109629469

SSEN:

122766606 122766860

HHIP:

117753607 117753609

HSP:	118098756 118098758

SMAU:

118287134 118287137

LCF:	108900033 108900035

SDU:	111224346 111224354

SLAL:

111673629 111673631 111673659

XGL:	120789958 120790041

HCQ:

109517521

SSCV:

125985721

SBIA:

133492935

PEE:

133396678

PTAO:

133470484

BPEC:

110165536 110165581

BSPL:

114853868 114854305 114854614 114854615

SJO:	128382486 128382843

SASA:

106590199 106590200

STRU:

115195719 115195720

OTW:	112227553 112245218

OMY:	110489876 110489879

OGO:	124039734 124039735

ONE:	115130320 115131105

OKI:	109899432 109899433

OKE:	118372679 118372691

SALP:

111953730

SNH:	120051110 120051113

CCLU:

121569932 121570630

ELS:

105031580

SFM:	108922735 108922775

PKI:	111850018 111850115

AANG:

118226015 118226024 118226025

LOC:	102689984 102690185

PSPA:

121324556 121324563 121324571 121329920

ARUT:

117408506 117420417 117421343 117421345 117421349

LCM:	102364780 106706579

RTP:

109917325

CPLA:

122551973 122555026

HOC:	132815982 132816861

LERI:

129699137 129699154

PMRN:

116941239 116941240

LRJ:	133345413 133345610

BFO:

118405736

BBEL:

109465410

SPU:	100126187(arc3) 100859964(arc4) 115918149 115918151 115922770 576085(arc2) 580868(arc1)

LPIC:

129264926 129266004 129279062 129279296 129279449

APLC:

110977913 110981710

SKO:

100370260

HRO:	HELRODRAFT_179637 HELRODRAFT_193621

LGI:	LOTGIDRAFT_150043 LOTGIDRAFT_218611

PVUL:

126821660 126830888

PCAN:

112555169 112555726 112555871

GAE:

121367392

HRF:	124117015 124117017 124117019 124122531

HRJ:	124262792 124262799 124262800 124262801 124267312

CRG:

105319809

CVN:

111133847

CANU:

128181121

OED:

125659704

MYI:	110451407 110458378

PMAX:

117342638 117342726

MMER:

123554776 123556012

RPHI:

132718611 132734862

DPOL:

127875390 127878167

LAK:	106153853 106155009 106155798 106159481 106159482 106169313 106180219

OVI:	T265_08021 T265_08022

NVE:	116618638 5503859 5505197

EPA:	110246357 110251379

ATEN:

116291709 116302029 116302620

ADF:	107339424 107340996

AMIL:

114948060 114961589

PDAM:

113669069 113675387

SPIS:

111329655

DGT:

114519185

XEN:

124439014

HMG:	100199121 100199929 100211840 101234797 101241800

HSY:	130621832 130654748 130654749 130655425 130655865

TAD:	TRIADDRAFT_19184 TRIADDRAFT_36890 TRIADDRAFT_51409

AQU:	105312071 105312710

SRE:	PTSG_13238

» show all

Reference

1 [PMID:2613697]

Authors

Imai T

Title

Purification and characterization of a pyridine nucleotide glycohydrolase from rabbit spleen.

Journal

J Biochem 106:928-37 (1989)
DOI:10.1093/oxfordjournals.jbchem.a122953

Reference

2 [PMID:8235624]

Authors

Howard M, Grimaldi JC, Bazan JF, Lund FE, Santos-Argumedo L, Parkhouse RM, Walseth TF, Lee HC

Title

Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38.

Journal

Science 262:1056-9 (1993)
DOI:10.1126/science.8235624

Reference

3 [PMID:8253715]

Authors

Takasawa S, Tohgo A, Noguchi N, Koguma T, Nata K, Sugimoto T, Yonekura H, Okamoto H

Title

Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP.

Journal

J Biol Chem 268:26052-4 (1993)

Sequence

[hsa:952]

Reference

4 [PMID:7961800]

Authors

Tohgo A, Takasawa S, Noguchi N, Koguma T, Nata K, Sugimoto T, Furuya Y, Yonekura H, Okamoto H

Title

Essential cysteine residues for cyclic ADP-ribose synthesis and hydrolysis by CD38.

Journal

J Biol Chem 269:28555-7 (1994)

Reference

5 [PMID:7663169]

Authors

Fryxell KB, O'Donoghue K, Graeff RM, Lee HC, Branton WD

Title

Functional expression of soluble forms of human CD38 in Escherichia coli and Pichia pastoris.

Journal

Protein Expr Purif 6:329-36 (1995)
DOI:10.1006/prep.1995.1043

Reference

6 [PMID:11866528]

Authors

Yamamoto-Katayama S, Ariyoshi M, Ishihara K, Hirano T, Jingami H, Morikawa K.

Title

Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities.

Journal

J Mol Biol 316:711-23 (2002)
DOI:10.1006/jmbi.2001.5386

Sequence

[hsa:683]

Reference

7 [PMID:16154090]

Authors

Liu Q, Kriksunov IA, Graeff R, Munshi C, Lee HC, Hao Q

Title

Crystal structure of human CD38 extracellular domain.

Journal

Structure 13:1331-9 (2005)
DOI:10.1016/j.str.2005.05.012

Sequence

[hsa:952]

Other DBs

ExplorEnz - The Enzyme Database:

3.2.2.6

IUBMB Enzyme Nomenclature:

3.2.2.6

ExPASy - ENZYME nomenclature database:

3.2.2.6

BRENDA, the Enzyme Database:

3.2.2.6

CAS:

9032-65-9

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