KEGG ENZYME: 3.5.1.106

ENZYME: 3.5.1.106

Entry

EC 3.5.1.106                Enzyme

Name

N-formylmaleamate deformylase;
NicD

Class

Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides

Sysname

N-formylmaleamic acid amidohydrolase

Reaction(IUBMB)

N-formylmaleamic acid + H2O = maleamate + formate [RN:R09126]

Reaction(KEGG)

R09126

Substrate

N-formylmaleamic acid [CPD:C18232];
H2O [CPD:C00001]

Product

maleamate [CPD:C01596];
formate [CPD:C00058]

Comment

The reaction is involved in the aerobic catabolism of nicotinic acid.

History

EC 3.5.1.106 created 2010

Pathway

ec00760

Nicotinate and nicotinamide metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K15357

N-formylmaleamate deformylase

Genes

NAI:	NECAME_18393

SMAR:

SM39_1769

SMAC:

SMDB11_1582

SMW:	SMWW4_v1c23240

SPE:

Spro_2310

SRR:	SerAS9_2267

SRL:	SOD_c21400(nicD)

SRY:	M621_11725

SPLY:

Q5A_011860(nicD)

SRS:	SerAS12_2267

SRA:	SerAS13_2268

SLQ:	M495_11495

SERF:

L085_17125

SQU:	E4343_04640

SFJ:	SAMEA4384070_2379

SOF:	NCTC11214_04490

SURI:

J0X03_12375

SNEM:

NLX84_11770

SNEV:

OI978_19640

GQU:	AWC35_02985

PAO:	Pat9b_5177

TCI:	A7K98_12085

TPTY:

NCTC11468_02200(fac-dex)

PPU:	PP_3943(nicD)

PPF:

Pput_1894

PPG:	PputGB1_3578

PPW:	PputW619_2141

PPT:

PPS_4059

PPB:	PPUBIRD1_1865

PPI:

YSA_08969

PPX:

T1E_5124

PPUT:

L483_21705

PPUN:

PP4_17790

PMON:

X969_19885

PMOT:

X970_19520

PALD:

LU682_010750(nicD)

PFS:

PFLU_2798

PFB:

VO64_0125

PAZO:

AYR47_21610

PMED:

E3Z27_20710

PTOL:

I7845_13255

PFW:	PF1751_v1c24690

PFF:	PFLUOLIPICF724385

PFX:	A7318_11835

PLUL:

FOB45_03915

PSK:	U771_14850

PFZ:	AV641_08720

PANR:

A7J50_2715

PSIL:

PMA3_12560

PYM:	AK972_2673

PGG:	FX982_03127

PVK:	EPZ47_21850

PEZ:	HWQ56_12825

PWY:	HU734_022650(nicD)

PTAE:

NCTC10697_01682

PPEG:

KUA23_13460

PNB:	NK667_12125

PTAI:

ICN73_23195(nicD)

PPAO:

K3169_11250

PSJY:

AA098_03895 AA098_17780 AA098_21330

AWU:	BEN71_18350

AGU:

AS4_40060

HAM:

HALO0542

HAXI:

HAALTHF_14220n

HSV:	HNO53_05760

HPRO:

LMS44_20680

HASO:

B2G49_16090

HVN:	EI420_01975

HOL:	HORIV_65070

HNP:	SR894_19000

HTT:	HZS52_07550

HTX:	EKK97_06045

ALCA:

ASALC70_00126(nicD_1) ASALC70_03087(nicD_2) ASALC70_04411(nicD_3)

ADI:

B5T_02295

MARS:

A8C75_16305

MRZ:	KDW95_18755

RPJ:	N234_04325 N234_24885

REH:	H16_A0924(h16_A0924) H16_B0812(h16_B0812)

CNC:	CNE_1c08740 CNE_2c07600

CUH:	BJN34_04905 BJN34_29425

REU:	Reut_A2513 Reut_B3787

CTI:	RALTA_A0869

CBW:	RR42_s0170 RR42_s1171

CGD:	CR3_3008(nicD)

CCUP:

BKK81_07365

CUP:	BKK80_06665

CUU:	BKK79_05485

CPAU:

EHF44_27010

COX:	E0W60_08955 E0W60_14765

CCAM:

M5D45_06900

CCAX:

KZ686_20180

CUK:	KB879_04565 KB879_08780

CNAN:

A2G96_05370

BSAV:

WS86_30275

BCM:	Bcenmc03_3485

BCH:	Bcen2424_4040

BCJ:

BCAM1143

BCEN:

DM39_3878

BCEO:

I35_4990

BMJ:	BMULJ_03961

BMU:

Bmul_4549

BMK:

DM80_3719

BMUL:

NP80_4070

BCED:

DM42_3947

BCON:

NL30_06915

BSEM:

WJ12_25615

BPSL:

WS57_08410

BMEC:

WJ16_24245

BSTG:

WT74_20830

BANN:

JFN94_22960 JFN94_25180

BARI:

NLX30_32980 NLX30_38910

BGD:	bgla_1g12680

BGO:

BM43_2600

BYI:	BYI23_D006290 BYI23_D011190

BUE:	BRPE67_DCDS08110 BRPE67_DCDS13320

BGP:	BGL_1c11610

BPLA:

bpln_1g11130

BUM:	AXG89_36970

BUI:	AX768_15620

BURK:

DM992_20100

BXE:

Bxe_C0215

BXB:

DR64_8216

BFN:

OI25_6800

BCAI:

K788_0007380

PTER:

C2L65_30590

PTRO:

G5S35_31880

PPAI:

E1956_29585

PSPU:

NA29_11645 NA29_13050

PVE:	UC34_12645

POX:	MB84_21135

PNR:	AT302_20390

CABA:

SBC2_37480(nicD_1) SBC2_53540(nicD_2)

BUO:	BRPE64_DCDS05930 BRPE64_DCDS10980

CABK:

NK8_47370 NK8_58480

BPAR:

BN117_0268 BN117_1483

BPA:	BPP0270 BPP2329

BBH:	BN112_1735 BN112_3144

BBR:	BB0273 BB1780

BBM:	BN115_0258 BN115_1682

BBX:	BBS798_0268 BBS798_1681

BAV:	BAV1530 BAV2743

BBRO:

BAU06_10305 BAU06_12290 BAU06_25030

BFZ:	BAU07_14195 BAU07_23445 BAU07_25065

BPDZ:

BBN53_17725

BOH:	AKI39_11510

BGM:	CAL15_11475 CAL15_12495

BGV:	CAL12_01125 CAL12_10375 CAL12_12825

AXY:	AXYL_02465

AXO:	NH44784_051901

AXN:	AX27061_3326

AXX:	ERS451415_03306(fac-dex)

ADT:	APT56_16395

AIS:	BUW96_02605 BUW96_28755

ASW:	CVS48_09650

ACHR:

C2U31_23375

ACHB:

DVB37_25105

APES:

FOC84_00575

AAEG:

RA224_20490

PUD:	G9Q38_04175

AKA:	TKWG_01100 TKWG_19800

AMIM:

MIM_c02040 MIM_c31090

AFA:	UZ73_10790 UZ73_14560 UZ73_14760

AFQ:	AFA_14970(nicD) AFA_15140(picE) AFA_18560(hpaD)

AAQU:

D3M96_15900 D3M96_16080

AAMM:

FE795_13830 FE795_14005

PHN:	PAEH1_03575 PAEH1_09755

ODI:

ODI_R3897

PIG:	EGT29_02750 EGT29_03385

ACK:	C380_17100

AAV:

Aave_3929

AAA:

Acav_3826

DAC:

Daci_1851

DEL:	DelCs14_4787

DTS:	BI380_15395

DHK:	BO996_08765

DLA:	I6G47_15025

VAP:	Vapar_4284

VAM:	C4F17_27980

CTES:

O987_23185

CRJ:	QMY55_00790

HYN:	F9K07_02930

HSE:	Hsero_1324

HSZ:	ACP92_06625

HEE:	hmeg3_19260

HFR:	G5S34_06835

MTIM:

DIR46_21150

XYK:	GT347_17960

XYG:	R9X41_15975

AZR:	CJ010_22085

MLN:	A9174_33980

HOE:	IMCC20628_03534

AAK:	AA2016_6583

ATA:	AWN88_01325

RLG:

Rleg_6043

RTR:	RTCIAT899_PC08595

RJG:	CCGE525_26740

RAD:	CO657_35875

RII:	FFM53_028500

RRG:	J3P73_36840

RAW:	NE851_01775

RSUL:

N2599_21410

RRHO:

PR018_21715

RTU:	PR017_19750

RBW:	RLCC275e_26415

SHZ:

shn_30290

SSUM:

Q9314_24295

BRK:	CWS35_28870

BGQ:	X265_13545

BARH:

WN72_44285

BEL:	BE61_17020

BQB:	J4P68_0007730

BBRA:

QA636_11875

BGK:	IC762_04970

BPAH:

QA639_37435

RBK:	E0H22_02835

HMC:	HYPMC_0200

PHL:

KKY_3787

AUB:	LXB15_07190

PSIN:

CAK95_12370 CAK95_14175

PPHR:

APZ00_25425

OAR:	OA238_c08160

CID:

P73_3893

CON:	TQ29_12585

PABY:

Ga0080574_TMP32

SAGU:

CDO87_22435

MALU:

KU6B_06550

PYE:	A6J80_00015

PSEW:

JHW44_20160

PFIS:

JHX87_02945

LVS:	LOKVESSMR4R_03233(nicD)

FAP:	GR316_10990

SNJ:	A7E77_04540

SMY:	BJP26_14895

SBAR:

H5V43_21645(ndpF)

GOY:	GLS_c14250

GAL:	A0U94_10305

GTI:	FXF46_02565

GSP:	IGS75_12420

GXL:

H845_1039

KEU:	S101446_01675(nicD)

KSC:	CD178_02876(nicD)

APT:	APA01_23740

APW:	APA42C_23740

APF:	APA03_23740

APU:	APA07_23740

APG:	APA12_23740

APQ:	APA22_23740

APX:	APA26_23740

APZ:	APA32_23740

APK:	APA386B_1208

ASV:	WG31_11895

APOM:

CPF11_08785

ATO:	CIW82_09440

ACET:

DS739_11625

KHA:	IFJ82_11080

NGU:	QN315_14030

ALI:	AZOLI_p20436

ABS:	AZOBR_p480010

ABQ:	ABAZ39_30185

ABF:	AMK58_25910

ATI:	AL072_30670

AZT:	TSH58p_19525

AZM:	DM194_20090 DM194_21875

AOZ:	HUE56_08290

AARE:

D3093_29345

AZS:	E6C72_22670

HADH:

FRZ61_46320

PARH:

I5S86_12080(nicD)

ROA:	Pd630_LPD07335

SVL:	Strvi_4760

SRC:	M271_44545

SMAL:

SMALA_0621

SSOI:

I1A49_06685

STRE:

GZL_07756

SNR:	SNOUR_35435

SALU:

DC74_1459

SALL:

SAZ_07820

SAUO:

BV401_06935

SBAT:

G4Z16_06585

SINE:

KI385_04395

SDUR:

M4V62_06950

SLON:

LGI35_43420

SANT:

QR300_41545

SYUN:

MOV08_36000

JME:	EEW87_17245

SAIU:

J4H86_13070

AOI:

AORI_4768

AJA:	AJAP_15800

AMQ:	AMETH_3942

AMYC:

CU254_15750

AMYY:

YIM_29085(nicD)

AACD:

LWP59_17620

AROO:

NQK81_43080

ATHM:

L1857_21430

PSEA:

WY02_22135

PSEE:

FRP1_20555

PSEH:

XF36_05350

PSEQ:

AD006_27975

PECQ:

AD017_07570

PHH:	AFB00_17885

PAUT:

Pdca_13690

PBRO:

HOP40_05470

ACTY:

OG774_13245

SBAE:

DSM104329_02316(nicD_1)

» show all

Reference

1 [PMID:18678916]

Authors

Jimenez JI, Canales A, Jimenez-Barbero J, Ginalski K, Rychlewski L, Garcia JL, Diaz E

Title

Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440.

Journal

Proc Natl Acad Sci U S A 105:11329-34 (2008)
DOI:10.1073/pnas.0802273105

Sequence

[ppu:PP_3943]

Other DBs

ExplorEnz - The Enzyme Database:

3.5.1.106

IUBMB Enzyme Nomenclature:

3.5.1.106

ExPASy - ENZYME nomenclature database:

3.5.1.106

UM-BBD (Biocatalysis/Biodegradation Database):

3.5.1.106

BRENDA, the Enzyme Database:

3.5.1.106

DBGET integrated database retrieval system